Published in J Biol Chem on November 12, 2014
Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. Hepatology (2015) 1.48
Oxidative stress: a concept in redox biology and medicine. Redox Biol (2015) 1.36
DAMPs from Cell Death to New Life. Front Immunol (2015) 1.11
Plant immunity triggered by engineered in vivo release of oligogalacturonides, damage-associated molecular patterns. Proc Natl Acad Sci U S A (2015) 1.04
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. J Lipid Res (2016) 0.95
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta (2015) 0.92
Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci (2015) 0.92
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry (2015) 0.90
Nerve Growth Factor Is Regulated by Toll-Like Receptor 2 in Human Intervertebral Discs. J Biol Chem (2015) 0.87
Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition. Biomed Res Int (2015) 0.82
Pattern Recognition Receptors in Cancer Progression and Metastasis. Cancer Growth Metastasis (2015) 0.82
Decorin as a multivalent therapeutic agent against cancer. Adv Drug Deliv Rev (2015) 0.82
IL-1 Contributes to the Anti-Cancer Efficacy of Ingenol Mebutate. PLoS One (2016) 0.81
Nanoparticle-Based and Bioengineered Probes and Sensors to Detect Physiological and Pathological Biomarkers in Neural Cells. Front Neurosci (2015) 0.81
TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity. Immunol Rev (2015) 0.81
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. J Neurosci (2016) 0.79
Soluble Uric Acid Activates the NLRP3 Inflammasome. Sci Rep (2017) 0.79
Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. J Biol Chem (2015) 0.78
Bacterial Stimulation of Toll-Like Receptor 4 Drives Macrophages To Hemophagocytose. Infect Immun (2015) 0.78
The danger model: questioning an unconvincing theory. Immunol Cell Biol (2015) 0.78
Immunoregulatory roles of versican proteolysis in the myeloma microenvironment. Blood (2016) 0.78
Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications. Mucosal Immunol (2016) 0.77
Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain Behav Immun (2016) 0.77
Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells. Front Cell Dev Biol (2015) 0.77
Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche. J Leukoc Biol (2017) 0.77
Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J (2016) 0.76
The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease. J Immunol Res (2016) 0.76
γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis. Sci Rep (2016) 0.75
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun (2017) 0.75
Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development. Front Immunol (2017) 0.75
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets. J Leukoc Biol (2016) 0.75
The western-type diet induces anti-HMGB1 autoimmunity in Apoe(-/-) mice. Atherosclerosis (2016) 0.75
Neutrophils, from cradle to grave and beyond. Immunol Rev (2016) 0.75
Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells. Sci Rep (2016) 0.75
Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells. Open Biol (2016) 0.75
Caspase-1 Activation Protects Lung Endothelial Barrier Function during Infection-Induced Stress. Am J Respir Cell Mol Biol (2016) 0.75
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J (2016) 0.75
Hyaluronic Acid in Vascular and Immune Homeostasis during Normal Pregnancy and Preeclampsia. Acta Naturae (2016) 0.75
Cryptic activity within the Type III1 domain of fibronectin regulates tissue inflammation and angiogenesis. Curr Top Pept Protein Res (2016) 0.75
Stressed and Inflamed, Can GSK3 Be Blamed? Trends Biochem Sci (2016) 0.75
Inflammasomes in the urinary tract: a disease-based review. Am J Physiol Renal Physiol (2016) 0.75
Generation and Feasibility Assessment of a New Vehicle for Cell-Based Therapy for Treating Corneal Endothelial Dysfunction. PLoS One (2016) 0.75
Multi-receptor detection of individual bacterial products by the innate immune system. Nat Rev Immunol (2017) 0.75
Viperid Envenomation Wound Exudate Contributes to Increased Vascular Permeability via a DAMPs/TLR-4 Mediated Pathway. Toxins (Basel) (2016) 0.75
Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. Int J Mol Sci (2017) 0.75
Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular. Lung (2017) 0.75
Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells to different stimuli. PLoS One (2017) 0.75
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. Nat Commun (2017) 0.75
The immune response to secondary necrotic cells. Apoptosis (2017) 0.75
Cathepsin-S degraded decorin are elevated in fibrotic lung disorders - development and biological validation of a new serum biomarker. BMC Pulm Med (2017) 0.75
Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats. Neurochem Res (2017) 0.75
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation. Sci Rep (2017) 0.75
ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells. Oncotarget (2017) 0.75
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature (2002) 19.77
HMG-1 as a late mediator of endotoxin lethality in mice. Science (1999) 17.72
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol (2007) 12.00
Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature (2010) 11.24
DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol (2006) 10.73
Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
Molecular identification of a danger signal that alerts the immune system to dying cells. Nature (2003) 8.90
Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 8.87
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature (2009) 6.67
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52
The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem (2001) 4.74
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol (2012) 4.72
Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55
S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol (2006) 4.20
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med (2009) 3.87
Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol (2001) 3.76
Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem (1992) 3.64
Hyaluronan in tissue injury and repair. Annu Rev Cell Dev Biol (2007) 3.62
DAMPening inflammation by modulating TLR signalling. Mediators Inflamm (2010) 3.29
