Published in Diabetologia on February 09, 2008
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia (2010) 3.48
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res (2011) 2.83
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes (2013) 2.70
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes (2008) 2.09
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes (2009) 1.90
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes (2009) 1.87
Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest (2011) 1.80
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Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes (2009) 1.50
Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. PLoS One (2008) 1.41
Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One (2008) 1.40
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest (2013) 1.39
Genomics of type 2 diabetes mellitus: implications for the clinician. Nat Rev Endocrinol (2009) 1.34
TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study. Diabetologia (2009) 1.33
Physiologic characterization of type 2 diabetes-related loci. Curr Diab Rep (2010) 1.24
Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. J Clin Endocrinol Metab (2009) 1.17
TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women. Am J Clin Nutr (2009) 1.17
Zinc transporter 8 (ZnT8) and β cell function. Trends Endocrinol Metab (2014) 1.14
Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics. Curr Genomics (2009) 1.14
Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion. BMC Med Genet (2010) 1.13
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes (2011) 1.13
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The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PLoS One (2012) 1.11
TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet (2014) 1.10
TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program. PLoS One (2011) 1.04
Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Diabetes (2010) 1.03
A likelihood ratio-based Mann-Whitney approach finds novel replicable joint gene action for type 2 diabetes. Genet Epidemiol (2012) 1.00
In vivo misfolding of proinsulin below the threshold of frank diabetes. Diabetes (2011) 1.00
Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. Diabetes (2009) 0.99
SLC30A8 mutations in type 2 diabetes. Diabetologia (2014) 0.99
Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One (2009) 0.99
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SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. PLoS One (2009) 0.99
The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Diabetes (2010) 0.92
CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. J Biol Chem (2012) 0.92
Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients. Eur J Clin Pharmacol (2010) 0.91
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. Diabetologia (2013) 0.89
Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals. PLoS One (2012) 0.88
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Expression of the diabetes-associated gene TCF7L2 in adult mouse brain. J Comp Neurol (2009) 0.86
Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance. Mol Endocrinol (2015) 0.85
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Zinc transporters and their role in the pancreatic β-cell. J Diabetes Investig (2012) 0.85
Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial beta-cell protection in individuals with type 2 diabetes. Diabetes Obes Metab (2010) 0.84
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Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells. Diabetologia (2014) 0.82
The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function. J Clin Endocrinol Metab (2014) 0.82
Validation of the association of TCF7L2 and SLC30A8 gene polymorphisms with post-transplant diabetes mellitus in Asian Indian population. Intractable Rare Dis Res (2015) 0.82
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In type 2 diabetes patients, insulin glargine is associated with lower postprandial release of intact proinsulin compared with sulfonylurea treatment. J Diabetes Sci Technol (2012) 0.82
Update on genetics and diabetic retinopathy. Clin Ophthalmol (2015) 0.81
Clinical translation of genetic predictors for type 2 diabetes. Curr Opin Endocrinol Diabetes Obes (2009) 0.81
Protective alleles and modifier variants in human health and disease. Nat Rev Genet (2015) 0.81
The physiological role of drug transporters. Protein Cell (2015) 0.80
IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes. Growth Horm IGF Res (2010) 0.80
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Hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes: a meta-analysis. PLoS One (2012) 0.80
Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus. J Diabetes Investig (2016) 0.79
Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish. Diabetologia (2014) 0.79
Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology (2016) 0.78
Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies. BMC Med Genet (2009) 0.78
Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells. BMC Res Notes (2014) 0.78
Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets. BMC Genet (2013) 0.78
Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis. PLoS One (2014) 0.78
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus. Antioxid Redox Signal (2016) 0.78
Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis. Med Sci Monit (2015) 0.77
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Association of rs7754840 G/C polymorphisms in CDKAL1 with type 2 diabetes: a meta-analysis of 70141 subjects. Int J Clin Exp Med (2015) 0.76
Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study. BMC Endocr Disord (2014) 0.76
Islet biology, the CDKN2A/B locus and type 2 diabetes risk. Diabetologia (2016) 0.76
A micro-RNA expression signature for human NAFLD progression. J Gastroenterol (2016) 0.76
Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain. J Chem Neuroanat (2012) 0.75
Type 2 Diabetes Mellitus and the Association of Candidate Genes in Asian Indian Population from Hyderabad, India. J Clin Diagn Res (2015) 0.75
Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison's disease. Endocrine (2016) 0.75
Zinc-rs13266634 and the arrival of diabetes pharmacogenetics: the "zinc mystique". Diabetes (2014) 0.75
Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women. BMC Cancer (2017) 0.75
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes (2017) 0.75
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia (2007) 3.34
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. Diabetologia (2007) 2.16
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The effects of skin temperature and testing site on blood glucose measurements taken by a modern blood glucose monitoring device. Diabetes Technol Ther (2005) 1.82
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Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia (2005) 1.64
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study. Diabetologia (2008) 1.53
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Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia (2008) 1.12
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