Published in Nat Genet on May 01, 2008
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet (2008) 2.49
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol (2010) 2.43
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol (1985) (2010) 2.07
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature (2011) 1.98
Systems genetics approaches to understand complex traits. Nat Rev Genet (2013) 1.97
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol (2015) 1.91
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Genome Res (2010) 1.45
Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance. J Cardiovasc Magn Reson (2012) 1.15
MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart. Age (Dordr) (2012) 1.06
Systems-based approaches to cardiovascular disease. Nat Rev Cardiol (2012) 1.04
Translational regulation shapes the molecular landscape of complex disease phenotypes. Nat Commun (2015) 1.02
Genetics of hypertension: from experimental animals to humans. Biochim Biophys Acta (2009) 1.00
Emerging directions in the genetics of atrial fibrillation. Circ Res (2014) 0.96
Postmortem cardiac tissue maintains gene expression profile even after late harvesting. BMC Genomics (2012) 0.95
Effects of deep sedation or general anesthesia on cardiac function in mice undergoing cardiovascular magnetic resonance. J Cardiovasc Magn Reson (2009) 0.95
Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules. PLoS Genet (2014) 0.95
Genome-wide co-expression analysis in multiple tissues. PLoS One (2008) 0.93
Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. PLoS Genet (2012) 0.93
Mixed Linear Model Approaches of Association Mapping for Complex Traits Based on Omics Variants. Sci Rep (2015) 0.89
Identification of a novel gene for diabetic traits in rats, mice, and humans. Genetics (2014) 0.89
Recent advances in genetics of the spontaneously hypertensive rat. Curr Hypertens Rep (2010) 0.89
The emerging role for rat models in gene discovery. Mamm Genome (2011) 0.89
Alternative splicing and transcriptome profiling of experimental autoimmune encephalomyelitis using genome-wide exon arrays. PLoS One (2009) 0.88
Effects of low-level laser irradiation on mesenchymal stem cell proliferation: a microarray analysis. Lasers Med Sci (2011) 0.87
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans. Cardiovasc Res (2012) 0.87
Comparative analysis of gene expression profiles in normal hip human cartilage and cartilage from patients with necrosis of the femoral head. Arthritis Res Ther (2016) 0.87
Natural variation of histone modification and its impact on gene expression in the rat genome. Genome Res (2014) 0.86
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat. Physiol Genomics (2011) 0.85
Functional genomics applied to cardiovascular medicine. Circulation (2011) 0.85
Integrative genomics in cardiovascular medicine. Cardiovasc Res (2012) 0.84
Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Hypertension (2009) 0.83
Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling. EBioMedicine (2015) 0.83
Understanding cardiovascular disease: a journey through the genome (and what we found there). Dis Model Mech (2012) 0.81
Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease. PLoS Genet (2014) 0.79
From integrative genomics to systems genetics in the rat to link genotypes to phenotypes. Dis Model Mech (2016) 0.79
Autoimmunoreactive IgGs from patients with postural orthostatic tachycardia syndrome. Proteomics Clin Appl (2012) 0.78
Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. PLoS One (2013) 0.78
Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients. J Am Heart Assoc (2015) 0.77
Wars2 is a determinant of angiogenesis. Nat Commun (2016) 0.77
Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. PLoS One (2017) 0.75
Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat. Dis Model Mech (2017) 0.75
Proteomic profiling of posterior longitudinal ligament of cervical spine. Int J Clin Exp Med (2015) 0.75
Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression. G3 (Bethesda) (2016) 0.75
Small leucine-rich repeat proteoglycans in corneal inflammation and wound healing. Exp Eye Res (2016) 0.75
Dual Linkage of a Locus to Left Ventricular Mass and a Cardiac Gene Co-Expression Network Driven by a Chromosome Domain. Front Cardiovasc Med (2014) 0.75
Relating quantitative variation within a behavior to variation in transcription. Evolution (2017) 0.75
Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling. Cell Commun Signal (2017) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet (2007) 11.09
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet (2005) 7.82
Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet (2007) 7.42
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53
Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. Nat Genet (2007) 4.49
ECM remodeling in hypertensive heart disease. J Clin Invest (2007) 4.03
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76
Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation (2000) 3.68
Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet (2006) 2.80
Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circ Res (2004) 2.31
TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med (2000) 2.29
Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential. Circ Res (1999) 2.18
The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest (2003) 2.10
Proteoglycans of the extracellular matrix and growth control. J Cell Physiol (2001) 2.01
Genetical genomics in humans and model organisms. Trends Genet (2005) 1.97
A20 is dynamically regulated in the heart and inhibits the hypertrophic response. Circulation (2003) 1.94
Practical value of cardiac magnetic resonance imaging for clinical quantification of aortic valve stenosis: comparison with echocardiography. Circulation (2003) 1.73
