| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
|
Science
|
2007
|
37.88
|
|
2
|
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
Nat Genet
|
2008
|
35.06
|
|
3
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
|
4
|
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
Nat Genet
|
2010
|
16.96
|
|
5
|
Genome-wide association analysis identifies 20 loci that influence adult height.
|
Nat Genet
|
2008
|
16.92
|
|
6
|
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
|
Nat Genet
|
2008
|
15.94
|
|
7
|
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
Nature
|
2011
|
13.23
|
|
8
|
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
Nat Genet
|
2007
|
12.65
|
|
9
|
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
Nat Genet
|
2012
|
11.09
|
|
10
|
Variants in MTNR1B influence fasting glucose levels.
|
Nat Genet
|
2008
|
10.85
|
|
11
|
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
Nat Genet
|
2010
|
8.48
|
|
12
|
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
Nat Genet
|
2012
|
7.59
|
|
13
|
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
Nat Genet
|
2013
|
7.44
|
|
14
|
A common variant of HMGA2 is associated with adult and childhood height in the general population.
|
Nat Genet
|
2007
|
6.87
|
|
15
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
|
16
|
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.
|
Nat Genet
|
2008
|
5.93
|
|
17
|
An obesity-associated FTO gene variant and increased energy intake in children.
|
N Engl J Med
|
2008
|
5.88
|
|
18
|
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
|
PLoS Genet
|
2009
|
5.81
|
|
19
|
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
Nat Genet
|
2011
|
5.56
|
|
20
|
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.
|
N Engl J Med
|
2014
|
5.47
|
|
21
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
|
22
|
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|
Nat Genet
|
2009
|
4.61
|
|
23
|
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
|
Diabetes
|
2008
|
4.57
|
|
24
|
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
|
Nat Genet
|
2010
|
4.42
|
|
25
|
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
Nat Genet
|
2014
|
4.13
|
|
26
|
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.
|
Nat Genet
|
2007
|
3.94
|
|
27
|
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
|
Lancet Neurol
|
2012
|
3.93
|
|
28
|
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
|
N Engl J Med
|
2016
|
3.88
|
|
29
|
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
|
Diabetes
|
2008
|
3.76
|
|
30
|
Common variants in WFS1 confer risk of type 2 diabetes.
|
Nat Genet
|
2007
|
3.58
|
|
31
|
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
|
Pharmacol Rev
|
2006
|
3.48
|
|
32
|
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
|
Nat Genet
|
2012
|
3.40
|
|
33
|
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.
|
Hum Mol Genet
|
2010
|
3.34
|
|
34
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
|
35
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
|
36
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
|
37
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
|
38
|
The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.
|
J Allergy Clin Immunol
|
2008
|
2.53
|
|
39
|
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
PLoS Genet
|
2012
|
2.34
|
|
40
|
Tailored second-line therapy in asthmatic children with the Arg(16) genotype.
|
Clin Sci (Lond)
|
2013
|
2.25
|
|
41
|
Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability.
|
BMC Med Genet
|
2006
|
2.25
|
|
42
|
Genetically determined height and coronary artery disease.
|
N Engl J Med
|
2015
|
2.24
|
|
43
|
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
|
J Allergy Clin Immunol
|
2006
|
2.22
|
|
44
|
Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
|
Diabetes
|
2007
|
2.03
|
|
45
|
Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood.
|
J Invest Dermatol
|
2006
|
2.00
|
|
46
|
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development.
|
PLoS Genet
|
2011
|
1.82
|
|
47
|
Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.
|
Cancer Res
|
2004
|
1.75
|
|
48
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
|
49
|
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.
|
J Allergy Clin Immunol
|
2011
|
1.68
|
|
50
|
Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness.
|
Int J Epidemiol
|
2012
|
1.67
|
|
51
|
A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.
|
J Allergy Clin Immunol
|
2008
|
1.65
|
|
52
|
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
Diabetes
|
2008
|
1.64
|
|
53
|
Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol.
|
J Allergy Clin Immunol
|
2009
|
1.61
|
|
54
|
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
|
Hum Mol Genet
|
2009
|
1.61
|
|
55
|
Underlying genetic models of inheritance in established type 2 diabetes associations.
|
Am J Epidemiol
|
2009
|
1.60
|
|
56
|
Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
|
Am J Respir Crit Care Med
|
2008
|
1.55
|
|
57
|
The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice.
|
Atherosclerosis
|
2005
|
1.55
|
|
58
|
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.
|
Nat Genet
|
2012
|
1.52
|
|
59
|
Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis.
|
J Allergy Clin Immunol
|
2007
|
1.45
|
|
60
|
Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach.
|
Diabetes
|
2013
|
1.44
|
|
61
|
Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.
|
PLoS Med
|
2008
|
1.43
|
|
62
|
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
|
Diabetes
|
2009
|
1.34
|
|
63
|
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
|
J Allergy Clin Immunol
|
2013
|
1.30
|
|
64
|
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.
|
Diabetes
|
2011
|
1.29
|
|
65
|
Energy intakes of children after preloads: adjustment, not compensation.
|
Am J Clin Nutr
|
2005
|
1.28
|
|
66
|
Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.
