Published in Blood on March 04, 2008
Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies. Front Immunol (2012) 1.12
Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J Immunol (2011) 1.04
Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. J Immunol (2008) 1.01
RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest (2015) 0.99
Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol (2011) 0.94
Conformational switching in ezrin regulates morphological and cytoskeletal changes required for B cell chemotaxis. J Immunol (2011) 0.92
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation. Immunity (2011) 0.89
Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction. Exp Cell Res (2013) 0.89
Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation. J Thromb Haemost (2009) 0.88
Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells. Immunol Cell Biol (2011) 0.88
The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow. J Biol Chem (2013) 0.88
The actin-bundling protein L-plastin is essential for marginal zone B cell development. J Immunol (2011) 0.87
Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. Arterioscler Thromb Vasc Biol (2014) 0.85
Rap1 and its effector RIAM are required for lymphocyte trafficking. Blood (2015) 0.85
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood (2010) 0.84
Division of labor during primary humoral immunity. Immunol Res (2013) 0.83
Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function. EMBO Rep (2015) 0.82
SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proc Natl Acad Sci U S A (2010) 0.80
Rap GTPase-mediated adhesion and migration: A target for limiting the dissemination of B-cell lymphomas? Cell Adh Migr (2010) 0.80
An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment. Langmuir (2012) 0.79
Rap signaling in normal lymphocyte development and leukemia genesis. Immune Netw (2009) 0.75
The scat mouse model highlights RASA3, a GTPase activating protein, as a key regulator of vertebrate erythropoiesis and megakaryopoiesis. Small GTPases (2012) 0.75
CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner. Oncotarget (2016) 0.75
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature (1998) 11.41
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature (1996) 10.67
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A (1998) 7.69
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature (1998) 7.38
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell (1997) 7.18
B cell development pathways. Annu Rev Immunol (2001) 6.94
A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature (2000) 6.89
Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol (2005) 5.22
Mast cells in the development of adaptive immune responses. Nat Immunol (2005) 4.96
Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity (2001) 4.92
Marginal-zone B cells. Nat Rev Immunol (2002) 4.87
Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature (1998) 4.62
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol (2000) 4.57
B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J Exp Med (1999) 4.52
The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity (1999) 4.24
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell (1997) 3.93
The Ly-1 B cell lineage. Immunol Rev (1986) 3.59
Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol (2001) 3.36
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature (2001) 3.24
Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity (2000) 3.06
Defective lymphoid development in mice lacking Jak3. Science (1995) 3.04
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science (1995) 3.00
Integrin-mediated long-term B cell retention in the splenic marginal zone. Science (2002) 3.00
The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem (1998) 2.88
Immunodeficiency in protein kinase cbeta-deficient mice. Science (1996) 2.79
Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur J Immunol (1997) 2.77
RAFTK/Pyk2-mediated cellular signalling. Cell Signal (2000) 2.76
IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J Immunol (1999) 2.73
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68
B1 cells: similarities and differences with other B cell subsets. Curr Opin Immunol (2001) 2.57
Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest (2005) 2.46
Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. J Biol Chem (2001) 2.44
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity (1995) 2.40
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol (2004) 2.40
Activation of a signaling cascade by cytoskeleton stretch. Dev Cell (2004) 2.35
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science (1997) 2.33
B-1 cells: the lineage question revisited. Immunol Rev (2000) 2.06
The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity (2001) 2.04
Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines. J Immunol (2001) 1.95
Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing. Immunity (2007) 1.92
The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr Biol (2000) 1.86
Migrant mu+ delta+ and static mu+ delta- B lymphocyte subsets. Eur J Immunol (1982) 1.71
Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol (2003) 1.70
Positive versus negative signaling by lymphocyte antigen receptors. Annu Rev Immunol (1998) 1.66
Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion. Mol Cell Biol (2006) 1.53
Mast cell signal transduction from the high-affinity IgE receptor. Curr Opin Immunol (2003) 1.49
Chemokines in lymphopoiesis and lymphoid organ development. Curr Opin Immunol (2001) 1.47
Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. Blood (2007) 1.45
Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat Immunol (2001) 1.41
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase. J Cell Sci (2001) 1.41
Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood (2005) 1.33
Human marginal-zone B cells. Immunol Today (1998) 1.31
The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes. J Biol Chem (2003) 1.30
Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity (1996) 1.22
The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration. J Immunol (2002) 1.20
Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol (2007) 1.17
Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol Cell Biol (2001) 1.17
Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1. J Biol Chem (2003) 1.16
Antigen-dependent B-cell development. Curr Opin Immunol (2002) 1.14
Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Immunity (2006) 1.03
Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J Biol Chem (2003) 1.01
Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1. J Biol Chem (2001) 1.00
Activation of the Rap1 GTPase by the B cell antigen receptor. J Biol Chem (1998) 0.99
Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase. Mol Cell Biol (2001) 0.99
The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. Eur J Immunol (2006) 0.98
In search of a function for the Ras-like GTPase Rap1. FEBS Lett (1997) 0.93
CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood (2005) 0.92
The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci. Semin Immunol (1999) 0.90
BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion. Oncogene (2006) 0.89
Regulation of immune responses and hematopoiesis by the Rap1 signal. Adv Immunol (2007) 0.86
Ena/VASP family: new partners, bigger enigma. Dev Cell (2004) 0.78
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem (2007) 10.41
Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity (2005) 3.14
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol (2002) 2.70
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest (2013) 2.66
Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell (2012) 2.58
Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest (2005) 2.46
Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell (2005) 2.26
In Vivo 3D Digital Atlas Database of the Adult C57BL/6J Mouse Brain by Magnetic Resonance Microscopy. Front Neuroanat (2008) 1.85
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nat Genet (2003) 1.82
End-stage liver disease in persons with hemophilia and transfusion-associated infections. Blood (2002) 1.73
Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol (2003) 1.70
Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. Blood (2011) 1.68
Development of alopecia areata is associated with higher central and peripheral hypothalamic-pituitary-adrenal tone in the skin graft induced C3H/HeJ mouse model. J Invest Dermatol (2008) 1.62
Joint range-of-motion limitations among young males with hemophilia: prevalence and risk factors. Blood (2003) 1.60
Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem (2002) 1.59
Clinical use of a rapid collagen binding assay for von Willebrand factor cleaving protease in patients with thrombotic thrombocytopenic purpura. Thromb Haemost (2002) 1.57
The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol (2004) 1.54
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem (2008) 1.54
Dynamic interaction networks in a hierarchically organized tissue. Mol Syst Biol (2010) 1.51
STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem (2012) 1.51
The Malmö International Brother Study (MIBS). Genetic defects and inhibitor development in siblings with severe hemophilia A. Haematologica (2005) 1.51
Cell-cell interaction networks regulate blood stem and progenitor cell fate. Mol Syst Biol (2009) 1.49
Hair follicles from alopecia areata patients exhibit alterations in immune privilege-associated gene expression in advance of hair loss. J Invest Dermatol (2010) 1.48
Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion. Blood (2003) 1.47
Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. Blood (2007) 1.45
Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A (2006) 1.44
The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) and fluoxetine on post-stroke depression. J Altern Complement Med (2008) 1.43
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity (2006) 1.40
MicroRNA-223 regulates FOXO1 expression and cell proliferation. FEBS Lett (2012) 1.35
The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood (2004) 1.33
Content-based retrieval of focal liver lesions using bag-of-visual-words representations of single- and multiphase contrast-enhanced CT images. J Digit Imaging (2012) 1.33
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med (2010) 1.32
Autographa californica multiple nucleopolyhedrovirus nucleocapsid assembly is interrupted upon deletion of the 38K gene. J Virol (2006) 1.31
The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol (2013) 1.26
LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigs. Genome Biol (2007) 1.25
Development of robust hepatitis C virus genotype 4 subgenomic replicons. Gastroenterology (2012) 1.25
How we treat a hemophilia A patient with a factor VIII inhibitor. Blood (2008) 1.24
Identification of Shp-2 as a Stat5A phosphatase. J Biol Chem (2003) 1.23
Bax-inhibiting peptide derived from mouse and rat Ku70. Biochem Biophys Res Commun (2004) 1.22
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood (2006) 1.21
Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood (2008) 1.19
Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family. J Immunol (2007) 1.19
STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output. Exp Hematol (2007) 1.19
PERT: a method for expression deconvolution of human blood samples from varied microenvironmental and developmental conditions. PLoS Comput Biol (2012) 1.18
Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. J Biol Chem (2003) 1.17
Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology (2008) 1.17
Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol (2007) 1.17
MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol (2004) 1.16
Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo. J Immunol (2007) 1.16
CXCR3/ligands are significantly involved in the tumorigenesis of basal cell carcinomas. Am J Pathol (2010) 1.15
Isolation and culture of pulmonary endothelial cells from neonatal mice. J Vis Exp (2010) 1.13
Negative regulation of lymphocyte activation by the adaptor protein LAX. J Immunol (2005) 1.13
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. J Biol Chem (2007) 1.12
Genetic variation and relationships of eighteen Chinese indigenous pig breeds. Genet Sel Evol (2003) 1.08
An improved strategy for high-level production of TEV protease in Escherichia coli and its purification and characterization. Protein Expr Purif (2006) 1.07
Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effects. J Neurosci (2006) 1.07
The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood (2002) 1.07
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood (2009) 1.07
Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation. J Immunol (2007) 1.06
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol (2007) 1.06
The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. J Biol Chem (2011) 1.04
Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. J Immunol (2006) 1.04
The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. Eur J Immunol (2009) 1.02
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. Mol Cell Biol (2006) 1.01
Genetic relationships among twelve Chinese indigenous goat populations based on microsatellite analysis. Genet Sel Evol (2002) 1.01
Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. J Immunol (2008) 1.01
Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. J Biol Chem (2011) 1.01
Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Blood (2005) 1.00
The Centre for Modeling Human Disease Gene Trap resource. Nucleic Acids Res (2004) 1.00
Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1. Mol Biol Cell (2005) 0.99
Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. J Exp Med (2011) 0.98
Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. J Exp Med (2010) 0.97
Hepatitis C in adults and adolescents with hemophilia: a randomized, controlled trial of interferon alfa-2b and ribavirin. Hepatology (2002) 0.97
NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. Blood (2004) 0.97
Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R. J Immunol (2002) 0.97
Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess. Biol Blood Marrow Transplant (2006) 0.96