The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.

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Published in J Exp Med on June 01, 1991

Authors

S M Canfield1, S L Morrison

Author Affiliations

1: Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032.

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