Published in Chem Biol on February 01, 2008
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed Engl (2009) 8.15
A fluorophore ligase for site-specific protein labeling inside living cells. Proc Natl Acad Sci U S A (2010) 2.91
A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Nat Chem (2013) 2.61
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction. Nat Chem (2012) 2.37
A general method to improve fluorophores for live-cell and single-molecule microscopy. Nat Methods (2015) 2.36
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol (2009) 2.10
Organelle-targetable fluorescent probes for imaging hydrogen peroxide in living cells via SNAP-Tag protein labeling. J Am Chem Soc (2010) 1.99
Labeling live cells by copper-catalyzed alkyne--azide click chemistry. Bioconjug Chem (2010) 1.86
Choosing an effective protein bioconjugation strategy. Nat Chem Biol (2011) 1.82
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization. Proc Natl Acad Sci U S A (2012) 1.82
Designer proteins: applications of genetic code expansion in cell biology. Nat Rev Mol Cell Biol (2012) 1.72
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. J Cell Biol (2012) 1.65
Boronate oxidation as a bioorthogonal reaction approach for studying the chemistry of hydrogen peroxide in living systems. Acc Chem Res (2011) 1.63
Development of SNAP-tag fluorogenic probes for wash-free fluorescence imaging. Chembiochem (2011) 1.51
Advances in fluorescence labeling strategies for dynamic cellular imaging. Nat Chem Biol (2014) 1.47
Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase. J Am Chem Soc (2009) 1.41
An in vivo covalent TMP-tag based on proximity-induced reactivity. ACS Chem Biol (2009) 1.34
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chem Res Toxicol (2011) 1.30
Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA. Nat Chem (2012) 1.30
Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nat Protoc (2010) 1.28
Septin stability and recycling during dynamic structural transitions in cell division and development. Curr Biol (2008) 1.27
Chemical tags for labeling proteins inside living cells. Acc Chem Res (2011) 1.26
Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One. ACS Chem Biol (2008) 1.25
Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions. Nat Protoc (2013) 1.25
Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping. Nat Protoc (2015) 1.25
Eight years of single-molecule localization microscopy. Histochem Cell Biol (2014) 1.24
Site-specific N-terminal labeling of proteins using sortase-mediated reactions. Nat Protoc (2013) 1.19
Two-color STED microscopy in living cells. Biomed Opt Express (2011) 1.19
MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation. Mol Biol Cell (2011) 1.18
Imaging proteins inside cells with fluorescent tags. Trends Biotechnol (2011) 1.17
Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J Am Chem Soc (2012) 1.15
Fluorescence applications in molecular neurobiology. Neuron (2010) 1.13
In vivo stable tumor-specific painting in various colors using dehalogenase-based protein-tag fluorescent ligands. Bioconjug Chem (2009) 1.11
Second-generation covalent TMP-tag for live cell imaging. J Am Chem Soc (2012) 1.11
High-performance probes for light and electron microscopy. Nat Methods (2015) 1.10
Measuring mitochondrial function in intact cardiac myocytes. J Mol Cell Cardiol (2011) 1.07
π-Clamp-mediated cysteine conjugation. Nat Chem (2015) 1.06
Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant. ACS Chem Biol (2012) 1.06
Lighting up multiprotein complexes: lessons from GPCR oligomerization. Trends Biotechnol (2010) 1.06
Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET. J Biol Chem (2010) 1.05
Indo-1 derivatives for local calcium sensing. ACS Chem Biol (2009) 1.03
Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release. Proc Natl Acad Sci U S A (2012) 1.02
SNAP-, CLIP- and Halo-tag labelling of budding yeast cells. PLoS One (2013) 1.00
Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol (2011) 1.00
Reuse, replace, recycle. Specificity in subunit inheritance and assembly of higher-order septin structures during mitotic and meiotic division in budding yeast. Cell Cycle (2009) 1.00
An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. J Am Chem Soc (2008) 0.98
Nanobodies and recombinant binders in cell biology. J Cell Biol (2015) 0.96
Clathrin-independent pathways do not contribute significantly to endocytic flux. Elife (2014) 0.96
Genetic code expansion enables live-cell and super-resolution imaging of site-specifically labeled cellular proteins. J Am Chem Soc (2015) 0.96
A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. J Am Chem Soc (2013) 0.95
