Published in Cancer Lett on April 10, 2008
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RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol (2011) 2.59
Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Mol Cell (2009) 2.50
Cortactin branches out: roles in regulating protrusive actin dynamics. Cell Motil Cytoskeleton (2008) 2.26
The cofilin activity cycle in lamellipodia and invadopodia. J Cell Biochem (2009) 1.99
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci (2010) 1.53
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. J Cell Biol (2011) 1.38
Cortactin in cell migration and cancer at a glance. J Cell Sci (2012) 1.34
Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. J Biol Chem (2010) 1.32
Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients. Int J Cancer (2010) 1.31
Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cells. Mol Cell Biol (2010) 1.30
EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation. J Biol Chem (2010) 1.27
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Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Oncogene (2010) 1.19
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence. PLoS One (2010) 1.17
Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon. Oncogene (2008) 1.16
Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. Mol Biol Cell (2008) 1.15
Cortactin controls cell motility and lamellipodial dynamics by regulating ECM secretion. Curr Biol (2011) 1.14
Invading one step at a time: the role of invadopodia in tumor metastasis. Oncogene (2013) 1.13
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Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function. J Cancer Sci Ther (2009) 1.11
Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells. J Cell Sci (2013) 1.04
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. J Biol Chem (2010) 0.96
Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. Eur J Cell Biol (2010) 0.95
Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res (2013) 0.92
Cortactin is implicated in murine zygotic development. Exp Cell Res (2009) 0.91
Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. J Immunol (2011) 0.91
The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading. PLoS One (2011) 0.91
Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts. J Cell Sci (2012) 0.90
The Golgi in cell migration: regulation by signal transduction and its implications for cancer cell metastasis. ScientificWorldJournal (2012) 0.90
Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASP. Cell Commun Signal (2009) 0.88
Cortactin colocalizes with filopodial actin and accumulates at IgCAM adhesion sites in Aplysia growth cones. J Neurosci Res (2009) 0.88
FAK competes for Src to promote migration against invasion in melanoma cells. Cell Death Dis (2014) 0.87
A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation. Oncotarget (2015) 0.87
Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression. Mod Pathol (2009) 0.87
Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions. Cell Adh Migr (2014) 0.86
SYK allelic loss and the role of Syk-regulated genes in breast cancer survival. PLoS One (2014) 0.86
HER2 carboxyl-terminal fragments regulate cell migration and cortactin phosphorylation. J Biol Chem (2009) 0.85
Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells. Mol Cell Biol (2010) 0.85
Gene expression of human lung cancer cell line CL1-5 in response to a direct current electric field. PLoS One (2011) 0.85
Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1. J Biol Chem (2012) 0.84
Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation. PLoS One (2012) 0.84
Identification of metastasis-suppressive microRNAs in primary melanoma. J Natl Cancer Inst (2015) 0.83
An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. Hum Mol Genet (2011) 0.83
Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration. Genes Cancer (2014) 0.83
Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes. J Am Soc Nephrol (2014) 0.82
Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading. PLoS One (2012) 0.81
Cortactin is involved in the entry of Coxiella burnetii into non-phagocytic cells. PLoS One (2012) 0.81
NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res (2014) 0.81
5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion. J Cell Biol (2016) 0.78
Regulation of invadopodia by mechanical signaling. Exp Cell Res (2015) 0.78
A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types. Clin Transl Med (2015) 0.78
Further insights into cortactin conformational regulation. Bioarchitecture (2011) 0.78
Releasing the brakes while hanging on: Cortactin effects on actin-driven motility. Bioarchitecture (2012) 0.78
pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1). PLoS One (2014) 0.78
Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells. Int J Mol Sci (2016) 0.76
TEM7 (PLXDC1), a key prognostic predictor for resectable gastric cancer, promotes cancer cell migration and invasion. Am J Cancer Res (2015) 0.76
Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia. Haematologica (2014) 0.76
Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1. Sci Rep (2016) 0.75
Src tyrosyl phosphorylates cortactin in response to prolactin. Biochem Biophys Res Commun (2015) 0.75
Constrained inference of protein interaction networks for invadopodium formation in cancer. IET Syst Biol (2016) 0.75
Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1β dependent upregulation of MYO3A gene in breast cancer cells. Oncoimmunology (2016) 0.75
Asporin enhances colorectal cancer metastasis through activating the EGFR/src/cortactin signaling pathway. Oncotarget (2016) 0.75
Clinical Implications of FADD Gene Amplification and Protein Overexpression in Taiwanese Oral Cavity Squamous Cell Carcinomas. PLoS One (2016) 0.75
Interaction Between Ezrin and Cortactin in Promoting Epithelial to Mesenchymal Transition in Breast Cancer Cells. Med Sci Monit (2017) 0.75
Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway. Oncotarget (2016) 0.75
Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/Mena(INV)-initiated invadopodium formation. Sci Rep (2016) 0.75
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Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells. Cell (2005) 4.71
Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. Annu Rev Biochem (2001) 4.54
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta (2006) 4.27
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol (2007) 4.23
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res (2006) 3.83
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Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol (2002) 3.34
Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape. J Cell Biol (2000) 3.30
Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. Cancer Res (2007) 3.30
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev (1999) 3.09
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Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol (2000) 2.94
An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene (1999) 2.86
Cortactin promotes cell motility by enhancing lamellipodial persistence. Curr Biol (2005) 2.78
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Profiling early head and neck cancer. Nat Rev Cancer (2005) 2.62
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat Cell Biol (2005) 2.50
Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Nat Cell Biol (2006) 2.48
Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. J Biol Chem (2004) 2.44
The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem (1998) 2.39
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36
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Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res Treat (2003) 2.14
Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation. J Cell Sci (2008) 2.06
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem (2003) 1.99
Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res (2002) 1.96
Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res (2006) 1.96
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol (2003) 1.92
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90
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Cortactin potentiates bone metastasis of breast cancer cells. Cancer Res (2001) 1.85
Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J Cell Biol (2004) 1.74
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Curr Biol (2003) 1.72
Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. EMBO J (2005) 1.69
A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation. Curr Biol (2007) 1.69
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Cortactin regulates cell migration through activation of N-WASP. J Cell Sci (2004) 1.61
A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis. EMBO J (2007) 1.57
Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. Oncogene (2006) 1.56
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A new role for cortactin in invadopodia: regulation of protease secretion. Eur J Cell Biol (2008) 1.52
Cortactin has an essential and specific role in osteoclast actin assembly. Mol Biol Cell (2006) 1.52
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Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol (2003) 1.50
p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells. J Biol Chem (1995) 1.48
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Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication. Cell Microbiol (2004) 1.40
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Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer. Clin Cancer Res (2007) 1.37
Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol (2004) 1.37
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Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hum Mol Genet (2003) 1.33
Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res (2006) 1.31
A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin. FASEB J (2006) 1.31
Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration. Mol Biol Cell (2005) 1.30
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Cortactin affects cell migration by regulating intercellular adhesion and cell spreading. Exp Cell Res (2006) 1.21
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BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration. Mol Biol Cell (2004) 0.87
Direct interaction between caldesmon and cortactin. Arch Biochem Biophys (2006) 0.85
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