Structure and mechanism of inhibition of plant acetohydroxyacid synthase.

PubWeight™: 1.45‹?› | Rank: Top 5%

🔗 View Article (PMID 18234503)

Published in Plant Physiol Biochem on January 14, 2008

Authors

Ronald G Duggleby1, Jennifer A McCourt, Luke W Guddat

Author Affiliations

1: RDBiotech, 22 Parklands Boulevard, Little Mountain, Queensland 4551, Australia. ron_duggleby@fastmail.com.au

Articles citing this

Branched-Chain Amino Acid Metabolism in Arabidopsis thaliana. Arabidopsis Book (2010) 1.12

Herbicide-resistant crops: utilities and limitations for herbicide-resistant weed management. J Agric Food Chem (2010) 0.99

The herbicide triflusulfuron-meth-yl. Acta Crystallogr Sect E Struct Rep Online (2011) 0.97

AHAS herbicide resistance endowing mutations: effect on AHAS functionality and plant growth. J Exp Bot (2010) 0.95

A technical breakthrough close at hand: feasible approaches toward establishing a gene-targeting genetic transformation system in seaweeds. Front Plant Sci (2014) 0.91

A pangenomic analysis of the Nannochloropsis organellar genomes reveals novel genetic variations in key metabolic genes. BMC Genomics (2014) 0.90

Single nucleotide mutation in the barley acetohydroxy acid synthase (AHAS) gene confers resistance to imidazolinone herbicides. Proc Natl Acad Sci U S A (2011) 0.87

ALOMYbase, a resource to investigate non-target-site-based resistance to herbicides inhibiting acetolactate-synthase (ALS) in the major grass weed Alopecurus myosuroides (black-grass). BMC Genomics (2015) 0.82

Molecular and phenotypic characterization of Als1 and Als2 mutations conferring tolerance to acetolactate synthase herbicides in soybean. Pest Manag Sci (2014) 0.81

Precision phenotyping of imidazolinone-induced chlorosis in sunflower. Breed Sci (2014) 0.80

Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrob Agents Chemother (2012) 0.80

Down-regulation of acetolactate synthase compromises Ol-1- mediated resistance to powdery mildew in tomato. BMC Plant Biol (2014) 0.79

Involvement of threonine deaminase FgIlv1 in isoleucine biosynthesis and full virulence in Fusarium graminearum. Curr Genet (2014) 0.78

A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases. Adv Enzymol Relat Areas Mol Biol (2011) 0.77

Acetohydroxyacid synthase FgIlv2 and FgIlv6 are involved in BCAA biosynthesis, mycelial and conidial morphogenesis, and full virulence in Fusarium graminearum. Sci Rep (2015) 0.77

Copy Number Variation in Acetolactate Synthase Genes of Thifensulfuron-Methyl Resistant Alopecurus aequalis (Shortawn Foxtail) Accessions in Japan. Front Plant Sci (2017) 0.76

Transformation of apple (Malus × domestica) using mutants of apple acetolactate synthase as a selectable marker and analysis of the T-DNA integration sites. Plant Cell Rep (2013) 0.75

The Effects of Herbicides Targeting Aromatic and Branched Chain Amino Acid Biosynthesis Support the Presence of Functional Pathways in Broomrape. Front Plant Sci (2017) 0.75

From dusk till dawn: the Arabidopsis thaliana sugar starving responsive network. Front Plant Sci (2014) 0.75

Assessment of genetic diversity among barley cultivars and breeding lines adapted to the US Pacific Northwest, and its implications in breeding barley for imidazolinone-resistance. PLoS One (2014) 0.75

Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation. PLoS One (2016) 0.75

Discovery of Putative Herbicide Resistance Genes and Its Regulatory Network in Chickpea Using Transcriptome Sequencing. Front Plant Sci (2017) 0.75

The Influence of the Plant Growth Regulator Maleic Hydrazide on Egyptian Broomrape Early Developmental Stages and Its Control Efficacy in Tomato under Greenhouse and Field Conditions. Front Plant Sci (2017) 0.75

Fitness of ALS-Inhibitors Herbicide Resistant Population of Loose Silky Bentgrass (Apera spica-venti). Front Plant Sci (2017) 0.75

Articles by these authors

The catalytic mechanisms of binuclear metallohydrolases. Chem Rev (2006) 1.50

Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors. J Mol Biol (2002) 1.24

Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase. Proc Natl Acad Sci U S A (2006) 1.21

Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. J Biol Chem (2002) 1.16

Structure-activity relationships for a new family of sulfonylurea herbicides. J Comput Aided Mol Des (2005) 1.13

Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry (2005) 1.12

Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proc Natl Acad Sci U S A (2004) 1.12

The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. J Biol Chem (2003) 1.08

Structure of CcmG/DsbE at 1.14 A resolution: high-fidelity reducing activity in an indiscriminately oxidizing environment. Structure (2002) 1.05

Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data. Eur J Biochem (2003) 0.95

Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallogr D Biol Crystallogr (2002) 0.94

The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. Protein Sci (2005) 0.93

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Struct Biol (2008) 0.91

Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction. Acc Chem Res (2012) 0.90

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Mol Pharmacol (2013) 0.89

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem (2009) 0.88

Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochim Biophys Acta (2007) 0.87

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS J (2009) 0.87

Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures. J Mol Biol (2009) 0.84

Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J Am Chem Soc (2008) 0.84

Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. FEBS J (2005) 0.83

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. J Med Chem (2013) 0.83

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Arch Biochem Biophys (2004) 0.83

The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. J Mol Biol (2005) 0.83

Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. J Inorg Biochem (2011) 0.83

Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. J Mol Biol (2012) 0.81

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases. J Med Chem (2012) 0.81

Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS J (2009) 0.80

Penicillin inhibitors of purple acid phosphatase. Bioorg Med Chem Lett (2012) 0.79

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem Biol Drug Des (2012) 0.78

The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochem J (2010) 0.78

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents. J Med Chem (2014) 0.78

Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. J Med Chem (2006) 0.78

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy. Mol Biochem Parasitol (2010) 0.78

Facile crystallization of Escherichia coli ketol-acid reductoisomerase. Acta Crystallogr D Biol Crystallogr (2004) 0.78

Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases? BMC Res Notes (2008) 0.77

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorg Med Chem (2011) 0.77

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs. Curr Top Med Chem (2011) 0.77

Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorg Med Chem Lett (2008) 0.77

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. J Med Chem (2012) 0.77

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorg Med Chem (2011) 0.77

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. J Med Chem (2013) 0.77

The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One (2013) 0.76

Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Org Biomol Chem (2015) 0.76

Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75

Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. J Agric Food Chem (2011) 0.75

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorg Med Chem Lett (2012) 0.75

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorg Med Chem (2009) 0.75

Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. J Biol Inorg Chem (2014) 0.75

Detection of HSV type-1 and type-2 IgG using an in vitro PCA based homogeneous immunoassay. Biochem Biophys Res Commun (2008) 0.75

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Eur J Med Chem (2013) 0.75