Published in Biochemistry on July 02, 2002
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proc Natl Acad Sci U S A (2006) 1.56
A water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV. J Am Chem Soc (2007) 1.42
Conformational changes in protein loops and helices induced by post-translational phosphorylation. PLoS Comput Biol (2006) 1.36
Markers of fitness in a successful enzyme superfamily. Curr Opin Struct Biol (2009) 1.31
The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state. Proc Natl Acad Sci U S A (2008) 1.19
The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell. Plant Cell (2005) 1.11
Crystal structure of the alpha-kinase domain of Dictyostelium myosin heavy chain kinase A. Sci Signal (2010) 1.04
Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis. Biochemistry (2009) 1.04
Crystal structure of a phosphatase with a unique substrate binding domain from Thermotoga maritima. Protein Sci (2003) 1.04
A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site. Proc Natl Acad Sci U S A (2006) 1.00
Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors. Anticancer Agents Med Chem (2008) 0.97
Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes. Proc Natl Acad Sci U S A (2010) 0.96
Crystal structure of trehalose-6-phosphate phosphatase-related protein: biochemical and biological implications. Protein Sci (2006) 0.94
Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci (2010) 0.94
Consequences of domain insertion on sequence-structure divergence in a superfold. Proc Natl Acad Sci U S A (2013) 0.91
Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage. Bioorg Chem (2006) 0.91
The tail of KdsC: conformational changes control the activity of a haloacid dehalogenase superfamily phosphatase. J Biol Chem (2009) 0.88
Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate. Proc Natl Acad Sci U S A (2012) 0.86
Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase. Biochemistry (2011) 0.86
Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases. Biochemistry (2015) 0.84
Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. J Biol Chem (2010) 0.83
A chemical phosphorylation-inspired design for Type I collagen biomimetic remineralization. Dent Mater (2010) 0.81
α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction. Proc Natl Acad Sci U S A (2014) 0.80
Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.79
Characterization of the CDP-2-glycerol biosynthetic pathway in Streptococcus pneumoniae. J Bacteriol (2010) 0.79
Crystallization and preliminary X-ray diffraction analysis of Pseudomonas aeruginosa phosphorylcholine phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.76
Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Yihx-encoded haloacid dehalogenase-like phosphatase HAD4 from Escherichia coli is a specific α-d-glucose 1-phosphate hydrolase useful for substrate-selective sugar phosphate transformations. J Mol Catal B Enzym (2014) 0.75
Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.75
The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. Science (2003) 3.41
Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol (2006) 3.10
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano (2009) 2.39
Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A (2010) 2.33
Phosphoryl group transfer: evolution of a catalytic scaffold. Trends Biochem Sci (2004) 2.26
A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. Mol Ther (2004) 2.16
The Enzyme Function Initiative. Biochemistry (2011) 1.87
Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility. Chem Biol (2007) 1.78
Large intestine-targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection. Nat Med (2012) 1.74
Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase. Biochemistry (2008) 1.68
An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. J Cell Biol (2010) 1.59
Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge. J Cell Biol (2008) 1.48
The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU. J Biol Chem (2003) 1.40
The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 1.40
Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states. Biochemistry (2004) 1.37
Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI. J Biol Chem (2006) 1.37
The origin of the electrostatic perturbation in acetoacetate decarboxylase. Nature (2009) 1.34
Nanoscale 3D cellular imaging by axial scanning transmission electron tomography. Nat Methods (2009) 1.32
Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis. Biochemistry (2008) 1.31
Markers of fitness in a successful enzyme superfamily. Curr Opin Struct Biol (2009) 1.31
Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily. Biochemistry (2006) 1.31
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. J Comp Neurol (2010) 1.30
X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase. J Biol Chem (2002) 1.30
HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131. Biochemistry (2005) 1.29
Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA. Biochemistry (2008) 1.28
Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J Gene Med (2006) 1.25
Chimeric ferritin nanocages for multiple function loading and multimodal imaging. Nano Lett (2011) 1.24
The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem (2006) 1.22
Arginine deiminase uses an active-site cysteine in nucleophilic catalysis of L-arginine hydrolysis. J Am Chem Soc (2004) 1.22
Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell (2005) 1.21
Analysis of the substrate specificity loop of the HAD superfamily cap domain. Biochemistry (2004) 1.20
The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state. Proc Natl Acad Sci U S A (2008) 1.19
Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia. J Biol Chem (2006) 1.19
Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide. Angew Chem Int Ed Engl (2004) 1.19
Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proc Natl Acad Sci U S A (2006) 1.18
Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex. Biochemistry (2008) 1.17
Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo. Dev Cell (2011) 1.14
Crystal structures representing the Michaelis complex and the thiouronium reaction intermediate of Pseudomonas aeruginosa arginine deiminase. J Biol Chem (2005) 1.13
Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery. Biomaterials (2012) 1.13
Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure. Structure (2005) 1.11
Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase. Biochemistry (2008) 1.11
The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex. Biochemistry (2002) 1.09
Kinetic, Raman, NMR, and site-directed mutagenesis studies of the Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase active site. Biochemistry (2002) 1.09
Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials (2012) 1.09
The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase. Biochemistry (2009) 1.07
Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase. J Am Chem Soc (2005) 1.05
Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis. Biochemistry (2005) 1.05
Mechanism of plasmid delivery by hydrodynamic tail vein injection. II. Morphological studies. J Gene Med (2006) 1.04
Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase. J Am Chem Soc (2012) 1.04
Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis. Biochemistry (2009) 1.04
Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase. Biochemistry (2011) 1.03
Engineering encodable lanthanide-binding tags into loop regions of proteins. J Am Chem Soc (2011) 1.02
The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway. J Bacteriol (2002) 1.02
Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function. Biochemistry (2006) 1.02
Characterization of the 4-hydroxybenzoyl-coenzyme A thioesterase from Arthrobacter sp. strain SU. Appl Environ Microbiol (2003) 1.01
Solution structure of Alg13: the sugar donor subunit of a yeast N-acetylglucosamine transferase. Structure (2008) 1.00
Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) . Biochemistry (2010) 1.00
Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. FASEB J (2008) 1.00
The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family. Biochemistry (2009) 1.00
Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members. J Biol Chem (2008) 0.99
Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily. Biochemistry (2004) 0.99
Crystal structure of human thioesterase superfamily member 2. Biochem Biophys Res Commun (2006) 0.99
Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Org Lett (2010) 0.99
Oxaloacetate hydrolase, the C-C bond lyase of oxalate secreting fungi. J Biol Chem (2007) 0.99
Evaluation of hydrodynamic limb vein injections in nonhuman primates. Hum Gene Ther (2010) 0.98
Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5. Oncotarget (2013) 0.97
Double-lanthanide-binding tags: design, photophysical properties, and NMR applications. J Am Chem Soc (2007) 0.97
Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate. Biochemistry (2006) 0.97
X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry (2004) 0.97
Adjuvant therapy for hepatocellular carcinoma: current situation and prospect. Drug Discov Ther (2013) 0.97
Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase. Biochemistry (2009) 0.97
The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin. Pigment Cell Melanoma Res (2010) 0.97
The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis. FEBS Lett (2002) 0.97
Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. J Cell Biol (2012) 0.96
Double-lanthanide-binding tags for macromolecular crystallographic structure determination. J Am Chem Soc (2007) 0.95
Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase. Protein Sci (2002) 0.95
Manipulating the power of an additional phase: a flower-like Au-Fe3O4 optical nanosensor for imaging protease expressions in vivo. ACS Nano (2011) 0.95
In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. Biochemistry (2006) 0.95
The phosphonopyruvate decarboxylase from Bacteroides fragilis. J Biol Chem (2003) 0.94