Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology.

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Published in Free Radic Biol Med on November 28, 2007

Authors

Melissa Kemp1, Young-Mi Go, Dean P Jones

Author Affiliations

1: The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.

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A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma. Clin Chim Acta (2008) 1.16

Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults. Hypertension (2008) 1.15

Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice. Gastroenterology (2009) 1.15

The nature of nurture: refining the definition of the exposome. Toxicol Sci (2013) 1.14

Quantification of redox conditions in the nucleus. Methods Mol Biol (2009) 1.13

Oxidative stress modulates PPAR gamma in vascular endothelial cells. Free Radic Biol Med (2010) 1.13

Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorectal adenoma patients: a randomized, controlled clinical trial. Cancer Prev Res (Phila) (2011) 1.13

Thiol/disulfide redox states in signaling and sensing. Crit Rev Biochem Mol Biol (2013) 1.13

Control of extracellular cysteine/cystine redox state by HT-29 cells is independent of cellular glutathione. Am J Physiol Regul Integr Comp Physiol (2007) 1.12

Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury. Am J Respir Cell Mol Biol (2008) 1.11

Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-kappaB activities. Free Radic Biol Med (2007) 1.11

Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells. Am J Physiol Regul Integr Comp Physiol (2003) 1.11

A network perspective on metabolism and aging. Integr Comp Biol (2010) 1.10

Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci (2006) 1.10

H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1. J Biol Chem (2003) 1.09

Mapping the cysteine proteome: analysis of redox-sensing thiols. Curr Opin Chem Biol (2011) 1.09

Metabolome-wide association study of neovascular age-related macular degeneration. PLoS One (2013) 1.09

Individual variation in macronutrient regulation measured by proton magnetic resonance spectroscopy of human plasma. Am J Physiol Regul Integr Comp Physiol (2009) 1.08

Current thoughts on the role of mitochondria and free radicals in the biology of aging. J Gerontol A Biol Sci Med Sci (2009) 1.08

Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with age-related macular degeneration. Am J Ophthalmol (2005) 1.08

High-performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring. Toxicology (2012) 1.08

Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake. J Nutr (2006) 1.08

Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients. JPEN J Parenter Enteral Nutr (2008) 1.07

Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia. Dis Model Mech (2012) 1.07

Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains. FASEB J (2004) 1.06

HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction. AIDS Res Ther (2009) 1.05

Discovery of metabolite features for the modelling and analysis of high-resolution NMR spectra. Int J Data Min Bioinform (2008) 1.04

Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition. Toxicol Sci (2008) 1.04

Protein Cysteines Map to Functional Networks According to Steady-state Level of Oxidation. J Proteomics Bioinform (2011) 1.04

Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of cd toxicity. Toxicol Sci (2014) 1.03

Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding. Am J Physiol Regul Integr Comp Physiol (2002) 1.02