Published in Dev Dyn on August 01, 2008
Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem (2010) 1.63
Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells. J Cell Biol (2010) 1.54
Myosin II is required for interkinetic nuclear migration of neural progenitors. Proc Natl Acad Sci U S A (2009) 1.53
Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet (2009) 1.33
Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis. Cilia (2013) 1.28
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. J Biol Chem (2010) 1.28
Temporal relationship between primary and motile ciliogenesis in airway epithelial cells. Am J Respir Cell Mol Biol (2010) 1.28
Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins. Cilia (2012) 1.27
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
Renal primary cilia lengthen after acute tubular necrosis. J Am Soc Nephrol (2009) 1.23
Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell (2010) 1.18
The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc Natl Acad Sci U S A (2010) 1.15
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J (2012) 1.13
Craniofacial ciliopathies: A new classification for craniofacial disorders. Am J Med Genet A (2010) 1.05
Zebrafish kidney development: basic science to translational research. Birth Defects Res C Embryo Today (2011) 1.02
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol (2013) 1.01
Cilia, Wnt signaling, and the cytoskeleton. Cilia (2012) 0.99
Cystic diseases of the kidney: ciliary dysfunction and cystogenic mechanisms. Pediatr Nephrol (2010) 0.98
Keeping the balance between proliferation and differentiation: the primary cilium. Curr Genomics (2011) 0.96
Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue. Cilia (2013) 0.94
Assembly and persistence of primary cilia in dividing Drosophila spermatocytes. Dev Cell (2012) 0.91
Dido3-dependent HDAC6 targeting controls cilium size. Nat Commun (2014) 0.88
Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry. Development (2011) 0.88
Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle. Nat Commun (2015) 0.87
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun (2016) 0.87
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1. PLoS One (2012) 0.86
RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium. Respir Res (2013) 0.85
Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis. PLoS One (2013) 0.84
Unique properties of Drosophila spermatocyte primary cilia. Biol Open (2013) 0.82
Axonemal positioning and orientation in three-dimensional space for primary cilia: what is known, what is assumed, and what needs clarification. Dev Dyn (2011) 0.80
Detection of primary cilia in human glioblastoma. J Neurooncol (2014) 0.79
Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy. Oncotarget (2016) 0.77
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects. Sci Rep (2015) 0.77
Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway. BMC Dev Biol (2016) 0.77
The fate of the primary cilium during myofibroblast transition. Mol Biol Cell (2014) 0.77
Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. PLoS One (2016) 0.76
Emerging roles for tubulin folding cofactors at the centrosome. Commun Integr Biol (2010) 0.76
The Biology of Ciliary Dynamics. Cold Spring Harb Perspect Biol (2017) 0.76
Phosphorylation-dependent Akt-Inversin interaction at the basal body of primary cilia. EMBO J (2016) 0.75
Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn (2016) 0.75
Centrosomes in the zebrafish (Danio rerio): a review including the related basal body. Cilia (2012) 0.75
STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Cell Cycle (2016) 0.75
Aurora A inhibition by MNL8054 promotes centriole elongation during Drosophila male meiosis. Cell Cycle (2015) 0.75
The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly. Mol Cells (2017) 0.75
Intraflagellar transport. Nat Rev Mol Cell Biol (2002) 10.86
Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39
The primary cilium as the cell's antenna: signaling at a sensory organelle. Science (2006) 6.79
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet (2005) 6.67
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell (2007) 6.50
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell (2004) 6.10
Flies without centrioles. Cell (2006) 6.06
Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87
The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol (2005) 5.84
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet (2003) 5.24
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol (2007) 5.09
Cilia and developmental signaling. Annu Rev Cell Dev Biol (2007) 4.88
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet (2005) 4.76
Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science (1999) 4.69
Mechanism limiting centrosome duplication to once per cell cycle. Nature (2006) 4.69
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet (2007) 4.63
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (2005) 4.32
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24
Aurora-A - a guardian of poles. Nat Rev Cancer (2005) 4.11
PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol (2005) 4.04
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. Nat Genet (2006) 3.97
In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Hum Mol Genet (2006) 3.90
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development (2003) 3.88
Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol (2007) 3.88
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet (2004) 3.86
The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol (2003) 3.85
Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol (2000) 3.84
Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet (2007) 3.79
Centrioles in the cell cycle. I. Epithelial cells. J Cell Biol (1982) 3.78
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 3.63
Lung development and repair: contribution of the ciliated lineage. Proc Natl Acad Sci U S A (2006) 3.57
Nodal flow and the generation of left-right asymmetry. Cell (2006) 3.52
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat Cell Biol (2003) 3.37
Centrosome defects and genetic instability in malignant tumors. Cancer Res (1998) 3.32
Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc Natl Acad Sci U S A (1998) 3.23
Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis. J Neurosci (2005) 3.19
The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. Nat Genet (2006) 3.19
Cep97 and CP110 suppress a cilia assembly program. Cell (2007) 3.15
The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. Hum Mol Genet (2006) 3.06
Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia. Nat Cell Biol (2005) 3.05
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat Genet (2007) 2.98
