Published in J Immunol on January 01, 2008
Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res Ther (2010) 1.94
The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol (2011) 1.76
Induction of T cell anergy: integration of environmental cues and infectious tolerance. Curr Opin Immunol (2010) 1.28
Ubiquitin makes its mark on immune regulation. Immunity (2010) 1.25
The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. J Biol Chem (2008) 1.23
TRAF molecules in cell signaling and in human diseases. J Mol Signal (2013) 1.22
The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells. Immunity (2012) 1.20
Regulation of T-cell responses by PTEN. Immunol Rev (2008) 1.15
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood (2010) 1.01
Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system. Immunol Rev (2015) 0.92
Cbl-b in T-cell activation. Semin Immunopathol (2010) 0.88
Mechanisms that regulate peripheral immune responses to control organ-specific autoimmunity. Clin Dev Immunol (2011) 0.83
TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol (2013) 0.80
Ubiquitin signaling in immune responses. Cell Res (2016) 0.80
Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A (2017) 0.75
Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling. Front Immunol (2015) 0.75
Does antigen masking by ubiquitin chains protect from the development of autoimmune diseases? Front Immunol (2014) 0.75
Ubiquitin enzymes in the regulation of immune responses. Crit Rev Biochem Mol Biol (2017) 0.75
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23
Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09
Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61
Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell (2013) 6.30
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity (2011) 5.43
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12
Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59
Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol (2006) 3.18
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem (2008) 2.97
Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol (2004) 2.79
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood (2007) 2.65
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. J Cell Biol (2010) 2.47
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol (2003) 2.47
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A (2010) 2.45
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44
TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36
Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology (2006) 2.33
Osteoimmunology: interactions of the bone and immune system. Endocr Rev (2008) 2.32
Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity (2002) 2.31
Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol Endocrinol (2007) 2.25
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med (2005) 2.21
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity (2002) 2.20
A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. J Invest Dermatol (2012) 2.05
The specificity and topology of chromatin interaction pathways in yeast. Mol Cell (2011) 2.04
A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J Exp Med (2002) 2.04
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04
Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol Rev (2012) 2.03
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes (2012) 2.02
Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads. J Immunol (2008) 1.98
Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 1.95
Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity (2008) 1.95
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 1.93
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc Natl Acad Sci U S A (2013) 1.90
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity (2002) 1.89
Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood (2012) 1.89
TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS One (2008) 1.86
Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nat Med (2002) 1.84
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med (2006) 1.84
Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol (2002) 1.82
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81
Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A (2007) 1.81
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79
IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med (2006) 1.76
CTLA4Ig: bridging the basic immunology with clinical application. Immunity (2006) 1.75
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol (2002) 1.74
Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. Hepatology (2008) 1.66
STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem (2008) 1.64
The role of total pancreatectomy and islet autotransplantation for chronic pancreatitis. Surg Clin North Am (2007) 1.63
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem (2005) 1.62
Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol (2005) 1.61
Impaired T cell function in RANTES-deficient mice. Clin Immunol (2002) 1.60
Organ transplantation: halfway through the first century. J Am Soc Nephrol (2004) 1.59
Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol (2005) 1.58
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis. J Clin Invest (2013) 1.57
Limy bile syndrome complicated with primary hyperparathyroidism. Intern Med (2003) 1.57
T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest (2014) 1.53
High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE (2007) 1.51
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol (2006) 1.51
The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest (2008) 1.50
The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol (2003) 1.50
Tregs and transplantation tolerance. J Clin Invest (2004) 1.49
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48
GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation (2009) 1.48
An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest (2013) 1.46
MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol (2008) 1.45
OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol (2012) 1.43
Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity (2009) 1.43
T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43
Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol (2006) 1.42
Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol (2008) 1.41
A novel serum metabolomics-based diagnostic approach for colorectal cancer. PLoS One (2012) 1.40
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Blood (2005) 1.38
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest (2011) 1.38
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38
Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. J Immunol (2006) 1.37
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol (2006) 1.37
An update on regulatory T cells in transplant tolerance and rejection. Nat Rev Nephrol (2010) 1.35