Cilia and developmental signaling.

Role of platelet-derived growth factors in physiology and medicine. Genes Dev (2008) 8.89

The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci (2009) 8.38

Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66

A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science (2010) 4.11

The primary cilium as a complex signaling center. Curr Biol (2009) 3.73

Functional genomic screen for modulators of ciliogenesis and cilium length. Nature (2010) 3.63

Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet (2008) 3.43

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc Natl Acad Sci U S A (2008) 3.21

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet (2008) 3.14

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med (2009) 2.99

Principles of planar polarity in animal development. Development (2011) 2.94

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev (2009) 2.59

Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat Med (2013) 2.55

The primary cilium at a glance. J Cell Sci (2010) 2.55

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A (2009) 2.43

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A (2008) 2.17

Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. Neuron (2011) 2.14

Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol (2009) 2.09

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04

Human hepatic stem cell and maturational liver lineage biology. Hepatology (2011) 1.99

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A (2009) 1.95

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev (2011) 1.94

Regulating the transition from centriole to basal body. J Cell Biol (2011) 1.93

Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development (2009) 1.93

FGF signalling during embryo development regulates cilia length in diverse epithelia. Nature (2009) 1.91

Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 gene. Am J Hum Genet (2010) 1.86

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell (2009) 1.83

The cell biological basis of ciliary disease. J Cell Biol (2008) 1.82

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol (2010) 1.81

The Hedgehog signal transduction network. Sci Signal (2012) 1.80

The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Dev Biol (2008) 1.76

The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol (2008) 1.75

Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors. Dev Dyn (2008) 1.73

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci U S A (2011) 1.71

Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev (2013) 1.65

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans. J Cell Biol (2010) 1.60

Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome. Am J Hum Genet (2009) 1.59

Mechanism and evolution of cytosolic Hedgehog signal transduction. Development (2010) 1.58

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A (2011) 1.58

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A (2009) 1.57

NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet (2011) 1.56

Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell (2011) 1.55

A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet (2009) 1.55

Cell cycle-dependent ciliogenesis and cancer. Cancer Res (2008) 1.54

Retrograde intraflagellar transport mutants identify complex A proteins with multiple genetic interactions in Chlamydomonas reinhardtii. Genetics (2009) 1.52

Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell (2015) 1.50

Role of primary cilia in brain development and cancer. Curr Opin Neurobiol (2010) 1.49

Joubert syndrome: insights into brain development, cilium biology, and complex disease. Semin Pediatr Neurol (2009) 1.48

Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A (2010) 1.46

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development (2009) 1.45

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins. Cell Mol Life Sci (2010) 1.45

Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS One (2009) 1.44

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One (2009) 1.42

Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback. Cold Spring Harb Perspect Biol (2009) 1.41

Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One (2011) 1.39

Basal body stability and ciliogenesis requires the conserved component Poc1. J Cell Biol (2009) 1.38

The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Dev Biol (2009) 1.38

Building it up and taking it down: the regulation of vertebrate ciliogenesis. Dev Dyn (2008) 1.38

Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues. J Histochem Cytochem (2010) 1.31

Direct interactions of intraflagellar transport complex B proteins IFT88, IFT52, and IFT46. J Biol Chem (2010) 1.31

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet (2009) 1.31

A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet (2010) 1.29

Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. J Biol Chem (2010) 1.28

Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins. Cilia (2012) 1.27

Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins. J Cell Sci (2009) 1.26

Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell (2010) 1.25

The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron (2010) 1.22

Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS One (2008) 1.21

ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells. J Am Soc Nephrol (2010) 1.20

Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development (2011) 1.20

How do cilia organize signalling cascades? Philos Trans R Soc Lond B Biol Sci (2014) 1.19

Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech (2010) 1.18

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Curr Opin Genet Dev (2013) 1.18

Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell (2010) 1.18

Neuronal ciliary signaling in homeostasis and disease. Cell Mol Life Sci (2010) 1.17

The relationship between sonic Hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol (2010) 1.16

Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet (2009) 1.16

Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat Neurosci (2013) 1.14

Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells. Kidney Blood Press Res (2008) 1.13

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling. Development (2010) 1.13