Visualizing protein partnerships in living cells and organisms. Curr Opin Chem Biol (2011) 0.95
Engineering a novel multifunctional green fluorescent protein tag for a wide variety of protein research. PLoS One (2008) 0.94
Single-particle tracking photoactivated localization microscopy for mapping single-molecule dynamics. Methods Enzymol (2010) 0.94
Evaluation of fluorophores to label SNAP-tag fused proteins for multicolor single-molecule tracking microscopy in live cells. Biophys J (2014) 0.94
BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues. Front Endocrinol (Lausanne) (2012) 0.92
A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate. J Am Chem Soc (2010) 0.92
Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses. Sci Rep (2016) 0.90
Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging. Br J Pharmacol (2011) 0.90
6-Carboxyfluorescein and structurally similar molecules inhibit DNA binding and repair by O⁶-alkylguanine DNA alkyltransferase. DNA Repair (Amst) (2011) 0.89
Bringing single-molecule spectroscopy to macromolecular protein complexes. Trends Biochem Sci (2012) 0.88
The design of Förster (fluorescence) resonance energy transfer (FRET)-based molecular sensors for Ran GTPase. Methods (2010) 0.88
Site-specific protein labeling using PRIME and chelation-assisted click chemistry. Nat Protoc (2013) 0.87
On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry. J Am Chem Soc (2016) 0.86
Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors. Curr Opin Biotechnol (2016) 0.86
Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation. Chem Biol (2014) 0.85
Live-cell protein labelling with nanometre precision by cell squeezing. Nat Commun (2016) 0.85
Near-infrared fluorescence imaging of mammalian cells and xenograft tumors with SNAP-tag. PLoS One (2012) 0.85
The use of HaloTag-based technology in flow and laser scanning cytometry analysis of live and fixed cells. BMC Res Notes (2011) 0.85
Lanthanide-based imaging of protein-protein interactions in live cells. Inorg Chem (2013) 0.85
Fluorescent labeling and modification of proteins. J Chem Biol (2013) 0.85
Single-molecule detection and tracking in plants. Protoplasma (2014) 0.85
Rapid, specific, no-wash, far-red fluorogen activation in subcellular compartments by targeted fluorogen activating proteins. ACS Chem Biol (2015) 0.85
Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Chem Biol (2015) 0.84
Activity and regulation of archaeal DNA alkyltransferase: conserved protein involved in repair of DNA alkylation damage. J Biol Chem (2011) 0.84
Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex. Chemistry (2012) 0.84
Understanding FRET as a research tool for cellular studies. Int J Mol Sci (2015) 0.84
Sortase-tag expressed protein ligation: combining protein purification and site-specific bioconjugation into a single step. Anal Chem (2013) 0.84
Ultrafast tissue staining with chemical tags. Proc Natl Acad Sci U S A (2014) 0.84
Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone. J Am Chem Soc (2013) 0.83
The Arabidopsis apyrase AtAPY1 is localized in the Golgi instead of the extracellular space. BMC Plant Biol (2012) 0.83
"Turn-on" protein fluorescence: in situ formation of cyanine dyes. J Am Chem Soc (2015) 0.82
Live imaging of mitosomes and hydrogenosomes by HaloTag technology. PLoS One (2012) 0.82
A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle. Open Biol (2014) 0.82
Signal transduction: From the atomic age to the post-genomic era. Cold Spring Harb Perspect Biol (2014) 0.82
Single molecule fluorescence detection and tracking in mammalian cells: the state-of-the-art and future perspectives. Int J Mol Sci (2012) 0.82
A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds. J Am Chem Soc (2014) 0.81
Mitosis puts sisters in a strained relationship: force generation at the kinetochore. Exp Cell Res (2012) 0.80
Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nat Protoc (2014) 0.80
Advances in chemical labeling of proteins in living cells. Cell Tissue Res (2015) 0.80
Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. ACS Cent Sci (2015) 0.80
Site-Directed RNA Editing in Vivo Can Be Triggered by the Light-Driven Assembly of an Artificial Riboprotein. J Am Chem Soc (2015) 0.80
Optical probes based on G protein-coupled receptors - added work or added value? Br J Pharmacol (2015) 0.80
Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells. J Am Chem Soc (2016) 0.80
Fluorescence nanoscopy. Methods and applications. J Chem Biol (2013) 0.79
Shedding light on biology of bacterial cells. Philos Trans R Soc Lond B Biol Sci (2016) 0.79
Rapid isolation and single-molecule analysis of ribonucleoproteins from cell lysate by SNAP-SiMPull. RNA (2015) 0.79
