Published in Acta Crystallogr D Biol Crystallogr on April 26, 2002
Altered dimer interface decreases stability in an amyloidogenic protein. J Biol Chem (2008) 1.50
Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. MAbs (2009) 1.20
The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain. Biochemistry (2010) 1.05
Structural alterations within native amyloidogenic immunoglobulin light chains. J Mol Biol (2009) 1.01
Light chain amyloidosis - current findings and future prospects. Curr Protein Pept Sci (2009) 0.96
A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. Structure (2010) 0.95
Amyloid formation in light chain amyloidosis. Curr Top Med Chem (2012) 0.86
Diagnostic accuracy of monoclonal antibody based serum immunoglobulin free light chain immunoassays in myeloma cast nephropathy. BMC Clin Pathol (2012) 0.80
Formation of amyloid fibers by monomeric light chain variable domains. J Biol Chem (2014) 0.78
Four crystal forms of a Bence-Jones protein. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.78
Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome. J Biol Chem (2008) 1.93
Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation. J Biol Chem (2002) 1.84
Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies. Immunol Cell Biol (2007) 1.59
The catalytic mechanisms of binuclear metallohydrolases. Chem Rev (2006) 1.50
Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiol Biochem (2008) 1.45
Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell (2005) 1.45
Challenges and advances in computational docking: 2009 in review. J Mol Recognit (2010) 1.42
Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer (2008) 1.28
Latest developments in molecular docking: 2010-2011 in review. J Mol Recognit (2013) 1.26
Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors. J Mol Biol (2002) 1.24
Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase. Proc Natl Acad Sci U S A (2006) 1.21
HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism. J Virol (2011) 1.16
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. J Biol Chem (2002) 1.16
A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress. J Biol Chem (2003) 1.13
Structure-activity relationships for a new family of sulfonylurea herbicides. J Comput Aided Mol Des (2005) 1.13
Structure activity relationship of dendrimer microbicides with dual action antiviral activity. PLoS One (2010) 1.12
Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry (2005) 1.12
Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proc Natl Acad Sci U S A (2004) 1.12
Proteomic studies of the intrinsically unstructured mammalian proteome. J Proteome Res (2006) 1.11
Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. J Immunol (2002) 1.10
An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes. Virology (2010) 1.08
A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease. Proc Natl Acad Sci U S A (2011) 1.08
The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. J Biol Chem (2003) 1.08
A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor. Proc Natl Acad Sci U S A (2003) 1.07
Structure of CcmG/DsbE at 1.14 A resolution: high-fidelity reducing activity in an indiscriminately oxidizing environment. Structure (2002) 1.05
Three-dimensional structures of carbohydrate determinants of Lewis system antigens: implications for effective antibody targeting of cancer. Immunol Cell Biol (2005) 1.03
Large-scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome. J Proteome Res (2009) 1.02
Autoantibody-catalyzed hydrolysis of amyloid beta peptide. J Biol Chem (2007) 1.00
Bovine IgM antibodies with exceptionally long complementarity-determining region 3 of the heavy chain share unique structural properties conferring restricted VH + Vlambda pairings. Int Immunol (2003) 0.97
Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and CDK11 in vitro. J Biol Chem (2002) 0.97
Molecular docking of carbohydrate ligands to antibodies: structural validation against crystal structures. J Chem Inf Model (2009) 0.97
Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data. Eur J Biochem (2003) 0.95
Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. Am J Respir Crit Care Med (2006) 0.94
Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1). PLoS Negl Trop Dis (2013) 0.93
Reactive oxygen species level defines two functionally distinctive stages of inflammatory dendritic cell development from mouse bone marrow. J Immunol (2010) 0.93
Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages. J Virol (2011) 0.93
Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. Mol Cell Biol (2005) 0.93
The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. Protein Sci (2005) 0.93
Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. J Biol Chem (2002) 0.93
Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection. PLoS One (2013) 0.92
Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5. J Leukoc Biol (2012) 0.92
