Published in J Am Chem Soc on February 08, 2006
The potential and challenges of nanopore sequencing. Nat Biotechnol (2008) 14.24
Continuous base identification for single-molecule nanopore DNA sequencing. Nat Nanotechnol (2009) 8.09
Nanopores: A journey towards DNA sequencing. Phys Life Rev (2012) 5.89
Nanopore sensors for nucleic acid analysis. Nat Nanotechnol (2011) 4.19
Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore. Proc Natl Acad Sci U S A (2009) 3.74
A single-molecule nanopore device detects DNA polymerase activity with single-nucleotide resolution. J Am Chem Soc (2008) 3.04
Single-molecule DNA detection with an engineered MspA protein nanopore. Proc Natl Acad Sci U S A (2008) 2.91
Landscape of next-generation sequencing technologies. Anal Chem (2011) 2.58
Sequencing technologies and genome sequencing. J Appl Genet (2011) 2.52
Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge. Proc Natl Acad Sci U S A (2008) 2.11
Identification of epigenetic DNA modifications with a protein nanopore. Chem Commun (Camb) (2010) 1.93
Exploring transmembrane transport through alpha-hemolysin with grid-steered molecular dynamics. J Chem Phys (2007) 1.70
Applications of biological pores in nanomedicine, sensing, and nanoelectronics. Curr Opin Biotechnol (2010) 1.66
Multi-nanopore force spectroscopy for DNA analysis. Biophys J (2006) 1.63
Outer membrane protein G: Engineering a quiet pore for biosensing. Proc Natl Acad Sci U S A (2008) 1.48
Crystal structure of the octameric pore of staphylococcal γ-hemolysin reveals the β-barrel pore formation mechanism by two components. Proc Natl Acad Sci U S A (2011) 1.43
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores. Proc Natl Acad Sci U S A (2010) 1.41
Nanopore detection of 8-oxo-7,8-dihydro-2'-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site. J Am Chem Soc (2010) 1.39
Ionic current blockades from DNA and RNA molecules in the alpha-hemolysin nanopore. Biophys J (2007) 1.37
Controlling molecular transport through nanopores. J R Soc Interface (2011) 1.30
DNA profiling using solid-state nanopores: detection of DNA-binding molecules. Nano Lett (2009) 1.29
Nanopore sequencing: from imagination to reality. Clin Chem (2014) 1.23
Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity. Nucleic Acids Res (2008) 1.22
Nanopore analysis of individual RNA/antibiotic complexes. ACS Nano (2011) 1.14
Solid-State and Biological Nanopore for Real-Time Sensing of Single Chemical and Sequencing of DNA. Nano Today (2013) 1.13
New Generations: Sequencing Machines and Their Computational Challenges. J Comput Sci Technol (2010) 1.12
Effect of noise on DNA sequencing via transverse electronic transport. Biophys J (2009) 1.10
Single molecule sensing by nanopores and nanopore devices. Analyst (2009) 1.09
Nanopore-based fourth-generation DNA sequencing technology. Genomics Proteomics Bioinformatics (2015) 1.05
Nanopore-based identification of individual nucleotides for direct RNA sequencing. Nano Lett (2013) 1.04
Ion selectivity of alpha-hemolysin with beta-cyclodextrin adapter. II. Multi-ion effects studied with grand canonical Monte Carlo/Brownian dynamics simulations. J Phys Chem B (2010) 1.02
Single-stranded DNA within nanopores: conformational dynamics and implications for sequencing; a molecular dynamics simulation study. Biophys J (2012) 1.01
Single molecule transcription profiling with AFM. Nanotechnology (2007) 0.99
Advances in Resistive Pulse Sensors: Devices bridging the void between molecular and microscopic detection. Nano Today (2011) 0.99
Encapsulating a single G-quadruplex aptamer in a protein nanocavity. J Phys Chem B (2008) 0.98
Review of massively parallel DNA sequencing technologies. Hugo J (2011) 0.96
Translocation of single-stranded DNA through the α-hemolysin protein nanopore in acidic solutions. Electrophoresis (2011) 0.95
Slowing and controlling the translocation of DNA in a solid-state nanopore. Nanoscale (2011) 0.95
Ion selectivity of alpha-hemolysin with a beta-cyclodextrin adapter. I. Single ion potential of mean force and diffusion coefficient. J Phys Chem B (2010) 0.92