Cytoplasmic delivery and selective, multicomponent labeling with oligoarginine-linked protein tags. Bioconjug Chem (2015) 0.79
Site-Specifically Labeled Immunoconjugates for Molecular Imaging-Part 2: Peptide Tags and Unnatural Amino Acids. Mol Imaging Biol (2016) 0.79
TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis. J Cell Sci (2014) 0.79
Portraying G protein-coupled receptors with fluorescent ligands. ACS Chem Biol (2014) 0.79
A general method for the covalent labeling of fusion proteins with small molecules in vivo. Nat Biotechnol (2002) 6.77
Labeling of fusion proteins with synthetic fluorophores in live cells. Proc Natl Acad Sci U S A (2004) 3.11
A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Nat Chem (2013) 2.61
Specific labeling of cell surface proteins with chemically diverse compounds. J Am Chem Soc (2004) 2.27
Overcoming transcription activator-like effector (TALE) DNA binding domain sensitivity to cytosine methylation. J Biol Chem (2012) 2.25
FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. Proc Natl Acad Sci U S A (2006) 2.04
How to obtain labeled proteins and what to do with them. Curr Opin Biotechnol (2010) 1.85
Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo. Chem Biol (2003) 1.76
Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA. Proc Natl Acad Sci U S A (2010) 1.73
Transforming a (beta/alpha)8--barrel enzyme into a split-protein sensor through directed evolution. Chem Biol (2004) 1.52
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A (2013) 1.51
Development of SNAP-tag fluorogenic probes for wash-free fluorescence imaging. Chembiochem (2011) 1.51
Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol (2008) 1.48
Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro. Methods (2004) 1.46
An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype. Infect Immun (2008) 1.45
A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis. Nat Chem Biol (2011) 1.42
Chemical probes shed light on protein function. Curr Opin Struct Biol (2007) 1.42
Chemical tools for biomolecular imaging. ACS Chem Biol (2007) 1.41
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis. J Am Chem Soc (2010) 1.35
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1. J Am Chem Soc (2011) 1.33
Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting. PLoS Pathog (2012) 1.27
Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex. Curr Biol (2013) 1.19
Photoactivatable and photoconvertible fluorescent probes for protein labeling. ACS Chem Biol (2010) 1.18
Adding value to fusion proteins through covalent labelling. Curr Opin Biotechnol (2005) 1.07
Allelic diversity of the Plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopes. PLoS One (2011) 1.07
Compact designer TALENs for efficient genome engineering. Nat Commun (2013) 1.06
Protein chemistry on the surface of living cells. Chembiochem (2005) 1.04
Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family. Plant Biotechnol J (2014) 1.04
Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling. Protein Eng Des Sel (2006) 1.04
Indo-1 derivatives for local calcium sensing. ACS Chem Biol (2009) 1.03
Multicolor imaging of cell surface proteins. J Am Chem Soc (2005) 1.02
Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism. Acta Crystallogr D Biol Crystallogr (2013) 1.01
Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma. Hepatology (2012) 1.01
Covalent and selective immobilization of fusion proteins. J Am Chem Soc (2003) 1.01
A concise synthesis of the Pennsylvania Green fluorophore and labeling of intracellular targets with O6-benzylguanine derivatives. Org Lett (2007) 1.00
Induced protein dimerization in vivo through covalent labeling. J Am Chem Soc (2003) 0.99
A caged, localizable rhodamine derivative for superresolution microscopy. ACS Chem Biol (2011) 0.98
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. Bioorg Med Chem (2010) 0.97
Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method. J Am Chem Soc (2011) 0.97
Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation. N Biotechnol (2012) 0.97
Engineering substrate specificity of O6-alkylguanine-DNA alkyltransferase for specific protein labeling in living cells. Chembiochem (2005) 0.96
Selective cross-linking of interacting proteins using self-labeling tags. J Am Chem Soc (2009) 0.96
Semisynthetic fluorescent sensor proteins based on self-labeling protein tags. J Am Chem Soc (2009) 0.95
Selective activity-based probes for cysteine cathepsins. Angew Chem Int Ed Engl (2008) 0.94
Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries. J Am Chem Soc (2013) 0.93
