Published in J Biol Chem on January 15, 1987
Structural analysis of substrate binding by the molecular chaperone DnaK. Science (1996) 6.13
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol (1999) 4.98
Heat shock proteins: molecular chaperones of protein biogenesis. Microbiol Rev (1993) 3.51
Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO J (1995) 3.22
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61
Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein. Proc Natl Acad Sci U S A (1991) 2.61
Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo. Mol Cell Biol (1996) 2.53
Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding. Proc Natl Acad Sci U S A (1991) 2.41
The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex. EMBO J (1998) 2.17
Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins. Mol Biol Cell (1993) 2.15
Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum. Mol Biol Cell (1993) 1.94
Stress response of yeast. Biochem J (1993) 1.79
Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. J Cell Biol (1989) 1.78
Genomic analysis of the Hsp70 superfamily in Arabidopsis thaliana. Cell Stress Chaperones (2001) 1.73
Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO J (1997) 1.57
In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum. Mol Biol Cell (1995) 1.53
Allostery in the Hsp70 chaperone proteins. Top Curr Chem (2013) 1.52
A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA. EMBO J (1991) 1.42
Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. Proc Natl Acad Sci U S A (2002) 1.35
Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A (1995) 1.31
Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. EMBO J (1996) 1.28
Cloning and characterization of the Brucella ovis heat shock protein DnaK functionally expressed in Escherichia coli. J Bacteriol (1992) 1.26
Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER. Mol Biol Cell (1998) 1.25
Mutations in the C-terminal fragment of DnaK affecting peptide binding. Proc Natl Acad Sci U S A (1996) 1.24
A gene encoding a DnaK/hsp70 homolog in Escherichia coli. Proc Natl Acad Sci U S A (1994) 1.24
Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1. J Biol Chem (2000) 1.24
FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity. EMBO J (2001) 1.22
The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import. EMBO J (1996) 1.22
Hsc70 is required for endocytosis and clathrin function in Drosophila. J Cell Biol (2002) 1.21
How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions. J Mol Biol (2015) 1.15
BiP mutants that are unable to interact with endoplasmic reticulum DnaJ proteins provide insights into interdomain interactions in BiP. Proc Natl Acad Sci U S A (2008) 1.15
Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum. Mol Cell Biol (2000) 1.13
Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone. J Neurosci Res (2008) 1.10
The hsp70-associating protein Hap46 binds to DNA and stimulates transcription. Proc Natl Acad Sci U S A (1999) 1.09
Antigenic analysis of the chlamydial 75-kilodalton protein. Infect Immun (1992) 1.04
Induced levels of heat shock proteins in a dnaK mutant of Lactococcus lactis. J Bacteriol (1998) 0.97
Topology and dynamics of the 10 kDa C-terminal domain of DnaK in solution. Protein Sci (1999) 0.96
Interference between proteins Hap46 and Hop/p60, which bind to different domains of the molecular chaperone hsp70/hsc70. Mol Cell Biol (1998) 0.95
Stch encodes the 'ATPase core' of a microsomal stress 70 protein. EMBO J (1994) 0.94
Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo. J Biol Chem (2009) 0.93
Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress Chaperones (2004) 0.91
Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities. Arch Biochem Biophys (2008) 0.91
Monoclonal antibody recognition and function of a DnaK (HSP70) epitope found in gram-negative bacteria. J Bacteriol (1993) 0.91
Isolation and characterization of a DnaJ-like protein in rats: the C-terminal 10-kDa domain of hsc70 is not essential for stimulating the ATP-hydrolytic activity of hsc70 by a DnaJ-like protein. Protein Sci (1998) 0.87
Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model (2010) 0.85
Heat shock protein 70 (Hsp70) inhibits oxidative phosphorylation and compensates ATP balance through enhanced glycolytic activity. J Appl Physiol (1985) (2012) 0.84
Multiple molecules of Hsc70 and a dimer of DjA1 independently bind to an unfolded protein. J Biol Chem (2010) 0.83
C-terminal amino acids are essential for human heat shock protein 70 dimerization. Cell Stress Chaperones (2014) 0.83
Binding of ATP and ATP analogues to the uncoating ATPase Hsc70 (70 kDa heat-shock cognate protein). Biochem J (1996) 0.83
High-level expression of soluble rat hsc70 in Escherichia coli: purification and characterization of the cloned enzyme. Biochem J (1993) 0.83
Candidate vaccine antigens identified by antibodies from mice vaccinated with 15- or 50-kilorad-irradiated cercariae of Schistosoma mansoni. Infect Immun (1993) 0.83