The evolution of nanopore sequencing. Front Genet (2015) 0.91
Probing Access Resistance of Solid-state Nanopores with a Scanning Probe Microscope Tip. Small (2011) 0.90
The effects of diffusion on an exonuclease/nanopore-based DNA sequencing engine. J Chem Phys (2012) 0.89
Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel. Isr J Chem (2013) 0.85
Integration of solid-state nanopores in a 0.5 μm CMOS foundry process. Nanotechnology (2013) 0.85
Nucleobase Recognition by Truncated α-Hemolysin Pores. ACS Nano (2015) 0.84
Structure and energetics of channel-forming protein-polysaccharide complexes inferred via computational statistical thermodynamics. J Phys Chem B (2006) 0.83
On the Feasibility of Using the Intrinsic Fluorescence of Nucleotides for DNA Sequencing. J Phys Chem C Nanomater Interfaces (2010) 0.83
Single-molecule investigation of G-quadruplex using a nanopore sensor. Methods (2012) 0.83
Light-regulated and cell-specific methylation of the maize PEPC promoter. J Exp Bot (2011) 0.82
Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate. Proc Natl Acad Sci U S A (2013) 0.82
Real-time label-free measurement of HIV-1 protease activity by nanopore analysis. Biosens Bioelectron (2014) 0.81
The NTD Nanoscope: potential applications and implementations. BMC Bioinformatics (2011) 0.79
Genomic sequencing in cancer. Cancer Lett (2012) 0.79
Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen. Cancer Lett (2014) 0.79
Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array. Proc Natl Acad Sci U S A (2016) 0.78
K(+) , Na(+) , and Mg(2+) on DNA translocation in silicon nitride nanopores. Electrophoresis (2012) 0.78
Next-generation sequencing: from understanding biology to personalized medicine. Biology (Basel) (2013) 0.78
Can an atomic force microscope sequence DNA using a nanopore? Biophys J (2007) 0.77
Channel-forming bacterial toxins in biosensing and macromolecule delivery. Toxins (Basel) (2014) 0.77
A stimuli-responsive nanopore based on a photoresponsive host-guest system. Sci Rep (2013) 0.76
Efficient mechanochemical synthesis of regioselective persubstituted cyclodextrins. Beilstein J Org Chem (2016) 0.75
Thermodynamics of competitive molecular channel transport: application to artificial nuclear pores. PLoS One (2010) 0.75
Why does β-cyclodextrin prefer to bind nucleotides with an adenine base rather than other 2'-deoxyribonucleoside 5'-monophosphates? J Mol Model (2017) 0.75
The potential and challenges of nanopore sequencing. Nat Biotechnol (2008) 14.24
Continuous base identification for single-molecule nanopore DNA sequencing. Nat Nanotechnol (2009) 8.09
Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore. Proc Natl Acad Sci U S A (2009) 3.74
Recognizing a single base in an individual DNA strand: a step toward DNA sequencing in nanopores. Angew Chem Int Ed Engl (2005) 2.83
Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge. Proc Natl Acad Sci U S A (2008) 2.11
Identification of epigenetic DNA modifications with a protein nanopore. Chem Commun (Camb) (2010) 1.93
Functional bionetworks from nanoliter water droplets. J Am Chem Soc (2007) 1.81
Interactions of peptides with a protein pore. Biophys J (2005) 1.79
Formation of droplet networks that function in aqueous environments. Nat Nanotechnol (2011) 1.78
Direct transfer of membrane proteins from bacteria to planar bilayers for rapid screening by single-channel recording. Nat Chem Biol (2006) 1.77
Single-molecule observation of the catalytic subunit of cAMP-dependent protein kinase binding to an inhibitor peptide. Chem Biol (2005) 1.74
Subunit composition of a bicomponent toxin: staphylococcal leukocidin forms an octameric transmembrane pore. Protein Sci (2002) 1.73
Stochastic sensing of nanomolar inositol 1,4,5-trisphosphate with an engineered pore. Chem Biol (2002) 1.69
A tissue-like printed material. Science (2013) 1.66
Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores. Nat Nanotechnol (2010) 1.65
Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore. Proc Natl Acad Sci U S A (2003) 1.62
Droplet networks with incorporated protein diodes show collective properties. Nat Nanotechnol (2009) 1.61