The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome. Am J Hum Genet (2006) 2.96
Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr Biol (2005) 2.86
Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sci U S A (1999) 2.85
Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells. Cell (1979) 2.84
Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest. Nat Cell Biol (2007) 2.76
MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome. Nat Genet (2006) 2.75
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell (2002) 2.74
The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat Cell Biol (2005) 2.52
The roles of cilia in developmental disorders and disease. Development (2006) 2.52
Role of primary cilia in the pathogenesis of polycystic kidney disease. J Am Soc Nephrol (2007) 2.44
The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. J Cell Biol (2005) 2.41
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature (2002) 2.40
Analysis of xbx genes in C. elegans. Development (2005) 2.39
NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. J Am Soc Nephrol (2008) 2.39
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J Neurochem (2001) 2.32
Polarity proteins control ciliogenesis via kinesin motor interactions. Curr Biol (2004) 2.28
The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem (2003) 2.18
Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells. J Cell Biol (2007) 2.15
Intraflagellar transport protein 27 is a small G protein involved in cell-cycle control. Curr Biol (2007) 2.15
RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1. J Cell Sci (2007) 2.14
Molecular characterization of centriole assembly in ciliated epithelial cells. J Cell Biol (2007) 2.13
Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndrome. Hum Mutat (2008) 2.03
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development (2002) 2.00
pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat Cell Biol (2007) 1.97
Cilia and the cell cycle? J Cell Biol (2005) 1.94
Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing. Hum Mutat (2008) 1.91
A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence. PLoS Genet (2006) 1.90
The resorption of primary cilia during mitosis in a vertebrate (PtK1) cell line. J Ultrastruct Res (1979) 1.89
Primary cilia of human endothelial cells disassemble under laminar shear stress. J Cell Biol (2004) 1.86
Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes. Hum Mol Genet (2005) 1.77
Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nat Genet (2006) 1.76
An aurora kinase is essential for flagellar disassembly in Chlamydomonas. Dev Cell (2004) 1.75
Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons. Proc Natl Acad Sci U S A (2007) 1.74
MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. J Cell Sci (2005) 1.73
The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. Development (2003) 1.71
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol (2006) 1.66
The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells. J Cell Sci (2007) 1.61
Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations. Proc Natl Acad Sci U S A (2005) 1.55
The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J Biol Chem (2001) 1.50
Polarity reveals intrinsic cell chirality. Proc Natl Acad Sci U S A (2007) 1.48
NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. J Am Soc Nephrol (2005) 1.47
Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res (2006) 1.44
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J Am Soc Nephrol (2006) 1.42
The key to left-right asymmetry. Cell (2006) 1.34
Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. J Cell Biol (2006) 1.34
Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii. Eukaryot Cell (2004) 1.32
Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. FEBS Lett (2006) 1.27
Sonic hedgehog opposes epithelial cell cycle arrest. J Cell Biol (1999) 1.20
Nek9, a novel FACT-associated protein, modulates interphase progression. J Biol Chem (2003) 1.08
Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene. Mol Biol Cell (2003) 1.07
The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery. Exp Cell Res (2004) 1.03
Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res (2007) 1.00
Phylogenetic analysis of the Neks reveals early diversification of ciliary-cell cycle kinases. PLoS One (2007) 0.98
The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett (2007) 0.95
The positive regulation of p53 by the tumor suppressor VHL. Cell Cycle (2006) 0.92
Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24
The primary cilium as the cell's antenna: signaling at a sensory organelle. Science (2006) 6.79
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol (2007) 5.09
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nat Genet (2011) 3.57
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med (2009) 2.99
Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev Cell (2010) 1.94
Hedgehog signaling controls T cell killing at the immunological synapse. Science (2013) 1.84
The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol (2008) 1.75
Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell (2010) 1.74
Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci U S A (2011) 1.68
Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access. J Cell Biol (2012) 1.55
Disruption of a ciliary B9 protein complex causes Meckel syndrome. Am J Hum Genet (2011) 1.40
The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr Biol (2009) 1.39
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc Natl Acad Sci U S A (2014) 1.07
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet (2012) 1.07
Floxin, a resource for genetically engineering mouse ESCs. Nat Methods (2009) 1.07
Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development (2011) 1.05
Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci U S A (2012) 0.95
The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells. Stem Cells Dev (2010) 0.94
A high-fat diet regulates gastrin and acid secretion through primary cilia. FASEB J (2012) 0.93
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J (2013) 0.93
Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells. Hum Mol Genet (2008) 0.92
Notch signaling can regulate endoderm formation in zebrafish. Dev Dyn (2004) 0.90
Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development (2013) 0.87
A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity. J Cell Sci (2014) 0.87
Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Cancer Res (2012) 0.84
Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right. Dev Cell (2010) 0.77
Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism. J Mol Endocrinol (2013) 0.76
Crippling SWI-SNF makes tumors GLI-ful. Nat Med (2010) 0.75
Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol (2017) 0.75