Expression and sulfogalactolipid binding specificity of the recombinant testis-specific cognate heat shock protein 70. Glycoconj J (1997) 0.82
Insight into residues involved in the structure and function of the breast cancer associated protein human gamma synuclein. J Mol Model (2010) 0.81
Transcriptional stimulation by the DNA binding protein Hap46/BAG-1M involves hsp70/hsc70 molecular chaperones. Nucleic Acids Res (2003) 0.79
Complementation of an Escherichia coli DnaK defect by Hsc70-DnaK chimeric proteins. J Bacteriol (2004) 0.77
Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions. J Mol Biol (2015) 0.76
Molecular cloning, phylogenetic analysis, and expression profiling of endoplasmic reticulum molecular chaperone BiP genes from bread wheat (Triticum aestivum L.). BMC Plant Biol (2014) 0.76
ATPase activity and molecular chaperone function of the stress70 proteins. Plant Physiol (1996) 0.75
Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology. Sci Rep (2015) 0.75
Crystallization and X-ray data analysis of the 10 kDa C-terminal lid subdomain from Caenorhabditis elegans Hsp70. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
SNAP receptors implicated in vesicle targeting and fusion. Nature (1993) 18.57
SNAREpins: minimal machinery for membrane fusion. Cell (1998) 16.97
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature (1998) 15.09
Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J Cell Biol (1994) 11.55
Reconstitution of the transport of protein between successive compartments of the Golgi measured by the coupled incorporation of N-acetylglucosamine. Cell (1984) 10.74
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66
Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi. Annu Rev Biochem (1987) 10.25
Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals. Nature (1995) 7.81
Synchronised transmembrane insertion and glycosylation of a nascent membrane protein. Nature (1977) 7.72
Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding. Nature (1995) 7.55
Mutations in human dynamin block an intermediate stage in coated vesicle formation. J Cell Biol (1993) 7.37
A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature (1989) 6.48
Control of EGF receptor signaling by clathrin-mediated endocytosis. Science (1996) 6.01
Peptide binding and release by proteins implicated as catalysts of protein assembly. Science (1989) 5.84
Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proc Natl Acad Sci U S A (1977) 5.51
Involvement of GTP-binding "G" proteins in transport through the Golgi stack. Cell (1987) 5.28
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF. Nature (1992) 5.27
Membrane asymmetry. Science (1977) 5.12
Uncoating ATPase is a member of the 70 kilodalton family of stress proteins. Cell (1986) 4.98
Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis. Nature (1999) 4.84
The rate of bulk flow from the endoplasmic reticulum to the cell surface. Cell (1987) 4.82
ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein. Cell (1991) 4.80
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature (2000) 4.67
Purification of a novel class of coated vesicles mediating biosynthetic protein transport through the Golgi stack. Cell (1989) 4.65
Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. Proc Natl Acad Sci U S A (1988) 4.63
A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell (1994) 4.47
Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack. Cell (1988) 4.37
Peptide-binding specificity of the molecular chaperone BiP. Nature (1991) 4.36
The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein. Cell (1993) 4.33
'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles. Nature (1991) 4.24
Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Cell (1991) 4.17
The golgi apparatus: two organelles in tandem. Science (1981) 4.15
A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin. Nature (1991) 4.09
The use of pHluorins for optical measurements of presynaptic activity. Biophys J (2000) 4.07
SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast. Cell (1990) 4.05
A new type of coated vesicular carrier that appears not to contain clathrin: its possible role in protein transport within the Golgi stack. Cell (1986) 4.04
Compartmental organization of the Golgi stack. Cell (1985) 4.02
Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J Cell Biol (1995) 3.92
Dissection of a single round of vesicular transport: sequential intermediates for intercisternal movement in the Golgi stack. Cell (1989) 3.78
An enzyme that removes clathrin coats: purification of an uncoating ATPase. J Cell Biol (1984) 3.77
Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein. Nature (1989) 3.62
N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion. J Cell Biol (1994) 3.59
Coated vesicles transport newly synthesized membrane glycoproteins from endoplasmic reticulum to plasma membrane in two successive stages. Proc Natl Acad Sci U S A (1980) 3.51
