PubRank

Steven Henikoff

Author PubWeight™ 383.30‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 2003 52.26
2 Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009 38.62
3 Accounting for human polymorphisms predicted to affect protein function. Genome Res 2002 14.10
4 Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 2010 12.39
5 Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nat Genet 2006 11.88
6 Unlocking the secrets of the genome. Nature 2009 11.80
7 Predicting the effects of amino acid substitutions on protein function. Annu Rev Genomics Hum Genet 2006 9.80
8 The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Mol Cell 2002 9.80
9 Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 2010 9.78
10 The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006 9.65
11 Genome-scale profiling of histone H3.3 replacement patterns. Nat Genet 2005 7.22
12 Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci U S A 2004 4.88
13 Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. Science 2010 4.72
14 Centromeric nucleosomes induce positive DNA supercoils. Cell 2009 4.57
15 DNA demethylation in the Arabidopsis genome. Proc Natl Acad Sci U S A 2007 4.55
16 SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acids Res 2012 4.45
17 Histone variants--ancient wrap artists of the epigenome. Nat Rev Mol Cell Biol 2010 4.45
18 Large-scale discovery of induced point mutations with high-throughput TILLING. Genome Res 2003 4.39
19 Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature 2008 4.20
20 Histone replacement marks the boundaries of cis-regulatory domains. Science 2007 4.06
21 Spectrum of chemically induced mutations from a large-scale reverse-genetic screen in Arabidopsis. Genetics 2003 3.70
22 Sequencing of a rice centromere uncovers active genes. Nat Genet 2004 3.66
23 CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primer) PCR primer design. Nucleic Acids Res 2003 3.55
24 DNA methylation profiling identifies CG methylation clusters in Arabidopsis genes. Curr Biol 2005 3.54
25 Phylogenomics of the nucleosome. Nat Struct Biol 2003 3.52
26 DNA demethylation by DNA repair. Trends Genet 2009 3.49
27 Genome-wide profiling of DNA methylation reveals transposon targets of CHROMOMETHYLASE3. Curr Biol 2002 3.37
28 Extensive demethylation of repetitive elements during seed development underlies gene imprinting. Science 2009 3.33
29 A comprehensive map of insulator elements for the Drosophila genome. PLoS Genet 2010 3.25
30 Tetrameric structure of centromeric nucleosomes in interphase Drosophila cells. PLoS Biol 2007 3.25
31 Histone H3 variants specify modes of chromatin assembly. Proc Natl Acad Sci U S A 2002 3.06
32 Centromeric localization and adaptive evolution of an Arabidopsis histone H3 variant. Plant Cell 2002 2.72
33 Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol 2013 2.71
34 Spreading of silent chromatin: inaction at a distance. Nat Rev Genet 2006 2.64
35 Discovery of induced point mutations in maize genes by TILLING. BMC Plant Biol 2004 2.57
36 Major evolutionary transitions in centromere complexity. Cell 2009 2.49
37 Discovery of chemically induced mutations in rice by TILLING. BMC Plant Biol 2007 2.46
38 Efficient discovery of DNA polymorphisms in natural populations by Ecotilling. Plant J 2004 2.45
39 A simple method for gene expression and chromatin profiling of individual cell types within a tissue. Dev Cell 2010 2.24
40 Epigenome characterization at single base-pair resolution. Proc Natl Acad Sci U S A 2011 2.22
41 Conflict begets complexity: the evolution of centromeres. Curr Opin Genet Dev 2002 2.14
42 Mismatch cleavage by single-strand specific nucleases. Nucleic Acids Res 2004 2.14
43 TILLING to detect induced mutations in soybean. BMC Plant Biol 2008 2.13
44 Genome-wide analysis of DNA methylation patterns. Development 2007 2.13