In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies. Mol Immunol (2009) 0.92
Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Struct Biol (2008) 0.91
CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity. Virology (2011) 0.91
Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1. Antiviral Res (2011) 0.91
Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia. Endocr Pathol (2004) 0.90
Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues. Retrovirology (2011) 0.90
Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction. Acc Chem Res (2012) 0.90
Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells. J Biol Chem (2012) 0.89
Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Mol Pharmacol (2013) 0.89
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem (2009) 0.88
A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology (2013) 0.88
Inhibition of destructive autoimmune arthritis in FcgammaRIIa transgenic mice by small chemical entities. Immunol Cell Biol (2008) 0.88
Measuring the impact of cigarette smoke on the UPR. Methods Enzymol (2011) 0.87
Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochim Biophys Acta (2007) 0.87
Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS J (2009) 0.87
Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody. Biochem J (2006) 0.87
A double mutation of MBP(83-99) peptide induces IL-4 responses and antagonizes IFN-gamma responses. J Neuroimmunol (2008) 0.86
Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis. J Clin Invest (2016) 0.86
Inhibition of human γ-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors. Biochem J (2013) 0.85
Three-dimensional structures of idiotypically related Fabs with intermediate and high affinity for fluorescein. J Mol Biol (2004) 0.84
A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI. J Biol Chem (2006) 0.84
Structural biology of carbohydrate xenoantigens. Expert Opin Biol Ther (2009) 0.84
Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J Am Chem Soc (2008) 0.84
Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures. J Mol Biol (2009) 0.84
Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. J Med Chem (2013) 0.83
Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. FEBS J (2005) 0.83
The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. J Mol Biol (2005) 0.83
Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Arch Biochem Biophys (2004) 0.83
Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. J Inorg Biochem (2011) 0.83
Polymorphisms and interspecies differences of the activating and inhibitory FcγRII of Macaca nemestrina influence the binding of human IgG subclasses. J Immunol (2013) 0.82
Construction of single-chain Fv with two possible CDR3H conformations but similar inter-molecular forces that neutralize bovine herpesvirus 1. Mol Immunol (2009) 0.82
Altered peptide ligands of myelin basic protein ( MBP87-99 ) conjugated to reduced mannan modulate immune responses in mice. Immunology (2009) 0.82
A possible role for metallic ions in the carbohydrate cluster recognition displayed by a Lewis Y specific antibody. PLoS One (2009) 0.82
Designing proteins to crystallize through beta-strand pairing. Protein Eng (2003) 0.82
An FcgammaRIIa-binding peptide that mimics the interaction between FcgammaRIIa and IgG. Mol Immunol (2007) 0.82
AutoMap: a tool for analyzing protein-ligand recognition using multiple ligand binding modes. J Mol Graph Model (2013) 0.81
Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. J Mol Biol (2012) 0.81
Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping. PLoS One (2012) 0.81
NPAS1 regulates branching morphogenesis in embryonic lung. Am J Respir Cell Mol Biol (2006) 0.81
Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95. J Mol Recognit (2003) 0.81
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases. J Med Chem (2012) 0.81
Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide. Immunology (2006) 0.81
Bub1-mediated adaptation of the spindle checkpoint. PLoS Genet (2011) 0.81
Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens. Biopolymers (2011) 0.81
A conserved host and pathogen recognition site on immunoglobulins: structural and functional aspects. Adv Exp Med Biol (2012) 0.80
Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps. Glycobiology (2010) 0.80
Dietary aspartyl-phenylalanine-1-methyl ester delays osteoarthritis and prevents associated bone loss in STR/ORT mice. Rheumatology (Oxford) (2011) 0.80
Mannosylation of mutated MBP83-99 peptides diverts immune responses from Th1 to Th2. Mol Immunol (2008) 0.80
Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications. Expert Opin Biol Ther (2011) 0.80
Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS J (2009) 0.80
Penicillin inhibitors of purple acid phosphatase. Bioorg Med Chem Lett (2012) 0.79
Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form. J Immunol (2010) 0.79