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood (2007) 3.09
Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J (2011) 3.04
New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal. EMBO J (2001) 3.04
HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep (2004) 3.00
NETs: a new strategy for using old weapons. Trends Immunol (2009) 2.98
Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem (2007) 2.82
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol Med (2012) 2.79
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science (2012) 2.66
Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem (1997) 2.57
IL-1beta processing in host defense: beyond the inflammasomes. PLoS Pathog (2010) 2.54
Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum (2005) 2.48
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med (2009) 2.45
Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab (2007) 2.31
Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu Rev Immunol (2011) 2.29
Induction of heat shock proteins in B-cell exosomes. J Cell Sci (2005) 2.21
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem (2009) 2.12
The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest (2010) 2.07
Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends Immunol (2011) 2.05
The structural biology of Toll-like receptors. Structure (2011) 2.04
Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest (2010) 1.97
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem (2009) 1.91
A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J Neurosci (2008) 1.85
Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ (2008) 1.84
Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4. J Am Soc Nephrol (2012) 1.73
Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. Blood (2012) 1.71
Histones trigger sterile inflammation by activating the NLRP3 inflammasome. Eur J Immunol (2013) 1.65
Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci (2011) 1.60
Dangers within: DAMP responses to damage and cell death in kidney disease. J Am Soc Nephrol (2011) 1.57
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal (2011) 1.50
Uric acid, evolution and primitive cultures. Semin Nephrol (2005) 1.49
Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal (2013) 1.48
Heat shock proteins as ligands of toll-like receptors. Curr Top Microbiol Immunol (2002) 1.42
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol (2013) 1.42
EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochem Pharmacol (2011) 1.41
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (2007) 1.40
A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response. J Biol Chem (2007) 1.26
Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis (2013) 1.25
Biological interplay between proteoglycans and their innate immune receptors in inflammation. FEBS J (2013) 1.22
Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. Blood (2003) 1.19
Biglycan: a multivalent proteoglycan providing structure and signals. J Histochem Cytochem (2012) 1.12
Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation. Curr Opin Genet Dev (2012) 1.11
Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle (2012) 1.11
Mitochondrial damage-associated molecular patterns and vascular function. Eur Heart J (2014) 1.06
The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation. PLoS Pathog (2011) 1.05
DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway. PLoS Pathog (2014) 1.05
Versatile role of heparanase in inflammation. Matrix Biol (2013) 1.05
Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4. Respir Res (2009) 1.05
Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4. PLoS One (2014) 1.04
Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis. J Am Soc Nephrol (2014) 1.03
ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages. PLoS One (2012) 1.03
DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy (2013) 1.02
RAGE and amyloid beta interactions: atomic force microscopy and molecular modeling. Biochim Biophys Acta (2005) 1.02
Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis Rheum (2010) 0.97
High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus. J Intern Med (2011) 0.96
The translocation of nuclear molecules during inflammation and cell death. Antioxid Redox Signal (2013) 0.96
The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death. Innate Immun (2012) 0.95
Functional Toll-like receptor 4 mutations modulate the response to fibrinogen. Thromb Haemost (2008) 0.94
Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases. Genomics Inform (2013) 0.94
Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol (2014) 0.93
Microbe- and danger-induced inflammation. Mol Immunol (2014) 0.91
Syndecans as modulators and potential pharmacological targets in cancer progression. Front Oncol (2014) 0.91
ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner. Autophagy (2012) 0.90
The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis. Biomarkers (2008) 0.88
Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals. Cell Death Dis (2014) 0.87
CD14 but not MD2 transmit signals from DAMP. Int Immunopharmacol (2009) 0.87
The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer? Immunol Cell Biol (2013) 0.86
Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury. J Surg Res (2014) 0.85
Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology. Biochim Biophys Acta (2014) 0.84
Hyaluronan regulation of endothelial barrier function in cancer. Adv Cancer Res (2014) 0.83
Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia. Mol Cell Neurosci (2014) 0.82
Soluble biglycan as a biomarker of inflammatory renal diseases. Int J Biochem Cell Biol (2014) 0.80
Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts. Glycobiology (2006) 0.80
Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction. PLoS One (2014) 0.79
A Comparative Study of Fibronectin Cleavage by MMP-1, -3, -13, and -14. Cartilage (2012) 0.78
S100A4 and uric acid promote mesenchymal stromal cell induction of IL-10+/IDO+ lymphocytes. J Immunol (2014) 0.78
The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro. Scand J Immunol (2014) 0.77
Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE). Biochim Biophys Acta (2014) 0.76