45 A protocol for TILLING and Ecotilling in plants and animals. Nat Protoc 2006 2.09
46 Chromatin immunoprecipitation reveals that the 180-bp satellite repeat is the key functional DNA element of Arabidopsis thaliana centromeres. Genetics 2003 2.05
47 Maize centromeres: organization and functional adaptation in the genetic background of oat. Plant Cell 2004 2.01
48 Chaperone-mediated assembly of centromeric chromatin in vitro. Proc Natl Acad Sci U S A 2006 1.98
49 Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. Genes Dev 2003 1.96
50 TILLING: practical single-nucleotide mutation discovery. Plant J 2006 1.94
51 Adaptive evolution of centromere proteins in plants and animals. J Biol 2004 1.90
52 The INTACT method for cell type-specific gene expression and chromatin profiling in Arabidopsis thaliana. Nat Protoc 2010 1.87
53 A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin 2012 1.82
54 Structure, dynamics, and evolution of centromeric nucleosomes. Proc Natl Acad Sci U S A 2007 1.81
55 Maintenance of chromatin states: an open-and-shut case. Curr Opin Cell Biol 2003 1.72
56 High-throughput TILLING for functional genomics. Methods Mol Biol 2003 1.70
57 Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res 2010 1.69
58 Centromere targeting element within the histone fold domain of Cid. Mol Cell Biol 2002 1.64
59 Epigenetic consequences of nucleosome dynamics. Cell 2002 1.60
60 Doxorubicin enhances nucleosome turnover around promoters. Curr Biol 2013 1.58
61 Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila. PLoS Genet 2005 1.57
62 Chromatin and siRNA pathways cooperate to maintain DNA methylation of small transposable elements in Arabidopsis. Genome Biol 2005 1.55
63 Automated band mapping in electrophoretic gel images using background information. Nucleic Acids Res 2005 1.49
64 Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone. Proc Natl Acad Sci U S A 2002 1.48
65 Tripartite organization of centromeric chromatin in budding yeast. Proc Natl Acad Sci U S A 2011 1.47
66 Genomic analysis of parent-of-origin allelic expression in Arabidopsis thaliana seeds. PLoS One 2011 1.45
67 Germline histone dynamics and epigenetics. Curr Opin Cell Biol 2007 1.42
68 Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans. PLoS Genet 2006 1.42
69 H2A.Z nucleosomes enriched over active genes are homotypic. Nat Struct Mol Biol 2010 1.41
70 DNA methylation dynamics in plant genomes. Biochim Biophys Acta 2007 1.41
71 Transcription and histone modifications in the recombination-free region spanning a rice centromere. Plant Cell 2005 1.37
72 Adaptive evolution of the histone fold domain in centromeric histones. Mol Biol Evol 2004 1.35
73 Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling. Genome Res 2012 1.32
74 A native chromatin purification system for epigenomic profiling in Caenorhabditis elegans. Nucleic Acids Res 2009 1.30
75 High-throughput discovery of rare human nucleotide polymorphisms by Ecotilling. Nucleic Acids Res 2006 1.28
76 Centromeres put epigenetics in the driver's seat. Trends Biochem Sci 2006 1.28
77 Heat shock reduces stalled RNA polymerase II and nucleosome turnover genome-wide. Genes Dev 2011 1.26
78 ISWI and CHD chromatin remodelers bind promoters but act in gene bodies. PLoS Genet 2013 1.25
79 Histone variants: dynamic punctuation in transcription. Genes Dev 2014 1.22
80 Centromeres convert but don't cross. PLoS Biol 2010 1.22
81 Histone variants in pluripotency and disease. Development 2013 1.21
82 Epigenomic profiling using microarrays. Biotechniques 2003 1.21
83 Silencing of transposons in plant genomes: kick them when they're down. Genome Biol 2004 1.15
84 Retention of induced mutations in a Drosophila reverse-genetic resource. Genetics 2008 1.14
85 The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1. Elife 2014 1.13
