Published in Pharmacol Ther on February 09, 2008
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov (2010) 2.68
Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers. Eur J Nucl Med Mol Imaging (2008) 2.41
Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol (2008) 1.77
Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol (2010) 1.60
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat. Exp Neurol (2011) 1.52
Test-retest analysis of a non-invasive method of quantifying [(11)C]-PBR28 binding in Alzheimer's disease. EJNMMI Res (2016) 1.46
Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury. J Neurosci Res (2010) 1.45
Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.43
Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. J Neuropathol Exp Neurol (2014) 1.29
Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma. Exp Neurol (2009) 1.26
Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA. J Cereb Blood Flow Metab (2012) 1.22
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat. Neuroscience (2012) 1.21
Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates. Environ Health Perspect (2008) 1.19
Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. J Nucl Med (2012) 1.12
Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev (2012) 1.12
Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc Natl Acad Sci U S A (2011) 1.10
Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein. J Nucl Med (2015) 1.08
Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J Neurosci (2014) 1.06
Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography. J Cereb Blood Flow Metab (2011) 1.05
Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation (2014) 1.03
Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injury. Exp Neurol (2011) 1.01
Positron emission tomography imaging of neuroinflammation. J Child Neurol (2009) 0.97
Imaging of microglia in patients with neurodegenerative disorders. Front Pharmacol (2012) 0.96
Synthesis of [(125)I]iodoDPA-713: a new probe for imaging inflammation. Biochem Biophys Res Commun (2009) 0.96
Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide. Biol Sex Differ (2011) 0.95
Searching for neuropathology: gliosis in schizophrenia. Biol Psychiatry (2010) 0.95
Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein. JAMA Neurol (2015) 0.94
Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state. Glia (2011) 0.94
PET imaging of lung inflammation with [18F]FEDAC, a radioligand for translocator protein (18 kDa). PLoS One (2012) 0.93
In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma. Transl Psychiatry (2016) 0.92
Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides. Biochemistry (2013) 0.92
Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation. Eur J Nucl Med Mol Imaging (2009) 0.92
Microwave-assisted Organic Synthesis of a High-affinity Pyrazolo-pyrimidinyl TSPO Ligand. Tetrahedron Lett (2010) 0.91
Microglial activation and progressive brain changes in schizophrenia. Br J Pharmacol (2016) 0.90
M1 and M2 immune activation in Parkinson's Disease: Foe and ally? Neuroscience (2014) 0.90
Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration. J Neuroinflammation (2015) 0.88
Sex differences in translocator protein 18 kDa (TSPO) in the heart: implications for imaging myocardial inflammation. J Cardiovasc Transl Res (2014) 0.88
Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment. Involvement of cell cycle activation. Cell Cycle (2014) 0.88
Neuroimaging of HIV-associated neurocognitive disorders (HAND). Curr Opin HIV AIDS (2014) 0.88
In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [(18)F]-FEPPA. Mol Psychiatry (2015) 0.87
Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT. Eur J Nucl Med Mol Imaging (2016) 0.87
Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study. J Neuroinflammation (2011) 0.87
Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis. Brain Res (2009) 0.86
Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study. PLoS One (2015) 0.86
Translocator protein (18 kDa): a promising therapeutic target and diagnostic tool for cardiovascular diseases. Oxid Med Cell Longev (2012) 0.86
A New Rabbit Model of Pediatric Traumatic Brain Injury. J Neurotrauma (2015) 0.85
Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal. Mol Endocrinol (2015) 0.85
Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging. J Neuroinflammation (2014) 0.85
Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor. Front Neurosci (2012) 0.85
Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab (2015) 0.85
Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease. Trends Neurosci (2015) 0.85
Evaluation of [¹²³I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation. Eur J Nucl Med Mol Imaging (2011) 0.84
Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for a protein related to TSPO. PLoS One (2009) 0.83
Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions? Biochemistry (2016) 0.82
Imaging of carrageenan-induced local inflammation and adjuvant-induced systemic arthritis with [(11)C]PBR28 PET. Nucl Med Biol (2013) 0.82
Regional sensitivity to neuroinflammation: in vivo and in vitro studies. Synapse (2011) 0.82
Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971. ACS Chem Neurosci (2014) 0.81
Translocator protein (Tspo) gene promoter-driven green fluorescent protein synthesis in transgenic mice: an in vivo model to study Tspo transcription. Cell Tissue Res (2012) 0.81
