Published in Curr Biol on August 24, 2000
Shaping cups into phagosomes and macropinosomes. Nat Rev Mol Cell Biol (2008) 3.62
Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. Am J Hum Genet (2003) 2.56
RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem (2008) 2.29
The vessel wall and its interactions. Blood (2008) 2.17
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. J Cell Biol (2003) 2.07
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J (2001) 1.74
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. J Exp Med (2007) 1.67
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol (2008) 1.66
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding. Blood (2014) 1.55
Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion. Mol Cell Biol (2006) 1.53
Biomedicine and diseases: the Klippel-Trenaunay syndrome, vascular anomalies and vascular morphogenesis. Cell Mol Life Sci (2005) 1.37
Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood (2005) 1.33
The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma. Oncogene (2011) 1.32
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Genetics (2003) 1.27
EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis. Cell Microbiol (2008) 1.26
EPAC proteins transduce diverse cellular actions of cAMP. Br J Pharmacol (2009) 1.25
An essential role for talin during alpha(M)beta(2)-mediated phagocytosis. Mol Biol Cell (2007) 1.24
Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol (2013) 1.23
Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol Cell Biol (2001) 1.17
A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor. EMBO J (2001) 1.14
Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol (2008) 1.13
A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. Blood (2008) 1.12
The unique N-terminus of R-ras is required for Rac activation and precise regulation of cell migration. Mol Biol Cell (2005) 1.11
Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell (2002) 1.09
A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol (2003) 1.09
Two distinct cytoplasmic regions of the beta2 integrin chain regulate RhoA function during phagocytosis. J Cell Biol (2006) 1.07
Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase. Mol Biol Cell (2002) 1.06
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J (2007) 1.04
Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion. Mol Cell Biol (2002) 1.02
Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase. Mol Cell Biol (2001) 0.99
Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues. Immunology (2005) 0.98
CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood (2007) 0.97
Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain. Nat Commun (2015) 0.93
The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. J Cell Sci (2011) 0.92
Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion. Cell Adh Migr (2011) 0.92
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. J Exp Med (2014) 0.91
The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins. J Virol (2003) 0.89
RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun (2014) 0.87
Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. J Immunol (2008) 0.87
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. Mol Biol Cell (2004) 0.86
Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages. J Biol Chem (2011) 0.86
Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction. Cell Rep (2015) 0.85
cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac. Br J Pharmacol (2012) 0.84
Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages. Exp Cell Res (2007) 0.83
R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming. Blood (2011) 0.83
Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A. Mol Biol Cell (2008) 0.83
Interaction of two phagocytic host defense systems: Fcγ receptors and complement receptor 3. J Biol Chem (2010) 0.83
The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors. J Signal Transduct (2012) 0.83
Radil controls neutrophil adhesion and motility through β2-integrin activation. Mol Biol Cell (2012) 0.82
Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation. PLoS One (2012) 0.82
Ras family of small GTPases in immunity and inflammation. Curr Opin Pharmacol (2012) 0.82
Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis. J Biol Chem (2009) 0.82
Platelet-neutrophil interactions under thromboinflammatory conditions. Cell Mol Life Sci (2015) 0.82
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms. Cell Immunol (2010) 0.81
NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages. PLoS One (2014) 0.80
An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment. Langmuir (2012) 0.79
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Regulator of G-Protein Signalling-14 (RGS14) Regulates the Activation of αMβ2 Integrin during Phagocytosis. PLoS One (2013) 0.78
CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia. J Immunol (2015) 0.78
Comparative Anatomy of Phagocytic and Immunological Synapses. Front Immunol (2016) 0.78
Rap1b is an effector of Axin2 regulating crosstalk of signaling pathways during skeletal development. J Bone Miner Res (2017) 0.77
Extracellular calcium elicits feedforward regulation of the Toll-like receptor-triggered innate immune response. Cell Mol Immunol (2015) 0.76
The tripeptide feG inhibits leukocyte adhesion. J Inflamm (Lond) (2008) 0.76
Macrophages phagocytose nonopsonized silica particles using a unique microtubule-dependent pathway. Mol Biol Cell (2014) 0.76
Leukocyte transcellular diapedesis: Rap1b is in control. Tissue Barriers (2015) 0.75
R-Ras deficiency does not affect papain-induced IgE production in mice. Immun Inflamm Dis (2017) 0.75
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Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol (1999) 5.29
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The development of a multi-disciplinary approach to the assessment and management of child sexual abuse in an inner city Health District. Health Trends (1988) 3.21
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr Biol (1996) 3.13
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