Published in Zhonghua Gan Zang Bing Za Zhi on January 01, 2008
The diploid genome sequence of an individual human. PLoS Biol (2007) 44.80
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature (2010) 18.69
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron (2011) 10.61
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell (2012) 6.07
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. J Transl Med (2010) 5.57
Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res (2007) 4.48
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol (2004) 4.41
Optical absorption enhancement in amorphous silicon nanowire and nanocone arrays. Nano Lett (2009) 4.35
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81
Microtubule assembly dynamics at the nanoscale. Curr Biol (2007) 3.02
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00
Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med (2002) 2.90
Removal of heavy metal ions from wastewaters: a review. J Environ Manage (2010) 2.87
Ice-shelf collapse from subsurface warming as a trigger for Heinrich events. Proc Natl Acad Sci U S A (2011) 2.83
Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res (2004) 2.79
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity (2011) 2.69
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet (2003) 2.67
Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china. Circ Cardiovasc Qual Outcomes (2010) 2.63
TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods (2012) 2.59
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell (2003) 2.55
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation (2006) 2.55
Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc Res (2009) 2.54
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat Biotechnol (2003) 2.53
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell (2010) 2.52
BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte. Cell Cycle (2010) 2.44
Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet (2002) 2.39
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.28
Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data. Nucleic Acids Res (2004) 2.17
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. J Struct Biol (2005) 2.15
Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity (2011) 2.15
Towards precise classification of cancers based on robust gene functional expression profiles. BMC Bioinformatics (2005) 2.01
Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem (2008) 1.98
Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol (2002) 1.94
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods (2013) 1.88
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood (2007) 1.86
Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy. Transplantation (2008) 1.84
Drosophila male germline stem cells do not asymmetrically segregate chromosome strands. J Cell Sci (2011) 1.83
Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure (2009) 1.79
Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol (2004) 1.74
Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells. Cancer Res (2011) 1.73
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene. J Immunol (2005) 1.68
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology (2005) 1.67
Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development (2003) 1.64
Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A (2010) 1.64
Host response after reconstruction of abdominal wall defects with porcine dermal collagen in a rat model. Am J Obstet Gynecol (2004) 1.56
Reconstruction of circulation in the fingertip without vein repair in zone I replantation. J Hand Surg Am (2008) 1.56
Interface engineered BaTiO₃/SrTiO₃ heterostructures with optimized high-frequency dielectric properties. ACS Appl Mater Interfaces (2012) 1.52
Risk factors associated with fluoroquinolone-resistant tuberculosis in a Beijing tuberculosis referral hospital. Respirology (2011) 1.50
Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan. Circ J (2013) 1.50
N-halosuccinimide/BF3-H2O, efficient electrophilic halogenating systems for aromatics. J Am Chem Soc (2004) 1.47
Cinnabar is not converted into methylmercury by human intestinal bacteria. J Ethnopharmacol (2011) 1.45
Potential for serious environmental threats from uncontrolled co-processing of wastes in cement kilns. Environ Sci Technol (2012) 1.44
Associations between interleukin-6 gene -174 C/G and -572 C/G polymorphisms and the risk of gastric cancer: a meta-analysis. J Surg Oncol (2012) 1.44
[Research on differential genes related with qi stagnation constitution]. Zhongguo Zhong Xi Yi Jie He Za Zhi (2011) 1.44
L-type calcium channel mutations in Japanese patients with inherited arrhythmias. Circ J (2013) 1.44
Bioinformatics analysis of alternative splicing. Brief Bioinform (2005) 1.44
Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection. Transplantation (2005) 1.43
Characteristics and treatment outcomes of patients with MDR and XDR tuberculosis in a TB referral hospital in Beijing: a 13-year experience. PLoS One (2011) 1.42
Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. J Biol Chem (2008) 1.41
Equivalence of two approaches for quantum-classical hybrid systems. J Chem Phys (2008) 1.39
XPC 939A>C and 499C>T polymorphisms and skin cancer risk: a meta-analysis. Asian Pac J Cancer Prev (2012) 1.39
One-stage surgical management for children with spinal tuberculosis by anterior decompression and posterior instrumentation. Int Orthop (2009) 1.39
2-Chloro-N-isopropyl-N-phenyl-acetamide. Acta Crystallogr Sect E Struct Rep Online (2010) 1.39
Effect of a Novel Stent on Re-Endothelialization, Platelet Adhesion, and Neointimal Formation. J Atheroscler Thromb (2015) 1.38
IDT SciTools: a suite for analysis and design of nucleic acid oligomers. Nucleic Acids Res (2008) 1.37
A wireless electronic nose system using a Fe2O3 gas sensing array and least squares support vector regression. Sensors (Basel) (2011) 1.37
Identifying gene regulatory networks in schizophrenia. Neuroimage (2010) 1.34
BC200 RNA in invasive and preinvasive breast cancer. Carcinogenesis (2004) 1.34
The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev (2012) 1.32
Origin of additional capacities in metal oxide lithium-ion battery electrodes. Nat Mater (2013) 1.30
Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization. J Oral Pathol Med (2005) 1.30
Imaging of mesenchymal stem cell transplant by bioluminescence and PET. J Nucl Med (2007) 1.29
Rapid positive selection of stable integrants following transfection of Plasmodium falciparum. Mol Biochem Parasitol (2002) 1.29
Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses. J Virol (2007) 1.27
Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels. PLoS Genet (2011) 1.25
The genome of the plant growth-promoting rhizobacterium Paenibacillus polymyxa M-1 contains nine sites dedicated to nonribosomal synthesis of lipopeptides and polyketides. J Bacteriol (2011) 1.25
No clinical benefit of gender-specific total knee arthroplasty. Acta Orthop (2014) 1.25
Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF). Carcinogenesis (2005) 1.24
Renal clearance of gamma-hydroxybutyric acid in rats: increasing renal elimination as a detoxification strategy. J Pharmacol Exp Ther (2005) 1.24
Fast spin state initialization in a singly charged InAs-GaAs quantum dot by optical cooling. Phys Rev Lett (2007) 1.22
Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest (2006) 1.22
[Prevalence and etiology of people with hearing impairment in China]. Zhonghua Liu Xing Bing Xue Za Zhi (2008) 1.22
Motion aftereffects transfer between touch and vision. Curr Biol (2009) 1.21
Structure of the S1S2 glutamate binding domain of GLuR3. Proteins (2009) 1.20
Traditional Chinese medicine herbal preparations in restless legs syndrome (RLS) treatment: a review and probable first description of RLS in 1529. Sleep Med Rev (2012) 1.20
The complete genome of Bacillus amyloliquefaciens subsp. plantarum CAU B946 contains a gene cluster for nonribosomal synthesis of iturin A. J Bacteriol (2012) 1.20
Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice. Mol Cell Neurosci (2007) 1.20
Molecular simulation of protein adsorption and desorption on hydroxyapatite surfaces. Biomaterials (2007) 1.20
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest (2009) 1.20
Supported employment outcomes of a randomized controlled trial of ACT and clubhouse models. Psychiatr Serv (2006) 1.19
A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nat Genet (2013) 1.19
Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. Nat Med (2013) 1.19
Design for hydrogen storage materials via observation of adsorption sites by computer tomography. J Phys Chem B (2007) 1.19
ASD: a comprehensive database of allosteric proteins and modulators. Nucleic Acids Res (2010) 1.18