BiP mutants that are unable to interact with endoplasmic reticulum DnaJ proteins provide insights into interdomain interactions in BiP.

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMC 2234109)

Published in Proc Natl Acad Sci U S A on January 18, 2008

Authors

Walid Awad1, Isaac Estrada, Ying Shen, Linda M Hendershot

Author Affiliations

1: Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Articles citing this

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J (2008) 1.51

Life and death of a BiP substrate. Semin Cell Dev Biol (2009) 1.40

Regulated release of ERdj3 from unfolded proteins by BiP. EMBO J (2008) 1.33

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. ACS Chem Biol (2010) 1.28

BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. EMBO J (2012) 1.14

Expression profile in rice panicle: insights into heat response mechanism at reproductive stage. PLoS One (2012) 1.03

Hsp70 structure, function, regulation and influence on yeast prions. Protein Pept Lett (2009) 1.01

Hsp70 protein complexes as drug targets. Curr Pharm Des (2013) 1.00

BiP availability distinguishes states of homeostasis and stress in the endoplasmic reticulum of living cells. Mol Biol Cell (2010) 0.95

Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. J Exp Med (2009) 0.94

Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface. J Biol Chem (2015) 0.93

BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions. J Mol Biol (2015) 0.93

Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities. Arch Biochem Biophys (2008) 0.91

J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem (2010) 0.90

Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. Cell Death Dis (2014) 0.88

Identification of potential tumor differentiation factor (TDF) receptor from steroid-responsive and steroid-resistant breast cancer cells. J Biol Chem (2011) 0.86

Structural and functional interactions between the cholera toxin A1 subunit and ERdj3/HEDJ, a chaperone of the endoplasmic reticulum. Infect Immun (2011) 0.86

ERdj3 regulates BiP occupancy in living cells. J Cell Sci (2013) 0.85

The Hsp40 J-domain stimulates Hsp70 when tethered by the client to the ATPase domain. J Biol Chem (2010) 0.84

Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects. Mol Biol Cell (2013) 0.82

Generation of human ER chaperone BiP in yeast Saccharomyces cerevisiae. Microb Cell Fact (2014) 0.80

The crystal structure of the human co-chaperone P58(IPK). PLoS One (2011) 0.79

Comparing the functional properties of the Hsp70 chaperones, DnaK and BiP. Biophys Chem (2010) 0.78

A Conserved Cysteine within the ATPase Domain of the Endoplasmic Reticulum Chaperone BiP is Necessary for a Complete Complement of BiP Activities. J Mol Biol (2016) 0.77

Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum. J Biol Chem (2015) 0.76

Spatial localisation of chaperone distribution in the endoplasmic reticulum of yeast. IET Syst Biol (2012) 0.76

Molecular signal networks and regulating mechanisms of the unfolded protein response. J Zhejiang Univ Sci B (2017) 0.75

Gene Expression Profile in the Long-Living Lotus: Insights into the Heat Stress Response Mechanism. PLoS One (2016) 0.75

Interaction of Pseudomonas aeruginosa Exotoxin A with the human Sec61 complex suppresses passive calcium efflux from the endoplasmic reticulum. Channels (Austin) (2013) 0.75

Articles cited by this

The Hsp70 and Hsp60 chaperone machines. Cell (1998) 13.79

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62

An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell (1986) 10.38

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell (2002) 6.95

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature (1990) 6.45

Structural analysis of substrate binding by the molecular chaperone DnaK. Science (1996) 6.13

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK. Proc Natl Acad Sci U S A (1991) 5.96

Peptide binding and release by proteins implicated as catalysts of protein assembly. Science (1989) 5.84

Peptide-binding specificity of the molecular chaperone BiP. Nature (1991) 4.36

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J (1997) 4.28

Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function. Cell Stress Chaperones (1998) 3.94

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell (1993) 3.93

Structural basis of interdomain communication in the Hsc70 chaperone. Mol Cell (2005) 3.34

Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones. Proc Natl Acad Sci U S A (1999) 3.30

The J-protein family: modulating protein assembly, disassembly and translocation. EMBO Rep (2004) 3.13

