Published in J Neurosci on March 05, 2008
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci (2012) 2.90
Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15
Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci (2011) 2.01
Microglial activation in stroke: therapeutic targets. Neurotherapeutics (2010) 1.84
Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience (2008) 1.73
Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68
Cytokines and perinatal brain damage. Clin Perinatol (2008) 1.50
Endogenous toll-like receptor ligands and their biological significance. J Cell Mol Med (2010) 1.41
The immunology of neurodegeneration. J Clin Invest (2012) 1.41
Microglia in ischemic brain injury. Future Neurol (2010) 1.36
Complexity of danger: the diverse nature of damage-associated molecular patterns. J Biol Chem (2014) 1.32
Microglia during development and aging. Pharmacol Ther (2013) 1.30
Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. Int J Environ Res Public Health (2011) 1.27
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27
Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration. Front Pharmacol (2012) 1.20
MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation. J Neurosci (2012) 1.17
Functional diversity of microglia - how heterogeneous are they to begin with? Front Cell Neurosci (2013) 1.14
Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application. Mediators Inflamm (2010) 1.11
Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. J Neuroinflammation (2008) 1.11
The brain's best friend: microglial neurotoxicity revisited. Front Cell Neurosci (2013) 1.09
Alcohol-induced interactive phosphorylation of Src and toll-like receptor regulates the secretion of inflammatory mediators by human astrocytes. J Neuroimmune Pharmacol (2010) 1.09
Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: a review and comparison to other methods of detection in thoracic aneurysm repair. Cell Stress Chaperones (2010) 1.07
Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury. J Neuroinflammation (2014) 1.04
Programmed death-1 pathway limits central nervous system inflammation and neurologic deficits in murine experimental stroke. Stroke (2011) 1.03
Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling. Invest Ophthalmol Vis Sci (2010) 1.01
Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss. Sleep (2011) 1.01
Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells. BMC Neurosci (2010) 1.00
A clear and present danger: endogenous ligands of Toll-like receptors. Neuromolecular Med (2009) 0.99
Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol (2013) 0.99
Pathophysiology and treatment of bacterial meningitis. Ther Adv Neurol Disord (2009) 0.98
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Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res (2013) 0.97
Innate immune regulation by toll-like receptors in the brain. ISRN Neurol (2012) 0.97
Activin A is essential for neurogenesis following neurodegeneration. Stem Cells (2009) 0.96
Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2. Am J Pathol (2009) 0.94
Expression of Toll-like receptors in the developing brain. PLoS One (2012) 0.93
Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis. Immunology (2014) 0.93
Oligodendrocyte-microglia cross-talk in the central nervous system. Immunology (2014) 0.93
Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO Mol Med (2012) 0.93
Carcinoma cells misuse the host tissue damage response to invade the brain. Glia (2013) 0.92
The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation. Mediators Inflamm (2016) 0.92
Regulation of toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia. J Neuroinflammation (2011) 0.91
Systemic inflammation impairs respiratory chemoreflexes and plasticity. Respir Physiol Neurobiol (2011) 0.91
Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders? Brain Behav (2012) 0.90
Mechanisms and potential therapeutic applications of microglial activation after brain injury. CNS Neurosci Ther (2014) 0.89
The role of TLR4 activation in photoreceptor mitochondrial oxidative stress. Invest Ophthalmol Vis Sci (2011) 0.88
Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location. J Biol Chem (2013) 0.86
It's all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection. Future Neurol (2009) 0.86
Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury. J Neuroinflammation (2013) 0.84
Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway. Mol Neurodegener (2015) 0.84
FUS Interacts with HSP60 to Promote Mitochondrial Damage. PLoS Genet (2015) 0.82
Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease. J Neuroinflammation (2014) 0.82
Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats. Evid Based Complement Alternat Med (2012) 0.82
Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators Inflamm (2015) 0.82
The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration. J Neuroinflammation (2014) 0.82
Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway. Cell Stress Chaperones (2014) 0.81
Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation. Sci Rep (2015) 0.80
Toll-like receptors as developmental tools that regulate neurogenesis during development: an update. Front Neurosci (2014) 0.80
