Published in Biochemistry on May 06, 2008
Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A. Antimicrob Agents Chemother (2009) 1.21
Substrate binding mode and its implication on drug design for botulinum neurotoxin A. PLoS Pathog (2008) 1.14
Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors. J Med Chem (2010) 1.08
Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design. PLoS One (2009) 1.07
A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate. Structure (2008) 1.03
Receptor and substrate interactions of clostridial neurotoxins. Toxicon (2009) 1.01
Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Org Lett (2010) 0.99
Clostridial neurotoxins: mechanism of SNARE cleavage and outlook on potential substrate specificity reengineering. Toxins (Basel) (2010) 0.95
Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F. Nat Struct Mol Biol (2009) 0.94
Small molecules showing significant protection of mice against botulinum neurotoxin serotype A. PLoS One (2010) 0.88
Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity. J Biol Chem (2010) 0.88
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies. Bioorg Med Chem (2012) 0.88
Botulinum toxin: bioweapon & magic drug. Indian J Med Res (2010) 0.86
Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A. PLoS One (2010) 0.84
SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E. J Biol Chem (2008) 0.84
You are lost without a map: Navigating the sea of protein structures. Biochim Biophys Acta (2014) 0.82
Glycine insertion at protease cleavage site of SNAP25 resists cleavage but enhances affinity for botulinum neurotoxin serotype A. Protein Sci (2012) 0.78
Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism. Curr Top Med Chem (2014) 0.77
Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency. Botulinum J (2011) 0.77
Retracted Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice. PLoS One (2012) 0.76
The C terminus of the catalytic domain of type A botulinum neurotoxin may facilitate product release from the active site. J Biol Chem (2013) 0.76
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Psychological reactions to terrorist attacks: findings from the National Study of Americans' Reactions to September 11. JAMA (2002) 8.10
Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science (2004) 5.64
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol (2008) 4.82
The genome of Cryptosporidium hominis. Nature (2004) 3.93
The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. Science (2003) 3.41
Sustaining access to antiretroviral therapy in the less-developed world: lessons from Brazil and Thailand. AIDS (2007) 3.27
Has global HIV incidence peaked? Lancet (2006) 3.26
Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol (2006) 3.10
Epidemiology of HIV infection in the Middle East and North Africa. AIDS (2010) 2.86
HIV prevalence in China: integration of surveillance data and a systematic review. Lancet Infect Dis (2013) 2.82
Is cardiopulmonary exercise testing a useful test before esophagectomy? Ann Thorac Surg (2008) 2.48
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. J Neurosci (2004) 2.38
Are HIV epidemics among men who have sex with men emerging in the Middle East and North Africa?: a systematic review and data synthesis. PLoS Med (2011) 2.18
Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids. Magn Reson Med (2003) 2.14
Multimorbidity - not just an older person's issue. Results from an Australian biomedical study. BMC Public Health (2010) 2.05
Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models. J Infect Dis (2011) 1.98
Cryptosporidiosis and microsporidiosis in ugandan children with persistent diarrhea with and without concurrent infection with the human immunodeficiency virus. Am J Trop Med Hyg (2005) 1.90
Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries. Environ Health Perspect (2006) 1.89
Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC Microbiol (2008) 1.89
The Enzyme Function Initiative. Biochemistry (2011) 1.87
Self-regulation of Candida albicans population size during GI colonization. PLoS Pathog (2007) 1.85
Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors. J Comb Chem (2006) 1.79
Prevalence of Enterocytozoon bieneusi in swine: an 18-month survey at a slaughterhouse in Massachusetts. Appl Environ Microbiol (2002) 1.78
Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility. Chem Biol (2007) 1.78
Activation of nuclear factor kappaB in obstructive sleep apnea: a pathway leading to systemic inflammation. Sleep Breath (2006) 1.76
Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi. PLoS Pathog (2009) 1.73
Absence of BRAF and NRAS mutations in uveal melanoma. Cancer Res (2003) 1.70
The role of civil society in protecting public health over commercial interests: lessons from Thailand. Lancet (2004) 1.67
Unethical clinical trials in Thailand: a community response. Lancet (2005) 1.66
Persistent placoid maculopathy: a new clinical entity. Ophthalmology (2007) 1.66
Cryptosporidium parvum in children with diarrhea in Mulago Hospital, Kampala, Uganda. Am J Trop Med Hyg (2003) 1.64
Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice. Exp Neurol (2004) 1.58
Respiratory cryptosporidiosis in HIV-seronegative children in Uganda: potential for respiratory transmission. Clin Infect Dis (2010) 1.56
Were arachnids the first to use combinatorial peptide libraries? Peptides (2005) 1.55
Quantitative determination of heme for forensic characterization of bacillus spores using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Chem (2004) 1.53
Enterocytozoon bieneusi among children with diarrhea attending Mulago Hospital in Uganda. Am J Trop Med Hyg (2002) 1.50
Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection. Infect Immun (2002) 1.49
HIV among people who inject drugs in Central and Eastern Europe and Central Asia: a systematic review with implications for policy. BMJ Open (2012) 1.49
Partner reduction and the prevention of HIV/AIDS. BMJ (2004) 1.49
Cryptosporidiosis in children in Sub-Saharan Africa: a lingering challenge. Clin Infect Dis (2008) 1.46