The role of ATP in the functional cycle of the DnaK chaperone system. J Mol Biol (1995) 3.00

Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation. J Cell Biol (2001) 2.53

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation. Cell (1998) 2.52

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein. J Biol Chem (1991) 2.47

Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ. Proc Natl Acad Sci U S A (1998) 2.44

Insights into Hsp70 chaperone activity from a crystal structure of the yeast Hsp110 Sse1. Cell (2007) 2.36

The ATPase core of a clathrin uncoating protein. J Biol Chem (1987) 2.28

A bipartite signaling mechanism involved in DnaJ-mediated activation of the Escherichia coli DnaK protein. J Biol Chem (1996) 2.26

Different conformations for the same polypeptide bound to chaperones DnaK and GroEL. Nature (1992) 2.13

Mutations in the DnaK chaperone affecting interaction with the DnaJ cochaperone. Proc Natl Acad Sci U S A (1998) 2.10

Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. J Biol Chem (2002) 1.99

Allosteric regulation of Hsp70 chaperones involves a conserved interdomain linker. J Biol Chem (2006) 1.90

Allosteric regulation of Hsp70 chaperones by a proline switch. Mol Cell (2006) 1.88

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides. EMBO J (1989) 1.79

Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. J Cell Biol (1989) 1.78

Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER. J Cell Biol (2002) 1.68

ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. Mol Biol Cell (2004) 1.66

BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+. J Biol Chem (1997) 1.65

In vitro dissociation of BiP-peptide complexes requires a conformational change in BiP after ATP binding but does not require ATP hydrolysis. J Biol Chem (1995) 1.62

BiP and immunoglobulin light chain cooperate to control the folding of heavy chain and ensure the fidelity of immunoglobulin assembly. Mol Biol Cell (1999) 1.58

In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum. Mol Biol Cell (1995) 1.53

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum. J Cell Biol (2005) 1.52

HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. J Biol Chem (2000) 1.50

Mutations within the nucleotide binding site of immunoglobulin-binding protein inhibit ATPase activity and interfere with release of immunoglobulin heavy chain. J Biol Chem (1993) 1.49

Mammalian Sec61 is associated with Sec62 and Sec63. J Biol Chem (2000) 1.47

ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem (2002) 1.44

Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes. Proc Natl Acad Sci U S A (2000) 1.39

Structural features required for the interaction of the Hsp70 molecular chaperone DnaK with its cochaperone DnaJ. J Biol Chem (1999) 1.37

Intragenic suppressors of Hsp70 mutants: interplay between the ATPase- and peptide-binding domains. Proc Natl Acad Sci U S A (1999) 1.27

cDNA cloning of the immunoglobulin heavy chain binding protein. Proc Natl Acad Sci U S A (1988) 1.16

Structure and energetics of an allele-specific genetic interaction between dnaJ and dnaK: correlation of nuclear magnetic resonance chemical shift perturbations in the J-domain of Hsp40/DnaJ with binding affinity for the ATPase domain of Hsp70/DnaK. Biochemistry (2003) 1.06

The cotranslational maturation of the type I membrane glycoprotein tyrosinase: the heat shock protein 70 system hands off to the lectin-based chaperone system. Mol Biol Cell (2005) 1.02

Real time kinetics of the DnaK/DnaJ/GrpE molecular chaperone machine action. J Biol Chem (1996) 1.01

Crystallization of a functionally intact Hsc70 chaperone. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.94

Articles by these authors

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol (2002) 3.87

The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer (2004) 3.86

A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell (2002) 3.56

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J Biol Chem (2003) 2.94

Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron (2006) 2.79

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy. Nat Genet (2005) 2.38

Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp. Mol Cell (2007) 2.20

ER chaperone functions during normal and stress conditions. J Chem Neuroanat (2004) 2.13

Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. J Biol Chem (2002) 1.99

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell (2009) 1.90

How antibodies fold. Trends Biochem Sci (2009) 1.88

SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci (2005) 1.87

Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem (2010) 1.85

ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. Mol Biol Cell (2004) 1.66

GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis. Mol Cell (2004) 1.64

High macrolide resistance in Streptococcus pyogenes strains isolated from children with pharyngitis in China. Pediatr Pulmonol (2009) 1.59

