Published in J Biol Chem on September 25, 2002
Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes. PLoS Biol (2006) 3.06
The fold of alpha-synuclein fibrils. Proc Natl Acad Sci U S A (2008) 2.82
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol (2004) 2.51
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain. Brain (2015) 2.32
alpha-Synuclein and neuronal cell death. Mol Neurodegener (2009) 1.85
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia. Acta Neuropathol (2010) 1.80
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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. J Neurosci (2012) 1.63
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55
In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence. J Biol Chem (2007) 1.19
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO J (2009) 1.16
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annu Rev Pharmacol Toxicol (2014) 1.09
LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease. Neuropathol Appl Neurobiol (2007) 1.08
Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol (2004) 1.04
Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation. Mol Biol Cell (2008) 1.04
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions. J Neuropathol Exp Neurol (2009) 1.03
17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy. PLoS One (2010) 1.01
Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death. J Biol Chem (2011) 0.97
Rotenone inhibits autophagic flux prior to inducing cell death. ACS Chem Neurosci (2012) 0.97
The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation. Toxicol Appl Pharmacol (2008) 0.95
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein. Nat Commun (2014) 0.94
Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal (2012) 0.93
Imaging nanometer-sized α-synuclein aggregates by superresolution fluorescence localization microscopy. Biophys J (2012) 0.92
The regulation of synaptic function by alpha-synuclein. Commun Integr Biol (2010) 0.91
Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates. Cell Death Differ (2014) 0.91
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation. PLoS Genet (2014) 0.90
In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. J Neural Transm (Vienna) (2007) 0.86
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Rep (2015) 0.85
Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies. J Biol Chem (2009) 0.83
In vitro aggregation assays for the characterization of α-synuclein prion-like properties. Prion (2014) 0.81
Protein misfolding specifies recruitment to cytoplasmic inclusion bodies. J Cell Biol (2016) 0.81
Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process. J Biol Chem (2015) 0.80
mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences. Aging Dis (2013) 0.79
Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation. J Chem Phys (2015) 0.78
Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson's disease. Antioxid Redox Signal (2014) 0.78
α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells. Neurosci Lett (2011) 0.78
Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. J Neurochem (2010) 0.78
Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease. Biomolecules (2015) 0.77
Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein. BMC Struct Biol (2004) 0.77
Parkinson's Disease: The Mitochondria-Iron Link. Parkinsons Dis (2016) 0.76
Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins. Int J Cell Biol (2013) 0.76
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation. Brain Res Bull (2016) 0.76
Amyloid-beta alters trafficking of internalized acetylcholinesterase and dextran. Int J Physiol Pathophysiol Pharmacol (2009) 0.75
The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. Acta Neuropathol Commun (2016) 0.75
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A (2009) 6.87
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci (2005) 3.93
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol (2008) 2.78
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem (2010) 2.67
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci (2004) 2.25
Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. J Biol Chem (2002) 2.19
Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J Biol Chem (2001) 2.03
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry (2002) 1.98
OASIS: online application for the survival analysis of lifespan assays performed in aging research. PLoS One (2011) 1.98
Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem (2001) 1.85
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.79
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A (2010) 1.78
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem Biophys Res Commun (2008) 1.71
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. J Neurosci (2012) 1.63
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem (2010) 1.60
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55
A hybrid approach to estimating national scale spatiotemporal variability of PM2.5 in the contiguous United States. Environ Sci Technol (2013) 1.51
Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein. Eur J Neurosci (2006) 1.43
A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. EMBO J (2004) 1.39
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab (2013) 1.37
Controlling the mass action of alpha-synuclein in Parkinson's disease. J Neurochem (2008) 1.34
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol (2010) 1.29
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med (2011) 1.12
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med (2013) 1.12
Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection. Aging (Albany NY) (2011) 1.09
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell (2013) 0.98
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure (2009) 0.97
A novel mechanism of interaction between alpha-synuclein and biological membranes. J Mol Biol (2006) 0.96
Enzymatic synthesis and properties of highly branched rice starch amylose and amylopectin cluster. J Agric Food Chem (2007) 0.96
Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities. J Neurosci Methods (2011) 0.95
A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. BMC Cell Biol (2010) 0.95
Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal (2012) 0.93
Mitochondria and organismal longevity. Curr Genomics (2012) 0.93
Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet (2012) 0.92
Dissociation of emotional decision-making from cognitive decision-making in chronic schizophrenia. Psychiatry Res (2007) 0.92
Porcelain heart: rapid progression of cardiac calcification in a patient with hemodialysis. J Cardiovasc Ultrasound (2012) 0.91