Characterization of protein transport between successive compartments of the Golgi apparatus: asymmetric properties of donor and acceptor activities in a cell-free system. Arch Biochem Biophys (1985) 3.43
Intracellular transport of class II MHC molecules directed by invariant chain. Nature (1990) 3.35
Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J Cell Biol (2000) 3.30
AP-2/Eps15 interaction is required for receptor-mediated endocytosis. J Cell Biol (1998) 3.30
Bidirectional transport by distinct populations of COPI-coated vesicles. Cell (1997) 3.24
Vesicle fusion following receptor-mediated endocytosis requires a protein active in Golgi transport. Nature (1989) 3.21
Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain. Proc Natl Acad Sci U S A (1999) 3.16
The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells. J Biol Chem (1997) 3.10
Sequential intermediates in the pathway of intercompartmental transport in a cell-free system. Cell (1984) 3.07
Binding of coatomer to Golgi membranes requires ADP-ribosylation factor. J Biol Chem (1993) 3.01
Attachment of terminal N-acetylglucosamine to asparagine-linked oligosaccharides occurs in central cisternae of the Golgi stack. Cell (1985) 2.97
Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J Cell Biol (2000) 2.91
Dynamin self-assembly stimulates its GTPase activity. J Biol Chem (1996) 2.87
Regulation of receptor-mediated endocytosis by Rho and Rac. Nature (1996) 2.84
Stepwise assembly of functionally active transport vesicles. Cell (1993) 2.80
Bimodal interaction of coatomer with the p24 family of putative cargo receptors. Science (1996) 2.76
Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments. J Cell Biol (1994) 2.75
Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science (2000) 2.70
Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms. J Cell Biol (1998) 2.67
A novel 115-kD peripheral membrane protein is required for intercisternal transport in the Golgi stack. J Cell Biol (1992) 2.67
Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature (1993) 2.65
Compartmentation of asparagine-linked oligosaccharide processing in the Golgi apparatus. J Cell Biol (1983) 2.65
Domain structure and intramolecular regulation of dynamin GTPase. EMBO J (1997) 2.63
Actin assembly plays a variable, but not obligatory role in receptor-mediated endocytosis in mammalian cells. Traffic (2000) 2.63
The planar organization of lecithin-cholesterol bilayers. J Biol Chem (1972) 2.62
Early and late functions associated with the Golgi apparatus reside in distinct compartments. Proc Natl Acad Sci U S A (1981) 2.61
Topological restriction of SNARE-dependent membrane fusion. Nature (2000) 2.58
Functional architecture of an intracellular membrane t-SNARE. Nature (2000) 2.57
Possible role for fatty acyl-coenzyme A in intracellular protein transport. Nature (1987) 2.56
Transport of vesicular stomatitis virus glycoprotein in a cell-free extract. Proc Natl Acad Sci U S A (1980) 2.53
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles. J Cell Biol (1993) 2.51
Multiple GTP-binding proteins participate in clathrin-coated vesicle-mediated endocytosis. J Cell Biol (1993) 2.51
SNAP family of NSF attachment proteins includes a brain-specific isoform. Nature (1993) 2.50
Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Cell (1999) 2.49
SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nat Cell Biol (1999) 2.48
Garrotes, springs, ratchets, and whips: putting dynamin models to the test. Traffic (2000) 2.45
A multisubunit particle implicated in membrane fusion. J Cell Biol (1992) 2.40
The debate about transport in the Golgi--two sides of the same coin? Cell (2000) 2.33
The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport. J Biol Chem (1992) 2.31
Regulation of signal transduction by endocytosis. Curr Opin Cell Biol (2000) 2.28
An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding. Proc Natl Acad Sci U S A (1995) 2.26
Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J Exp Med (2000) 2.25
Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins. Nature (1993) 2.21
Tightly regulated and inducible expression of dominant interfering dynamin mutant in stably transformed HeLa cells. Methods Enzymol (1995) 2.19
Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem (1997) 2.17
Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin. Proc Natl Acad Sci U S A (1996) 2.16
Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell (2000) 2.16
Dynamin GTPase, a force-generating molecular switch. Bioessays (1996) 2.15
Enzymatic recycling of clathrin from coated vesicles. Cell (1986) 2.13
The emergence of clathrin-independent pinocytic pathways. Curr Opin Cell Biol (1995) 2.12
Glycosylation of a membrane protein is restricted to the growing polypeptide chain but is not necessary for insertion as a transmembrane protein. Cell (1978) 2.11
Transport of the membrane glycoprotein of vesicular stomatitis virus to the cell surface in two stages by clathrin-coated vesicles. J Cell Biol (1980) 2.08
The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein. J Biol Chem (1992) 2.03