Published in Int J Biochem Cell Biol on January 20, 2008
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A (2009) 6.87
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med (2012) 3.98
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci (2010) 3.81
Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci (2009) 3.68
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol (2009) 3.55
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest (2011) 3.53
Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol (2010) 3.34
The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci (2013) 2.78
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem (2010) 2.67
Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci (2010) 2.29
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One (2011) 2.19
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One (2010) 2.15
Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener (2012) 2.11
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A (2013) 1.88
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nat Rev Neurosci (2013) 1.82
Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol (2010) 1.81
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia. Acta Neuropathol (2010) 1.80
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem (2012) 1.79
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. J Neurosci (2012) 1.63
Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. Mol Neurodegener (2012) 1.63
Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes. EMBO J (2016) 1.56
A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J (2014) 1.55
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55
Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci (2015) 1.53
α-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol (2012) 1.42
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. J Neurosci (2011) 1.35
Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol (2013) 1.32
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol (2013) 1.30
A deadly spread: cellular mechanisms of α-synuclein transfer. Cell Death Differ (2011) 1.27
Alpha-synuclein: from secretion to dysfunction and death. Cell Death Dis (2012) 1.25
A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation. J Neurochem (2010) 1.22
Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes. J Biol Chem (2012) 1.22
Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naïve patients with Parkinson's disease. J Clin Neurol (2011) 1.21
Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. J Neurosci (2009) 1.21
De novo generation of prion strains. Nat Rev Microbiol (2011) 1.17
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo. PLoS One (2012) 1.15
Protein aggregate spreading in neurodegenerative diseases: problems and perspectives. Neurosci Res (2011) 1.15
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med (2011) 1.12
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med (2013) 1.12
The prion hypothesis in Parkinson's disease: Braak to the future. Acta Neuropathol Commun (2013) 1.11
Interaction between pathogenic proteins in neurodegenerative disorders. J Cell Mol Med (2012) 1.06
The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein. PLoS One (2011) 1.06
Genetics and genomics of Parkinson's disease. Genome Med (2014) 1.04
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link? Mol Neurobiol (2012) 1.04
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem (2010) 1.04
α-Synuclein Alters Toll-Like Receptor Expression. Front Neurosci (2011) 1.04
Formation and propagation of tau oligomeric seeds. Front Neurol (2013) 1.04
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. J Biol Chem (2011) 1.03
Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol (2012) 1.01
Characterization of kinases involved in the phosphorylation of aggregated α-synuclein. J Neurosci Res (2010) 1.00
α-Synuclein: the long distance runner. Brain Pathol (2013) 0.99
Alpha-synuclein function and dysfunction on cellular membranes. Exp Neurobiol (2014) 0.99
Pathogenesis of Parkinson disease-the gut-brain axis and environmental factors. Nat Rev Neurol (2015) 0.98
Conformation determines the seeding potencies of native and recombinant Tau aggregates. J Biol Chem (2014) 0.95
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein. Nat Commun (2014) 0.94
Glia and alpha-synuclein in neurodegeneration: A complex interaction. Neurobiol Dis (2015) 0.93
Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal (2012) 0.93
Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies. PLoS One (2010) 0.93
Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. PLoS One (2012) 0.93
Exosomes-associated neurodegeneration and progression of Parkinson's disease. Am J Neurodegener Dis (2012) 0.92
Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection. Oxid Med Cell Longev (2016) 0.92
Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction. J Biol Chem (2014) 0.92
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathol (2015) 0.92
Alpha-synuclein spreading in Parkinson's disease. Front Neuroanat (2014) 0.90
Interaction between α-synuclein and other proteins in neurodegenerative disorders. ScientificWorldJournal (2011) 0.89
Prion-like propagation of protein aggregation and related therapeutic strategies. Neurotherapeutics (2013) 0.88
Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology. J Neurochem (2016) 0.88
Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases. Biogerontology (2014) 0.87
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders. Sci Signal (2015) 0.87
Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice. Exp Neurobiol (2011) 0.86
The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease. J Neurochem (2016) 0.85
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease. Neuroscience (2014) 0.85
Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation. Exp Neurobiol (2014) 0.84
Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. J Biol Chem (2012) 0.84
The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases. Front Physiol (2015) 0.83
Sequence-dependent internalization of aggregating peptides. J Biol Chem (2014) 0.82
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease. Hum Mol Genet (2015) 0.82
Alpha-synuclein promotes early neurite outgrowth in cultured primary neurons. J Neural Transm (Vienna) (2013) 0.81
In vitro aggregation assays for the characterization of α-synuclein prion-like properties. Prion (2014) 0.81
Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts. Transl Neurodegener (2013) 0.81
Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease. Brain Res (2014) 0.81
Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role. Biomolecules (2015) 0.81
Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease. Front Neurosci (2015) 0.80
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener (2015) 0.80
Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein. J Biol Chem (2014) 0.80
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities. Cell Mol Neurobiol (2016) 0.80
Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease. Prion (2012) 0.79
Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates. Cell Death Dis (2015) 0.79
Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease. Front Genet (2013) 0.79
Brain disposition of α-Synuclein: roles of brain barrier systems and implications for Parkinson's disease. Fluids Barriers CNS (2014) 0.78
Drug targets from genetics: α-synuclein. CNS Neurol Disord Drug Targets (2011) 0.78
Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function. Autophagy (2016) 0.78
Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model. J Neuroinflammation (2015) 0.78
Expression and Transport of α-Synuclein at the Blood-Cerebrospinal Fluid Barrier and Effects of Manganese Exposure. ADMET DMPK (2015) 0.78
Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases. Prion (2016) 0.78
Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology? Alzheimers Res Ther (2012) 0.78
LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease. Exp Neurobiol (2013) 0.78
Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells. PLoS One (2016) 0.78
Protein aggregates stimulate macropinocytosis facilitating their propagation. Prion (2016) 0.77
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease. Biomolecules (2015) 0.77
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A (2009) 6.87
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci (2005) 3.93
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem (2010) 2.67
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci (2004) 2.25
Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. J Biol Chem (2002) 2.19
Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J Biol Chem (2001) 2.03
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry (2002) 1.98
OASIS: online application for the survival analysis of lifespan assays performed in aging research. PLoS One (2011) 1.98
Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem (2001) 1.85
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.79
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A (2010) 1.78
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem Biophys Res Commun (2008) 1.71
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. J Neurosci (2012) 1.63
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem (2010) 1.60
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55
A hybrid approach to estimating national scale spatiotemporal variability of PM2.5 in the contiguous United States. Environ Sci Technol (2013) 1.51
Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells. J Biol Chem (2002) 1.44
Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein. Eur J Neurosci (2006) 1.43
Ni/NiO core/shell nanoparticles for selective binding and magnetic separation of histidine-tagged proteins. J Am Chem Soc (2006) 1.42
A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. EMBO J (2004) 1.39
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab (2013) 1.37
Controlling the mass action of alpha-synuclein in Parkinson's disease. J Neurochem (2008) 1.34
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol (2010) 1.29
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J Biol Chem (2005) 1.25
Structural and functional implications of C-terminal regions of alpha-synuclein. Biochemistry (2002) 1.25
A waferscale Si wire solar cell using radial and bulk p-n junctions. Nanotechnology (2010) 1.22
Parkin ubiquitinates and promotes the degradation of RanBP2. J Biol Chem (2005) 1.19
The Effects of Taping Prior to PNF Treatment on Lower Extremity Proprioception of Hemiplegic Patients. J Phys Ther Sci (2013) 1.12
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med (2011) 1.12
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med (2013) 1.12
A strong antireflective solar cell prepared by tapering silicon nanowires. Opt Express (2010) 1.09
Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection. Aging (Albany NY) (2011) 1.09
Optical properties of Si microwires combined with nanoneedles for flexible thin film photovoltaics. Opt Express (2011) 1.08
