Published in Exp Hematol on May 01, 2008
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell (2010) 4.21
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat Cell Biol (2010) 3.51
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer (2010) 3.48
Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner. Cell Stem Cell (2014) 1.81
Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell (2014) 1.27
Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood (2009) 1.17
The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs. Blood (2011) 1.02
Impact of notch signaling on inflammatory responses in cardiovascular disorders. Int J Mol Sci (2013) 0.96
NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB. J Clin Invest (2014) 0.96
Evaluation of mobilized peripheral blood CD34(+) cells from patients with severe coronary artery disease as a source of endothelial progenitor cells. Cytotherapy (2010) 0.86
Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment. Front Immunol (2016) 0.86
Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β. Oncotarget (2015) 0.82
CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med (2017) 0.78
Systems approach to the study of brain damage in the very preterm newborn. Front Syst Neurosci (2015) 0.76
Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis. J Bone Miner Res (2017) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Osteoblastic cells regulate the haematopoietic stem cell niche. Nature (2003) 19.60
Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17
Stem cells and their niches. Science (2006) 7.86
Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood (1998) 7.70
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature (2005) 6.60
Notch-mediated restoration of regenerative potential to aged muscle. Science (2003) 5.99
Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J (1994) 5.70
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med (2003) 4.69
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
Universal GFP reporter for the study of vascular development. Genesis (2000) 3.97
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity (2003) 3.73
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood (2002) 2.66
Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J Cell Sci (2000) 2.57
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med (2005) 2.15
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol (1997) 2.12
Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci U S A (1986) 2.06
The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood (1998) 2.05
Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics. Blood (1999) 2.02
Aorta-associated CD34+ hematopoietic cells in the early human embryo. Blood (1996) 2.02
Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood (2002) 2.00
Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors. Blood (1995) 1.94
Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. J Clin Invest (2002) 1.72
Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation. Blood (1999) 1.70
Hematopoietic stem cells and their niche. Trends Immunol (2005) 1.70
Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation (2007) 1.67
Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J (1999) 1.61
Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells. J Exp Med (1987) 1.61
Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control. Proc Natl Acad Sci U S A (2000) 1.59
Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest (1987) 1.36
Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J Biol Chem (1997) 1.36
Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein. Stem Cells (2006) 1.35
Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J Exp Med (2005) 1.35
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem (2000) 1.34
Modulated expression of notch1 during thymocyte development. Blood (1996) 1.31
Notch signalling in hematopoiesis. Semin Cell Dev Biol (2003) 1.26
Stra13 regulates satellite cell activation by antagonizing Notch signaling. J Cell Biol (2007) 1.24
A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. Blood (2000) 1.23
Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells. Blood (2001) 1.22
Continuous endothelial cell activation increases angiogenesis: evidence for the direct role of endothelium linking angiogenesis and inflammation. J Vasc Res (2006) 1.17
Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells. Exp Hematol (2004) 1.16
Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. EMBO J (2002) 1.10
Transendothelial migration of CD34+ and mature hematopoietic cells: an in vitro study using a human bone marrow endothelial cell line. Blood (1997) 1.07
Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts. Oncogene (2003) 1.03
Regulation of hematopoiesis by microvascular endothelium. Leuk Lymphoma (1997) 0.98
Isolation, characterization, and biologic features of bone marrow endothelial cells. J Lab Clin Med (1996) 0.98
Blood-forming endothelium in human ontogeny: lessons from in utero development and embryonic stem cell culture. Trends Cardiovasc Med (2006) 0.96
Leukemia-stimulated bone marrow endothelium promotes leukemia cell survival. Exp Hematol (2006) 0.92
Expression of hes6, a new member of the Hairy/Enhancer-of-split family, in mouse development. Mech Dev (2000) 0.86
Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB. Blood (2005) 0.86
Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells. J Immunol (2001) 0.84
Toward the rational design of cell fate modifiers: notch signaling as a target for novel biopharmaceuticals. Curr Pharm Biotechnol (2000) 0.83
Localisation of granulocyte macrophage colony-stimulating factor in human long-term bone marrow cultures. Biological and immunocytochemical characterisation. J Cell Sci (1993) 0.80
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature (2010) 15.28
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell (2007) 12.52
Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol (2010) 9.86
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med (2004) 9.80
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature (2006) 9.20
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (2002) 8.28
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet (2008) 7.30
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood (2004) 7.21
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature (2008) 6.61