Incidental unruptured intracranial aneurysms in patients with acute ischemic stroke. Cerebrovasc Dis (2008) 0.91
Eleven years of experience with the neurologic complications in Korean patients with acute aortic dissection: a retrospective study. BMC Neurol (2013) 0.91
Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice. PLoS One (2012) 0.90
Increased power spectral density in resting-state pain-related brain networks in fibromyalgia. Pain (2013) 0.90
Pentraxin 3 as a novel marker predicting congestive heart failure in subjects with acute coronary syndrome. Korean Circ J (2010) 0.90
Abundance of ADAM-8, -9, -10, -12, -15 and -17 and ADAMTS-1 in mouse uterus during the oestrous cycle. Reprod Fertil Dev (2005) 0.89
Egr-1 is necessary for fibroblast growth factor-2-induced transcriptional activation of the glial cell line-derived neurotrophic factor in murine astrocytes. J Biol Chem (2009) 0.89
3-D worm tracker for freely moving C. elegans. PLoS One (2013) 0.87
Analysis of location and prevalence of maxillary sinus septa. J Periodontal Implant Sci (2010) 0.87
Bioactivity of Ti-6Al-4V alloy implants treated with ibandronate after the formation of the nanotube TiO2 layer. J Biomed Mater Res B Appl Biomater (2012) 0.86
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet (2012) 0.86
Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice. Exp Neurobiol (2011) 0.86
Evaluation of Cardiac Function by Transthoracic Echocardiography in Subjects with ST-Segment Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention according to Valsartan Dose: The Valsartan One Center Trial. J Cardiovasc Ultrasound (2010) 0.86
Recurrence of blepharoptosis after a superiorly based muscle flap: treatment by frontalis muscle advancement. Plast Reconstr Surg (2005) 0.85
Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease. J Biol Chem (2012) 0.84
The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking. FEBS Lett (2013) 0.84
Effects of nutritional components on aging. Aging Cell (2014) 0.84
Enhanced light output of InGaN/GaN blue light emitting diodes with Ag nano-particles embedded in nano-needle layer. Opt Express (2012) 0.83
Sturge-Weber syndrome, without a facial port-wine stain, with epilepsy onset in the fifth decade. Epileptic Disord (2008) 0.83
Protective effects against H2O2-induced damage by enzymatic hydrolysates of an edible brown seaweed, sea tangle (Laminaria japonica). J Med Food (2009) 0.82
Synchrotron X-ray bioimaging of bone regeneration by artificial bone substitute of MegaGen Synthetic Bone and hyaluronate hydrogels. Tissue Eng Part C Methods (2010) 0.82
Working memory impairment in fibromyalgia patients associated with altered frontoparietal memory network. PLoS One (2012) 0.81
Korean mistletoe (Viscum album coloratum) extract extends the lifespan of nematodes and fruit flies. Biogerontology (2013) 0.81
Glucocerebrosidase, a new player changing the old rules in Lewy body diseases. Biol Chem (2013) 0.81
A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction. Hum Psychopharmacol (2002) 0.79
The Relationship Between Serum Pentraxin 3 and Central Obesity in ST-Segment Elevation Myocardial Infarction Patients. Korean Circ J (2010) 0.78
Purification and characterization of a novel peptide with inhibitory effects on colitis induced mice by dextran sulfate sodium from enzymatic hydrolysates of Crassostrea gigas. Fish Shellfish Immunol (2012) 0.78
Multiple non-cell autonomous actions of alpha-synuclein in neurodegenerative diseases: Is there a direct link? Cell Cycle (2010) 0.78
Are plasma homocysteine levels related to neurological severity and functional outcome after ischemic stroke in the Korean population? J Neurol Sci (2008) 0.78
Life-Threatening Anaphylactoid Reaction in an Acute Ischemic Stroke Patient With Intravenous rt-PA Thrombolysis, Followed by Successful Intra-Arterial Thrombolysis. J Clin Neurol (2008) 0.78
Intraoperative adjustment in strabismus surgery under topical anesthesia. Yonsei Med J (2006) 0.77
Neuroprotective effects of a novel peptide purified from venison protein. J Microbiol Biotechnol (2010) 0.77
Novel covalent modifications of alpha-synuclein during the recovery from proteasomal dysfunction. Biochem Biophys Res Commun (2006) 0.77
Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem (2008) 0.77
Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors. Acta Crystallogr D Biol Crystallogr (2012) 0.76
Chitooligosaccharides induce apoptosis in human myeloid leukemia HL-60 cells. Bioorg Med Chem Lett (2012) 0.76
The role of calpains in ligand-induced degradation of the glucocorticoid receptor. Biochem Biophys Res Commun (2008) 0.76
Three cases of non-surgical treatment of stent loss during percutaneous coronary intervention. Korean Circ J (2010) 0.75
Exercise-induced intranodal atrioventricular block. Korean Circ J (2012) 0.75
Effect of light and reductones on differentiation of Pleurotus ostreatus. J Microbiol (2011) 0.75
Tris(1,10-phenanthroline)copper(II) di-mu-iodo-bis(diiodomercurate) dimethyl sulfoxide monohydrate. Acta Crystallogr C (2006) 0.75
In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity. Food Chem Toxicol (2012) 0.75
Reappearance of thalamic ataxia after a second hemorrhage at the ipsilateral thalamus. J Clin Neurosci (2008) 0.75
Nanopatterned aluminum nitride template for high efficiency light-emitting diodes. Opt Express (2009) 0.75
Monosymptomatic rest tremor due to a midbrain arteriovenous malformation. Mov Disord (2008) 0.75
Selective processing of a follicular matrix metalloproteinase-2 isoform by human oviducal fluid. Reprod Fertil Dev (2003) 0.75
Precise expression profiling by stuffer-free multiplex ligation-dependent probe amplification. Anal Chem (2013) 0.75
ISAR Imaging of High-Speed Maneuvering Target Using Gapped Stepped-Frequency Waveform and Compressive Sensing. IEEE Trans Image Process (2017) 0.75
Opposite carrier dynamics and optical absorption characteristics under external electric field in nonpolar vs. polar InGaN/GaN based quantum heterostructures. Opt Express (2011) 0.75
Lack of direct role of parkin in the steady-state level and aggregation of alpha-synuclein and the clearance of pre-formed aggregates. Exp Neurol (2005) 0.75
Comparison of the Efficacy and Safety of Aripiprazole Versus Bupropion Augmentation in Patients With Major Depressive Disorder Unresponsive to Selective Serotonin Reuptake Inhibitors: A Randomized, Prospective, Open-Label Study. J Clin Psychopharmacol (2017) 0.75
Antioxidant activity of enzymatic extracts from Stellaria dichotoma. J Med Food (2008) 0.75
Antioxidant activity and protective effect of anthocyanin oligomers on H₂O₂-triggered G2/M arrest in retinal cells. J Agric Food Chem (2012) 0.75