Published in Pain on January 22, 2008
Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci (2009) 5.00
Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron (2012) 2.11
Neuron-glia crosstalk gets serious: role in pain hypersensitivity. Curr Opin Anaesthesiol (2008) 1.99
Chemokines and pain mechanisms. Brain Res Rev (2008) 1.43
Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury. Exp Neurol (2008) 1.34
Review of Dercum's disease and proposal of diagnostic criteria, diagnostic methods, classification and management. Orphanet J Rare Dis (2012) 1.27
The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries. Neuroscience (2010) 1.10
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One (2010) 1.08
Reverse transcription quantitative real-time polymerase chain reaction reference genes in the spared nerve injury model of neuropathic pain: validation and literature search. BMC Res Notes (2013) 0.96
Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord. Pain (2012) 0.89
Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat. J Neurosci Res (2009) 0.89
Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1. Mol Pain (2009) 0.89
Microglia in Alzheimer brain: a neuropathological perspective. Int J Alzheimers Dis (2012) 0.87
Gliotransmission modulates baseline mechanical nociception. Mol Pain (2011) 0.86
Different peripheral tissue injury induces differential phenotypic changes of spinal activated microglia. Clin Dev Immunol (2013) 0.80
Analgesic effect of minocycline in rat model of inflammation-induced visceral pain. Eur J Pharmacol (2014) 0.77
The Effect of Ethanolic Extract of Lippia Citriodora on Rats with Chronic Constriction Injury of Neuropathic pain. Cell J (2017) 0.75
Mammalian MAP kinase signalling cascades. Nature (2001) 18.89
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain (1988) 15.15
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain (1992) 9.17
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature (2005) 7.07
Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain (2000) 6.21
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature (2003) 6.04
Corpse clearance defines the meaning of cell death. Nature (2000) 6.01
Intrathecal methylprednisolone for intractable postherpetic neuralgia. N Engl J Med (2000) 5.64
The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci (2007) 5.38
Role of the immune system in chronic pain. Nat Rev Neurosci (2005) 4.10
Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci (2005) 4.01
p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci (2003) 3.72
The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A (2005) 3.59
Reactive microgliosis. Prog Neurobiol (1999) 3.55
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain (2005) 3.37
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc Natl Acad Sci U S A (2003) 3.17
The role of neuroinflammation and neuroimmune activation in persistent pain. Pain (2001) 3.15
Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem (2003) 2.42
Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology (1994) 2.32
A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST study. Rheumatology (Oxford) (2005) 2.23
Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci (2005) 2.16
Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Neurochem (2006) 2.14
A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem (2007) 2.05
The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp Neurol (1999) 1.98
The PINE study of epidural steroids and local anaesthetics to prevent postherpetic neuralgia: a randomised controlled trial. Lancet (2006) 1.95
Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav Immun (2006) 1.88
Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci (2003) 1.88
Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur J Pain (2006) 1.70
MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci U S A (1999) 1.59
Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med (2006) 1.57
Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain (2006) 1.42
Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem (2005) 1.41
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Eur J Neurosci (2005) 1.36
Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway. J Biol Chem (2002) 1.29
Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve. J Comp Neurol (2000) 1.23
Glial responses to synaptic damage and plasticity. J Neurosci Res (1999) 1.17
Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain. Pain (2002) 1.09
Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia. Mol Cell Neurosci (2005) 1.03
Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica. Pain (2000) 1.02
Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain. Neurosci Lett (1995) 1.01
Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis. Arthritis Rheum (2005) 0.99
Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection. Glia (1998) 0.98
Effect of betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines. Neurosci Lett (2005) 0.97
Distinct functional types of macrophage in dorsal root ganglia and spinal nerves proximal to sciatic and spinal nerve transections in the rat. Exp Neurol (2003) 0.96
Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Pain (1999) 0.94
Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats. Anesthesiology (2004) 0.93
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. FASEB J (2000) 0.92
Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain. Brain Res (2004) 0.86
Differential effects of FK506 and methotrexate on inflammatory cytokine levels in rat adjuvant-induced arthritis. J Rheumatol (2003) 0.86
Flow cytometric analysis of mammalian glial cultures treated with methotrexate. Glia (1990) 0.83
Toxicity of intrathecally administered cytotoxic drugs and their antitumor activity against an intrathecal Walker 256 carcinosarcoma model for meningeal carcinomatosis in the rat. Cancer Res (1989) 0.77
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron (2006) 8.57
Persistent postsurgical pain: risk factors and prevention. Lancet (2006) 8.46