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum. J Cell Biol (2005) 1.52

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J (2008) 1.51

Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways. J Biol Chem (2004) 1.45

BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. J Biol Chem (2002) 1.42

Magnetoelectric bending-mode structure based on Metglas/Pb(Zr,Ti)O₃ fiber laminates. IEEE Trans Ultrason Ferroelectr Freq Control (2011) 1.41

Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response. PLoS One (2010) 1.41

Life and death of a BiP substrate. Semin Cell Dev Biol (2009) 1.40

Regulated release of ERdj3 from unfolded proteins by BiP. EMBO J (2008) 1.33

Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell (2011) 1.31

ER stress and cancer. Cancer Biol Ther (2006) 1.28

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells. Mol Immunol (2009) 1.26

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes (2007) 1.22

Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids. Mol Cell (2010) 1.21

Characteristics of Streptococcus pyogenes strains isolated from Chinese children with scarlet fever. Acta Paediatr (2008) 1.19

Disulfide bonds in ER protein folding and homeostasis. Curr Opin Cell Biol (2010) 1.17

Building an antibody factory: a job for the unfolded protein response. Nat Immunol (2005) 1.17

Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response. Cell Stress Chaperones (2009) 1.16

Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. Antioxid Redox Signal (2009) 1.14

Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention. J Zhejiang Univ Sci B (2012) 1.13

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget (2014) 1.11

Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer (2010) 1.11

Identification of ERdj3 and OBF-1/BOB-1/OCA-B as direct targets of XBP-1 during plasma cell differentiation. J Immunol (2007) 1.11

Organization of the functions and components of the endoplasmic reticulum. Adv Exp Med Biol (2007) 1.10

Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children. J Med Microbiol (2012) 1.09

ERdj3, a luminal ER DnaJ homologue, binds directly to unfolded proteins in the mammalian ER: identification of critical residues. Biochemistry (2009) 1.08

ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum. Nat Struct Mol Biol (2005) 1.05

Family outbreak of severe pneumonia induced by H7N9 infection. Am J Respir Crit Care Med (2013) 1.04

Roles of Mir-144-ZFX pathway in growth regulation of non-small-cell lung cancer. PLoS One (2013) 1.03

Study on the distribution features of bone metastases in prostate cancer. Nucl Med Commun (2012) 1.03

Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like vascular endothelial growth factor (VEGF). J Biol Chem (2013) 1.03

Cigarette suppresses the expression of P4Halpha and vascular collagen production. Biochem Biophys Res Commun (2004) 1.02

Emerging roles of DNA-PK besides DNA repair. Cell Signal (2011) 1.02

ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery. J Biol Chem (2012) 1.00

pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin. Proc Natl Acad Sci U S A (2009) 0.99

Quality control of integral membrane proteins by assembly-dependent membrane integration. Mol Cell (2013) 0.99

The stressful road to antibody secretion. Nat Immunol (2003) 0.98

Oral administration of Cr(VI) induced oxidative stress, DNA damage and apoptotic cell death in mice. Toxicology (2006) 0.98

The mammalian endoplasmic reticulum as a sensor for cellular stress. Cell Stress Chaperones (2002) 0.97

Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation. Glia (2013) 0.97

Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes. Mutagenesis (2004) 0.96

Diagnosis, treatment and follow-up of 25 patients with melamine-induced kidney stones complicated by acute obstructive renal failure in Beijing Children's Hospital. Eur J Pediatr (2009) 0.95

Activation of the unfolded protein response is necessary and sufficient for reducing topoisomerase IIalpha protein levels and decreasing sensitivity to topoisomerase-targeted drugs. Mol Pharmacol (2005) 0.94

FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA. Int Immunol (2010) 0.94

Differential proteome profiling of pleural effusions from lung cancer and benign inflammatory disease patients. Biochim Biophys Acta (2012) 0.93

Genetic characterization and fine mapping of the blast resistance locus Pigm(t) tightly linked to Pi2 and Pi9 in a broad-spectrum resistant Chinese variety. Theor Appl Genet (2006) 0.92

