Published in Nature on September 08, 2010
Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet (2013) 7.13
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet (2012) 5.16
Oxysterols direct immune cell migration via EBI2. Nature (2011) 2.19
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet (2015) 2.04
Metagenomics and personalized medicine. Cell (2011) 2.00
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature (2011) 1.98
Systems genetics approaches to understand complex traits. Nat Rev Genet (2013) 1.97
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J (2011) 1.67
Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet (2011) 1.64
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet (2011) 1.60
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell (2013) 1.53
A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes (2014) 1.50
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat Genet (2015) 1.42
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet (2011) 1.40
Genome-virome interactions: examining the role of common viral infections in complex disease. Nat Rev Microbiol (2011) 1.38
Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium. PLoS One (2012) 1.31
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet (2011) 1.29
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood (2012) 1.26
Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS One (2013) 1.21
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet (2012) 1.20
Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun (2014) 1.20
Clinical features and outcomes of 98 children and adults with dense deposit disease. Pediatr Nephrol (2011) 1.13
Strategies to discover regulatory circuits of the mammalian immune system. Nat Rev Immunol (2011) 1.10
miR-451 regulates dendritic cell cytokine responses to influenza infection. J Immunol (2012) 1.08
Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes. PLoS Genet (2013) 1.03
G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Res (2015) 1.03
Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat Biotechnol (2013) 1.03
GO-Module: functional synthesis and improved interpretation of Gene Ontology patterns. Bioinformatics (2011) 1.02
Bayesian detection of expression quantitative trait loci hot spots. Genetics (2011) 1.00
The future of model organisms in human disease research. Nat Rev Genet (2011) 1.00
Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog (2013) 0.99
USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. Cell Death Dis (2012) 0.98
The continuum of personalized cardiovascular medicine: a position paper of the European Society of Cardiology. Eur Heart J (2014) 0.97
GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nat Rev Endocrinol (2013) 0.96
EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol (2011) 0.95
Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules. PLoS Genet (2014) 0.95
Type 1 diabetes is associated with enterovirus infection in gut mucosa. Diabetes (2012) 0.95
From genetics of inflammatory bowel disease towards mechanistic insights. Trends Immunol (2013) 0.94
The problems and promises of research into human immunology and autoimmune disease. Nat Med (2012) 0.94
Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes. Clin Exp Immunol (2012) 0.94
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet (2013) 0.93
Ten years of genetics and genomics: what have we achieved and where are we heading? Nat Rev Genet (2010) 0.93
Mid-gestational gene expression profile in placenta and link to pregnancy complications. PLoS One (2012) 0.91
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nat Commun (2015) 0.89
The emerging role for rat models in gene discovery. Mamm Genome (2011) 0.89
Infection as a cause of type 1 diabetes? Curr Opin Rheumatol (2012) 0.88
ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration. Bioinformatics (2011) 0.88
Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel. Genome Biol (2012) 0.88
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans. Cardiovasc Res (2012) 0.87
Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes. PLoS One (2012) 0.87
Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics. PLoS Comput Biol (2016) 0.86
Evidence of association with type 1 diabetes in the SLC11A1 gene region. BMC Med Genet (2011) 0.86
Natural variation of histone modification and its impact on gene expression in the rat genome. Genome Res (2014) 0.86
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat. Physiol Genomics (2011) 0.85
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. Arthritis Rheum (2012) 0.85
Oxysterol-EBI2 signaling in immune regulation and viral infection. Eur J Immunol (2014) 0.84
RNA-sequencing analysis of high glucose-treated monocytes reveals novel transcriptome signatures and associated epigenetic profiles. Physiol Genomics (2013) 0.84
Integrative genomics in cardiovascular medicine. Cardiovasc Res (2012) 0.84
Viral infections in type 1 diabetes mellitus - why the β cells? Nat Rev Endocrinol (2016) 0.83
Coanalysis of GWAS with eQTLs reveals disease-tissue associations. AMIA Jt Summits Transl Sci Proc (2012) 0.83
Type I diabetes mellitus: genetic factors and presumptive enteroviral etiology or protection. J Pathog (2014) 0.82
Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics (2014) 0.82
Understanding cardiovascular disease: a journey through the genome (and what we found there). Dis Model Mech (2012) 0.81
Salicylate prevents virus-induced type 1 diabetes in the BBDR rat. PLoS One (2013) 0.81
Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression. PLoS One (2012) 0.80
Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series. Genome Med (2016) 0.80
Phosphoproteome profiling of the macrophage response to different toll-like receptor ligands identifies differences in global phosphorylation dynamics. J Proteome Res (2014) 0.80
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation. Part Fibre Toxicol (2012) 0.79
Modelling local gene networks increases power to detect trans-acting genetic effects on gene expression. Genome Biol (2016) 0.79
From integrative genomics to systems genetics in the rat to link genotypes to phenotypes. Dis Model Mech (2016) 0.79
EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells. PLoS One (2013) 0.79
Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis. J Clin Cell Immunol (2014) 0.79
Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease. PLoS Genet (2014) 0.79
Bariatric Surgery Induces Disruption in Inflammatory Signaling Pathways Mediated by Immune Cells in Adipose Tissue: A RNA-Seq Study. PLoS One (2015) 0.78
Network representations of immune system complexity. Wiley Interdiscip Rev Syst Biol Med (2015) 0.78
Delineating the Hemostaseome as an aid to individualize the analysis of the hereditary basis of thrombotic and bleeding disorders. Hum Genet (2011) 0.78
VSEAMS: a pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes. Bioinformatics (2014) 0.78
Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes Susceptibility. J Immunol (2016) 0.77
Type 1 diabetes and gut microbiota: Friend or foe? Pharmacol Res (2015) 0.77
Metabolomics makes a mark: early changes associated with autoimmune diabetes. Diabetes (2011) 0.77
Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity. Hum Mol Genet (2013) 0.77
Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. PLoS One (2012) 0.77
Multi-omics approaches to disease. Genome Biol (2017) 0.76
A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Diabetes (2016) 0.76
MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues. Bioinformatics (2015) 0.76
The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages. Sci Rep (2016) 0.76
Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis. PLoS One (2016) 0.75
Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages. Am J Hum Genet (2015) 0.75
Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression. G3 (Bethesda) (2016) 0.75
Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes. Elife (2016) 0.75
Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model. PLoS One (2017) 0.75
EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies. Blood (2016) 0.75
Cofunctional Subpathways Were Regulated by Transcription Factor with Common Motif, Common Family, or Common Tissue. Biomed Res Int (2015) 0.75
Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes. Rev Diabet Stud (2012) 0.75
Molecular pathway alterations in CD4 T-cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes. Results Immunol (2014) 0.75
7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases. Front Pharmacol (2015) 0.75
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J Exp Med (2015) 0.75
Network science for the identification of novel therapeutic targets in epilepsy. F1000Res (2016) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Genetic dissection of transcriptional regulation in budding yeast. Science (2002) 25.01
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
Genetic mapping in human disease. Science (2008) 15.12
IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet (2003) 11.84
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet (2005) 7.82
Nonresolving inflammation. Cell (2010) 7.74
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48
Molecular networks as sensors and drivers of common human diseases. Nature (2009) 6.14
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
SNP and haplotype mapping for genetic analysis in the rat. Nat Genet (2008) 2.96
Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood (1993) 2.90
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies. Bioinformatics (2008) 2.52
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol (2010) 2.43
EBI2 mediates B cell segregation between the outer and centre follicle. Nature (2009) 2.20
Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity (2009) 2.09
PASTAA: identifying transcription factors associated with sets of co-regulated genes. Bioinformatics (2008) 1.82
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. Biostatistics (2008) 1.72
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Nat Genet (2008) 1.67
Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A (2008) 1.66
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Genome Res (2010) 1.45
Diabetes: A virus-gene collaboration. Nature (2009) 1.25
Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes Immun (2009) 1.22
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science (2008) 29.99
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics (2002) 20.59
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing. Bioinformatics (2002) 19.27
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
A gene expression map of Arabidopsis thaliana development. Nat Genet (2005) 17.39
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
IntAct: an open source molecular interaction database. Nucleic Acids Res (2004) 15.02
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered (2003) 14.37
Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72
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Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
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