|
Arterioscler Thromb Vasc Biol
|
2004
|
1.26
|
|
67
|
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
|
Diabetes
|
2013
|
1.25
|
|
68
|
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe).
|
Invest Ophthalmol Vis Sci
|
2011
|
1.22
|
|
69
|
Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.
|
PLoS One
|
2010
|
1.19
|
|
70
|
A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study.
|
Pharmacogenet Genomics
|
2008
|
1.19
|
|
71
|
Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study.
|
Pharmacogenet Genomics
|
2008
|
1.18
|
|
72
|
Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight.
|
BMC Genet
|
2002
|
1.15
|
|
73
|
Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.
|
Nat Genet
|
2013
|
1.15
|
|
74
|
Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly.
|
J Invest Dermatol
|
2008
|
1.14
|
|
75
|
Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study.
|
Circulation
|
2005
|
1.13
|
|
76
|
Filaggrin variants confer susceptibility to asthma.
|
J Allergy Clin Immunol
|
2008
|
1.12
|
|
77
|
The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study.
|
Circ Cardiovasc Genet
|
2009
|
1.07
|
|
78
|
Glycemic exposure and blood pressure influencing progression and remission of diabetic retinopathy: a longitudinal cohort study in GoDARTS.
|
Diabetes Care
|
2013
|
1.07
|
|
79
|
Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan.
|
J Invest Dermatol
|
2008
|
1.06
|
|
80
|
Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families.
|
Acta Derm Venereol
|
2008
|
1.03
|
|
81
|
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway.
|
Diabetes
|
2013
|
1.02
|
|
82
|
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
|
Diabetes
|
2012
|
1.00
|
|
83
|
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.
|
J Allergy Clin Immunol
|
2008
|
0.96
|
|
84
|
Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study.
|
Nucl Recept
|
2005
|
0.95
|
|
85
|
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.
|
Diabetes
|
2009
|
0.95
|
|
86
|
Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth.
|
Pediatr Allergy Immunol
|
2010
|
0.93
|
|
87
|
Diclofenac antagonizes peroxisome proliferator-activated receptor-gamma signaling.
|
Mol Pharmacol
|
2002
|
0.92
|
|
88
|
Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line.
|
Oncogene
|
2005
|
0.91
|
|
89
|
Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study.
|
J Clin Endocrinol Metab
|
2010
|
0.90
|
|
90
|
Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
|
J Allergy Clin Immunol
|
2010
|
0.89
|
|
91
|
The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.
|
Ann Allergy Asthma Immunol
|
2011
|
0.88
|
|
92
|
Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients.
|
J Cyst Fibros
|
2011
|
0.88
|
|
93
|
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.
|
Biol Psychiatry
|
2013
|
0.87
|
|
94
|
Peroxisome proliferator-activated receptor agonists, hyperlipidaemia, and atherosclerosis.
|
Pharmacol Ther
|
2002
|
0.87
|
|
95
|
Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease.
|
Thorax
|
2012
|
0.86
|
|
96
|
Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta.
|
PLoS One
|
2009
|
0.86
|
|
97
|
Filaggrin null alleles are not associated with psoriasis.
|
J Invest Dermatol
|
2007
|
0.86
|
|
98
|
Variants of the peroxisome proliferator-activated receptor gamma- and beta-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children.
|
Am J Clin Nutr
|
2007
|
0.84
|
|
99
|
A single nucleotide polymorphism on exon-4 of the gene encoding PPARdelta is associated with reduced height in adults and children.
|
J Clin Endocrinol Metab
|
2009
|
0.83
|
|
100
|
Overweight and obesity in deltaF508 homozygous cystic fibrosis.
|
J Pediatr
|
2005
|
0.82
|
|
101
|
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
|
Hypertension
|
2012
|
0.82
|
|
102
|
Prevalent and rare mutations in the gene encoding filaggrin in Japanese patients with ichthyosis vulgaris and atopic dermatitis.
|
J Invest Dermatol
|
2008
|
0.81
|
|
103
|
Genetic loci for retinal arteriolar microcirculation.
|
PLoS One
|
2013
|
0.80
|
|
104
|
Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.
|
Pharmacogenet Genomics
|
2013
|
0.80
|
|
105
|
Measurement of urinary total desmosine and isodesmosine using isotope-dilution liquid chromatography-tandem mass spectrometry.
|
Anal Chem
|
2010
|
0.79
|
|
106
|
State of play of pharmacogenetics and personalized medicine in heart failure.
|
Cardiovasc Ther
|
2013
|
0.77
|
|
107
|
Fluorescence-based ligand-binding assays for peroxisome proliferator-activated receptors.
|
Methods Enzymol
|
2002
|
0.77
|
|
108
|
Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo.
|
PPAR Res
|
2012
|
0.77
|
|
109
|
Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids.
|
Pharmacogenomics
|
2014
|
0.76
|
|
110
|
Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort.
|
PLoS One
|
2009
|
0.75
|
|
111
|
Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus.
|
BMC Genet
|
2003
|
0.75
|
|
112
|
Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors.
|
Pharmacogenet Genomics
|
2016
|
0.75
|
|
113
|
Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study.
|
Pharmacogenet Genomics
|
2017
|
0.75
|
|
114
|
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals.
|
Circ Cardiovasc Genet
|
2017
|
0.75
|