Hydroxysafflor Yellow A Attenuates Neuron Damage by Suppressing the Lipopolysaccharide-Induced TLR4 Pathway in Activated Microglial Cells. Cell Mol Neurobiol (2016) 0.79
Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS). Curr Neuropharmacol (2014) 0.79
HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis. J Neuroinflammation (2016) 0.79
Thrombin antithrombin complex and IL-18 serum levels in stroke patients. Neurol Int (2010) 0.78
Neuroimmune Response in Ischemic Preconditioning. Neurotherapeutics (2016) 0.77
Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia. J Physiol (2016) 0.77
Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like Receptor 2 and 4. PLoS One (2015) 0.77
Repetitive acute intermittent hypoxia does not promote generalized inflammatory gene expression in the rat CNS. Respir Physiol Neurobiol (2015) 0.77
The impact of inflammation on respiratory plasticity. Exp Neurol (2016) 0.76
Crystallins and neuroinflammation: The glial side of the story. Biochim Biophys Acta (2015) 0.76
Hypothermia reduces toll-like receptor 3-activated microglial interferon-β and nitric oxide production. Mediators Inflamm (2013) 0.76
TLR4 mutation and HSP60-induced cell death in adult mouse cardiac myocytes. Cell Stress Chaperones (2015) 0.76
Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. Infect Immun (2010) 0.76
Qing Hua Chang Yin attenuates lipopolysaccharide-induced inflammatory response in human intestinal cells by inhibiting NF-κB activation. Exp Ther Med (2013) 0.76
Eotaxin-2 increased toll-like receptor 4 expression in endothelial cells in vitro and exacerbates high-cholesterol diet-induced atherogenesis in vivo. Am J Transl Res (2016) 0.75
Microglial Function across the Spectrum of Age and Gender. Int J Mol Sci (2017) 0.75
Oxymatrine inhibits microglia activation via HSP60-TLR4 signaling. Biomed Rep (2016) 0.75
HSP60 mediates the neuroprotective effects of curcumin by suppressing microglial activation. Exp Ther Med (2016) 0.75
DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson's disease. J Neuroinflammation (2013) 0.75
Neuroprotective effect of heat shock protein 60 on matrine-suppressed microglial activation. Exp Ther Med (2017) 0.75
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. Nat Commun (2017) 0.75
Role of microglia in methamphetamine-induced neurotoxicity. Int J Physiol Pathophysiol Pharmacol (2017) 0.75
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol (2008) 7.35
Regulation of miRNA expression during neural cell specification. Eur J Neurosci (2005) 5.27
Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J (2006) 4.34
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling. Nat Neurosci (2010) 3.21
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci (2012) 2.90
Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol (2008) 2.71
The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron (2006) 2.55
Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest (2002) 2.50
Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection. Hepatology (2012) 2.42
Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology (2010) 2.23
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol (2009) 2.12
Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J (2005) 2.04
Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron (2005) 2.01
A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci (2003) 1.95
Migration of monocytes after intracerebral injection at entorhinal cortex lesion site. J Leukoc Biol (2012) 1.93
Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J Neuroimmunol (2007) 1.85
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol (2006) 1.76
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc Natl Acad Sci U S A (2010) 1.76
CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J Neurosci (2004) 1.57
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J Neurochem (2003) 1.48
Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. J Exp Med (2003) 1.47
The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci (2011) 1.46
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology (2005) 1.45
An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. Eur J Neurosci (2004) 1.43
Selenium and brain function: a poorly recognized liaison. Brain Res Brain Res Rev (2004) 1.42
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal. Proc Natl Acad Sci U S A (2012) 1.36
The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect (2006) 1.32
Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. Ann Neurol (2009) 1.32
Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest (2005) 1.32
The role of T helper cells in neuroprotection and regeneration. J Neuroimmunol (2007) 1.30
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell (2009) 1.29
TLR2 mediates neuroinflammation and neuronal damage. J Immunol (2007) 1.26
Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. J Exp Med (2003) 1.25
Timing the valve replacement in infective endocarditis involving the brain. J Neurol (2004) 1.23
Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol (2002) 1.21
Triptans reduce the inflammatory response in bacterial meningitis. J Cereb Blood Flow Metab (2002) 1.20
Multiple sclerosis - candidate mechanisms underlying CNS atrophy. Trends Neurosci (2010) 1.19
Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity. FASEB J (2002) 1.16
Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization. Brain (2009) 1.11
Dual phases of apoptosis in pneumococcal meningitis. J Infect Dis (2004) 1.11
Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO. J Cereb Blood Flow Metab (2012) 1.11
Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis. Hepatology (2007) 1.10
Thalamic sensory strokes with and without pain: differences in lesion patterns in the ventral posterior thalamus. J Neurol Neurosurg Psychiatry (2012) 1.10
Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction. Mol Biol Cell (2009) 1.09
Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages. Eur J Neurosci (2002) 1.09
Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci (2002) 1.09
Neuronal damage in brain inflammation. Arch Neurol (2007) 1.07
Pneumolysin causes neuronal cell death through mitochondrial damage. Infect Immun (2007) 1.07
miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling. EMBO J (2012) 1.07
TRAIL limits excessive host immune responses in bacterial meningitis. J Clin Invest (2007) 1.05
Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. FASEB J (2005) 1.01
Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3- regulatory T cells suppressing autoimmune hepatitis. Hepatology (2009) 1.01
Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide. Infect Immun (2006) 1.00
Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Eur J Neurosci (2004) 1.00
Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans? Brain Res (2009) 0.99
The cytokine/neurotrophin axis in peripheral axon outgrowth. Eur J Neurosci (2006) 0.99
Safety and toxicity of radioembolization plus Sorafenib in advanced hepatocellular carcinoma: analysis of the European multicentre trial SORAMIC. Liver Int (2014) 0.98
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest (2015) 0.97
In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Proteomics (2014) 0.97
TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. J Immunol (2007) 0.97
Impact of HMG-CoA reductase inhibition on brain pathology. Trends Pharmacol Sci (2007) 0.96
IDO (indolamine 2,3-dioxygenase) expression and function in the CNS. Adv Exp Med Biol (2003) 0.96
Neuroprotection by T-cells depends on their subtype and activation state. J Neuroimmunol (2002) 0.96
Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. J Neurosci (2003) 0.96
CNS-irrelevant T-cells enter the brain, cause blood-brain barrier disruption but no glial pathology. Eur J Neurosci (2007) 0.96
Role of the transmembrane potential in the membrane proton leak. Biophys J (2010) 0.96
The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. EMBO J (2007) 0.95
Analysis of lipid experiments (ALEX): a software framework for analysis of high-resolution shotgun lipidomics data. PLoS One (2013) 0.95
Hyperpolarization-activated cation currents in human epileptogenic neocortex. Epilepsia (2009) 0.94
Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta (2009) 0.94
Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma. Am J Gastroenterol (2007) 0.94
Expression of Toll-like receptors in the developing brain. PLoS One (2012) 0.93
Identification of neuronal cell death in a model of degeneration in the hippocampus. Brain Res Brain Res Protoc (2003) 0.93
Absence of IL-1β positively affects neurological outcome, lesion development and axonal plasticity after spinal cord injury. J Neuroinflammation (2013) 0.92
Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain. J Exp Med (2004) 0.92
Increased T-helper 2 cytokines in bile from patients with IgG4-related cholangitis disrupt the tight junction-associated biliary epithelial cell barrier. Gastroenterology (2013) 0.92
TACE plus sorafenib for the treatment of hepatocellular carcinoma: results of the multicenter, phase II SOCRATES trial. Cancer Chemother Pharmacol (2014) 0.91
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in central nervous system inflammation. J Mol Med (Berl) (2009) 0.90
Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability. J Neurosci (2013) 0.90
Astrocytes protect the CNS: antigen-specific T helper cell responses are inhibited by astrocyte-induced upregulation of CTLA-4 (CD152). J Mol Med (Berl) (2004) 0.90
Plasticity-related genes (PRGs/LRPs): a brain-specific class of lysophospholipid-modifying proteins. Biochim Biophys Acta (2008) 0.89
Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus. FASEB J (2003) 0.89
Green-fluorescent-protein-expressing mice as models for the study of axonal growth and regeneration in vitro. Brain Res Rev (2006) 0.89
Hepatocellular carcinoma: computed-tomography-guided high-dose-rate brachytherapy (CT-HDRBT) ablation of large (5-7 cm) and very large (>7 cm) tumours. Eur Radiol (2011) 0.89
Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis. J Infect Dis (2010) 0.89
Dendritic compartment and neuronal output mode determine pathway-specific long-term potentiation in the piriform cortex. J Neurosci (2009) 0.88
Components of neuronal chloride transport in rat and human neocortex. J Physiol (2011) 0.88
Entorhinal cortex lesion in the mouse induces transsynaptic death of perforant path target neurons. Brain Pathol (2004) 0.87
Molecular analysis of Nogo expression in the hippocampus during development and following lesion and seizure. FASEB J (2003) 0.86