The dynamic cilium in human diseases. Pathogenetics (2009) 1.13

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. EMBO J (2012) 1.12

Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell (2011) 1.12

Centrosomal localization of Diversin and its relevance to Wnt signaling. J Cell Sci (2009) 1.12

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res (2012) 1.11

Subunit interactions and organization of the Chlamydomonas reinhardtii intraflagellar transport complex A proteins. J Biol Chem (2011) 1.11

Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development (2011) 1.10

Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis. Dev Dyn (2008) 1.10

Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis. J Clin Invest (2012) 1.09

RFX2 is broadly required for ciliogenesis during vertebrate development. Dev Biol (2011) 1.06

Exploring the transcriptome of ciliated cells using in silico dissection of human tissues. PLoS One (2012) 1.06

Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium. Sci Signal (2012) 1.04

Ciliary diffusion barrier: the gatekeeper for the primary cilium compartment. Cytoskeleton (Hoboken) (2011) 1.04

Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. PLoS One (2008) 1.04

Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells. Cell Cycle (2009) 1.04

The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J Neurosci (2013) 1.03

Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol (2010) 1.03

Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells. J Cell Biol (2012) 1.03

Polycystic kidney disease: pathogenesis and potential therapies. Biochim Biophys Acta (2010) 1.02

Intraflagellar transport at a glance. J Cell Sci (2009) 1.02

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45

Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46

Intraflagellar transport. Nat Rev Mol Cell Biol (2002) 10.86

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82

The ciliopathies: an emerging class of human genetic disorders. Annu Rev Genomics Hum Genet (2006) 9.56

Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43

Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38

Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev (1999) 8.36

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell (1998) 8.16

Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol (1986) 7.71

Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons. J Cell Biol (1998) 7.22

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol (2000) 7.04

The primary cilium as the cell's antenna: signaling at a sensory organelle. Science (2006) 6.79

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet (2005) 6.67

A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Natl Acad Sci U S A (1993) 6.50

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15

Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell (2004) 6.10

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell (2000) 6.08

Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature (2003) 5.96

Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87

Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol (2003) 5.40

Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov (2006) 5.30

The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20

A human syndrome caused by immotile cilia. Science (1976) 5.16

Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell (2004) 5.02

The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane. J Cell Biol (1995) 4.78

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet (2005) 4.76

Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell (2003) 4.73

Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A (2003) 4.47

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (2005) 4.32

Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A (1979) 4.32

The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol Biol Cell (2006) 4.18

Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A (1999) 4.11

PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol (2005) 4.04

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet (1993) 3.99

Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. Nat Genet (2006) 3.97

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development (2004) 3.97

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet (2004) 3.86

The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development (1997) 3.78

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development (2000) 3.74

Tissue/planar cell polarity in vertebrates: new insights and new questions. Development (2007) 3.66

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development (1997) 3.66

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 3.63

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell (2006) 3.62

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell (1996) 3.60

G-protein signaling through tubby proteins. Science (2001) 3.59

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature (2002) 3.47

beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene (2006) 3.43

Functional coordination of intraflagellar transport motors. Nature (2005) 3.43

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development (2006) 3.39

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol (1999) 3.32

Dynamic association of proteasomal machinery with the centrosome. J Cell Biol (1999) 3.30

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature (2001) 3.23

Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J Cell Biol (1999) 3.14

Planar signaling and morphogenesis in Drosophila. Dev Cell (2002) 3.12

Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proc Natl Acad Sci U S A (2004) 3.11

The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. Hum Mol Genet (2006) 3.06

The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein. J Cell Biol (1994) 3.04

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev (1999) 2.94

Intraflagellar transport is essential for endochondral bone formation. Development (2006) 2.90

Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells. Cell (1979) 2.84

Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci (2006) 2.73

PDGF receptors as cancer drug targets. Cancer Cell (2003) 2.66

Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene. Oncogene (2001) 2.63

Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci U S A (2004) 2.54

Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. PLoS Genet (2005) 2.52

Polygenic control of Caenorhabditis elegans fat storage. Nat Genet (2006) 2.46

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science (2002) 2.45

De novo formation of left-right asymmetry by posterior tilt of nodal cilia. PLoS Biol (2005) 2.42

Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects. J Cell Biol (1998) 2.41

