Published in J Biol Chem on March 13, 2008
IgG subclasses and allotypes: from structure to effector functions. Front Immunol (2014) 1.95
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. J Biol Chem (2008) 1.80
6th Annual European Antibody Congress 2010: November 29-December 1, 2010, Geneva, Switzerland. MAbs (2011) 1.61
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies. Cancer Cell (2014) 1.55
Human IgG2 antibody disulfide rearrangement in vivo. J Biol Chem (2008) 1.45
Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats. MAbs (2010) 1.43
Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function. MAbs (2012) 1.41
Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. MAbs (2009) 1.20
Structural and functional characterization of the trifunctional antibody catumaxomab. MAbs (2010) 1.19
Direct observation of disulfide isomerization in a single protein. Nat Chem (2011) 1.17
Stability of IgG isotypes in serum. MAbs (2010) 1.17
Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies. MAbs (2012) 1.07
Increased aggregation propensity of IgG2 subclass over IgG1: role of conformational changes and covalent character in isolated aggregates. Protein Sci (2010) 1.00
Developability studies before initiation of process development: improving manufacturability of monoclonal antibodies. MAbs (2013) 0.97
Development and validation of an antibody-dependent cell-mediated cytotoxicity-reporter gene assay. MAbs (2012) 0.97
A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis. Ther Adv Musculoskelet Dis (2011) 0.96
The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies. Protein Sci (2010) 0.94
Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability. J Biol Chem (2012) 0.89
In vitro and in vivo modifications of recombinant and human IgG antibodies. MAbs (2014) 0.88
The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge. MAbs (2011) 0.88
Discovery of undefined protein cross-linking chemistry: a comprehensive methodology utilizing 18O-labeling and mass spectrometry. Anal Chem (2013) 0.87
5th European Antibody Congress 2009: November 30–December 2, 2009, Geneva, Switzerland. MAbs (2011) 0.87
Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors. J Immunol (2013) 0.87
Disulphide bond reduction of a therapeutic monoclonal antibody during cell culture manufacturing operations. BMC Proc (2011) 0.84
Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res (2014) 0.84
Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding. Protein Sci (2010) 0.84
Complementary MS methods assist conformational characterization of antibodies with altered S-S bonding networks. J Am Soc Mass Spectrom (2013) 0.83
The effect of tensile stress on the conformational free energy landscape of disulfide bonds. PLoS One (2014) 0.81
Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice. Arthritis Res Ther (2012) 0.81
Enhancing Protein Disulfide Bond Cleavage by UV Excitation and Electron Capture Dissociation for Top-Down Mass Spectrometry. Int J Mass Spectrom (2015) 0.80
Relative stabilities of IgG1 and IgG4 Fab domains: influence of the light-heavy interchain disulfide bond architecture. Protein Sci (2012) 0.80
Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress. Protein Sci (2013) 0.80
Viremic HIV Controllers Exhibit High Plasmacytoid Dendritic Cell-Reactive Opsonophagocytic IgG Antibody Responses against HIV-1 p24 Associated with Greater Antibody Isotype Diversification. J Immunol (2015) 0.79
Influence of immunoglobulin isotype on therapeutic antibody function. Blood (2016) 0.78
Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability. J Biol Chem (2016) 0.78
Three-dimensional structure of the human myeloma IgG2. PLoS One (2013) 0.78
On the perplexingly low rate of transport of IgG2 across the human placenta. PLoS One (2014) 0.77
4th European Antibody Congress 2008: December 1-3, 2008, Geneva, Switzerland. MAbs (2009) 0.77
Cysteine racemization on IgG heavy and light chains. J Biol Chem (2013) 0.76
Posttranslational Modifications and the Immunogenicity of Biotherapeutics. J Immunol Res (2016) 0.76
Alleviating nonlinear behavior of disulfide isoforms in the reversed-phase liquid chromatography of IgG2. J Chromatogr A (2015) 0.75
5th Annual Monoclonal Antibodies Conference: March 24-25, 2009, London, UK. MAbs (2010) 0.75
Protected hinge in the immunoglobulin G2-A2 disulfide isoform. Protein Sci (2014) 0.75
