Published in J Clin Invest on March 01, 2008
A history of the American Society for Clinical Investigation. J Clin Invest (2009) 2.23
Plus ça change, plus c'est la même chose. J Clin Invest (2012) 0.75
Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99
Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12
Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59
Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol (2004) 2.79
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol (2003) 2.47
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44
TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36
Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. J Invest Dermatol (2012) 2.05
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes (2012) 2.02
Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 1.95
Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity (2008) 1.95
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 1.93
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity (2002) 1.89
Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat Med (2002) 1.84
Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A (2007) 1.81
CTLA4Ig: bridging the basic immunology with clinical application. Immunity (2006) 1.75
Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol (2005) 1.61
Impaired T cell function in RANTES-deficient mice. Clin Immunol (2002) 1.60
Organ transplantation: halfway through the first century. J Am Soc Nephrol (2004) 1.59
Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol (2005) 1.58
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58
T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest (2014) 1.53
High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE (2007) 1.51
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol (2006) 1.51
The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest (2008) 1.50
The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol (2003) 1.50
Tregs and transplantation tolerance. J Clin Invest (2004) 1.49
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48
An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest (2013) 1.46
MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol (2008) 1.45
T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43
Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol (2006) 1.42
Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol (2008) 1.41
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38
Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. J Immunol (2006) 1.37
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol (2006) 1.37
An update on regulatory T cells in transplant tolerance and rejection. Nat Rev Nephrol (2010) 1.35
Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA (2012) 1.33
Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells. J Immunol (2005) 1.32
CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett (2007) 1.29
Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun (2007) 1.26
Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant (2003) 1.21
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19
Heterologous immunity and homeostatic proliferation as barriers to tolerance. Curr Opin Immunol (2004) 1.19
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest (2010) 1.17
A role for IL-27 in limiting T regulatory cell populations. J Immunol (2011) 1.17
Regulation of T-cell responses by PTEN. Immunol Rev (2008) 1.15
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest (2012) 1.15
The innate immune system in allograft rejection and tolerance. J Immunol (2007) 1.13
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest (2002) 1.12
Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. J Immunol (2004) 1.10
Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. J Exp Med (2002) 1.07
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A (2009) 1.06
New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J Immunol (2011) 1.06
The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering. J Exp Med (2002) 1.05
Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. J Immunol Methods (2012) 1.04
The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol (2010) 1.03
TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol (2003) 1.03
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood (2010) 1.01
The physician's voice in the health care debate. J Clin Invest (2009) 1.01
Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity (2013) 1.00
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A (2013) 0.97
New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo. Am J Transplant (2003) 0.97
Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. J Immunol (2002) 0.97
Regulation of T cell homeostasis and responses by pten. Front Immunol (2012) 0.97
Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood (2011) 0.96
Signals and pathways controlling regulatory T cells. Immunol Rev (2014) 0.95
A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection. J Invest Dermatol (2006) 0.95
Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunol Rev (2003) 0.95
Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol (2008) 0.95
Routes to transplant tolerance versus rejection; the role of cytokines. Immunity (2004) 0.95
The contribution of direct TLR signaling to T cell responses. Immunol Res (2009) 0.94
A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation (2010) 0.94
Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. J Immunol (2003) 0.93
Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection. J Am Soc Nephrol (2006) 0.93
Homeostatic T cell proliferation as a barrier to T cell tolerance. Philos Trans R Soc Lond B Biol Sci (2005) 0.91
Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol (2011) 0.90
Tolerance: one transplant for life. Transplantation (2014) 0.89
After further review. J Clin Invest (2009) 0.89
Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection. Am J Transplant (2005) 0.89
Mechanism of T cell-mediated endothelial apoptosis. Transplantation (2002) 0.89
Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. J Immunol (2006) 0.88
Innate immunity in transplant tolerance and rejection. Immunol Rev (2011) 0.88
Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol (2012) 0.87
EGR-2 is not required for in vivo CD4 T cell mediated immune responses. PLoS One (2010) 0.85
Lymphocyte depletion as a barrier to immunological tolerance. Contrib Nephrol (2005) 0.85
Marking a path to transplant tolerance. J Clin Invest (2008) 0.85
Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol (2013) 0.84
Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest (2016) 0.83
Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages. Eur J Immunol (2005) 0.83
Challenges in the pursuit of immune tolerance. Immunol Rev (2011) 0.83
Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation. J Immunol (2003) 0.83
Regulatory cells and cell signatures in clinical transplantation tolerance. Curr Opin Immunol (2011) 0.82
Editorial position on publishing articles on human organ transplantation. J Clin Invest (2012) 0.82
T-cell energy metabolism as a controller of cell fate in transplantation. Curr Opin Organ Transplant (2015) 0.81