Published in Int J Mol Sci on March 26, 2013
Tumor cell vascular mimicry: Novel targeting opportunity in melanoma. Pharmacol Ther (2016) 0.86
EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway. Oxid Med Cell Longev (2015) 0.82
An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment. J Immunol Res (2016) 0.79
The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy. Hum Mol Genet (2015) 0.79
Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2/STAT3 Signaling. Oxid Med Cell Longev (2016) 0.77
Increased Vascularization in the Vulnerable Upstream Regions of Both Early and Advanced Human Carotid Atherosclerosis. PLoS One (2016) 0.77
Microarray analysis provides new insights into the function of apolipoprotein O in HepG2 cell line. Lipids Health Dis (2013) 0.76
Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis. Cell Death Dis (2016) 0.76
Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model. J Am Heart Assoc (2014) 0.76
The role of Notch pathway in cardiovascular diseases. Glob Cardiol Sci Pract (2013) 0.76
Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice. PLoS One (2016) 0.75
Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma. Sarcoma (2016) 0.75
Notch signaling in cerebrovascular diseases (Review). Mol Med Rep (2016) 0.75
Targeting the Monocyte-Macrophage Lineage in Solid Organ Transplantation. Front Immunol (2017) 0.75
Notch4 signaling pathway in a Kawasaki disease mouse model induced by Lactobacillus casei cell wall extract. Exp Ther Med (2017) 0.75
Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression. PLoS One (2017) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell (1996) 23.99
Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature (2003) 20.48
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09
HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol (2003) 7.32
Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell (2005) 7.07
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature (2006) 6.56
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell (2011) 6.12
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J (2004) 4.77
Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol (2012) 4.52
Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A (2008) 4.20
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development (1996) 3.84
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood (2010) 3.82
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet (2006) 3.55
Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol (2010) 3.53
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature (2000) 3.51
The immune system and cardiac repair. Pharmacol Res (2008) 3.42
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell (2010) 3.34
Chronic DLL4 blockade induces vascular neoplasms. Nature (2010) 3.14
Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature (2010) 3.06
The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. J Clin Invest (2000) 3.02
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer (2007) 2.96
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol (2006) 2.94
Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res (2010) 2.89
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol (2000) 2.83
Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays (2004) 2.59
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56
Endothelial proliferation in tumours and normal tissues: continuous labelling studies. Br J Cancer (1984) 2.55
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 2.47
Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation (2001) 2.46
Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell (2010) 2.29
Nitric oxide and oxidative stress in vascular disease. Pflugers Arch (2010) 2.29
A dynamic notch injury response activates epicardium and contributes to fibrosis repair. Circ Res (2010) 2.23
Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J (2005) 2.16
Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res (2005) 2.16
Notch signaling in cancer. Curr Mol Med (2006) 2.14
Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res (2004) 2.10
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A (2000) 2.05
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood (2007) 2.01
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A (2008) 1.93
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Smooth Muscle alpha-actin is a direct target of Notch/CSL. Circ Res (2006) 1.90
Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. Curr Biol (2004) 1.87
Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol (2001) 1.84
Mechanisms of disease: Toll-like receptors in cardiovascular disease. Nat Clin Pract Cardiovasc Med (2007) 1.83
DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci (2005) 1.82
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol (2012) 1.81
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res (2006) 1.77
Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med (2009) 1.77
Notch signaling represses myocardin-induced smooth muscle cell differentiation. J Biol Chem (2005) 1.71
Cardiac allograft vasculopathy: recent developments. Circulation (2008) 1.71
Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur J Immunol (2008) 1.68
Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. Proc Natl Acad Sci U S A (2004) 1.67
Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation (2007) 1.67
Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity. J Immunol (2006) 1.65
Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation (2002) 1.63
Molecular dynamics of the compensatory response to myocardial infarct. J Mol Cell Cardiol (2004) 1.63
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol (2004) 1.61
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats. Exp Cell Res (2004) 1.57
Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation. Circ Res (2002) 1.55
Roles of the Notch gene in Drosophila wing morphogenesis. Mech Dev (1994) 1.53
Transforming growth factor-beta (TGF- 1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression. J Biol Chem (2007) 1.52
Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. Mol Cell Biol (2002) 1.52
Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages. J Immunol (2010) 1.49
Notch and vascular smooth muscle cell phenotype. Circ Res (2008) 1.48
Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J (2004) 1.45
TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J Clin Invest (2008) 1.43
Inflammation in myocardial diseases. Circ Res (2012) 1.41
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS One (2010) 1.41
Notch1 upregulates LPS-induced macrophage activation by increasing NF-kappaB activity. Eur J Immunol (2009) 1.39
Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation. J Biol Chem (2010) 1.38
Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis. Gastroenterology (2005) 1.37
Notch signaling in normal and disease States: possible therapies related to glycosylation. Curr Mol Med (2007) 1.37
Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J Exp Med (2007) 1.35
Vascular responses to hypoxia and ischemia. Arterioscler Thromb Vasc Biol (2009) 1.34
IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways. Mol Biol Cell (2003) 1.31
Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways. J Biol Chem (2003) 1.29
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A (2012) 1.26
Control of the adaptive response of the heart to stress via the Notch1 receptor pathway. J Exp Med (2008) 1.24
Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. J Immunol (2009) 1.22
Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase. Dev Cell (2011) 1.22
HRT1 modulates vascular smooth muscle cell proliferation and apoptosis. Biochem Biophys Res Commun (2003) 1.22
Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation. J Biol Chem (2011) 1.21
Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. J Biol Chem (2002) 1.19
Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB J (2006) 1.17
Molecular genetics of aortic valve disease. Curr Opin Cardiol (2006) 1.16
Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts. J Immunol (2013) 0.96
The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J Immunol (2009) 0.93
Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels. Mol Med (2002) 0.84
Regulation of alpha1,3galactosyltransferase expression in pig endothelial cells. Implications for xenotransplantation. Eur J Biochem (2002) 0.76