Assessment of disulfide and hinge modifications of monoclonal antibodies. Electrophoresis (2016) 0.75
PDADMAC flocculation of Chinese hamster ovary cells: enabling a centrifuge-less harvest process for monoclonal antibodies. MAbs (2015) 0.75
Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum. Cell Logist (2017) 0.75
Disulfide Bond Characterization of Endogenous IgG3 Monoclonal Antibodies Using LC-MS: An Investigation of IgG3 Disulfide-mediated Isoforms. Anal Methods (2016) 0.75
The covalent structure of an entire gammaG immunoglobulin molecule. Proc Natl Acad Sci U S A (1969) 5.90
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science (2001) 5.39
Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science (2007) 4.52
A universal algorithm for fast and automated charge state deconvolution of electrospray mass-to-charge ratio spectra. J Am Soc Mass Spectrom (1998) 3.04
Prediction of low-energy collision-induced dissociation spectra of peptides. Anal Chem (2004) 2.80
Structural studies of immunoglobulin G. Nature (1969) 2.63
Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteins. J Mol Biol (1968) 2.57
Downstream processing of monoclonal antibodies--application of platform approaches. J Chromatogr B Analyt Technol Biomed Life Sci (2006) 2.16
Contrasting IgG structures reveal extreme asymmetry and flexibility. J Mol Biol (2002) 2.10
IgG4 breaking the rules. Immunology (2002) 1.93
Identification of disulfide-bridged substructures within human von Willebrand factor. Biochemistry (1987) 1.89
The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. J Exp Med (1991) 1.88
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. J Biol Chem (2008) 1.80
Prediction of low-energy collision-induced dissociation spectra of peptides with three or more charges. Anal Chem (2005) 1.36
The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds. Mol Immunol (2001) 1.35
Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites. Immunology (1999) 1.29
Modulation of the effector functions of a human IgG1 through engineering of its hinge region. J Immunol (2006) 1.25
Intrachain disulfide bond in the core hinge region of human IgG4. Protein Sci (1997) 1.24
Intrachain disulphide bridges in immunoglobulin G heavy chains. The Fc fragment. Biochem J (1968) 1.22
Human IgG2 can form covalent dimers. J Immunol (2003) 1.21
Inter heavy-light chain disulphide bridge in immune globulins. Nature (1967) 1.20
Disulphide bridges of a human immunoglobulin G protein. Nature (1967) 1.15
The structural basis for the functional versatility of immunoglobulin G1. Can J Biochem (1978) 1.12
Association of antibody chains at different stages of folding: prolyl isomerization occurs after formation of quaternary structure. J Mol Biol (1995) 1.08
The structural requirements for complement activation by IgG: does it hinge on the hinge? Immunol Today (1995) 1.07
Optimization of a reversed-phase high-performance liquid chromatography/mass spectrometry method for characterizing recombinant antibody heterogeneity and stability. J Chromatogr A (2006) 1.05
Alternatively folded states of an immunoglobulin. Biochemistry (1991) 1.05
The influence of the hinge region length in binding of human IgG to human Fcgamma receptors. Hum Immunol (1998) 1.05
Conformational analysis of the eight-membered ring of the oxidized cysteinyl-cysteine unit implicated in nicotinic acetylcholine receptor ligand recognition. J Am Chem Soc (2001) 1.00
Determination of tryptophan oxidation of monoclonal antibody by reversed phase high performance liquid chromatography. J Chromatogr A (2007) 0.96
Development of an analytical reversed-phase high-performance liquid chromatography-electrospray ionization mass spectrometry method for characterization of recombinant antibodies. J Chromatogr A (2004) 0.92
Characterizing closely spaced, complex disulfide bond patterns in peptides and proteins by liquid chromatography/electrospray ionization tandem mass spectrometry. J Mass Spectrom (2002) 0.92
Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation. Biochemistry (1998) 0.89
Intradomain disulfide bonds impede formation of the alternatively folded state of antibody chains. J Mol Biol (2002) 0.85
Disulphide bridges of the heavy chain of human immunoglobulin G2. Biochem J (1971) 0.82
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
