Wnt/beta-catenin signaling pathway as a novel cancer drug target.

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood (2006) 2.53

Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res (2008) 2.18

Genetics of hepatocellular carcinoma. World J Gastroenterol (2007) 1.64

BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med (2008) 1.54

Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer. J Biol Chem (2012) 1.47

MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J (2009) 1.37

Natural products and colon cancer: current status and future prospects. Drug Dev Res (2008) 1.34

Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk. Genes Cancer (2013) 1.28

Breast cancer stem cells: implications for therapy of breast cancer. Breast Cancer Res (2008) 1.26

Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome. Genes Chromosomes Cancer (2011) 1.18

Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival. Clin Cancer Res (2011) 1.15

Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem (2012) 1.14

Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res (2008) 1.10

Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin Orthop Relat Res (2008) 1.06

PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. Oncogene (2010) 1.06

Modulation of Wnt/β-catenin signaling pathway by bioactive food components. Carcinogenesis (2011) 1.06

Pharmacological modulation of beta-catenin and its applications in cancer therapy. J Cell Mol Med (2013) 1.03

Prediction of potential drug targets based on simple sequence properties. BMC Bioinformatics (2007) 1.01

Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes. J Immunol (2011) 1.00

A systematic screen for micro-RNAs regulating the canonical Wnt pathway. PLoS One (2011) 1.00

Defective osteogenic differentiation in the development of osteosarcoma. Sarcoma (2011) 0.98

Emerging therapeutic strategies for targeting chronic myeloid leukemia stem cells. Stem Cells Int (2013) 0.93

Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response. J Med Chem (2012) 0.93

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer. Oncotarget (2014) 0.91

Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin. Cancer Prev Res (Phila) (2013) 0.90

The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wnt/β-Catenin Signaling Pathways. Evid Based Complement Alternat Med (2012) 0.90

Multiple tumor suppressor microRNAs regulate telomerase and TCF7, an important transcriptional regulator of the Wnt pathway. PLoS One (2014) 0.89

Overexpression of long non-coding RNA HOTTIP increases chemoresistance of osteosarcoma cell by activating the Wnt/β-catenin pathway. Am J Transl Res (2016) 0.88

Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease. World J Surg (2008) 0.87

Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biol Ther (2015) 0.87

Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways. Biomed Res Int (2013) 0.87

Modulation of β-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways. Int J Med Sci (2013) 0.85

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. J Med Chem (2015) 0.85

Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma. Sarcoma (2013) 0.85

Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma. J Biol Chem (2015) 0.84

Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells. PLoS One (2012) 0.84

Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin (2015) 0.83

Chemoprevention by white currant is mediated by the reduction of nuclear beta-catenin and NF-kappaB levels in Min mice adenomas. Eur J Nutr (2008) 0.82

Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells. Cancer Biol Ther (2015) 0.82

Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities. J Mol Signal (2013) 0.81

A Resource of Quantitative Functional Annotation for Homo sapiens Genes. G3 (Bethesda) (2012) 0.80

Lung cancer-initiating cells: a novel target for cancer therapy. Target Oncol (2013) 0.80

Prediction of signaling cross-talks contributing to acquired drug resistance in breast cancer cells by Bayesian statistical modeling. BMC Syst Biol (2015) 0.80

The Current and Future Therapies for Human Osteosarcoma. Curr Cancer Ther Rev (2013) 0.79

Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt/β-catenin signaling and PI3K/Akt survival pathway. Cell Death Dis (2014) 0.79

Oncogenesis and cancer stem cells: current opinions and future directions. J Cell Mol Med (2009) 0.78

Lactobacilli Differentially Modulate mTOR and Wnt/ β-Catenin Pathways in Different Cancer Cell Lines. Iran J Cancer Prev (2016) 0.78

Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One (2016) 0.77

From chronic liver disorders to hepatocellular carcinoma: Molecular and genetic pathways. World J Gastrointest Oncol (2010) 0.77

Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. J Biol Chem (2016) 0.77

Breast cancer stem cells, pathways and therapeutic perspectives 2011. Indian J Surg (2012) 0.77

Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin. Mol Cancer Ther (2016) 0.77

In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways. Oncotarget (2016) 0.76

Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. Oncol Lett (2012) 0.76

Increased nuclear β-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia. Med Oral Patol Oral Cir Bucal (2015) 0.76

Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation. Exp Mol Med (2015) 0.76

DH9, a novel PPARγ agonist suppresses the proliferation of ADPKD epithelial cells: An association with an inhibition of β-catenin signaling. Invest New Drugs (2009) 0.76

Lithium Attenuates TGF-β(1)-Induced Fibroblasts to Myofibroblasts Transition in Bronchial Fibroblasts Derived from Asthmatic Patients. J Allergy (Cairo) (2012) 0.76

Lemur tyrosine kinase-3 is a significant prognostic marker for patients with colorectal cancer. Int J Clin Exp Pathol (2014) 0.75

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation. Oncotarget (2016) 0.75

Atrial natriuretic peptide: a magic bullet for cancer therapy targeting Wnt signaling and cellular pH regulators. Curr Med Chem (2014) 0.75

Signaling Pathways in Thyroid Cancer and Their Therapeutic Implications. J Clin Med Res (2016) 0.75

LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974. Sci Rep (2017) 0.75

Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells. Biomol Ther (Seoul) (2016) 0.75

TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response. PLoS One (2015) 0.75

Beta-catenin mediates soft tissue contracture in clubfoot. Clin Orthop Relat Res (2009) 0.75

Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. Int J Endocrinol (2016) 0.75

Downregulation of microRNA-30d promotes cell proliferation and invasion by targeting LRH-1 in colorectal carcinoma. Int J Mol Med (2017) 0.75

Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells. Oncotarget (2017) 0.75

Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells. Integr Med Res (2017) 0.75

Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21

The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23

High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A (2013) 6.88

Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis (2013) 6.60

Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58

Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81

Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol (2007) 5.53

A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc (2007) 5.15

Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63

Coupled oscillators control morning and evening locomotor behaviour of Drosophila. Nature (2004) 4.55

Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21

PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51

Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res (2009) 3.44

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41

Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg Am (2003) 3.36

Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell (2003) 3.36

A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Nature (2005) 3.35

Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study. J Am Coll Cardiol (2012) 3.19

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17

Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15

Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell (2008) 3.15

Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell (2005) 3.04

MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res (2011) 3.03

Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation. Blood (2009) 2.92

The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83

A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli. J Exp Med (2004) 2.81

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci (2008) 2.77

Heritability of alternative splicing in the human genome. Genome Res (2007) 2.76

Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol (2010) 2.68

Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother (2012) 2.65

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54

Retracted CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy. Sci Transl Med (2013) 2.51

A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45

Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res (2008) 2.44

Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol (2002) 2.43

c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41

Prognosis of patients taking selective serotonin reuptake inhibitors before coronary artery bypass grafting. Am J Cardiol (2006) 2.40

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity (2013) 2.39

Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. J Biol Chem (2004) 2.35

In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol (2006) 2.33

Agricultural origins and the isotopic identity of domestication in northern China. Proc Natl Acad Sci U S A (2009) 2.32

Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study. J Antimicrob Chemother (2011) 2.30

Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Proc Natl Acad Sci U S A (2004) 2.29

Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. J Orthop Res (2007) 2.26

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature (2012) 2.26

The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25

Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types. PLoS One (2009) 2.21

Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res (2008) 2.18

Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood (2007) 2.18

CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol (2006) 2.15

Gaussian Bare-Bones Differential Evolution. IEEE Trans Cybern (2013) 2.08

Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07

Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res (2004) 2.07

Efficacy of platelet-rich plasma combined with allograft bone in the management of displaced intra-articular calcaneal fractures: a prospective cohort study. J Orthop Res (2012) 2.04

Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients. J Transl Med (2013) 2.04

High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China. Clin Infect Dis (2010) 2.02

Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry (2006) 1.96

Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. Planta Med (2007) 1.96

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet (2012) 1.96

COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95

MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic Acids Res (2010) 1.94

Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology (2013) 1.93

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem (2004) 1.93

Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Antimicrob Agents Chemother (2008) 1.91

The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease. Neuron (2002) 1.91

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat (2009) 1.90

ANOSVA: a statistical method for detecting splice variation from expression data. Bioinformatics (2005) 1.88

Regulation of osteogenic differentiation during skeletal development. Front Biosci (2008) 1.88

A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc Natl Acad Sci U S A (2003) 1.87

Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis (2008) 1.87

Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J (2005) 1.85