86 Intergenic locations of rice centromeric chromatin. PLoS Biol 2008 1.13
87 Phylogeny as the basis for naming histones. Trends Genet 2013 1.12
88 The CentO satellite confers translational and rotational phasing on cenH3 nucleosomes in rice centromeres. Proc Natl Acad Sci U S A 2013 1.11
89 Tech.Sight. Phage display. Affinity selection from biological libraries. Science 2002 1.11
90 Positive selection of Iris, a retroviral envelope-derived host gene in Drosophila melanogaster. PLoS Genet 2005 1.09
91 Transcribing through the nucleosome. Trends Biochem Sci 2014 1.07
92 Quantitative epigenetics. Nat Genet 2003 1.07
93 Fly-TILL: reverse genetics using a living point mutation resource. Fly (Austin) 2008 1.05
94 Labile H3.3+H2A.Z nucleosomes mark 'nucleosome-free regions'. Nat Genet 2009 1.05
95 Epigenetic inheritance in Arabidopsis: selective silence. Curr Opin Genet Dev 2005 1.03
96 Mot1 redistributes TBP from TATA-containing to TATA-less promoters. Mol Cell Biol 2013 1.02
97 Histone variants and modifications in plant gene regulation. Curr Opin Plant Biol 2010 1.02
98 Capturing the dynamic epigenome. Genome Biol 2010 1.01
99 Surveying the epigenomic landscape, one base at a time. Genome Biol 2012 0.99
100 Holocentromeres are dispersed point centromeres localized at transcription factor hotspots. Elife 2014 0.98
101 High-throughput TILLING for Arabidopsis. Methods Mol Biol 2006 0.94
102 Reconstitution of hemisomes on budding yeast centromeric DNA. Nucleic Acids Res 2013 0.93
103 Chromatin-based transcriptional punctuation. Genes Dev 2009 0.92
104 High-resolution mapping defines the cooperative architecture of Polycomb response elements. Genome Res 2014 0.90
105 Gene regulation: A chromatin thermostat. Nature 2010 0.90
106 Biotin-tag affinity purification of a centromeric nucleosome assembly complex. Cell Cycle 2006 0.87
107 Anthracyclines induce double-strand DNA breaks at active gene promoters. Mutat Res 2015 0.86
108 Versatile assembler. Nature 2003 0.86
109 Sixty years of genome biology. Genome Biol 2013 0.85
110 DNA methylation and demethylation in Arabidopsis. Arabidopsis Book 2008 0.82
111 Salt fractionation of nucleosomes for genome-wide profiling. Methods Mol Biol 2012 0.81
112 Mapping regulatory factors by immunoprecipitation from native chromatin. Curr Protoc Mol Biol 2015 0.81
113 Baculovirus-encoded protein expression for epigenomic profiling in Drosophila cells. Fly (Austin) 2010 0.81
114 Measuring genome-wide nucleosome turnover using CATCH-IT. Methods Enzymol 2012 0.81
115 ENCODE and our very busy genome. Nat Genet 2007 0.81
116 Using the blocks database to recognize functional domains. Curr Protoc Bioinformatics 2002 0.80
117 TILLING and ecotilling for rice. Methods Mol Biol 2013 0.80
118 Epigenomics: a roadmap to chromatin. Science 2008 0.79
119 The heat shock response: A case study of chromatin dynamics in gene regulation. Biochem Cell Biol 2013 0.78
120 Chromatin roadblocks to reprogramming 50 years on. BMC Biol 2012 0.77
121 Beyond the central dogma. Bioinformatics 2002 0.76
122 Chromatin: packaging without nucleosomes. Curr Biol 2012 0.76
123 Cell type-specific affinity purification of nuclei for chromatin profiling in whole animals. Methods Mol Biol 2015 0.76
124 Catching a glimpse of nucleosome dynamics. Cell Cycle 2010 0.76
125 Epigenetics & Chromatin celebrates its first anniversary. Epigenetics Chromatin 2009 0.75
126 Corrigendum: ChEC-seq kinetics discriminates transcription factor binding sites by DNA sequence and shape in vivo. Nat Commun 2017 0.75
127 Corrigendum: ChEC-seq kinetics discriminates transcription factor binding sites by DNA sequence and shape in vivo. Nat Commun 2015 0.75
128 Self-perpetuating structural states in biology, disease, and genetics. Proc Natl Acad Sci U S A 2002 0.75