PatternHunter: faster and more sensitive homology search. Bioinformatics (2002) 35.65
ZOOM! Zillions of oligos mapped. Bioinformatics (2008) 29.78
Epidermal electronics. Science (2011) 8.65
The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell (2003) 6.86
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol (2009) 5.27
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med (2010) 4.74
PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry. Rapid Commun Mass Spectrom (2003) 4.56
Random-coil behavior and the dimensions of chemically unfolded proteins. Proc Natl Acad Sci U S A (2004) 4.44
An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol (2013) 4.04
Human infection with avian influenza A H7N9 virus: an assessment of clinical severity. Lancet (2013) 3.90
APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat Struct Mol Biol (2010) 3.61
Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia. N Engl J Med (2002) 3.31
Mental health system in China: history, recent service reform and future challenges. World Psychiatry (2011) 3.23
The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture. Proc Natl Acad Sci U S A (2006) 3.19
Incidence and clinical complications of myelodysplastic syndromes among United States Medicare beneficiaries. J Clin Oncol (2010) 2.93
DNACompress: fast and effective DNA sequence compression. Bioinformatics (2002) 2.82
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature (2011) 2.71
A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One (2007) 2.47
Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum (2009) 2.43
Discovering patterns to extract protein-protein interactions from full texts. Bioinformatics (2004) 2.42
Molecular censusing doubles giant panda population estimate in a key nature reserve. Curr Biol (2006) 2.39
NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res (2013) 2.37
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors. J Clin Invest (2013) 2.30
RAPTOR: optimal protein threading by linear programming. J Bioinform Comput Biol (2003) 2.27
Regulation of p53 target gene expression by peptidylarginine deiminase 4. Mol Cell Biol (2008) 2.27
Economic evaluation of denosumab compared with zoledronic acid in hormone-refractory prostate cancer patients with bone metastases. J Manag Care Pharm (2011) 2.25
Waterproof AlInGaP optoelectronics on stretchable substrates with applications in biomedicine and robotics. Nat Mater (2010) 2.20
"Nerve combing" for trigeminal neuralgia without vascular compression: report of 10 cases. Clin J Pain (2009) 2.01
From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis. Schizophr Res (2005) 2.00
Global impact of oncogenic Src on a phosphotyrosine proteome. J Proteome Res (2008) 1.94
Quantitative profiling of proteins in complex mixtures using liquid chromatography and mass spectrometry. J Proteome Res (2003) 1.90
Rapid evolution of expression and regulatory divergences after yeast gene duplication. Proc Natl Acad Sci U S A (2005) 1.88
Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetic patients. Diabetes Care (2009) 1.82
Increasing fluoroquinolone resistance in Campylobacter jejuni, Pennsylvania, USA,1982-2001. Emerg Infect Dis (2002) 1.81
L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice. J Lipid Res (2008) 1.80
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. J Biol Chem (2008) 1.80
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. Nat Genet (2011) 1.77
Dynamically tunable hemispherical electronic eye camera system with adjustable zoom capability. Proc Natl Acad Sci U S A (2011) 1.74
Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview. Ultrason Sonochem (2004) 1.70
High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans. Glycobiology (2011) 1.68
Cav3.1 (alpha1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation. Circ Res (2003) 1.66
Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis. Mol Cell Proteomics (2009) 1.66
Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway. J Bacteriol (2006) 1.66
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces. Structure (2010) 1.65
RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway. Hepatology (2011) 1.64
Surgery for patients with Marfan syndrome with type A dissection involving the aortic arch using total arch replacement combined with stented elephant trunk implantation: the acute versus the chronic. J Thorac Cardiovasc Surg (2011) 1.62
