Published in J Immunol on June 01, 2008
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol (2009) 1.70
Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. Aeruginosa infection. PLoS One (2009) 1.31
Inhibitor and activator: dual functions for SHIP in immunity and cancer. Ann N Y Acad Sci (2010) 1.25
Intraphagosomal measurement of the magnitude and duration of the oxidative burst. Traffic (2009) 1.22
Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane. J Virol (2011) 1.18
Inositol polyphosphate 5-phosphatase7 regulates the production of reactive oxygen species and salt tolerance in Arabidopsis. Plant Physiol (2011) 0.92
p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation. J Biol Chem (2010) 0.90
Translocation or just location? Pseudopodia affect fluorescent signals. J Cell Biol (2009) 0.88
Biochemistry of the phagosome: the challenge to study a transient organelle. ScientificWorldJournal (2011) 0.87
Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis. Arch Biochem Biophys (2011) 0.86
New insights into the regulation of neutrophil NADPH oxidase activity in the phagosome: a focus on the role of lipid and Ca(2+) signaling. Antioxid Redox Signal (2012) 0.85
Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities. Front Immunol (2012) 0.82
Transient increase in cyclic AMP localized to macrophage phagosomes. PLoS One (2010) 0.81
IgE cross-linking critically impairs human monocyte function by blocking phagocytosis. J Allergy Clin Immunol (2013) 0.76
Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis. Commun Integr Biol (2016) 0.75
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (2002) 18.89
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell (1990) 9.60
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature (1998) 7.92
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science (1993) 7.86
NADPH oxidase: an update. Blood (1999) 7.65
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J (2000) 7.48
Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools. J Cell Biol (1998) 6.70
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature (1988) 5.88
A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J Cell Biol (1996) 5.52
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol (2000) 3.63
Fluorescence resonance energy transfer-based stoichiometry in living cells. Biophys J (2002) 3.46
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev (1998) 3.40
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J (1995) 3.19
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem (1994) 3.08
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol (2005) 2.97
Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. J Exp Med (1989) 2.74
PI-loting membrane traffic. Nat Cell Biol (2004) 2.71
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis. Mol Biol Cell (2004) 2.49
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol (2001) 2.45
Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J Biol Chem (1999) 2.43
SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity (1998) 2.39
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
Molecular basis of phosphorylation-induced activation of the NADPH oxidase. Cell (2003) 2.31
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J (1998) 2.29
Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J Cell Biol (2001) 2.28
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase. Proc Natl Acad Sci U S A (1994) 2.25
The uniformity of phagosome maturation in macrophages. J Cell Biol (2004) 2.13
Alterations in the protein composition of maturing phagosomes. J Clin Invest (1992) 2.07
Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane. J Immunol (2001) 2.04
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med (2006) 2.03
Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med (2006) 2.01
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. Proc Natl Acad Sci U S A (1994) 1.92
Human VPS34 and p150 are Rab7 interacting partners. Traffic (2003) 1.86
Plasticity of the tubular lysosomal compartment in macrophages. J Cell Sci (1990) 1.66
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell (2003) 1.59
Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells. Curr Biol (1994) 1.55
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol (2001) 1.49
A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med (2000) 1.42
The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558). J Biol Chem (1999) 1.36
Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med (2000) 1.34
Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes. Mol Biol Cell (2007) 1.28
Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells. J Biol Chem (2001) 1.27
Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct from mannose 6-phosphate receptor/gamma-adaptin vesicles at the trans-Golgi network. J Biol Chem (1998) 1.24
PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation. EMBO J (2006) 1.22
A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18). J Exp Med (2001) 1.20
Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif. Mol Cell Biol (1997) 1.06
Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori. J Leukoc Biol (2005) 1.01
Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells. J Immunol (2002) 0.94
Simultaneous presence of p47(phox) and flavocytochrome b-245 are required for the activation of NADPH oxidase by anionic amphiphiles. Evidence for an intermediate state of oxidase activation. J Biol Chem (1999) 0.94
FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways. Blood (2006) 0.89
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Biochem Biophys Res Commun (1996) 0.88
The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. Blood (2005) 0.87
Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation. FEBS Lett (1998) 0.81
Fluorescence resonance energy transfer-based stoichiometry in living cells. Biophys J (2002) 3.46
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities. Adv Drug Deliv Rev (2003) 3.25
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature (2011) 2.93
Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis. Mol Biol Cell (2004) 2.49
A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis. PLoS Biol (2006) 2.37
pH-dependent regulation of lysosomal calcium in macrophages. J Cell Sci (2002) 2.32
The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. J Cell Biol (2002) 2.29
The uniformity of phagosome maturation in macrophages. J Cell Biol (2004) 2.13
Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells. J Cell Biol (2007) 2.08
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog (2009) 1.99
Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. Blood (2012) 1.80
Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. Blood (2004) 1.73
Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion. PLoS One (2008) 1.67
Phosphoinositide-3-kinase-independent contractile activities associated with Fcgamma-receptor-mediated phagocytosis and macropinocytosis in macrophages. J Cell Sci (2003) 1.67
The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokines. Clin Cancer Res (2007) 1.66
Interleukin-21 enhances NK cell activation in response to antibody-coated targets. J Immunol (2006) 1.58
MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One (2009) 1.55
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals. Cancer Cell (2012) 1.52
The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. Am J Respir Cell Mol Biol (2006) 1.52
Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. Blood (2007) 1.51
Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains. Biochemistry (2005) 1.50
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol (2008) 1.49
Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice. J Immunol (2006) 1.48
miR-155 regulates IFN-γ production in natural killer cells. Blood (2012) 1.47
Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuoles. Cell Microbiol (2006) 1.41
Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes. Cell Microbiol (2006) 1.39
Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP. PLoS Pathog (2006) 1.38
Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther (2007) 1.38
Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages. Mol Biol Cell (2002) 1.36
Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells. Cancer Res (2006) 1.32
The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol (2004) 1.31
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. J Clin Invest (2011) 1.30
Determination of the physical environment within the Chlamydia trachomatis inclusion using ion-selective ratiometric probes. Cell Microbiol (2002) 1.29
Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages. J Cell Sci (2009) 1.28
Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes. Mol Biol Cell (2007) 1.28
Activation of nuclear factor of activated T cells by human T-lymphotropic virus type 1 accessory protein p12(I). J Virol (2002) 1.27
Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. Blood (2008) 1.26
The role of the activated macrophage in clearing Listeria monocytogenes infection. Front Biosci (2007) 1.26
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood (2009) 1.25
Francisella tularensis induces IL-23 production in human monocytes. J Immunol (2007) 1.24
Localized reactive oxygen and nitrogen intermediates inhibit escape of Listeria monocytogenes from vacuoles in activated macrophages. J Immunol (2003) 1.24
Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties. J Immunol (2013) 1.18
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. J Biol Chem (2004) 1.18
Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. J Immunol (2004) 1.17
A FRET analysis to unravel the role of cholesterol in Rac1 and PI 3-kinase activation in the InlB/Met signalling pathway. Cell Microbiol (2006) 1.13
The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem (2003) 1.12
A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis. Mol Biol Cell (2009) 1.11
Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med (2009) 1.10
The role of ROS and RNS in regulating life and death of blood monocytes. Curr Pharm Des (2004) 1.06
Calcium spikes in activated macrophages during Fcgamma receptor-mediated phagocytosis. J Leukoc Biol (2002) 1.05
The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk. Mol Immunol (2008) 1.04
Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position. J Biol Chem (2006) 1.04
Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response. Mol Immunol (2008) 1.04
Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis. Proc Natl Acad Sci U S A (2010) 1.03
C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling. Am J Physiol Heart Circ Physiol (2005) 1.03
Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt. Mol Immunol (2005) 0.99
Three-dimensional FRET reconstruction microscopy for analysis of dynamic molecular interactions in live cells. Biophys J (2008) 0.98
C-reactive protein induces signaling through Fc gamma RIIa on HL-60 granulocytes. J Immunol (2002) 0.98
Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection. Thromb Haemost (2006) 0.97
Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism. J Immunol (2011) 0.97
Technical advance: Caspase-1 activation and IL-1β release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage. J Leukoc Biol (2010) 0.96
MiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis. Front Cell Infect Microbiol (2012) 0.96
Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy. Clin Cancer Res (2010) 0.96
Molecular analysis of expression and function of hFcgammaRIIbl and b2 isoforms in myeloid cells. Mol Immunol (2005) 0.95
Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway. PLoS One (2009) 0.95
Francisella tularensis regulates autophagy-related host cell signaling pathways. Autophagy (2009) 0.95
The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia. Br J Haematol (2009) 0.95
Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysin. Cell Microbiol (2007) 0.94
Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine. Antimicrob Agents Chemother (2005) 0.93
Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12. Cancer Res (2005) 0.93
Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome. Proc Natl Acad Sci U S A (2011) 0.92
SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling. J Immunol (2004) 0.91
Fcgamma receptor signaling in phagocytes. Int J Hematol (2006) 0.91
N-way FRET microscopy of multiple protein-protein interactions in live cells. PLoS One (2013) 0.91
Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response. Curr Pharm Des (2006) 0.91
FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways. Blood (2006) 0.89
Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties. J Pharmacol Exp Ther (2006) 0.89
Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt. Front Microbiol (2011) 0.88
A growth factor signaling cascade confined to circular ruffles in macrophages. Biol Open (2012) 0.88
Coordination of the Rab5 cycle on macropinosomes. Traffic (2011) 0.88
The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells. J Biol Chem (2003) 0.88
The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. Blood (2005) 0.87
Toll-like receptor 2 ligands regulate monocyte Fcγ receptor expression and function. J Biol Chem (2013) 0.87
An NF-κB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium. Toxicol Sci (2011) 0.86
Ruffles limit diffusion in the plasma membrane during macropinosome formation. J Cell Sci (2011) 0.86
Live cell fluorescence microscopy to study microbial pathogenesis. Cell Microbiol (2009) 0.85
Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium. Biochem Biophys Res Commun (2011) 0.85
SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. J Biol Chem (2003) 0.84
Two-photon imaging of multiple fluorescent proteins by phase-shaping and linear unmixing with a single broadband laser. Opt Express (2013) 0.84
IFNgamma enhances IL-23 production during Francisella infection of human monocytes. FEBS Lett (2008) 0.82
The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma. PLoS One (2009) 0.82
Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages. J Immunol (2012) 0.81
LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis. PLoS One (2011) 0.81
Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion. Infect Immun (2007) 0.81
Transient increase in cyclic AMP localized to macrophage phagosomes. PLoS One (2010) 0.81
Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1β. J Biol Chem (2012) 0.79