Genetics of hypertension: from experimental animals to humans.

Evidence for a link between gut microbiota and hypertension in the Dahl rat. Physiol Genomics (2015) 1.66

Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study. Cardiovasc Diabetol (2011) 1.07

Analysis of early hypertension and clinical outcome with bevacizumab: results from seven phase III studies. Oncologist (2013) 0.99

Elevated BP after AKI. J Am Soc Nephrol (2015) 0.93

Investigation of homocysteine-pathway-related variants in essential hypertension. Int J Hypertens (2012) 0.87

Elevated blood pressure: Our family's fault? The genetics of essential hypertension. World J Cardiol (2014) 0.82

Genes influencing circadian differences in blood pressure in hypertensive mice. PLoS One (2011) 0.81

Genetics of hypertension: discoveries from the bench to human populations. Am J Physiol Renal Physiol (2013) 0.80

Effects of hypertension and exercise on cardiac proteome remodelling. Biomed Res Int (2014) 0.77

The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation. Retrovirology (2012) 0.76

STK39 and WNK1 Are Potential Hypertension Susceptibility Genes in the BELHYPGEN Cohort. Medicine (Baltimore) (2016) 0.75

Aggregate blood pressure responses to serial dietary sodium and potassium intervention: defining responses using independent component analysis. BMC Genet (2015) 0.75

Association of Mbo I-RFLP at the Renin Locus (rs2368564) with Essential Hypertension. Indian J Clin Biochem (2016) 0.75

High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass. Physiol Genomics (2016) 0.75

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension (2003) 63.78

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet (2002) 40.37

Global burden of hypertension: analysis of worldwide data. Lancet (2005) 32.76

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40

2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens (2007) 20.09

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33

Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet (2008) 11.80

Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54

Molecular mechanisms of human hypertension. Cell (2001) 11.17

Global burden of blood-pressure-related disease, 2001. Lancet (2008) 11.09

Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet (2006) 9.87

A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol (1985) 9.70

Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods (2004) 9.52

Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature (2006) 9.30

Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71

Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet (2005) 7.82

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65

A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet (2005) 7.64

Finding genes that underlie complex traits. Science (2002) 7.39

Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet (1996) 5.95

Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell (1994) 5.29

Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med (2004) 4.92

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet (1999) 4.48

Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet (1996) 3.84

CD36 deficiency associated with insulin resistance. Lancet (2001) 3.82

Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndromes. J Pediatr (1992) 3.78

Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet (1996) 3.71

Essential hypertension. Part I: definition and etiology. Circulation (2000) 3.59

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58

Genome-wide mapping of human loci for essential hypertension. Lancet (2003) 3.53

Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet (1997) 3.51

A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature (1992) 3.40

Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation (2005) 3.14

Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet (2007) 3.04

Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology (2000) 3.01

Genetic analysis of inherited hypertension in the rat. Physiol Rev (2000) 2.78

The genetic dissection of essential hypertension. Nat Rev Genet (2006) 2.77

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci U S A (1995) 2.69

Molecular physiology of the WNK kinases. Annu Rev Physiol (2008) 2.58

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet (2002) 2.46

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum Mol Genet (2005) 2.27

Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science (2000) 2.21

Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. Hypertension (2008) 1.96

Essential hypertension. Lancet (2003) 1.79

Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nat Genet (1998) 1.73

The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol (1977) 1.70

Identification of hypertension-related genes through an integrated genomic-transcriptomic approach. Circ Res (2005) 1.67

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Nat Genet (2008) 1.67

Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis. J Hypertens (2007) 1.67

Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. Can Med Assoc J (1966) 1.58

Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: substitution mapping and renal expression analysis. Hypertension (2005) 1.58

Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Nat Genet (1992) 1.55

Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet (1995) 1.50

Consomic rat model systems for physiological genomics. Acta Physiol Scand (2004) 1.50

Application of chromosomal substitution techniques in gene-function discovery. J Physiol (2004) 1.47

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet (2008) 1.38

Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. PLoS One (2009) 1.32

Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet (2008) 1.31

Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3. Hum Mol Genet (2004) 1.29

Positional identification of hypertension susceptibility genes on chromosome 2. Hypertension (2004) 1.25

Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T? Hypertension (2008) 1.25

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. Proc Natl Acad Sci U S A (1992) 1.23

Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. Physiol Genomics (2008) 1.21

Renal regional proteomes in young Dahl salt-sensitive rats. Hypertension (2008) 1.20

Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects. J Clin Endocrinol Metab (1991) 1.19

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet (2008) 1.19

A review of the genetics of essential hypertension. Curr Opin Cardiol (2007) 1.17

A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res (2008) 1.13

Cotransporters, WNKs and hypertension: an update. Curr Opin Nephrol Hypertens (2008) 1.13

Blood pressure and its correlates in an African tribe in urban and rural environments. J Epidemiol Community Health (1984) 1.13

Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. Proc Natl Acad Sci U S A (1992) 1.09

Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. Mamm Genome (2003) 1.09

NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases. Clin Sci (Lond) (2008) 1.07

Genetic study of the CD36 gene in a French diabetic population. Diabetes Metab (2004) 1.02

Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. Hypertension (1996) 1.01

Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene. Lancet (1996) 1.01

Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. Pharmacogenomics (2009) 0.96

Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure. Hypertension (2009) 0.96

Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. Hypertension (2005) 0.95

Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains. J Hypertens (2004) 0.95

Glutathione S-transferase variants and hypertension. J Hypertens (2008) 0.95

Common genetic mechanisms of blood pressure elevation in two independent rodent models of human essential hypertension. Am J Hypertens (2005) 0.94

Dissecting complex traits: recent advances in hypertension genomics. Genome Med (2009) 0.93

Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2. Hypertension (2000) 0.92

Autosomal dominant hypocalcemia with mild type 5 Bartter syndrome. J Nephrol (2006) 0.92

WNK kinases, renal ion transport and hypertension. Am J Nephrol (2008) 0.91

Microarray analysis of rat chromosome 2 congenic strains. Hypertension (2002) 0.91

Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Physiol Genomics (2003) 0.90

Multiple quantitative trait loci for blood pressure interacting epistatically and additively on Dahl rat chromosome 2. Hypertension (2005) 0.90

Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension. Physiol Res (2003) 0.90

Type IV Bartter syndrome: report of two new cases. Pediatr Nephrol (2006) 0.90

Adducin polymorphism: detection and impact on hypertension and related disorders. Hypertension (2005) 0.87

Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis. Hypertension (2007) 0.86

Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Hum Mol Genet (2003) 0.86

Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study. Hypertension (2006) 0.86

Genetics of the human renin angiotensin system. J Mol Med (Berl) (2008) 0.86

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27

Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med (2012) 6.93

Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med (2011) 6.34

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet (2012) 5.16

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55

Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension (2013) 3.33

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. Eur Heart J (2009) 3.02

Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28

Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability. BMC Med Genet (2006) 2.25

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet (2010) 2.24

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04

Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension (2003) 2.00

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96

Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics (2010) 1.90

Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension (2011) 1.89

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst (2012) 1.83

Long-term and ultra long-term blood pressure variability during follow-up and mortality in 14,522 patients with hypertension. Hypertension (2013) 1.76

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72

Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke (2009) 1.71

Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. Int J Epidemiol (2012) 1.67

HLA has strongest association with IgA nephropathy in genome-wide analysis. J Am Soc Nephrol (2010) 1.64

Copy-number disorders are a common cause of congenital kidney malformations. Am J Hum Genet (2012) 1.63

VisGenome: visualization of single and comparative genome representations. Bioinformatics (2007) 1.61

Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr (2010) 1.61

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol (2011) 1.61

Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med (2010) 1.59

Blood pressure and blood selenium: a cross-sectional and longitudinal population study. Eur Heart J (2007) 1.58

CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics Clin Appl (2008) 1.57

Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. J Hypertens (2005) 1.53

Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension (2013) 1.52

Should diabetes be considered a coronary heart disease risk equivalent?: results from 25 years of follow-up in the Renfrew and Paisley survey. Diabetes Care (2005) 1.52

Genetic basis of blood pressure and hypertension. Trends Genet (2012) 1.51

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats. Mol Ther (2004) 1.50

Association of central and peripheral pulse pressure with intermediate cardiovascular phenotypes. J Hypertens (2012) 1.49

Metabolomic study of carotid-femoral pulse-wave velocity in women. J Hypertens (2015) 1.49

Urinary proteomic biomarkers in coronary artery disease. Mol Cell Proteomics (2007) 1.47

Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44

Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. J Hypertens (2009) 1.44

TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. J Hypertens (2015) 1.43

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet (2013) 1.30

Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet (2013) 1.27

Urinary proteomics for prediction of preeclampsia. Hypertension (2011) 1.20

Novel biomarkers for predicting preeclampsia. Trends Cardiovasc Med (2008) 1.20

Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments. Mass Spectrom Rev (2009) 1.19

NEDD4L in essential hypertension. J Hypertens (2014) 1.19

Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. Hum Mol Genet (2012) 1.18

Gene expression profiling in whole blood of patients with coronary artery disease. Clin Sci (Lond) (2010) 1.17

Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS One (2009) 1.16

NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension (2002) 1.15

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension (2013) 1.14

A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res (2008) 1.13

Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension (2009) 1.11

Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. Hypertension (2002) 1.11

Strategies to reduce oxidative stress in cardiovascular disease. Clin Sci (Lond) (2004) 1.11

miR-21 and miR-214 are consistently modulated during renal injury in rodent models. Am J Pathol (2011) 1.10

Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. J Hypertens (2010) 1.09

Association of the human Y chromosome with cholesterol levels in the general population. Arterioscler Thromb Vasc Biol (2003) 1.06

Evaluation of urine proteome pattern analysis for its potential to reflect coronary artery atherosclerosis in symptomatic patients. J Proteome Res (2009) 1.05

Preeclampsia and future maternal health. J Hypertens (2010) 1.03

Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. J Hypertens (2008) 1.03

Differential effects of 17beta-estradiol upon stroke damage in stroke prone and normotensive rats. J Cereb Blood Flow Metab (2004) 1.02

Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation (2007) 1.02

The Y chromosome effect on blood pressure in two European populations. Hypertension (2002) 1.02

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genet (2013) 1.02

Functional duality of astrocytes in myelination. J Neurosci (2011) 1.01