Genetic viability and population history of the giant panda, putting an end to the "evolutionary dead end"? Mol Biol Evol (2007) 1.61
Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats. Hypertension (2009) 1.61
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. Cancer Res (2005) 1.61
Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects. Brain Res (2009) 1.60
Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci (2002) 1.58
The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia (2013) 1.58
A systematic review of p53 as a biomarker of survival in patients with osteosarcoma. Tumour Biol (2013) 1.57
Stretchable GaAs photovoltaics with designs that enable high areal coverage. Adv Mater (2011) 1.56
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics (2012) 1.55
Evaluation of strong cation exchange versus isoelectric focusing of peptides for multidimensional liquid chromatography-tandem mass spectrometry. J Proteome Res (2008) 1.55
Th1 and Th17 cells induce proliferative glomerulonephritis. J Am Soc Nephrol (2009) 1.55
Discovering patterns to extract protein-protein interactions from the literature: Part II. Bioinformatics (2005) 1.55
ExonHunter: a comprehensive approach to gene finding. Bioinformatics (2005) 1.55
Methodological reporting quality of randomized controlled trials in three spine journals from 2010 to 2012. Eur Spine J (2014) 1.55
Aberrant subclavian artery pathologies and Kommerell's diverticulum: a review and analysis of published endovascular/hybrid treatment options. J Endovasc Ther (2012) 1.54
Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. Clin Cancer Res (2012) 1.53
Rapid formin-mediated actin-filament elongation is essential for polarized plant cell growth. Proc Natl Acad Sci U S A (2009) 1.52
Comparative and phylogenomic studies on the mitochondrial genomes of Pentatomomorpha (Insecta: Hemiptera: Heteroptera). BMC Genomics (2008) 1.52
DJ-1 may contribute to metastasis of non-small cell lung cancer. Mol Biol Rep (2011) 1.52
Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India. Virology (2009) 1.51
Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies. PLoS Comput Biol (2010) 1.51
The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer. Clin Cancer Res (2010) 1.51
Scale-invariant registration of monocular endoscopic images to CT-scans for sinus surgery. Med Image Anal (2005) 1.50
Coordinated regulation of SIV replication and immune responses in the CNS. PLoS One (2009) 1.49
The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice. J Lipid Res (2009) 1.48
Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in Vitiligo. Acta Derm Venereol (2015) 1.48
Multifunctional epidermal electronics printed directly onto the skin. Adv Mater (2013) 1.47
Mitochondrial evidence for multiple radiations in the evolutionary history of small apes. BMC Evol Biol (2010) 1.47
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet (2011) 1.46
Outcomes of resecting subependymal giant cell astrocytoma (SEGA) among patients with SEGA-related tuberous sclerosis complex: a national claims database analysis. Curr Med Res Opin (2012) 1.46
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China. J Clin Microbiol (2005) 1.46
Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes. Nat Commun (2011) 1.46
Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int (2012) 1.45
Human IgG2 antibody disulfide rearrangement in vivo. J Biol Chem (2008) 1.45
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther (2004) 1.42
Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther (2008) 1.42
There may be a same mechanism of the left-right handedness and left-right convex curve pattern of adolescent idiopathic scoliosis. Med Hypotheses (2010) 1.41
Real-time interactive MRI-guided cardiac surgery: aortic valve replacement using a direct apical approach. Magn Reson Med (2006) 1.41
Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer. J Thorac Oncol (2007) 1.40
Increased plasma CgA levels associated with nonalcoholic fatty liver disease. Turk J Gastroenterol (2015) 1.40
Analysis of DNA and hemoglobin adducts and sister chromatid exchanges in a human population occupationally exposed to propylene oxide: a pilot study. Cancer Epidemiol Biomarkers Prev (2002) 1.40