alpha-Synuclein exhibits competitive interaction between calmodulin and synthetic membranes. J Neurochem (2002) 1.06
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease. Glia (2008) 1.05
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. J Biol Chem (2006) 1.03
Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. J Neurochem (2006) 1.03
Highly electrocatalytic Cu₂ZnSn(S₁-xSex)₄ counter electrodes for quantum-dot-sensitized solar cells. ACS Appl Mater Interfaces (2013) 0.99
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell (2013) 0.98
Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation. BMB Rep (2009) 0.98
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure (2009) 0.97
A stamped PEDOT:PSS-silicon nanowire hybrid solar cell. Nanotechnology (2012) 0.97
Enzymatic synthesis and properties of highly branched rice starch amylose and amylopectin cluster. J Agric Food Chem (2007) 0.96
A novel mechanism of interaction between alpha-synuclein and biological membranes. J Mol Biol (2006) 0.96
Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities. J Neurosci Methods (2011) 0.95
A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. BMC Cell Biol (2010) 0.95
Seed-dependent accelerated fibrillation of alpha-synuclein induced by periodic ultrasonication treatment. J Microbiol Biotechnol (2007) 0.94
Mitochondria and organismal longevity. Curr Genomics (2012) 0.93
Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal (2012) 0.93
Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet (2012) 0.92
Dissociation of emotional decision-making from cognitive decision-making in chronic schizophrenia. Psychiatry Res (2007) 0.92
Porcelain heart: rapid progression of cardiac calcification in a patient with hemodialysis. J Cardiovasc Ultrasound (2012) 0.91
Single transconjunctival incision and two-point fixation for the treatment of noncomminuted zygomatic complex fracture. J Korean Med Sci (2006) 0.91
Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol. Anal Biochem (2007) 0.91
Incidental unruptured intracranial aneurysms in patients with acute ischemic stroke. Cerebrovasc Dis (2008) 0.91
Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein. Biochemistry (2004) 0.91
Eleven years of experience with the neurologic complications in Korean patients with acute aortic dissection: a retrospective study. BMC Neurol (2013) 0.91
Impairment of microtubule system increases alpha-synuclein aggregation and toxicity. Biochem Biophys Res Commun (2007) 0.90
Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice. PLoS One (2012) 0.90
Increased power spectral density in resting-state pain-related brain networks in fibromyalgia. Pain (2013) 0.90
Pentraxin 3 as a novel marker predicting congestive heart failure in subjects with acute coronary syndrome. Korean Circ J (2010) 0.90
Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress. PLoS One (2009) 0.89
Lipid interaction of alpha-synuclein during the metal-catalyzed oxidation in the presence of Cu2+ and H2O2. J Neurochem (2003) 0.89
Abundance of ADAM-8, -9, -10, -12, -15 and -17 and ADAMTS-1 in mouse uterus during the oestrous cycle. Reprod Fertil Dev (2005) 0.89
Egr-1 is necessary for fibroblast growth factor-2-induced transcriptional activation of the glial cell line-derived neurotrophic factor in murine astrocytes. J Biol Chem (2009) 0.89
Molecular cloning of the phytase gene from Citrobacter braakii and its expression in Saccharomyces cerevisiae. Biotechnol Lett (2006) 0.88
Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. J Biol Chem (2003) 0.88
3-D worm tracker for freely moving C. elegans. PLoS One (2013) 0.87
Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets. Blood (2002) 0.87
Nardostachys jatamansi protects against cerulein-induced acute pancreatitis. Pancreas (2010) 0.87
Analysis of location and prevalence of maxillary sinus septa. J Periodontal Implant Sci (2010) 0.87
Bioactivity of Ti-6Al-4V alloy implants treated with ibandronate after the formation of the nanotube TiO2 layer. J Biomed Mater Res B Appl Biomater (2012) 0.86
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet (2012) 0.86
The Changes of Electromyography in the Upper Trapezius and Supraspinatus of Women College Students According to the Method of Bag-carrying and Weight. J Phys Ther Sci (2013) 0.86
Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice. Exp Neurobiol (2011) 0.86
Evaluation of Cardiac Function by Transthoracic Echocardiography in Subjects with ST-Segment Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention according to Valsartan Dose: The Valsartan One Center Trial. J Cardiovasc Ultrasound (2010) 0.86
Cost-effectiveness of bevacizumab-based therapy versus cisplatin plus pemetrexed for the first-line treatment of advanced non-squamous NSCLC in Korea and Taiwan. Asia Pac J Clin Oncol (2011) 0.85
Recurrence of blepharoptosis after a superiorly based muscle flap: treatment by frontalis muscle advancement. Plast Reconstr Surg (2005) 0.85
14-3-3 sigma and 14-3-3 zeta plays an opposite role in cell growth inhibition mediated by transforming growth factor-beta 1. Mol Cells (2010) 0.85
Incorporation of a self-aligned selective emitter to realize highly efficient (12.8%) Si nanowire solar cells. Nanoscale (2014) 0.84
The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking. FEBS Lett (2013) 0.84
Radiating amyloid fibril formation on the surface of lipid membranes through unit-assembly of oligomeric species of α-synuclein. PLoS One (2012) 0.84
Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. J Biol Chem (2012) 0.84