A primary hydrogen-deuterium isotope effect observed at the single-molecule level. Nat Chem (2010) 1.58
Protein detection by nanopores equipped with aptamers. J Am Chem Soc (2012) 1.55
Protein nanopores with covalently attached molecular adapters. J Am Chem Soc (2007) 1.55
Real-time stochastic detection of multiple neurotransmitters with a protein nanopore. ACS Nano (2012) 1.52
Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore. Nano Lett (2010) 1.51
Outer membrane protein G: Engineering a quiet pore for biosensing. Proc Natl Acad Sci U S A (2008) 1.48
Single DNA rotaxanes of a transmembrane pore protein. Angew Chem Int Ed Engl (2004) 1.48
Partitioning of individual flexible polymers into a nanoscopic protein pore. Biophys J (2003) 1.45
Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis. FEBS Lett (2008) 1.44
Controlled translocation of individual DNA molecules through protein nanopores with engineered molecular brakes. Nano Lett (2011) 1.42
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores. Proc Natl Acad Sci U S A (2010) 1.41
Multiple base-recognition sites in a biological nanopore: two heads are better than one. Angew Chem Int Ed Engl (2010) 1.41
Asymmetric droplet interface bilayers. J Am Chem Soc (2008) 1.41
Single protein pores containing molecular adapters at high temperatures. Angew Chem Int Ed Engl (2005) 1.39
Screening blockers against a potassium channel with a droplet interface bilayer array. J Am Chem Soc (2008) 1.35
Membrane protein stoichiometry determined from the step-wise photobleaching of dye-labelled subunits. Chembiochem (2007) 1.33
Multistep protein unfolding during nanopore translocation. Nat Nanotechnol (2013) 1.29
Analysis of single nucleic acid molecules with protein nanopores. Methods Enzymol (2010) 1.29
Probing distance and electrical potential within a protein pore with tethered DNA. Biophys J (2002) 1.29
A storable encapsulated bilayer chip containing a single protein nanopore. J Am Chem Soc (2007) 1.28
Stochastic detection of motor protein-RNA complexes by single-channel current recording. Chemphyschem (2007) 1.24
Kinetics of a reversible covalent-bond-forming reaction observed at the single-molecule level. Angew Chem Int Ed Engl (2002) 1.21
Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab (2013) 1.18
DNA strands from denatured duplexes are translocated through engineered protein nanopores at alkaline pH. Nano Lett (2009) 1.17
Stochastic detection of enantiomers. J Am Chem Soc (2006) 1.17
Catalyzing the translocation of polypeptides through attractive interactions. J Am Chem Soc (2007) 1.17
Electrical behavior of droplet interface bilayer networks: experimental analysis and modeling. J Am Chem Soc (2007) 1.15
Simultaneous measurement of ionic current and fluorescence from single protein pores. J Am Chem Soc (2009) 1.14
Folding of a monomeric porin, OmpG, in detergent solution. Biochemistry (2003) 1.14
The leukocidin pore: evidence for an octamer with four LukF subunits and four LukS subunits alternating around a central axis. Protein Sci (2005) 1.13
An engineered ClyA nanopore detects folded target proteins by selective external association and pore entry. Nano Lett (2012) 1.13
Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF. Science (2013) 1.13
Temperature-responsive protein pores. J Am Chem Soc (2006) 1.10
Properties of Bacillus cereus hemolysin II: a heptameric transmembrane pore. Protein Sci (2002) 1.09
Single-molecule covalent chemistry with spatially separated reactants. Angew Chem Int Ed Engl (2003) 1.08
Urea facilitates the translocation of single-stranded DNA and RNA through the alpha-hemolysin nanopore. Biophys J (2010) 1.08
Direct introduction of single protein channels and pores into lipid bilayers. J Am Chem Soc (2005) 1.07
Membrane-protein structure: Piercing insights. Nature (2009) 1.07
Catalytic subunit of protein kinase A caged at the activating phosphothreonine. J Am Chem Soc (2002) 1.06
Individual RNA base recognition in immobilized oligonucleotides using a protein nanopore. Nano Lett (2012) 1.06
A genetically encoded pore for the stochastic detection of a protein kinase. Chembiochem (2006) 1.04
