Published in Nature on February 22, 2001
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Neurosignals (2008) 1.73
R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther (2007) 1.63
CRTC3 links catecholamine signalling to energy balance. Nature (2010) 1.55
RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes Dev (2007) 1.42
C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron (2007) 1.36
How regulators of G protein signaling achieve selective regulation. J Mol Biol (2006) 1.34
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proc Natl Acad Sci U S A (2008) 1.27
Olfactory CNG channel desensitization by Ca2+/CaM via the B1b subunit affects response termination but not sensitivity to recurring stimulation. Neuron (2008) 1.26
Rgs5 targeting leads to chronic low blood pressure and a lean body habitus. Mol Cell Biol (2008) 1.19
Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells. J Biol Chem (2007) 1.16
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem (2009) 1.16
Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation. PLoS One (2011) 1.15
Generation and characterization of rgs5 mutant mice. Mol Cell Biol (2008) 1.13
Activity-regulated genes as mediators of neural circuit plasticity. Prog Neurobiol (2011) 1.13
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med (2011) 1.08
PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel. Proc Natl Acad Sci U S A (2002) 1.08
Modulation of the olfactory CNG channel by Ptdlns(3,4,5)P3. J Membr Biol (2004) 1.06
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell (2006) 1.06
Non-canonical functions of RGS proteins. Cell Signal (2010) 1.05
The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. Biochem J (2003) 1.03
Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation. J Cell Sci (2007) 1.00
Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis. Proc Natl Acad Sci U S A (2005) 0.98
Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.97
Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity. J Biol Chem (2010) 0.97
The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum. Sci Signal (2012) 0.95
A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood (2011) 0.93
A finer tuning of G-protein signaling through regulated control of RGS proteins. Am J Physiol Heart Circ Physiol (2012) 0.91
Regulators of G-protein signaling in the heart and their potential as therapeutic targets. Circ Res (2011) 0.90
Control of striatal signaling by g protein regulators. Front Neuroanat (2011) 0.87
Translational control by RGS2. J Cell Biol (2009) 0.86
Regulation of Smad-mediated gene transcription by RGS3. Mol Pharmacol (2008) 0.85
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev (2017) 0.83
Ric-8A, a Galpha protein guanine nucleotide exchange factor potentiates taste receptor signaling. Front Cell Neurosci (2009) 0.83
Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction. Nutr Metab (Lond) (2005) 0.83
De novo transcriptomes of olfactory epithelium reveal the genes and pathways for spawning migration in japanese grenadier anchovy (Coilia nasus). PLoS One (2014) 0.82
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity. Mol Pharmacol (2015) 0.81
Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS. Psychopharmacology (Berl) (2005) 0.81
Type-specific inositol 1,4,5-trisphosphate receptor localization in the vomeronasal organ and its interaction with a transient receptor potential channel, TRPC2. J Neurochem (2002) 0.81
RGS2 is a feedback inhibitor of melatonin production in the pineal gland. FEBS Lett (2013) 0.81
Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart. Trends Cardiovasc Med (2013) 0.81
Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J Biol Chem (2012) 0.80
Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D. Immunology (2005) 0.80
Role of Cholinergic Innervation and RGS2 in Atrial Arrhythmia. Front Physiol (2012) 0.79
Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study. Int J Hypertens (2010) 0.79
Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset. Front Psychol (2014) 0.79
A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. J Biol Chem (2010) 0.78
Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs. Development (2015) 0.78
Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2. PLoS One (2012) 0.78
Impaired response of regulator of Gαq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats. Hypertens Res (2015) 0.77
Genetic associations with hypertension: meta-analyses of six candidate genetic variants. Genet Test Mol Biomarkers (2013) 0.77
The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity. Biochem Pharmacol (2016) 0.76
RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer's disease: genome-wide transcriptomic profiling and bioinformatics data mining. Transl Psychiatry (2016) 0.75
Inhibition of the Binding between RGS2 and β-Tubulin Interferes with Spindle Formation and Chromosome Segregation during Mouse Oocyte Maturation In Vitro. PLoS One (2016) 0.75
Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer. J Mol Cell Cardiol (2011) 0.75
Cilia- and flagella-associated protein 69 regulates olfactory transduction kinetics in mice. J Neurosci (2017) 0.75
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A (1990) 16.34
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A (1996) 12.89
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14
Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospective study of US adults. JAMA (1998) 11.90
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell (1995) 11.72
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med (1986) 9.86
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A (1997) 7.52
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (1995) 7.05
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 6.91
Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science (2001) 6.47
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone. Proc Natl Acad Sci U S A (1989) 6.32
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A (1980) 6.31