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet (2006) 8.32
Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain (2009) 7.11
The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci (2007) 5.38
Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci (2009) 5.00
A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol (2011) 4.95
Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci (2003) 4.69
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell (2011) 4.65
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron (2002) 4.27
p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci (2003) 3.72
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci (2002) 3.32
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature (2007) 3.23
Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci (2002) 3.21
Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov (2009) 2.88
Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. Int J Cancer (2012) 2.80
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci (2007) 2.78
Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron (2010) 2.69
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron (2006) 2.60
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci (2002) 2.60
Bacteria activate sensory neurons that modulate pain and inflammation. Nature (2013) 2.56
Can we conquer pain? Nat Neurosci (2002) 2.56
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci (2007) 2.40
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
Nociceptors are interleukin-1beta sensors. J Neurosci (2008) 2.26
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med (2012) 2.25
BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol (2007) 2.18
Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci (2005) 2.16
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell (2013) 2.14
Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron (2012) 2.11
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem (2005) 2.07
Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Mol Cell Neurosci (2003) 2.02
T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci (2009) 1.91
DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem (2005) 1.89
The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci (2006) 1.88
A novel tool for the assessment of pain: validation in low back pain. PLoS Med (2009) 1.75
Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nat Neurosci (2003) 1.75
Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J Neurosci (2007) 1.70
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci (2012) 1.66
DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. J Neurosci (2004) 1.64
Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. Clin Chem (2007) 1.64
Differential analgesic sensitivity of two distinct neuropathic pain models. Anesth Analg (2004) 1.63
The transcription factor ATF-3 promotes neurite outgrowth. Mol Cell Neurosci (2006) 1.62
Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion. Pain (2009) 1.61
Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. Anesthesiology (2003) 1.59
Selectively targeting pain in the trigeminal system. Pain (2010) 1.59
No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends Neurosci (2009) 1.54
Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology (2009) 1.52
Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival. Neuron (2002) 1.46
Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. J Neurosci (2009) 1.44
Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol Med (2002) 1.42
Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia. Pain (2012) 1.42
Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn. J Physiol (2003) 1.42
Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. Pain (2005) 1.41
CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature (2013) 1.41
Adult neuron survival strategies--slamming on the brakes. Nat Rev Neurosci (2004) 1.39
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci (2003) 1.38
Pain TRPs. Neuron (2005) 1.32
Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest (2011) 1.31
Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity. J Pharmacol Exp Ther (2006) 1.30
Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. J Neurosci (2005) 1.29
Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. Hum Mol Genet (2005) 1.29
Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci (2004) 1.27
Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats. Mol Pain (2005) 1.26
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype. Eur J Pain (2008) 1.26
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Gastroenterology (2004) 1.25
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci (2013) 1.25
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation. Cancer Res (2003) 1.20
COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest (2009) 1.18
TrpA1 regulates thermal nociception in Drosophila. PLoS One (2011) 1.15
Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol (2013) 1.14
Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci (2008) 1.13
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. J Am Coll Cardiol (2008) 1.13
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. J Neurosci (2008) 1.10
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci (2005) 1.10
Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol (2013) 1.09
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One (2010) 1.08
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci (2013) 1.06
Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain (2013) 1.06
Pathophysiology and treatment of pain in joint disease. Adv Drug Deliv Rev (2006) 1.05
Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population. Br J Clin Pharmacol (2002) 1.05
Selective up-regulation of the growth arrest DNA damage-inducible gene Gadd45 alpha in sensory and motor neurons after peripheral nerve injury. Eur J Neurosci (2003) 1.03
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci (2012) 1.03