Solubilized benzoyl peroxide versus benzoyl peroxide/clindamycin in the treatment of moderate acne. J Drugs Dermatol (2008) 1.45
Interinstitutional and interstate teleneuropathology. J Pathol Inform (2011) 1.44
The evolution of display technologies in PACS applications. Comput Med Imaging Graph (2003) 1.43
Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis. Biochemistry (2002) 1.43
The elasticity of single titin molecules using a two-bead optical tweezers assay. Biophys J (2004) 1.43
Nitric oxide modifies the sarcoplasmic reticular calcium release channel in endotoxemia by both guanosine-3',5' (cyclic) phosphate-dependent and independent pathways. Crit Care Med (2006) 1.41
An unusual complication of asthma--the exploding inhaler. Burns (2003) 1.39
Piglet models of acute or chronic Clostridium difficile illness. J Infect Dis (2010) 1.38
The sixth right of medication administration: right response. Nurse Educ (2004) 1.38
Human antibody against shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications. Infect Immun (2005) 1.38
Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo. Biochem Biophys Res Commun (2006) 1.36
Cryptosporidium hominis: experimental challenge of healthy adults. Am J Trop Med Hyg (2006) 1.35
IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era. Int J Cancer (2009) 1.35
Respondent driven sampling--where we are and where should we be going? Sex Transm Infect (2012) 1.35
The origin of the electrostatic perturbation in acetoacetate decarboxylase. Nature (2009) 1.34
Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med (2010) 1.34
An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. J Microbiol Methods (2009) 1.34
HIV-1 molecular epidemiology evidence and transmission patterns in the Middle East and North Africa. Sex Transm Infect (2010) 1.33
Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic. PLoS Med (2007) 1.33
Evaluation of large-scale combination HIV prevention programs: essential issues. J Acquir Immune Defic Syndr (2011) 1.32
Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily. Biochemistry (2006) 1.31
The reduced genome of the parasitic microsporidian Enterocytozoon bieneusi lacks genes for core carbon metabolism. Genome Biol Evol (2010) 1.30
HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131. Biochemistry (2005) 1.29
Association of genital shedding of herpes simplex virus type 2 and HIV-1 among sex workers in rural Zimbabwe. AIDS (2006) 1.27
Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosens Bioelectron (2006) 1.26
The shikimate pathway and its branches in apicomplexan parasites. J Infect Dis (2002) 1.25
Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease. J Infect Dis (2012) 1.25
HIV epidemic appraisals for assisting in the design of effective prevention programmes: shifting the paradigm back to basics. PLoS One (2012) 1.25
A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model. PLoS One (2012) 1.24
The Strengthening Washington D.C. Families project: a randomized effectiveness trial of family-based prevention. Prev Sci (2006) 1.23
Production and characterization of protective human antibodies against Shiga toxin 1. Infect Immun (2002) 1.23
The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem (2006) 1.22
HSV-2 serology can be predictive of HIV epidemic potential and hidden sexual risk behavior in the Middle East and North Africa. Epidemics (2010) 1.22
Infectivity of a Cryptosporidium parvum isolate of cervine origin for healthy adults and interferon-gamma knockout mice. J Infect Dis (2002) 1.22
A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun (2012) 1.22
Identification of genotypically mixed Cryptosporidium parvum populations in humans and calves. Mol Biochem Parasitol (2003) 1.21
Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infect Immun (2009) 1.21
Analysis of the substrate specificity loop of the HAD superfamily cap domain. Biochemistry (2004) 1.20
The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state. Proc Natl Acad Sci U S A (2008) 1.19
Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide. Angew Chem Int Ed Engl (2004) 1.19
Intracellular neutralization of shiga toxin 2 by an a subunit-specific human monoclonal antibody. Infect Immun (2008) 1.19
Is there a difference in health estimates between people with listed and unlisted telephone numbers? Aust N Z J Public Health (2005) 1.19
Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi. PLoS One (2007) 1.16
Imaging System for Creating 3D Block-Face Cryo-Images Of Whole Mice. Proc SPIE Int Soc Opt Eng (2006) 1.16
A pig model of the human gastrointestinal tract. Gut Microbes (2013) 1.15
Inferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis. Appl Environ Microbiol (2008) 1.15
ArachnoServer: a database of protein toxins from spiders. BMC Genomics (2009) 1.13
Characterizing trends in HIV infection among men who have sex with men in Australia by birth cohorts: results from a modified back-projection method. J Int AIDS Soc (2009) 1.13
Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants. Infect Immun (2003) 1.12
CT based computerized identification and analysis of human airways: a review. Med Phys (2012) 1.11
Is sexual contact with sex workers important in driving the HIV epidemic among men in rural Zimbabwe? J Acquir Immune Defic Syndr (2005) 1.11
Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure. Structure (2005) 1.11
Image Segmentation, Registration and Visualization of Serial MR Images for Therapeutic Assessment of Polycystic Kidney Disease in Transgenic Mice. Conf Proc IEEE Eng Med Biol Soc (2005) 1.09
Experimental evidence for genetic recombination in the opportunistic pathogen Cryptosporidium parvum. Mol Biochem Parasitol (2002) 1.09
Increased adherence and actin pedestal formation by dam-deficient enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol (2007) 1.09
The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex. Biochemistry (2002) 1.09
Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Pediatr Blood Cancer (2008) 1.09
The ophthalmic practice of the future. Arch Ophthalmol (2012) 1.07