The cellular world according to Hsp90. Nat Struct Mol Biol (2007) 0.92

Low birth weight is associated with components of the metabolic syndrome. Metabolism (2010) 0.92

Photodynamic therapy for symptomatic circumscribed macular choroidal hemangioma in Chinese patients. Am J Ophthalmol (2010) 0.92

UPR activation alters chemosensitivity of tumor cells. Cancer Biol Ther (2006) 0.92

A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins. J Biol Chem (2012) 0.90

Endogenous nitric oxide activation protects against cigarette smoking induced apoptosis in endothelial cells. FEBS Lett (2005) 0.90

RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice. BMC Pharmacol (2008) 0.90

J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem (2010) 0.90

Diagnosis and treatment of melamine-associated urinary calculus complicated with acute renal failure in infants and young children. Chin Med J (Engl) (2009) 0.89

C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome. J Biol Chem (2012) 0.89

Ultrasonographic diagnosis of urinary calculus caused by melamine in children. Chin Med J (Engl) (2009) 0.89

The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions. J Biol Chem (2009) 0.87

Sex at the origin: an Asian population of the rice blast fungus Magnaporthe oryzae reproduces sexually. Mol Ecol (2012) 0.87

The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s. J Biol Chem (2013) 0.86

2-methoxyestradiol induces spindle aberrations, chromosome congression failure, and nondisjunction in mouse oocytes. Biol Reprod (2007) 0.85

Combined analysis of genome-wide-linked susceptibility loci to Kawasaki disease in Han Chinese. Hum Genet (2013) 0.85

Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD. Mol Biol Cell (2014) 0.85

Manipulation of the oocyte: possible damage to the spindle apparatus. Reprod Biomed Online (2002) 0.85

Urinary CD80 levels as a diagnostic biomarker of minimal change disease. Pediatr Nephrol (2014) 0.85

Ethanol acutely modulates mGluR1-dependent long-term depression in cerebellum. Alcohol Clin Exp Res (2010) 0.84

Long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses requires presynaptic and postsynaptic signaling cascades. J Neurosci (2014) 0.84

Insulin increases glutamate transporter GLT1 in cultured astrocytes. Biochem Biophys Res Commun (2011) 0.84

Molecular analysis of Streptococcus pyogenes strains isolated from Chinese children with pharyngitis. Diagn Microbiol Infect Dis (2011) 0.83

Examination of a second node of translational control in the unfolded protein response. J Cell Sci (2013) 0.83

Cerebellar long-term depression is deficient in Niemann-Pick type C disease mice. Cerebellum (2011) 0.82

c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. J Biol Chem (2013) 0.82

Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes. Atherosclerosis (2008) 0.82

Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport. Traffic (2013) 0.82

Neuroprotective effects of Lycium barbarum polysaccharides in lipopolysaccharide-induced BV2 microglial cells. Mol Med Rep (2013) 0.82

[Melamine related urinary calculus and acute renal failure in infants]. Zhonghua Er Ke Za Zhi (2008) 0.81

[Explanation on "the treatment of the urinary calculus of the infant fed with melamine polluted formula milk"]. Zhonghua Er Ke Za Zhi (2008) 0.81

[Detection rates of atherosclerosis by carotid versus lower limb ultrasonography in newly diagnosed type 2 diabetics]. Zhonghua Yi Xue Za Zhi (2013) 0.81

VSI: a visual saliency-induced index for perceptual image quality assessment. IEEE Trans Image Process (2014) 0.80

Novel oligo(ethylene glycol)-based molecularly imprinted magnetic nanoparticles for thermally modulated capture and release of lysozyme. ACS Appl Mater Interfaces (2014) 0.80

Differential-mode vibrational noise cancellation structure for Metglas/Pb(Zr,Ti)O₃ fiber magnetoelectric laminates. IEEE Trans Ultrason Ferroelectr Freq Control (2011) 0.80

Blockade of glutamate transporters facilitates cerebellar synaptic long-term depression. Neuroreport (2009) 0.80

Intra-Golgi formation of IgM-glycosaminoglycan complexes promotes Ig deposition. J Immunol (2011) 0.80