Homeostatic T cell proliferation as a barrier to T cell tolerance.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 1569537)

Published in Philos Trans R Soc Lond B Biol Sci on September 29, 2005

Authors

Somia P Hickman1, Laurence A Turka

Author Affiliations

1: University of Pennsylvania, 700 Clinical Research Building, Philadelphia, 19104-6144, USA.

Articles cited by this

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity (2000) 15.44

Tolerogenic dendritic cells. Annu Rev Immunol (2001) 13.77

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol (2000) 12.81

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med (2000) 9.78

Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol (2000) 9.15

Turnover of naive- and memory-phenotype T cells. J Exp Med (1994) 8.07

Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol (1999) 7.60

Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med (2002) 7.11

Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science (2000) 6.22

Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (1999) 6.20

The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity (1999) 6.10

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol (2001) 5.95

Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med (2002) 5.64

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res (2001) 5.48

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity (2002) 5.38

Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol (2002) 5.10

Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med (2000) 5.07

"Infectious" transplantation tolerance. Science (1993) 4.98

Control of intestinal inflammation by regulatory T cells. Immunol Rev (2001) 4.73

Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med (2000) 4.54

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med (2003) 4.39

Cutting edge: naive T cells masquerading as memory cells. J Immunol (2000) 4.27

Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest (2003) 4.14

Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12

Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol (2003) 3.86

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med (1998) 3.82

Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med (2001) 3.69

Identification of regulatory T cells in tolerated allografts. J Exp Med (2002) 3.60

A potential role for interleukin-7 in T-cell homeostasis. Blood (2001) 3.56

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol (1998) 3.56

Expression of two T cell receptor alpha chains: dual receptor T cells. Science (1993) 3.54

The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol (2002) 3.47

IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol (2001) 3.22

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol (1994) 2.86

Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity (2003) 2.80

Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol (1999) 2.79

Homeostatic T cell proliferation: how far can T cells be activated to self-ligands? J Exp Med (2000) 2.55

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54

Autologous regulation of naive T cell homeostasis within the T cell compartment. J Immunol (2001) 2.52

Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol (2003) 2.47

Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol (2002) 2.42

Transplantation tolerance induced by CTLA4-Ig. Transplantation (1994) 2.36

Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J Immunol (2004) 2.28

Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol (2000) 2.24

CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol (2003) 2.19

T cell regulation as a side effect of homeostasis and competition. J Exp Med (2003) 2.15

CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol (2003) 2.11

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A (1995) 2.06

The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J Immunol (2000) 2.04

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease. J Exp Med (1994) 2.02

Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant (1999) 1.96

Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance. J Immunol (2002) 1.85

Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells. J Immunol (2003) 1.80

From naive to memory T cells. Immunol Rev (1996) 1.76

The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells. J Immunol (2002) 1.71

Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med (2003) 1.71

Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci U S A (2000) 1.69

Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest (1998) 1.67

The molecular program induced in T cells undergoing homeostatic proliferation. Proc Natl Acad Sci U S A (2004) 1.66

Sensory adaptation in naive peripheral CD4 T cells. J Exp Med (2001) 1.65

Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. J Virol (2000) 1.64

CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism. J Clin Invest (2004) 1.63

Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur J Immunol (1995) 1.62

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors. Proc Natl Acad Sci U S A (2001) 1.61

Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. J Immunol (2002) 1.55

Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J Immunol (2000) 1.55

Il-12 enhances CD8 T cell homeostatic expansion. J Immunol (2001) 1.51

Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance. J Immunol (2001) 1.49

Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity. J Immunol (1993) 1.45

A ligand for the chemokine receptor CCR7 can influence the homeostatic proliferation of CD4 T cells and progression of autoimmunity. J Immunol (2001) 1.43

Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol (2003) 1.41

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat Med (2001) 1.40

A closer look at homeostatic proliferation of CD4+ T cells: costimulatory requirements and role in memory formation. J Immunol (2001) 1.39

Cell division in the compartment of naive and memory T lymphocytes. Eur J Immunol (1996) 1.36

Characterization of murine bone marrow and spleen-derived stromal cells: analysis of leukocyte marker and growth factor mRNA transcript levels. Blood (1989) 1.22

Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors. Proc Natl Acad Sci U S A (2004) 1.14

Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion. J Exp Med (1995) 1.14

IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression. J Immunol (2003) 1.11

CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection. J Immunol (1999) 1.01

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol (2003) 1.00

Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease. Transplantation (2002) 1.00

Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. J Exp Med (2001) 0.96

Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease. Blood (1997) 0.89

Managing the highly sensitized transplant recipient and B cell tolerance. Curr Opin Immunol (2001) 0.88

Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms. J Immunol (2002) 0.86

Graft rejection in sensitized recipients. Ann Transplant (1996) 0.85

Graft hyporeactivity induced by donor-derived dendritic cell progenitors. Transplant Proc (2000) 0.76

Articles by these authors

(truncated to the top 100)

Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99

Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12

Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59

Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol (2004) 2.79

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52

Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol (2003) 2.47

TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44

TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36

Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26

A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. J Invest Dermatol (2012) 2.05

The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04

Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes (2012) 2.02

Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 1.95

Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity (2008) 1.95

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 1.93

The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity (2002) 1.89

Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat Med (2002) 1.84

Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A (2007) 1.81

CTLA4Ig: bridging the basic immunology with clinical application. Immunity (2006) 1.75

Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol (2005) 1.61

Impaired T cell function in RANTES-deficient mice. Clin Immunol (2002) 1.60

Organ transplantation: halfway through the first century. J Am Soc Nephrol (2004) 1.59

Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol (2005) 1.58

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58

T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest (2014) 1.53

High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE (2007) 1.51

Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol (2006) 1.51

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest (2008) 1.50

The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol (2003) 1.50

Tregs and transplantation tolerance. J Clin Invest (2004) 1.49

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48

An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest (2013) 1.46

MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol (2008) 1.45

T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43

Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol (2006) 1.42

Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol (2008) 1.41

Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38

Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. J Immunol (2006) 1.37

Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol (2006) 1.37

An update on regulatory T cells in transplant tolerance and rejection. Nat Rev Nephrol (2010) 1.35

Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA (2012) 1.33

Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells. J Immunol (2005) 1.32

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett (2007) 1.29

Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun (2007) 1.26

Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant (2003) 1.21

Heterologous immunity and homeostatic proliferation as barriers to tolerance. Curr Opin Immunol (2004) 1.19

Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19

Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest (2010) 1.17

A role for IL-27 in limiting T regulatory cell populations. J Immunol (2011) 1.17

Regulation of T-cell responses by PTEN. Immunol Rev (2008) 1.15

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest (2012) 1.15

The innate immune system in allograft rejection and tolerance. J Immunol (2007) 1.13

Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest (2002) 1.12

Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. J Immunol (2004) 1.10

Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. J Exp Med (2002) 1.07

New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J Immunol (2011) 1.06

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A (2009) 1.06

The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering. J Exp Med (2002) 1.05

Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. J Immunol Methods (2012) 1.04

TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol (2003) 1.03

The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol (2010) 1.03

The physician's voice in the health care debate. J Clin Invest (2009) 1.01

TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood (2010) 1.01

Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity (2013) 1.00

MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A (2013) 0.97

Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. J Immunol (2002) 0.97

New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo. Am J Transplant (2003) 0.97

Regulation of T cell homeostasis and responses by pten. Front Immunol (2012) 0.97

Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood (2011) 0.96

Signals and pathways controlling regulatory T cells. Immunol Rev (2014) 0.95

A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection. J Invest Dermatol (2006) 0.95

Routes to transplant tolerance versus rejection; the role of cytokines. Immunity (2004) 0.95

Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol (2008) 0.95

Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunol Rev (2003) 0.95

Animal house. J Clin Invest (2008) 0.94

A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation (2010) 0.94

The contribution of direct TLR signaling to T cell responses. Immunol Res (2009) 0.94

Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. J Immunol (2003) 0.93

Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection. J Am Soc Nephrol (2006) 0.93

Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol (2011) 0.90

Tolerance: one transplant for life. Transplantation (2014) 0.89

After further review. J Clin Invest (2009) 0.89

Mechanism of T cell-mediated endothelial apoptosis. Transplantation (2002) 0.89

Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection. Am J Transplant (2005) 0.89

Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. J Immunol (2006) 0.88

Innate immunity in transplant tolerance and rejection. Immunol Rev (2011) 0.88

Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol (2012) 0.87

Marking a path to transplant tolerance. J Clin Invest (2008) 0.85

EGR-2 is not required for in vivo CD4 T cell mediated immune responses. PLoS One (2010) 0.85

Lymphocyte depletion as a barrier to immunological tolerance. Contrib Nephrol (2005) 0.85

Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol (2013) 0.84

Challenges in the pursuit of immune tolerance. Immunol Rev (2011) 0.83

Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation. J Immunol (2003) 0.83

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest (2016) 0.83

Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages. Eur J Immunol (2005) 0.83

Regulatory cells and cell signatures in clinical transplantation tolerance. Curr Opin Immunol (2011) 0.82

Editorial position on publishing articles on human organ transplantation. J Clin Invest (2012) 0.82

T-cell energy metabolism as a controller of cell fate in transplantation. Curr Opin Organ Transplant (2015) 0.81