PubRank

Judith Campisi

Author PubWeight™ 187.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008 11.43
2 Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003 8.42
3 Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009 7.74
4 The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010 7.58
5 Four faces of cellular senescence. J Cell Biol 2011 6.86
6 Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003 5.61
7 Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 2009 4.47
8 Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol 2003 4.05
9 Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 2005 3.96
10 A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One 2009 3.83
11 Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010 3.79
12 Aging and genome maintenance: lessons from the mouse? Science 2003 3.72
13 Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 2013 3.47
14 Puzzles, promises and a cure for ageing. Nature 2008 3.23
15 Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 2012 3.21
16 The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 2002 3.16
17 Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 2006 3.00
18 Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A 2009 2.82
19 Two faces of p53: aging and tumor suppression. Nucleic Acids Res 2007 2.78
20 p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011 2.61
21 TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem 2004 2.52
22 MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) 2009 2.49
23 Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol 2007 2.42
24 A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One 2010 2.38
25 DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci 2010 2.34
26 Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev 2010 2.32
27 Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A 2003 2.24
28 The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle 2011 2.15
29 Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem 2011 2.11
30 Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 2002 2.08
31 Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell 2012 2.03
32 Ageing: balancing regeneration and cancer. Nature 2006 1.88
33 Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004 1.76
34 Telomeres, aging and cancer: in search of a happy ending. Oncogene 2002 1.69
35 Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol 2005 1.64
36 A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle 2009 1.58
37 Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) 2012 1.57
38 Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2003 1.55
39 Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. J Biol Chem 2002 1.50
40 Oncogene-induced senescence pathways weave an intricate tapestry. Cell 2007 1.47
41 Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell 2010 1.43
42 Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci 2002 1.42
43 Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol 2003 1.32
44 A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem 2002 1.27
45 Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach. Mol Cell Proteomics 2010 1.26
46 Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron 2011 1.26
47 Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res 2006 1.26
48 p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol 2013 1.25
49 Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res 2004 1.24
50 WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell 2003 1.23
51 SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res 2003 1.22
52 The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev 2005 1.22
53 Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Genet 2005 1.22
54 The role of inflammation in age-related disease. Aging (Albany NY) 2013 1.22
55 Quantification of epithelial cells in coculture with fibroblasts by fluorescence image analysis. Cytometry 2002 1.21
56 p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A 2007 1.18
57 Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res 2002 1.18
58 Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci 2005 1.17
59 ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle 2004 1.15
60 Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol 2008 1.14
61 Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Mol Cell Biol 2006 1.13
62 Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol 2004 1.08
63 The demographic and biomedical case for late-life interventions in aging. Sci Transl Med 2010 1.08
64 Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell 2012 1.08
65 Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. PLoS Genet 2010 1.06
66 Between Scylla and Charybdis: p53 links tumor suppression and aging. Mech Ageing Dev 2002 1.05
67 The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep 2003 1.03
68 Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells 2014 1.01
69 Aging: past, present and future. Aging (Albany NY) 2009 1.01
70 Senescent cells and their secretory phenotype as targets for cancer therapy. Interdiscip Top Gerontol 2013 1.00
71 Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics 2012 0.99
72 mTORC1 and p53: clash of the gods? Cell Cycle 2013 0.98
73 Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair (Amst) 2005 0.98
74 p53: Pro-aging or pro-longevity? Aging (Albany NY) 2010 0.98
75 Fragile fugue: p53 in aging, cancer and IGF signaling. Nat Med 2004 0.93
76 Hypoxia-inducible factor-1 and neuroglobin expression. Neurosci Lett 2012 0.93
77 GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. Differentiation 2011 0.92
78 Cancer and aging: more puzzles, more promises? Cell Cycle 2008 0.92
79 A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res 2008 0.91
80 Genomic instability, aging, and cellular senescence. Ann N Y Acad Sci 2004 0.91
81 Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res 2008 0.90
82 p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell 2010 0.88
83 ATM suppresses SATB1-induced malignant progression in breast epithelial cells. PLoS One 2012 0.87
84 miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity. Stem Cells 2014 0.87
85 Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells. PLoS One 2008 0.86
86 Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Genomics 2003 0.85
87 Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models. Aging Cell 2005 0.84
88 Meeting report: Translational Research at the Aging and Cancer Interface. Cancer Res 2007 0.84
89 The aging factor in health and disease: the promise of basic research on aging. Aging Clin Exp Res 2004 0.81
90 MicroRNAs: an important player in maintaining a balance between inflammation and tumor suppression. Cell Cycle 2009 0.80
91 Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation. Biochem Biophys Res Commun 2012 0.79
92 When DNA damage goes invisible. Cell Cycle 2009 0.78
93 Interview with Judith Campisi, Ph.D. Interview by Vicki Glaser. Rejuvenation Res 2011 0.77
94 Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease. Biogerontology 2011 0.77
95 The second international conference "genetics of aging and longevity". Aging (Albany NY) 2012 0.77
96 Matters of life and breath: A role for hypoxia in determining cell state. Aging (Albany NY) 2012 0.76
97 No restriction points in life and science. Cell Cycle 2002 0.76
98 Estela Medrano: a life of gentle passion. Aging Cell 2011 0.75