Published in Mol Cell Biol on February 11, 2008
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell Biochem Biophys (2009) 1.79
Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload. Proc Natl Acad Sci U S A (2010) 1.38
Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling. Mol Pharmacol (2010) 1.15
Regulation of GPCR signaling in hypertension. Biochim Biophys Acta (2010) 1.02
Optimising experimental design for high-throughput phenotyping in mice: a case study. Mamm Genome (2010) 0.98
Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chem Biol Drug Des (2008) 0.94
Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model. J Lipid Res (2010) 0.91
Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. Mol Endocrinol (2011) 0.91
Regulators of G-protein signaling in the heart and their potential as therapeutic targets. Circ Res (2011) 0.90
Control of striatal signaling by g protein regulators. Front Neuroanat (2011) 0.87
ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet (2013) 0.87
ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol (2014) 0.87
Relationship between RGS5 expression and differentiation and angiogenesis of gastric carcinoma. World J Gastroenterol (2010) 0.86
R4 Regulator of G Protein Signaling (RGS) Proteins in Inflammation and Immunity. AAPS J (2015) 0.84
Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. J Hypertens (2011) 0.84
Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness. J Biol Chem (2011) 0.83
Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance. PLoS One (2012) 0.83
PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality. Am J Physiol Cell Physiol (2011) 0.83
RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med (2014) 0.82
Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J Exp Med (2012) 0.81
Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation. J Mol Cell Biol (2010) 0.81
Association between regulator of G protein signaling 9-2 and body weight. PLoS One (2011) 0.80
Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease. Pulm Circ (2016) 0.79
Regulator of G-Protein Signaling 5 Reduces HeyA8 Ovarian Cancer Cell Proliferation and Extends Survival in a Murine Tumor Model. Biochem Res Int (2012) 0.79
A unifying hypothesis for scleroderma: identifying a target cell for scleroderma. Curr Rheumatol Rep (2011) 0.79
Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury. PLoS One (2014) 0.78
Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function. Prog Mol Biol Transl Sci (2015) 0.75
GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism. Med Hypotheses (2009) 0.75
Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. PLoS One (2013) 0.75
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature (2005) 2.55
RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc Natl Acad Sci U S A (2005) 2.35
Multiple genes for essential-hypertension susceptibility on chromosome 1q. Am J Hum Genet (2006) 2.34
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33
Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles. Immunity (2005) 1.96
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proc Natl Acad Sci U S A (2005) 1.91
Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. Blood (2004) 1.77
Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. FASEB J (2003) 1.76
Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am J Pathol (2003) 1.74
RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. Nature (2001) 1.62
Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ Res (2000) 1.60
Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins. J Biol Chem (2006) 1.44
Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. Nat Clin Pract Nephrol (2006) 1.40
Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol (2002) 1.38
Sphingosine-1-phosphate signaling in the cardiovascular system. Curr Opin Pharmacol (2007) 1.24
The endothelium-derived hyperpolarizing factor: insights from genetic animal models. Kidney Int (2007) 1.22
Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II. J Hypertens (2006) 1.20
A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media. Circ Res (2000) 1.20
RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol (2004) 1.10
Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap. Arterioscler Thromb Vasc Biol (2005) 1.10
Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice. Exp Physiol (2007) 1.09
Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. Circulation (2005) 1.08
Regulator of G protein signaling 5 marks peripheral arterial smooth muscle cells and is downregulated in atherosclerotic plaque. J Vasc Surg (2004) 1.00
Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.97
Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele. Diabetes (2007) 0.96
Endothelium-dependent and -independent relaxation and VASP serines 157/239 phosphorylation by cyclic nucleotide-elevating vasodilators in rat aorta. Biochem Pharmacol (2003) 0.90
Gene expression profile of the Gs-coupled prostacyclin receptor in human vascular smooth muscle cells. Biochem Pharmacol (2004) 0.84
Nitric oxide modulates Gi-protein expression and adenylyl cyclase signaling in vascular smooth muscle cells. Free Radic Biol Med (2006) 0.81
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol (2012) 4.72
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal (2010) 3.23
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J Biol Chem (2008) 2.63
Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J Biol Chem (2003) 2.28
Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles. Immunity (2005) 1.96
Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol Cell Biol (2010) 1.81
Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. FASEB J (2003) 1.76
Adoptive immunotherapy of human gastric cancer with ex vivo expanded T cells. Arch Pharm Res (2010) 1.55
Induction of dendritic cell maturation by β-glucan isolated from Sparassis crispa. Int Immunopharmacol (2010) 1.53
Toll-like receptor signaling alters the expression of regulator of G protein signaling proteins in dendritic cells: implications for G protein-coupled receptor signaling. J Immunol (2004) 1.47
B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. Immunity (2009) 1.47
RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13. J Immunol (2002) 1.33
Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [¹⁸F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography. Antimicrob Agents Chemother (2012) 1.32
Identification of RGS2 and type V adenylyl cyclase interaction sites. J Biol Chem (2003) 1.28
Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. Matrix Biol (2009) 1.23
Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice. Mol Cell Biol (2004) 1.20
IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa. Blood (2012) 1.14
Natural and edible biopolymer poly-gamma-glutamic acid: synthesis, production, and applications. Chem Rec (2005) 1.12
Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol (2007) 1.12
The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling. Genes Cells (2004) 1.09
Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1. Autophagy (2010) 1.06
Regulation of chemokine-induced lymphocyte migration by RGS proteins. Methods Enzymol (2004) 1.05
TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones. J Exp Med (2009) 1.04
The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression. Nat Immunol (2013) 1.04
Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization. Blood (2011) 1.03
Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation. J Biol Chem (2004) 1.03
The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. Biochem J (2003) 1.03
RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. J Leukoc Biol (2006) 1.03
Patterning of coronary arteries in wildtype and connexin43 knockout mice. Dev Dyn (2006) 1.03
Rat model of metastatic breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation. J Transl Med (2009) 1.03
Oral administration of high molecular mass poly-gamma-glutamate induces NK cell-mediated antitumor immunity. J Immunol (2007) 1.02
Impaired trafficking of Gnai2+/- and Gnai2-/- T lymphocytes: implications for T cell movement within lymph nodes. J Immunol (2007) 1.02
Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing. Eur J Immunol (2006) 1.02
Antitumor activity of cytokine-induced killer cells against human lung cancer. Int Immunopharmacol (2007) 1.01
Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice. Blood (2011) 1.00
Antitumor activity of cytokine-induced killer cells in nude mouse xenograft model. Arch Pharm Res (2009) 0.97
B cells productively engage soluble antigen-pulsed dendritic cells: visualization of live-cell dynamics of B cell-dendritic cell interactions. J Immunol (2005) 0.97
Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. J Immunol (2011) 0.96
Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and L-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases. Food Chem Toxicol (2011) 0.96
Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells. Dev Dyn (2008) 0.96
Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Arch Pharm Res (2007) 0.95
Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Pharmacol Ther (2011) 0.95
Regulation of immune function by G protein-coupled receptors, trimeric G proteins, and RGS proteins. Prog Mol Biol Transl Sci (2009) 0.95
Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma. Int Immunopharmacol (2007) 0.94
Enzymatic synthesis of high-molecular-mass poly-gamma-glutamate and regulation of its stereochemistry. Appl Environ Microbiol (2004) 0.93
Chemoattract receptor signaling and its role in lymphocyte motility and trafficking. Curr Top Microbiol Immunol (2009) 0.91
RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock. J Biol Chem (2004) 0.91
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol (2006) 0.91
A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell (2011) 0.90
Characteristics of a new enantioselective thermostable dipeptidase from Brevibacillus borstelensis BCS-1 and its application to synthesis of a D-amino-acid-containing dipeptide. Appl Environ Microbiol (2004) 0.90
Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta. Mol Pharmacol (2008) 0.89
Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice. Int Immunopharmacol (2008) 0.89
Low dose estrogen supplementation reduces mortality of mice in estrogen-dependent human tumor xenograft model. Biol Pharm Bull (2009) 0.89
Resveratrol down-regulates interferon-γ-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation. J Nutr Biochem (2010) 0.89
MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity. J Infect Dis (2011) 0.88
Induction of atopic eczema/dermatitis syndrome-like skin lesions by repeated topical application of a crude extract of Dermatophagoides pteronyssinus in NC/Nga mice. Int Immunopharmacol (2006) 0.88
1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol (2012) 0.87
Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings. Food Chem Toxicol (2010) 0.87
Inhibition of bone marrow-derived dendritic cell maturation by glabridin. Int Immunopharmacol (2010) 0.87
A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells. Biochem Pharmacol (2009) 0.87
Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4. Int Immunopharmacol (2006) 0.87
Retracted GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. Proc Natl Acad Sci U S A (2009) 0.87
Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus. Phytother Res (2008) 0.87
Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3). J Biol Chem (2014) 0.86
The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites. Mol Cell Biol (2012) 0.86
Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes. Exp Dermatol (2011) 0.86
alpha-Viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages. J Pharmacol Sci (2010) 0.85
Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse. Int Immunopharmacol (2009) 0.85
(E)-2,4-Bis(p-hydroxyphenyl)-2-butenal inhibits tumor growth via suppression of NF-κB and induction of death receptor 6. Apoptosis (2014) 0.85
Effects of ultra high molecular weight poly-gamma-glutamic acid from Bacillus subtilis (chungkookjang) on corneal wound healing. J Microbiol Biotechnol (2010) 0.84
Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-kappaB in macrophages. J Pharmacol Exp Ther (2008) 0.84
Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Exp Dermatol (2008) 0.84
Equol inhibits nitric oxide production and inducible nitric oxide synthase gene expression through down-regulating the activation of Akt. Int Immunopharmacol (2007) 0.84
Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model. Int Immunopharmacol (2008) 0.84
The protein phosphatase 2A B56γ regulatory subunit is required for heart development. Dev Dyn (2014) 0.84
Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice. Int Immunopharmacol (2007) 0.83
Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition. J Biol Chem (2012) 0.83
Oral administration of live attenuated Salmonella enterica serovar Typhimurium expressing chicken interferon-α alleviates clinical signs caused by respiratory infection with avian influenza virus H9N2. Vet Microbiol (2011) 0.83
Intravital two-photon imaging of adoptively transferred B lymphocytes in inguinal lymph nodes. Methods Mol Biol (2009) 0.83
Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness. J Biol Chem (2011) 0.83
New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid. Chem Biodivers (2010) 0.83