Detection and quantification of remote microglial activation in rodent models of focal ischaemia using the TSPO radioligand CLINDE. Eur J Nucl Med Mol Imaging (2010) 0.81
Evaluation of [(11)C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis. Eur J Nucl Med Mol Imaging (2015) 0.81
Imaging Striatal Microglial Activation in Patients with Parkinson's Disease. PLoS One (2015) 0.81
Translocator protein 18 kDa (TSPO) expression in multiple sclerosis patients. J Neuroimmune Pharmacol (2012) 0.81
Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation? J Neuroinflammation (2016) 0.80
Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice. J Neuroinflammation (2016) 0.80
Kinetic analysis of the translocator protein positron emission tomography ligand [(18)F]GE-180 in the human brain. Eur J Nucl Med Mol Imaging (2016) 0.80
The relationship between serial [(18) F]PBR06 PET imaging of microglial activation and motor function following stroke in mice. Mol Imaging Biol (2014) 0.79
Aging and the neurovascular unit. Ann N Y Acad Sci (2012) 0.79
[18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain. Eur J Nucl Med Mol Imaging (2014) 0.79
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition. Metab Brain Dis (2013) 0.79
Control of hypercholesterolemia and atherosclerosis using the cholesterol recognition/interaction amino acid sequence of the translocator protein TSPO. Steroids (2012) 0.79
Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats. Mol Imaging Biol (2017) 0.78
In vivo imaging of system xc- as a novel approach to monitor multiple sclerosis. Eur J Nucl Med Mol Imaging (2015) 0.78
Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. J Med Chem (2010) 0.78
Persistent region-dependent neuroinflammation, NMDA receptor loss and atrophy in an animal model of penetrating brain injury. Future Neurol (2012) 0.78
TSPO Finds NOX2 in Microglia for Redox Homeostasis. Trends Pharmacol Sci (2016) 0.78
Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward. Toxicol Sci (2015) 0.77
Evolving understanding of translocator protein 18 kDa (TSPO). Pharmacol Res (2015) 0.77
Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [11C]DPA-713 positron emission tomography. Lupus (2016) 0.77
PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide. J Nucl Med (2015) 0.77
Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [(18)F]DPA-714 PET. Eur J Nucl Med Mol Imaging (2015) 0.77
[18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain. Theranostics (2015) 0.77
TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. Neurobiol Dis (2015) 0.76
(18)F-DPA-714 PET Imaging for Detecting Neuroinflammation in Rats with Chronic Hepatic Encephalopathy. Theranostics (2016) 0.76
Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype. J Huntingtons Dis (2015) 0.76
Shutting down the pore: The search for small molecule inhibitors of the mitochondrial permeability transition. Biochim Biophys Acta (2016) 0.76
Translocator protein (TSPO) role in aging and Alzheimer's disease. Curr Aging Sci (2014) 0.76
Microglial immunophenotype in dementia with Alzheimer's pathology. J Neuroinflammation (2016) 0.76
A specific dietary intervention to restore brain structure and function after ischemic stroke. Theranostics (2017) 0.76
Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant. J Cereb Blood Flow Metab (2016) 0.75
Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model. Biomed Opt Express (2013) 0.75
Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging. Mol Imaging (2016) 0.75
Lentiviral-Mediated Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Ameliorates LPS-Induced Cognitive Impairment in Mice. Front Pharmacol (2016) 0.75
The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis. PLoS One (2015) 0.75
Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study. Int J Alzheimers Dis (2016) 0.75
Insight into the Molecular Imaging of Alzheimer's Disease. Int J Biomed Imaging (2016) 0.75
Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci (2016) 0.75
Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS One (2015) 0.75
Randomised clinical trial: exploratory phase 2 study of ONO-2952 in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther (2016) 0.75
Biomarker and more: can translocator protein 18 kDa predict recovery from brain injury and myocarditis? Biomark Med (2014) 0.75
Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism (2016) 0.75
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (2005) 14.43
Microglia: a sensor for pathological events in the CNS. Trends Neurosci (1996) 12.00
ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55
Mitochondrial control of cell death. Nat Med (2000) 9.17
Simplified reference tissue model for PET receptor studies. Neuroimage (1996) 8.28
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci (2006) 5.15
The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci (2006) 4.93
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med (1999) 4.88
Reactive microgliosis. Prog Neurobiol (1999) 3.55
In-vivo measurement of activated microglia in dementia. Lancet (2001) 3.51
The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol (2001) 3.47
Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. Proc Natl Acad Sci U S A (1977) 3.13
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain (2000) 2.84
