PubRank

Mark T Bedford

Author PubWeight™ 124.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep 2006 5.19
2 Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science 2006 4.54
3 p53 is regulated by the lysine demethylase LSD1. Nature 2007 4.53
4 A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev 2008 3.16
5 Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem 2006 3.14
6 The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell 2007 2.94
7 The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem 2001 2.63
8 Protein arginine methyltransferases and cancer. Nat Rev Cancer 2012 2.56
9 Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A 2003 2.50
10 Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol 2009 2.50
11 PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep 2002 2.11
12 Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol 2010 2.07
13 Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol 2005 2.02
14 Small molecule regulators of protein arginine methyltransferases. J Biol Chem 2004 1.99
15 Histone arginine methylation. FEBS Lett 2010 1.95
16 Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell 2003 1.87
17 TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell 2010 1.80
18 Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol 2012 1.77
19 Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J 2004 1.74
20 Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol 2013 1.72
21 Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A 2006 1.69
22 Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem 2007 1.68
23 PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem 2005 1.67
24 Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS One 2009 1.66
25 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics 2013 1.53
26 A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res 2009 1.49
27 WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene 2004 1.47
28 Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett 2002 1.46
29 Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol 2010 1.42
30 A protein-domain microarray identifies novel protein-protein interactions. Biochem J 2002 1.42
31 Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol 2011 1.40
32 Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). Biochem J 2005 1.40
33 Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol 2010 1.37
34 Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem 2004 1.35
35 Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem 2007 1.35
36 Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. J Cell Sci 2009 1.33
37 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res 2002 1.33
38 Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J 2010 1.27
39 Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol 2009 1.26
40 Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell 2012 1.23
41 Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo. J Biol Chem 2005 1.22
42 Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep 2013 1.22
43 The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem 2005 1.21
44 Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem 2007 1.21
45 CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep 2008 1.21
46 Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One 2009 1.18
47 Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol 2008 1.17
48 Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem 2009 1.16
49 WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer 2007 1.13
50 epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem 2008 1.13
51 Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell 2013 1.12
52 IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis 2009 1.12
53 Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res 2010 1.10
54 PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat Struct Mol Biol 2012 1.09
55 Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J Mol Biol 2011 1.04
56 MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun 2011 1.04
57 Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem 2009 1.02
58 Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep 2011 1.02
59 Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. J Biol Chem 2013 1.02
60 Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev 2011 1.00
61 CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development 2010 0.99
62 Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PLoS One 2012 0.99
63 Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. J Proteome Res 2010 0.98
64 Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J Biol Chem 2011 0.98
65 Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem 2007 0.97
66 Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol 2009 0.94
67 Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem 2011 0.94
68 Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY) 2012 0.93
69 Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem 2011 0.93
70 Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem 2010 0.90
71 AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 2010 0.89
72 Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chem Sci 2011 0.88
73 Methods applied to the study of protein arginine methylation. Methods Enzymol 2012 0.88
74 Techniques in protein methylation. Methods Mol Biol 2004 0.88
75 Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst 2011 0.88
76 Protein methylation and DNA repair. Mutat Res 2007 0.88
77 Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem 2011 0.87
78 Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PLoS One 2012 0.85
79 A TR-FRET-based functional assay for screening activators of CARM1. Chembiochem 2013 0.83
80 Xenoestrogens regulate the activity of arginine methyltransferases. Chembiochem 2010 0.82
81 Protein-domain microarrays. Methods Mol Biol 2004 0.80
82 Titivated for destruction: the methyl degron. Mol Cell 2012 0.79
83 Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. J Mol Biol 2009 0.79
84 Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. J Med Chem 2012 0.78
85 Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. J Biol Chem 2014 0.78
86 Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol 2012 0.78
87 Correction: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS Pathog 2017 0.75
88 Reprogramming the histone code. Chem Biol 2007 0.75