Relations of left ventricular mass to demographic and hemodynamic variables in American Indians: the Strong Heart Study. Circulation (1997) 1.66
Heritability of left ventricular mass: the Framingham Heart Study. Hypertension (1997) 1.63
Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity. Circulation (2004) 1.37
Mixed signals in heart failure: cancer rules. J Clin Invest (2002) 1.36
Mimecan/osteoglycin-deficient mice have collagen fibril abnormalities. Mol Vis (2002) 1.27
Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Clin Invest (1995) 1.18
Indices of pulse wave analysis are better predictors of left ventricular mass reduction than cuff pressure. Am J Hypertens (2007) 1.15
Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy. J Exp Med (2007) 1.06
Transcriptional alterations in the left ventricle of three hypertensive rat models. Physiol Genomics (2006) 0.98
Differential splicing and alternative polyadenylation generate multiple mimecan mRNA transcripts. J Biol Chem (1997) 0.85
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature (2006) 9.30
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet (2005) 7.82
Finding genes that underlie complex traits. Science (2002) 7.39
Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia. Lancet (2002) 6.11
Truncations of titin causing dilated cardiomyopathy. N Engl J Med (2012) 6.07
Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet (2007) 5.93
Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol (2002) 5.74
Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol (2006) 5.58
Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. N Engl J Med (2002) 5.42
Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. JAMA (2013) 5.19
DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol (2004) 4.96
Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol (2003) 4.36
Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? Circ Res (2012) 4.06
miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res (2008) 3.96
Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing. J Cardiovasc Magn Reson (2013) 3.87
MiR423-5p as a circulating biomarker for heart failure. Circ Res (2010) 3.83
Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet (2010) 3.75
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell (2009) 3.55
Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension (2004) 3.51
Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J (2013) 3.50
Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol (2010) 3.50
Role of endocytosis in cellular uptake of sex steroids. Cell (2005) 3.49
Left-dominant arrhythmogenic cardiomyopathy: an under-recognized clinical entity. J Am Coll Cardiol (2008) 3.42
Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. N Engl J Med (2016) 3.40
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem (2002) 3.22
Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. Am Heart J (2004) 3.15
A single breath-hold multiecho T2* cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload. J Magn Reson Imaging (2003) 3.11
The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries. Eur Heart J (2007) 3.11
Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation (2004) 3.05
SNP and haplotype mapping for genetic analysis in the rat. Nat Genet (2008) 2.96
Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging (2002) 2.95
Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation (2008) 2.95
NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study. Eur Heart J (2005) 2.93
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol (2002) 2.87
Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009. J Am Acad Dermatol (2010) 2.87
Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance. J Cardiovasc Magn Reson (2008) 2.85
Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death? J Mol Med (Berl) (2004) 2.81
Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet (2006) 2.80
Left ventricular mass: reliability of M-mode and 2-dimensional echocardiographic formulas. Hypertension (2002) 2.77
Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial. Circulation (2012) 2.71
Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis. J Am Coll Cardiol (2011) 2.66
Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. Br J Haematol (2004) 2.59
Management of chronic heart failure guided by individual N-terminal pro-B-type natriuretic peptide targets: results of the PRIMA (Can PRo-brain-natriuretic peptide guided therapy of chronic heart failure IMprove heart fAilure morbidity and mortality?) study. J Am Coll Cardiol (2010) 2.50
Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study. Am J Respir Crit Care Med (2005) 2.49
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol (2010) 2.43
Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance. Eur Heart J (2006) 2.35
On T2* magnetic resonance and cardiac iron. Circulation (2011) 2.33
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol (2008) 2.32
Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circ Res (2004) 2.31
The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Am Coll Cardiol (2004) 2.31
Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol (2006) 2.29
Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study. J Am Coll Cardiol (2012) 2.28
Distribution and functional impact of DNA copy number variation in the rat. Nat Genet (2008) 2.20
Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of fallot and its relationship to adverse markers of clinical outcome. Circulation (2006) 2.18
Long-term use of contraceptive depot medroxyprogesterone acetate in young women impairs arterial endothelial function assessed by cardiovascular magnetic resonance. Circulation (2002) 2.16