Microglial activation and dopamine terminal loss in early Parkinson's disease. Ann Neurol (2005) 2.77
Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proc Natl Acad Sci U S A (1983) 2.76
Functional plasticity of microglia: a review. Glia (1988) 2.76
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A (1992) 2.72
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis (2005) 2.59
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev (1999) 2.57
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol Dis (2004) 2.29
The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol (2006) 2.10
The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem (1986) 2.03
Microglial activation in presymptomatic Huntington's disease gene carriers. Brain (2007) 1.93
Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev (1999) 1.92
Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology (2006) 1.88
Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int (2002) 1.82
Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys. Exp Neurol (2003) 1.80
Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science (1980) 1.76
Reference and target region modeling of [11C]-(R)-PK11195 brain studies. J Nucl Med (2007) 1.76
Quantitative aspects of reactive gliosis: a review. Neurochem Res (1992) 1.74
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids (1997) 1.69
Microglial cell population dynamics in the injured adult central nervous system. Brain Res Brain Res Rev (2005) 1.67
Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids (2003) 1.63
PET visualization of microglia in multiple sclerosis patients using [11C]PK11195. Eur J Neurol (2003) 1.59
GABAergic modulation of benzodiazepine binding site sensitivity. Nature (1978) 1.58
Microglial response to brain injury: a brief synopsis. Toxicol Pathol (2000) 1.57
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci (2002) 1.57
Modulating astrogliosis after neurotrauma. J Neurosci Res (2001) 1.56
11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. J Nucl Med (2007) 1.53
Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study. Neuroimage (2004) 1.52
Role of microglia in the central nervous system's immune response. Neurol Res (2005) 1.50
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia. J Neurocytol (1997) 1.49
Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor. Proc Natl Acad Sci U S A (1987) 1.47
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195. Neurology (2000) 1.47
The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem (1990) 1.44
PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res (1997) 1.43
Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci (1995) 1.42
The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore. J Exp Med (2002) 1.39
Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands. Proc Natl Acad Sci U S A (1993) 1.38
Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor. Proc Natl Acad Sci U S A (1989) 1.38
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des (2007) 1.36
[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis. Neurology (1999) 1.36
Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein. Mol Endocrinol (2001) 1.36
Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp Neurol (2000) 1.32
Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies. Life Sci (1983) 1.31
Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion. J Cereb Blood Flow Metab (1991) 1.27
Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain (2004) 1.27
Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain. Proc Natl Acad Sci U S A (1986) 1.26
In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain (2001) 1.26
Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology (1991) 1.26
Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity. J Neurochem (2000) 1.25
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies. Life Sci (1983) 1.25
Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity. Expert Opin Drug Saf (2005) 1.24
Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res (2007) 1.24
Targeted molecular imaging agents for cellular-scale bimodal imaging. Bioconjug Chem (2004) 1.24
Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS. J Neurovirol (2005) 1.23
PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Exp Cell Res (1998) 1.23
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy. Mov Disord (2006) 1.22
Benzodiazepines that bind at peripheral sites inhibit cell proliferation. Proc Natl Acad Sci U S A (1984) 1.22
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology (2003) 1.22
Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand. Bioorg Med Chem (2005) 1.21
Imaging brain inflammation with [(11)C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats. J Cereb Blood Flow Metab (2007) 1.20
Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain. Synapse (2004) 1.20
Specific high-affinity saturable binding of [3H] R05-4864 to benzodiazepine binding sites in the rat cerebral cortex. Eur J Pharmacol (1981) 1.19
In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke. Neuroreport (2000) 1.18
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study. Mult Scler (2005) 1.17
Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control. Mol Pharmacol (1989) 1.17
Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity. Neuroscience (2003) 1.17
Structural and functional study of reconstituted peripheral benzodiazepine receptor. Biochem Biophys Res Commun (2001) 1.17
Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke. Stroke (2006) 1.17
In vivo detection of microglial activation in frontotemporal dementia. Ann Neurol (2004) 1.15
VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. J Neurochem (2007) 1.15
Brain kinetics and specific binding of [11C]PK 11195 to omega 3 sites in baboons: positron emission tomography study. Eur J Pharmacol (1991) 1.15
PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. J Clin Invest (2004) 1.15
Development of ligands for the peripheral benzodiazepine receptor. Curr Med Chem (2006) 1.13
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. Neurobiol Dis (2005) 1.13
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation. J Neurochem (2007) 1.12
Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. J Neurochem (2002) 1.12
Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies. J Cereb Blood Flow Metab (2005) 1.11
Benzodiazepine receptor-mediated chemotaxis of human monocytes. Science (1985) 1.10
Structure and function of the peripheral-type benzodiazepine receptor in steroidogenic cells. Proc Soc Exp Biol Med (1998) 1.10
Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells. Life Sci (1993) 1.06
Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. J Biol Chem (1989) 1.06
Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors. Eur J Pharmacol (1999) 1.04
In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol Pharmacol (1994) 1.04
Labelling of "peripheral-type" benzodiazepine binding sites in the rat brain by using [3H]PK 11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization. J Neurochem (1983) 1.03
Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. J Neurosci Res (2005) 1.03
Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat. Regul Pept (1990) 1.03
Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination. Toxicol Sci (2006) 1.01
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci (2006) 5.15
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther (2007) 2.71
Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol Appl Pharmacol (2007) 2.17
Lead neurotoxicity: from exposure to molecular effects. Brain Res Brain Res Rev (2005) 1.69
In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology (2006) 1.54
Effects of chronic manganese exposure on cognitive and motor functioning in non-human primates. Brain Res (2006) 1.27
Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain (2004) 1.27
Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates. Environ Health Perspect (2008) 1.19
VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. J Neurochem (2007) 1.15
Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Neurotoxicology (2005) 1.01
An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge. Neuroimage (2006) 1.01
Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination. Toxicol Sci (2006) 1.01
Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Brain Res Dev Brain Res (2002) 0.97
Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging. Hum Mol Genet (2013) 0.95
Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: potential role of NMDA receptor-dependent BDNF signaling. Toxicol Sci (2010) 0.95
Silica-based nanoparticle uptake and cellular response by primary microglia. Environ Health Perspect (2010) 0.95
Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state. Glia (2011) 0.94
Molecular neurobiology of lead (Pb(2+)): effects on synaptic function. Mol Neurobiol (2010) 0.94
The impact of environmental metals in young urbanites' brains. Exp Toxicol Pathol (2012) 0.91
Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates. Toxicol Lett (2012) 0.91
Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibition. Neurotoxicology (2010) 0.89
Sex differences in translocator protein 18 kDa (TSPO) in the heart: implications for imaging myocardial inflammation. J Cardiovasc Transl Res (2014) 0.88
Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders. Toxicol Sci (2012) 0.88
Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates. Neurotoxicology (2010) 0.87
Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain. Brain Res Dev Brain Res (2003) 0.87
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain. Toxicol Sci (2009) 0.87
Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats. Brain Res (2005) 0.86
Prenatal lead exposure and schizophrenia: a plausible neurobiologic connection. Environ Health Perspect (2004) 0.84
In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Mol Imaging (2005) 0.84
Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. J Biol Chem (2012) 0.83
Prenatal lead exposure and schizophrenia: further evidence and more neurobiological connections. Environ Health Perspect (2009) 0.81
Developmental lead exposure impairs extinction of conditioned fear in young adult rats. Neurotoxicology (2008) 0.81
BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity. J Neurochem (2014) 0.79
Enhanced nitric oxide production during lead (Pb²⁺) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons. Brain Res (2011) 0.77
Experience-dependent regulation of zif268 gene expression and spatial learning. Exp Neurol (2006) 0.77
Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype. J Huntingtons Dis (2015) 0.76
Biomarker and more: can translocator protein 18 kDa predict recovery from brain injury and myocarditis? Biomark Med (2014) 0.75