Site-specific, covalent labeling of recombinant antibody fragments via fusion to an engineered version of 6-O-alkylguanine DNA alkyltransferase. Bioconjug Chem (2009) 0.93
Boosting the sensitivity of ligand-protein screening by NMR of long-lived states. J Am Chem Soc (2012) 0.93
Measuring in vivo protein half-life. Chem Biol (2011) 0.92
Semisynthesis of fluorescent metabolite sensors on cell surfaces. J Am Chem Soc (2011) 0.91
Phosphopantetheinyl transferase-catalyzed formation of bioactive hydrogels for tissue engineering. J Am Chem Soc (2010) 0.91
Bicyclic peptide inhibitor reveals large contact interface with a protease target. ACS Chem Biol (2012) 0.91
A fluorescent sensor for GABA and synthetic GABA(B) receptor ligands. J Am Chem Soc (2012) 0.91
A split-protein sensor for studying protein-protein interaction in mycobacteria. J Microbiol Methods (2008) 0.90
A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red. ACS Chem Biol (2014) 0.89
Polycyclic peptide therapeutics. ChemMedChem (2013) 0.89
A fusion of disciplines: chemical approaches to exploit fusion proteins for functional genomics. Chembiochem (2003) 0.89
Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases. ChemMedChem (2012) 0.88
Ultrafast excited state dynamics of the protonated Schiff base of all-trans retinal in solvents. Biophys J (2005) 0.88
A designed protein for the specific and covalent heteroconjugation of biomolecules. Bioconjug Chem (2008) 0.88
Total syntheses of amphidinolide H and G. Angew Chem Int Ed Engl (2007) 0.87
WhiB5, a transcriptional regulator that contributes to Mycobacterium tuberculosis virulence and reactivation. Infect Immun (2012) 0.87
Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5). Biophys J (2010) 0.87
Chemical development of intracellular protein heterodimerizers. Chem Biol (2013) 0.86
Total syntheses of amphidinolides B1, B4, G1, H1 and structure revision of amphidinolide H2. Chemistry (2009) 0.86
Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins. Bioorg Med Chem Lett (2004) 0.86
Evolving the substrate specificity of O6-alkylguanine-DNA alkyltransferase through loop insertion for applications in molecular imaging. ACS Chem Biol (2006) 0.86
A covalent chemical genotype-phenotype linkage for in vitro protein evolution. Chembiochem (2007) 0.86
Searching for the protein targets of bioactive molecules. Chimia (Aarau) (2011) 0.86
Targeted photoswitchable probe for nanoscopy of biological structures. Chembiochem (2010) 0.85
Peptide ligands stabilized by small molecules. Angew Chem Int Ed Engl (2014) 0.85
Directed evolution of the suicide protein O⁶-alkylguanine-DNA alkyltransferase for increased reactivity results in an alkylated protein with exceptional stability. Biochemistry (2012) 0.85
Caged substrates for protein labeling and immobilization. Chembiochem (2008) 0.84
Localizable and highly sensitive calcium indicator based on a BODIPY fluorophore. Anal Chem (2010) 0.84
Functional and immunological characterization of the var2CSA-DBL5epsilon domain of a placental Plasmodium falciparum isolate. Mol Biochem Parasitol (2010) 0.84
Enzymatic cyclisation of peptides with a transglutaminase. Chembiochem (2011) 0.83
Phage selection of bicyclic peptides. Methods (2013) 0.83
Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy. J Med Chem (2013) 0.83
A semisynthetic fluorescent sensor protein for glutamate. J Am Chem Soc (2012) 0.82
Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs. Science (2013) 0.82
Post-translational modification of genetically encoded polypeptide libraries. Curr Opin Chem Biol (2011) 0.82
Synthesis and photochemical properties of oligo-ortho-azobenzenes. J Org Chem (2011) 0.82
Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides. Chembiochem (2012) 0.82
Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag. Dev Dyn (2011) 0.82
Cell-permeant and photocleavable chemical inducer of dimerization. Angew Chem Int Ed Engl (2014) 0.82
Investigating endocytic pathways to the endoplasmic reticulum and to the cytosol using SNAP-trap. Traffic (2012) 0.81
Covalent labeling of cell-surface proteins for in-vivo FRET studies. FEBS Lett (2006) 0.81
Protein function microarrays based on self-immobilizing and self-labeling fusion proteins. Chembiochem (2006) 0.81
Protein-functionalized polymer brushes. Biomacromolecules (2005) 0.81
Examining reactivity and specificity of cytochrome c peroxidase by using combinatorial mutagenesis. Chembiochem (2002) 0.81
Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids. Chembiochem (2013) 0.81
Visualizing biochemical activities in living cells through chemistry. Chimia (Aarau) (2011) 0.81
Substrates for improved live-cell fluorescence labeling of SNAP-tag. Curr Pharm Des (2013) 0.81