Published in J Exp Med on July 31, 2006
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A (2014) 2.86
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. Blood (2009) 2.35
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med (2006) 2.03
Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol (2008) 1.81
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal (2009) 1.71
Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest (2007) 1.47
Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity. Antioxid Redox Signal (2012) 1.46
AHR-mediated immunomodulation: the role of altered gene transcription. Biochem Pharmacol (2008) 1.46
Redox control of renal function and hypertension. Antioxid Redox Signal (2008) 1.45
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood (2009) 1.34
Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus. MBio (2013) 1.26
PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation. EMBO J (2006) 1.22
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol (2007) 1.17
Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus. Infect Immun (2008) 1.15
A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox. Mol Biol Cell (2006) 1.14
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase. J Biol Chem (2007) 1.09
The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther (2009) 1.04
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases. Antioxid Redox Signal (2009) 1.01
Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice. Am J Pathol (2008) 0.98
SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages. J Immunol (2008) 0.97
Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases. Biochim Biophys Acta (2013) 0.97
Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. EMBO J (2007) 0.96
PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils. J Cell Sci (2011) 0.93
Neutrophil-Mediated Phagocytosis of Staphylococcus aureus. Front Immunol (2014) 0.93
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia. Blood (2011) 0.92
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2010) 0.91
p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol (2012) 0.91
p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation. J Biol Chem (2010) 0.90
Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2. J Leukoc Biol (2012) 0.88
A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis. Mol Biol Cell (2009) 0.87
Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity (2011) 0.87
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production. Eur J Immunol (2011) 0.86
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase. Blood (2010) 0.86
Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer. Int J Cancer (2013) 0.84
Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun (2012) 0.84
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol (2008) 0.84
A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase. J Biol Chem (2010) 0.82
Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. J Biol Chem (2014) 0.81
Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin. Int J Biochem Cell Biol (2010) 0.80
Intracellular killing of bacteria: is Dictyostelium a model macrophage or an alien? Cell Microbiol (2014) 0.77
The role of autophagy in Crohn's disease. Cells (2012) 0.76
Animal models of human granulocyte diseases. Hematol Oncol Clin North Am (2012) 0.76
Role of an SNP in Alternative Splicing of Bovine NCF4 and Mastitis Susceptibility. PLoS One (2015) 0.75
PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation. J Immunol (2016) 0.75
Extracellular Superoxide Dismutase Enhances Recruitment of Immature Neutrophils to the Liver. Infect Immun (2016) 0.75
NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol (2004) 12.93
Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature (2002) 7.53
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38
Redox redux: revisiting PTPs and the control of cell signaling. Cell (2005) 5.10
Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood (1998) 5.02
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest (1987) 4.80
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64
The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med (1995) 4.25
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell (2002) 3.80
Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J Cell Biol (1989) 3.68
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol (2001) 3.63
Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59
Syk is required for integrin signaling in neutrophils. Immunity (2002) 3.39
Primate defensins. Nat Rev Microbiol (2004) 3.29
Chronic granulomatous disease. Curr Opin Immunol (2003) 3.24
Respiratory burst in human neutrophils. J Immunol Methods (1999) 3.16
A requirement for phosphatidylinositol 3-kinase in pseudopod extension. J Biol Chem (1999) 3.08
Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J (2005) 3.02
Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol (1996) 2.96
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J Leukoc Biol (2004) 2.51
The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem (2004) 2.48
Phagocytosis and innate immunity. Curr Opin Immunol (2002) 2.47
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems. Biochim Biophys Acta (2004) 2.39
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry (2002) 2.31
Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. EMBO J (2002) 2.09
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med (2006) 2.03
Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation. J Leukoc Biol (2005) 1.94
CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation. J Cell Biol (1994) 1.89
PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol Cell (2003) 1.78
Anti-opsonic properties of staphylokinase. Microbes Infect (2005) 1.69
Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions. EMBO J (2001) 1.69
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains. Biochem J (1993) 1.68
Differences in oxygen metabolism of phagocytosing monocytes and neutrophils. J Clin Invest (1978) 1.66
Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst. J Immunol (2001) 1.64
Two transduction sequences are necessary for neutrophil activation by receptor agonists. J Biol Chem (1988) 1.62
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell (2003) 1.59
Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation. Proc Natl Acad Sci U S A (2003) 1.59
The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals. J Biol Chem (1984) 1.57
Dual role of phagocytic NADPH oxidase in bacterial killing. Blood (2004) 1.56
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol (2001) 1.49
The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase. EMBO J (2002) 1.41
How do neutrophils and pathogens interact? Curr Opin Microbiol (2004) 1.40
Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox. J Biol Chem (2002) 1.36
The molecular basis of chronic granulomatous disease. Springer Semin Immunopathol (1998) 1.33
Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox. Biochem J (1996) 1.29
Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. J Cell Sci (1997) 1.29
p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. J Biol Chem (1998) 1.24
Regulation of neutrophil function by Rac GTPases. Curr Opin Hematol (2003) 1.23
Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency. J Biol Chem (2001) 1.23
The PX domain as a novel phosphoinositide- binding module. Biochem Biophys Res Commun (2001) 1.22
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. Biochem J (1998) 1.17
Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. J Biol Chem (2004) 1.12
The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. Biochem Biophys Res Commun (2001) 1.12
Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. J Biol Chem (2002) 1.12
Purification of the 260 kDa cytosolic complex involved in the superoxide production of guinea pig neutrophils. FEBS Lett (1993) 1.12
Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system. J Biol Chem (1995) 1.11
A novel cytosolic component, p40phox, of respiratory burst oxidase associates with p67phox and is absent in patients with chronic granulomatous disease who lack p67phox. Biochem Biophys Res Commun (1994) 1.10
Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts. J Biol Chem (2005) 1.09
Involvement of p40phox in activation of phagocyte NADPH oxidase through association of its carboxyl-terminal, but not its amino-terminal, with p67phox. J Exp Med (1996) 1.08
p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain. J Biol Chem (1997) 1.08
Functional modules and expression of mouse p40(phox) and p67(phox), SH3-domain-containing proteins involved in the phagocyte NADPH oxidase complex. Eur J Biochem (1998) 1.08
Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt. Biochem Biophys Res Commun (2004) 1.07
Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals. J Immunol (2004) 1.06
Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region. Biochemistry (2003) 1.06
The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. J Immunol (2003) 1.05
Phosphorylated p40PHOX as a negative regulator of NADPH oxidase. Biochemistry (2004) 1.02
p40(phox) Participates in the activation of NADPH oxidase by increasing the affinity of p47(phox) for flavocytochrome b(558). Biochem J (2000) 0.99
Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. J Immunol (2004) 0.99
Phosphorylation of p40-phox during activation of neutrophil NADPH oxidase. J Leukoc Biol (1999) 0.95
The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. Immunology (2004) 0.91
Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system. Immunol Lett (1999) 0.90
Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking". J Biol Chem (1998) 0.87
TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor. J Immunol (1995) 0.85
The Ku70 autoantigen interacts with p40phox in B lymphocytes. J Cell Sci (1999) 0.79
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell (2002) 3.80
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry. Nat Methods (2011) 2.56
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism. Mol Cell (2011) 2.50
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Lett (2003) 2.11
P-Rex1 regulates neutrophil function. Curr Biol (2005) 1.97
PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal (2011) 1.95
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol (2006) 1.76
The PX domain: a new phosphoinositide-binding module. J Cell Sci (2002) 1.60
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. J Biol Chem (2004) 1.49
p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Curr Biol (2005) 1.43
P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett (2004) 1.33
SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor. PLoS One (2011) 1.28
The molecular basis of the differential subcellular localization of FYVE domains. J Biol Chem (2004) 1.23
The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. Blood (2011) 1.23
PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation. EMBO J (2006) 1.22
ARAP3 is a PI3K- and rap-regulated GAP for RhoA. Curr Biol (2004) 1.15
PI3K class IB pathway in neutrophils. Sci STKE (2007) 1.11
PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis. Science (2007) 1.10
ARAP3 is essential for formation of lamellipodia after growth factor stimulation. J Cell Sci (2006) 1.09
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A (2013) 1.07
Two distinct functions for PI3-kinases in macropinocytosis. J Cell Sci (2013) 1.03
Co-occurrence of the West European (Gr.III) and North American (Gr.I) ribotypes of Alexandrium tamarense (Dinophyceae) in Shetland, Scotland. Protist (2010) 1.03
Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. J Immunol (2002) 1.03
PI3K signaling in neutrophils. Curr Top Microbiol Immunol (2010) 1.02
The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase. Adv Enzyme Regul (2004) 1.02
The development of an evaluation framework for injury surveillance systems. BMC Public Health (2009) 1.00
The relationship between phytoplankton distribution and water column characteristics in North West European shelf sea waters. PLoS One (2012) 1.00
LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin. J Biol Chem (2002) 0.99
Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol (2011) 0.98
Synthesis of knowledge on marine biodiversity in European Seas: from census to sustainable management. PLoS One (2013) 0.97
Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival. PLoS One (2012) 0.97
Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate. Methods Enzymol (2007) 0.96
Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse. PLoS One (2013) 0.95
Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits. Biochem J (2002) 0.93
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. EMBO J (2012) 0.92
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2010) 0.91
Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach. J Lipid Res (2006) 0.91
RhoG regulates the neutrophil NADPH oxidase. J Immunol (2006) 0.89
The role of PI3Ks in the regulation of the neutrophil NADPH oxidase. Biochem Soc Symp (2007) 0.89
Structural determinants of LL5beta subcellular localisation and association with filamin C. Cell Signal (2006) 0.86
PI3K class IB pathway. Sci STKE (2007) 0.86
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase. Blood (2010) 0.86
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes. Org Biomol Chem (2009) 0.85
Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus. Ann N Y Acad Sci (2012) 0.82
The phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice. Arthritis Rheumatol (2014) 0.81
Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3. J Immunol (2012) 0.80
The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation. FEBS J (2014) 0.80
Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines. PLoS One (2013) 0.78
Purification of ARAP3 and characterization of GAP activities. Methods Enzymol (2006) 0.77
3D time series analysis of cell shape using Laplacian approaches. BMC Bioinformatics (2013) 0.76