Nanopore-based identification of individual nucleotides for direct RNA sequencing. Nano Lett (2013) 1.04
Role of the amino latch of staphylococcal alpha-hemolysin in pore formation: a co-operative interaction between the N terminus and position 217. J Biol Chem (2005) 1.03
Stochastic detection of monovalent and bivalent protein-ligand interactions. Angew Chem Int Ed Engl (2004) 1.02
Single-molecule detection of nitrogen mustards by covalent reaction within a protein nanopore. J Am Chem Soc (2008) 1.02
The internal cavity of the staphylococcal alpha-hemolysin pore accommodates approximately 175 exogenous amino acid residues. Biochemistry (2005) 1.01
Cloning and porin activity of the major outer membrane protein P1 from Coxiella burnetii. Infect Immun (2002) 0.98
Stochastic sensing of TNT with a genetically engineered pore. Chembiochem (2005) 0.98
DNA stretching and optimization of nucleobase recognition in enzymatic nanopore sequencing. Nanotechnology (2015) 0.98
Functional truncated membrane pores. Proc Natl Acad Sci U S A (2014) 0.97
Protein components for nanodevices. Curr Opin Chem Biol (2005) 0.97
Translocating kilobase RNA through the Staphylococcal α-hemolysin nanopore. Nano Lett (2013) 0.97
Rapid assembly of a multimeric membrane protein pore. Biophys J (2011) 0.95
Photoisomerization of an individual azobenzene molecule in water: an on-off switch triggered by light at a fixed wavelength. J Am Chem Soc (2006) 0.93
Single-molecule detection of 5-hydroxymethylcytosine in DNA through chemical modification and nanopore analysis. Angew Chem Int Ed Engl (2013) 0.93
Prepore for a breakthrough. Nat Struct Mol Biol (2005) 0.92
Single-molecule interrogation of a bacterial sugar transporter allows the discovery of an extracellular inhibitor. Nat Chem (2013) 0.92
Carriers versus adapters in stochastic sensing. Chemphyschem (2005) 0.92
Nucleobase recognition at alkaline pH and apparent pKa of single DNA bases immobilised within a biological nanopore. Chem Commun (Camb) (2011) 0.91
Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli. PLoS One (2011) 0.91
Molecular dynamics simulations of DNA within a nanopore: arginine-phosphate tethering and a binding/sliding mechanism for translocation. Biochemistry (2011) 0.91
Single-molecule kinetics of two-step divalent cation chelation. Angew Chem Int Ed Engl (2010) 0.89
Inactivation of the KcsA potassium channel explored with heterotetramers. J Gen Physiol (2010) 0.89
Nanotechnology: Holes with an edge. Nature (2010) 0.88
Orientation of the monomeric porin OmpG in planar lipid bilayers. Chembiochem (2008) 0.88
Tetrameric assembly of KvLm K+ channels with defined numbers of voltage sensors. Proc Natl Acad Sci U S A (2012) 0.87
Formation of a chiral center and pyrimidal inversion at the single-molecule level. Angew Chem Int Ed Engl (2007) 0.87
Porphyrins for probing electrical potential across lipid bilayer membranes by second harmonic generation. Angew Chem Int Ed Engl (2013) 0.85
Rates and stoichiometries of metal ion probes of cysteine residues within ion channels. Biophys J (2013) 0.85
Assembly of the Bi-component leukocidin pore examined by truncation mutagenesis. J Biol Chem (2005) 0.84
Kinetics of a three-step reaction observed at the single-molecule level. Angew Chem Int Ed Engl (2003) 0.84
S-nitrosothiol chemistry at the single-molecule level. Angew Chem Int Ed Engl (2012) 0.84
Tuning the cavity of cyclodextrins: altered sugar adaptors in protein pores. J Am Chem Soc (2011) 0.84
Lipid-coated hydrogel shapes as components of electrical circuits and mechanical devices. Sci Rep (2012) 0.83
Peptide backbone mutagenesis of putative gating hinges in a potassium ion channel. Chembiochem (2008) 0.83
Continuous stochastic detection of amino acid enantiomers with a protein nanopore. Angew Chem Int Ed Engl (2012) 0.83
Construction and manipulation of functional three-dimensional droplet networks. ACS Nano (2014) 0.83
An engineered dimeric protein pore that spans adjacent lipid bilayers. Nat Commun (2013) 0.82
Detection of 3'-end RNA uridylation with a protein nanopore. ACS Nano (2013) 0.82