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature (2005) 6.60
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature (2005) 5.54
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature (2010) 5.43
Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell (2012) 4.67
Effects of mammography screening under different screening schedules: model estimates of potential benefits and harms. Ann Intern Med (2009) 4.60
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med (2007) 4.22
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med (2005) 4.17
Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest (2005) 4.10
Therapeutic targeting of a stem cell niche. Nat Biotechnol (2007) 3.88
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell (2008) 3.84
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol (2005) 3.83
Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell (2005) 3.77
The hematopoietic stem cell in its place. Nat Immunol (2006) 3.70
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell (2008) 3.62
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature (2010) 3.55
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest (2003) 3.19
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med (2005) 3.19
Xist RNA is a potent suppressor of hematologic cancer in mice. Cell (2013) 2.93
Limiting factors in murine hematopoietic stem cell assays. Cell Stem Cell (2007) 2.89
The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood (2009) 2.85
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell (2011) 2.77
CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells (2009) 2.76
PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest (2008) 2.68
Sickle hemoglobin confers tolerance to Plasmodium infection. Cell (2011) 2.67
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood (2002) 2.66
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol (2007) 2.65
In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol (2004) 2.65
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood (2007) 2.64
A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nat Protoc (2007) 2.59
Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. J Clin Oncol (2006) 2.58
A central role for free heme in the pathogenesis of severe sepsis. Sci Transl Med (2010) 2.54
MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A (2010) 2.53
Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med (2013) 2.48
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood (2005) 2.47
Prospects for stem cell-based therapy. Cell (2008) 2.45
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature (2011) 2.44
Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res (2006) 2.42
BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest (2013) 2.34
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med (2004) 2.32
Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A (2012) 2.23
Direct determination of molecular haplotypes by chromosome microdissection. Nat Methods (2010) 2.21
Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A (2008) 2.15
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med (2005) 2.15
Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci U S A (2009) 2.11
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell (2012) 2.06
Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects. AIDS (2003) 2.05
Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res (2004) 2.04
Differential stem- and progenitor-cell trafficking by prostaglandin E2. Nature (2013) 1.99
Tipping the balance of benefits and harms to favor screening mammography starting at age 40 years: a comparative modeling study of risk. Ann Intern Med (2012) 1.99
Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol (2002) 1.99
Noninvasive detection of fetal subchromosome abnormalities via deep sequencing of maternal plasma. Am J Hum Genet (2013) 1.99
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood (2005) 1.98
Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. Cell Stem Cell (2008) 1.94
Magnetic resonance imaging for evaluation of Crohn's disease: validation of parameters of severity and quantitative index of activity. Inflamm Bowel Dis (2010) 1.91
Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia. Cancer Cell (2013) 1.89
Differential H3K4 methylation identifies developmentally poised hematopoietic genes. Dev Cell (2008) 1.89
Primitive hematopoietic cells resist HIV-1 infection via p21. J Clin Invest (2007) 1.88
A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol Ther (2002) 1.83
Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling. Blood (2012) 1.83
VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism. Circ Res (2003) 1.82
Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest (2008) 1.81
Diabetes impairs hematopoietic stem cell mobilization by altering niche function. Sci Transl Med (2011) 1.75
Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood (2013) 1.72
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence. Blood (2012) 1.72
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
The hematopoietic stem cell niche--home for friend and foe? Cytometry B Clin Cytom (2012) 1.70
Health care costs and resource utilization, including patient burden, associated with novel-agent-based treatment versus other therapies for multiple myeloma: findings using real-world claims data. Oncologist (2013) 1.70
Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation (2007) 1.67
SIRT3 reverses aging-associated degeneration. Cell Rep (2013) 1.65
The haematopoietic stem cell niche at a glance. J Cell Sci (2011) 1.63
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood (2011) 1.61
Stem-cell ecology and stem cells in motion. Blood (2008) 1.61
Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. Am J Surg Pathol (2005) 1.61
Biomimetic platforms for human stem cell research. Cell Stem Cell (2011) 1.58
Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A (2011) 1.55
Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation. Cell (2013) 1.55
Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase. Science (2013) 1.50
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice. Stem Cells Dev (2007) 1.50
A watermarking-based medical image integrity control system and an image moment signature for tampering characterization. IEEE J Biomed Health Inform (2013) 1.49