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 5.92
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell (2001) 5.86
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev (1994) 5.68
Genetic diversity and disease control in rice. Nature (2000) 5.34
An essential role for Rac in Ras transformation. Nature (1995) 5.34
Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes. J Immunol (1986) 5.19
Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial. Ann Oncol (2009) 5.08
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell (1999) 4.76
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med (2000) 4.54
Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology (2002) 4.45
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res (2001) 4.38
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest (1997) 4.31
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature (1999) 4.29
Demethylation-induced developmental pleiotropy in Arabidopsis. Science (1996) 4.25
Overland heroin trafficking routes and HIV-1 spread in south and south-east Asia. AIDS (2000) 4.24
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys (1992) 4.12
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem Hoppe Seyler (1994) 4.09
A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A (2000) 4.06
Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol (2001) 3.92
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med (2000) 3.89
Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J (2005) 3.84
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Two regulatory genes of the maize anthocyanin pathway are homologous: isolation of B utilizing R genomic sequences. Plant Cell (1989) 3.83
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76
Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia. Endoscopy (2007) 3.75
Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control (2001) 3.74
Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell (1995) 3.70
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
A role for Rho in Ras transformation. Proc Natl Acad Sci U S A (1995) 3.59
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell (1995) 3.56
Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature (1999) 3.51
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ (2009) 3.43
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2. Proc Natl Acad Sci U S A (1998) 3.34
A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. J Exp Med (1998) 3.32
Evidence of an association between non-Hodgkin's lymphoma and skin cancer. BMJ (1995) 3.30
Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J Immunol (1986) 3.29
Pulsed-field fingerprinting of listeriae: identification of genomic divisions for Listeria monocytogenes and their correlation with serovar. Appl Environ Microbiol (1994) 3.24
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature (1998) 3.23
RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits. Nature (1996) 3.20
Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression. Proc Natl Acad Sci U S A (1990) 3.18
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature (2001) 3.09
Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol (2000) 3.08
Oxidative chemistry of peroxynitrite. Methods Enzymol (1994) 3.03
Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia (2003) 3.00
A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature (1987) 3.00
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res (1994) 2.98
Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation (2000) 2.97
Rates of dementia in three ethnoracial groups. Int J Geriatr Psychiatry (1999) 2.92
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A (1999) 2.83
Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature (1996) 2.83
Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet (1998) 2.81
VDJ recombination. Immunol Today (1992) 2.74
Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol (1996) 2.70
Bcl-2 family proteins are essential for platelet survival. Cell Death Differ (2007) 2.67
Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J Virol (1995) 2.66
Clinical and genetic studies of Birt-Hogg-Dubé syndrome. J Med Genet (2002) 2.65
Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature (1997) 2.64
The Arabidopsis sex1 mutant is defective in the R1 protein, a general regulator of starch degradation in plants, and not in the chloroplast hexose transporter. Plant Cell (2001) 2.63
Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med (2000) 2.61
The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut (1999) 2.60
Cancer in patients with ataxia-telangiectasia and in their relatives in the nordic countries. J Natl Cancer Inst (2001) 2.59
Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev (1996) 2.58
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol (1998) 2.54
Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J Immunol (1998) 2.52
Characterization of a Na+/H+ antiporter gene of Escherichia coli. Proc Natl Acad Sci U S A (1987) 2.51
Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport (2000) 2.49
Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A (2001) 2.44
Effect of tumor necrosis factor alpha on mitogen-activated human B cells. J Exp Med (1987) 2.42
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene (2011) 2.42
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci U S A (1999) 2.41
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med (2001) 2.40
Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite. Arch Biochem Biophys (1992) 2.37
Differential sensitivity of human B cell subsets to activation signals delivered by anti-mu antibody and proliferative signals delivered by a monoclonal B cell growth factor. J Exp Med (1983) 2.34
Nucleotide sequence of a ribosome attachment site of bacteriophage f2 RNA. Biochem Biophys Res Commun (1970) 2.32
Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection. J Virol (1996) 2.32
Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol (2001) 2.32