Cilia-related diseases. J Pathol (2004) 2.39

Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J Cell Biol (2006) 2.32

Polarity proteins control ciliogenesis via kinesin motor interactions. Curr Biol (2004) 2.28

Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron (2004) 2.27

The left-right axis in the mouse: from origin to morphology. Development (2006) 2.27

Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet (2005) 2.24

Movement of motor and cargo along cilia. Nature (1999) 2.21

Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport. Cell Mol Life Sci (2006) 2.19

Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res (2000) 2.13

Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. Diabetes (2005) 2.11

Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr Biol (2003) 2.06

Flagellar assembly in two hundred and fifty easy-to-follow steps. Trends Genet (1995) 2.03

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc Natl Acad Sci U S A (2005) 2.02

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development (2003) 1.98

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol (2004) 1.97

Polycystins and mechanosensation in renal and nodal cilia. Bioessays (2004) 1.96

Platelet-derived growth factor-modulated proteins: constitutive synthesis by a transformed cell line. Proc Natl Acad Sci U S A (1981) 1.90

Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol (2006) 1.82

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development (2006) 1.76

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development (2000) 1.75

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development (2004) 1.73

MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. J Cell Sci (2005) 1.73

The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. Development (2003) 1.71

An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development. Dev Cell (2002) 1.70

oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo. Curr Biol (2006) 1.68

Dicer is essential for mouse development. Nat Genet (2003) 15.87

The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81

Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38

Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87

The graded response to Sonic Hedgehog depends on cilia architecture. Dev Cell (2007) 5.35

Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science (2002) 4.47

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development (2006) 3.39

Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol (2004) 2.80

Intraflagellar transport and cilium-based signaling. Cell (2006) 2.35

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev Dyn (2008) 2.30

Tcf3: a transcriptional regulator of axis induction in the early embryo. Development (2003) 2.26

The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat Genet (2010) 2.25

LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development (2006) 2.22

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell (2012) 2.18

p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell (2006) 2.06

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A (2009) 1.95

Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Curr Biol (2007) 1.81

Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A (2005) 1.77

Complex interactions between genes controlling trafficking in primary cilia. Nat Genet (2011) 1.65

Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor. Proc Natl Acad Sci U S A (2005) 1.65

Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev Biol (2005) 1.62

A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet (2009) 1.55

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J Cell Biol (2012) 1.54

Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways. EMBO J (2006) 1.53

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr Biol (2002) 1.52

Morphogenesis of the node and notochord: the cellular basis for the establishment and maintenance of left-right asymmetry in the mouse. Dev Dyn (2008) 1.50

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development (2011) 1.48

Patterning cell types in the dorsal spinal cord: what the mouse mutants say. Nat Rev Neurosci (2003) 1.46

Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS One (2009) 1.44

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A (2014) 1.41

Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron (2010) 1.41

Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development (2006) 1.38

The primary cilium as a Hedgehog signal transduction machine. Methods Cell Biol (2009) 1.35

Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse. Birth Defects Res A Clin Mol Teratol (2005) 1.30

Drosophila Ik2, a member of the I kappa B kinase family, is required for mRNA localization during oogenesis. Development (2006) 1.28

Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation. Cell (2003) 1.25

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development (2007) 1.21

Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev Cell (2007) 1.21

Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse. PLoS Biol (2010) 1.17

Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense. Proc Natl Acad Sci U S A (2006) 1.16

FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development (2004) 1.15

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum Mol Genet (2011) 1.13

Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development (2008) 1.06

The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol (2007) 1.06

Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A (2011) 1.04

Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A (2005) 1.03

Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development (2013) 1.01

Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00

Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet (2011) 0.97

Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development (2011) 0.96

Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo. Proc Natl Acad Sci U S A (2011) 0.95

Left-right patterning in the mouse requires Epb4.1l5-dependent morphogenesis of the node and midline. Dev Biol (2010) 0.91

Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse. Dev Dyn (2006) 0.88

Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol (2012) 0.86

Drosophila Rel proteins are central regulators of a robust, multi-organ immune network. J Cell Sci (2010) 0.83

SnapShot: mouse primitive streak. Cell (2011) 0.81

Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism. Dev Biol (2010) 0.78

Centrioles in the mouse: cilia and beyond. Cell Cycle (2014) 0.75

Hopeful monsters and morphogens at the beach. Nat Cell Biol (2002) 0.75