Published in J Immunol on August 15, 2006
Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol (2009) 4.66
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family. Immunol Rev (2011) 2.54
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol (2010) 1.42
Molecular mechanisms for adaptive tolerance and other T cell anergy models. Semin Immunol (2007) 1.38
Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK. J Immunol (2008) 1.34
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance. Proc Natl Acad Sci U S A (2009) 1.14
Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. J Immunol (2012) 1.08
Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol (2011) 1.04
Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proc Natl Acad Sci U S A (2012) 1.01
Key role of ERK pathway signaling in lupus. Autoimmunity (2010) 0.99
Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues. J Immunol (2014) 0.92
Phospho-flow cytometry based analysis of differences in T cell receptor signaling between regulatory T cells and CD4+ T cells. J Immunol Methods (2011) 0.85
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis. Proc Natl Acad Sci U S A (2012) 0.85
Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells. Shock (2011) 0.84
The TCR repertoires of regulatory and conventional T cells specific for the same foreign antigen are distinct. J Immunol (2012) 0.84
Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases. Lipids Health Dis (2012) 0.84
Role of T cell-nuclear factor κB in transplantation. Transplant Rev (Orlando) (2011) 0.83
T cell Receptor Signal Transduction in T lymphocytes. J Clin Cell Immunol (2012) 0.83
SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling. Mol Cell Proteomics (2014) 0.82
Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions. J Biol Chem (2009) 0.81
Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells. PLoS One (2012) 0.80
First insight into the kinome of human regulatory T cells. PLoS One (2012) 0.80
IL-2 Expression in Activated Human Memory FOXP3(+) Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of T Cell Activation. Front Immunol (2012) 0.80
Stable IL-2 decision making by endogenous c-Fos amounts in peripheral memory T-helper cells. J Biol Chem (2012) 0.80
Statins increase the frequency of circulating CD4+ FOXP3+ regulatory T cells in healthy individuals. J Immunol Res (2015) 0.78
Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction. PLoS One (2015) 0.78
Monoclonal regulatory T cells provide insights into T cell suppression. Sci Rep (2016) 0.77
Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function. Eur J Immunol (2014) 0.77
Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. J Biol Chem (2016) 0.76
The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells. Eur J Microbiol Immunol (Bp) (2017) 0.75
Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling. Cell Mol Life Sci (2017) 0.75
Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99
Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12
Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med (2005) 3.17
Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol (2004) 2.79
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol (2003) 2.47
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44
TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36
Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med (2005) 2.09
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. J Invest Dermatol (2012) 2.05
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes (2012) 2.02
Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 1.95
Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity (2008) 1.95
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 1.93
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity (2002) 1.89
Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells. J Immunol (2006) 1.88
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J Biol Chem (2006) 1.84
Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat Med (2002) 1.84
Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A (2007) 1.81
CTLA4Ig: bridging the basic immunology with clinical application. Immunity (2006) 1.75
Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol (2005) 1.61
Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes. J Immunol (2007) 1.61
Impaired T cell function in RANTES-deficient mice. Clin Immunol (2002) 1.60
Organ transplantation: halfway through the first century. J Am Soc Nephrol (2004) 1.59
Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol (2005) 1.58
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58
T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest (2014) 1.53
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J Immunol (2005) 1.52
High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE (2007) 1.51
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol (2006) 1.51
The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest (2008) 1.50
The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol (2003) 1.50
Tregs and transplantation tolerance. J Clin Invest (2004) 1.49
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48
An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest (2013) 1.46
Factors associated with aortic stiffness and its change over time in peritoneal dialysis patients. Nephrol Dial Transplant (2010) 1.46
MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol (2008) 1.45
BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol (2004) 1.44
T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43
Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol (2006) 1.42
Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol (2008) 1.41
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol (2006) 1.37
An update on regulatory T cells in transplant tolerance and rejection. Nat Rev Nephrol (2010) 1.35
Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA (2012) 1.33
Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells. J Immunol (2005) 1.32
B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol (2005) 1.31
CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett (2007) 1.29
Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun (2007) 1.26
Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant (2003) 1.21
Heterologous immunity and homeostatic proliferation as barriers to tolerance. Curr Opin Immunol (2004) 1.19
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest (2010) 1.17
A role for IL-27 in limiting T regulatory cell populations. J Immunol (2011) 1.17
Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells. J Immunol (2008) 1.16
Regulation of T-cell responses by PTEN. Immunol Rev (2008) 1.15
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest (2012) 1.15
Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. J Immunol (2003) 1.15
Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep (2012) 1.14
The innate immune system in allograft rejection and tolerance. J Immunol (2007) 1.13
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest (2002) 1.12
Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. J Immunol (2004) 1.10
Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. J Exp Med (2002) 1.07
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A (2009) 1.06
New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J Immunol (2011) 1.06
The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering. J Exp Med (2002) 1.05
Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation. J Biol Chem (2009) 1.05
Opposing roles for the cyclin-dependent kinase inhibitor p27kip1 in the control of CD4+ T cell proliferation and effector function. J Immunol (2005) 1.05
Comparative analysis of E2F family member oncogenic activity. PLoS One (2007) 1.04
Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. J Immunol Methods (2012) 1.04
The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol (2010) 1.03
TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol (2003) 1.03
In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates. J Exp Med (2011) 1.01
IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells. J Am Soc Nephrol (2013) 1.01
The physician's voice in the health care debate. J Clin Invest (2009) 1.01
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood (2010) 1.01
Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity (2013) 1.00
The role of cyclin-dependent kinases in T-cell development, proliferation, and function. Crit Rev Immunol (2006) 0.98
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A (2013) 0.97
Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem (2008) 0.97
Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. J Immunol (2002) 0.97
New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo. Am J Transplant (2003) 0.97
Regulation of T cell homeostasis and responses by pten. Front Immunol (2012) 0.97
Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood (2011) 0.96
Signals and pathways controlling regulatory T cells. Immunol Rev (2014) 0.95
Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol (2008) 0.95