Published in Biochemistry on February 22, 2005
Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase. Proc Natl Acad Sci U S A (2006) 1.21
Structure-activity relationships for a new family of sulfonylurea herbicides. J Comput Aided Mol Des (2005) 1.13
The herbicide triflusulfuron-meth-yl. Acta Crystallogr Sect E Struct Rep Online (2011) 0.97
Direct activation of Epac by sulfonylurea is isoform selective. Chem Biol (2011) 0.91
Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents. Antimicrob Agents Chemother (2013) 0.83
The structures of pyruvate oxidase from Aerococcus viridans with cofactors and with a reaction intermediate reveal the flexibility of the active-site tunnel for catalysis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.79
Multiple Mechanisms Increase Levels of Resistance in Rapistrum rugosum to ALS Herbicides. Front Plant Sci (2016) 0.79
A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases. Adv Enzymol Relat Areas Mol Biol (2011) 0.77
Preliminary X-ray crystallographic studies of the catalytic subunit of Escherichia coli AHAS II with its cofactors. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families. Proc Natl Acad Sci U S A (2017) 0.75
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2005) 3.97
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
Human sulfotransferases and their role in chemical metabolism. Toxicol Sci (2005) 2.27
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity (2011) 2.11
The catalytic mechanisms of binuclear metallohydrolases. Chem Rev (2006) 1.50
NMR analysis of covalent intermediates in thiamin diphosphate enzymes. Biochemistry (2003) 1.48
Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiol Biochem (2008) 1.45
Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. J Biol Chem (2002) 1.42
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor. Immunity (2009) 1.40
Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors. J Mol Biol (2002) 1.24
Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase. Proc Natl Acad Sci U S A (2006) 1.21
A new approach to 'megaprimer' polymerase chain reaction mutagenesis without an intermediate gel purification step. BMC Biotechnol (2004) 1.19
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. J Biol Chem (2002) 1.16
Structure-activity relationships for a new family of sulfonylurea herbicides. J Comput Aided Mol Des (2005) 1.13
Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proc Natl Acad Sci U S A (2004) 1.12
The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. J Biol Chem (2003) 1.08
The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates. J Biol Chem (2005) 1.06
Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3. J Biol Chem (2004) 1.05
Structure of CcmG/DsbE at 1.14 A resolution: high-fidelity reducing activity in an indiscriminately oxidizing environment. Structure (2002) 1.05
Regulatory interactions in Arabidopsis thaliana acetohydroxyacid synthase. FEBS Lett (2002) 0.99
Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data. Eur J Biochem (2003) 0.95
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallogr D Biol Crystallogr (2002) 0.94
The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. Protein Sci (2005) 0.93
Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Struct Biol (2008) 0.91
Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction. Acc Chem Res (2012) 0.90
Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Mol Pharmacol (2013) 0.89
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem (2009) 0.88
Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS J (2009) 0.87
Thiamin nutrition and catalysis-induced instability of thiamin diphosphate. Br J Nutr (2006) 0.87
Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochim Biophys Acta (2007) 0.87
How an enzyme answers multiple-choice questions. Trends Biochem Sci (2005) 0.86
Mechanisms of acetohydroxyacid synthases. Curr Opin Chem Biol (2005) 0.86
Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures. J Mol Biol (2009) 0.84
Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J Am Chem Soc (2008) 0.84
Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. J Med Chem (2013) 0.83
A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. J Biol Chem (2013) 0.83
The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. J Mol Biol (2005) 0.83
Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Arch Biochem Biophys (2004) 0.83
Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. FEBS J (2005) 0.83
Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. J Inorg Biochem (2011) 0.83
A CFTR chloride channel activator prevents HrpN(ea)-induced cell death in Arabidopsis thaliana suspension cells. Plant Physiol Biochem (2005) 0.81
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases. J Med Chem (2012) 0.81
Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. J Mol Biol (2012) 0.81
Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS J (2009) 0.80
Penicillin inhibitors of purple acid phosphatase. Bioorg Med Chem Lett (2012) 0.79
Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem Biol Drug Des (2012) 0.78
Facile crystallization of Escherichia coli ketol-acid reductoisomerase. Acta Crystallogr D Biol Crystallogr (2004) 0.78
The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochem J (2010) 0.78
Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. J Med Chem (2006) 0.78
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy. Mol Biochem Parasitol (2010) 0.78
Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases? BMC Res Notes (2008) 0.77
Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorg Med Chem Lett (2008) 0.77
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorg Med Chem (2011) 0.77
6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs. Curr Top Med Chem (2011) 0.77
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. J Med Chem (2013) 0.77
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. J Med Chem (2012) 0.77
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorg Med Chem (2011) 0.77
Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Org Biomol Chem (2015) 0.76
The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One (2013) 0.76
Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
Mutations in the regulatory subunit of yeast acetohydroxyacid synthase affect its activation by MgATP. Biochem J (2006) 0.75
A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorg Med Chem Lett (2012) 0.75
Biochemical characterization of two mutants of human pyruvate dehydrogenase, F205L and T231A of the E1alpha subunit. J Inherit Metab Dis (2003) 0.75
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorg Med Chem (2009) 0.75
Synthesis, crystal structure and herbicidal activity of mimics of intermediates of the KARI reaction. Pest Manag Sci (2005) 0.75
The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Eur J Med Chem (2013) 0.75
Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. J Biol Inorg Chem (2014) 0.75
Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. J Agric Food Chem (2011) 0.75