Published in Sci Signal on May 20, 2008
FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer (2014) 2.46
FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer (2009) 1.35
Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest (2009) 1.22
Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci (Landmark Ed) (2010) 1.20
Focal adhesion kinase as a cancer therapy target. Anticancer Agents Med Chem (2010) 1.19
Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics. Sci Signal (2013) 1.10
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Mol Cancer Ther (2012) 1.10
Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem (2009) 1.10
FAK and p53 protein interactions. Anticancer Agents Med Chem (2011) 1.09
FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PLoS One (2011) 1.04
Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol Carcinog (2009) 0.99
Targeting FAK in human cancer: from finding to first clinical trials. Front Biosci (Landmark Ed) (2014) 0.99
MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells. Anticancer Agents Med Chem (2014) 0.97
Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array. BMC Genomics (2009) 0.97
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer (2013) 0.96
FAK dimerization controls its kinase-dependent functions at focal adhesions. EMBO J (2014) 0.93
Dentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells. J Biol Chem (2011) 0.93
Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem (2012) 0.91
Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes. J Neurochem (2010) 0.87
In oral squamous cell carcinoma, high FAK expression is correlated with low P53 expression. Virchows Arch (2012) 0.86
Targeting the p53 pathway. Surg Oncol Clin N Am (2013) 0.82
FAK and Nanog cross talk with p53 in cancer stem cells. Anticancer Agents Med Chem (2013) 0.82
A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem (2013) 0.81
Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma. Int J Mol Sci (2017) 0.80
Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights. J Histochem Cytochem (2014) 0.79
NANOG: a promising target for digestive malignant tumors. World J Gastroenterol (2014) 0.79
Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells. Anticancer Agents Med Chem (2014) 0.78
High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer (2014) 0.78
Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex. Cancers (Basel) (2014) 0.76
Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis. PLoS One (2016) 0.75
FAK signalling controls insulin sensitivity through regulation of adipocyte survival. Nat Commun (2017) 0.75
Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices. Sci Rep (2017) 0.75
Phosphotyrosine profiling of curcumin-induced signaling. Clin Proteomics (2016) 0.75
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science (2004) 9.52
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A (1992) 8.46
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity (1998) 7.35
FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol (2000) 6.54
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell (1995) 5.73
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res (1995) 3.38
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res (2000) 3.03
The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem (2000) 2.17
Expression of focal adhesion kinase gene and invasive cancer. Lancet (1993) 1.93
Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann Surg Oncol (1996) 1.87
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem (2005) 1.83
Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem (2002) 1.82
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol (2004) 1.79
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol (2006) 1.76
Focal adhesion kinase and p53 signaling in cancer cells. Int Rev Cytol (2007) 1.64
Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin Cancer Res (2003) 1.61
Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites. Biochim Biophys Acta (2004) 1.60
p53 regulates FAK expression in human tumor cells. Mol Carcinog (2008) 1.52
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat (2004) 1.49
PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. J Biol Chem (2003) 1.32
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res (2006) 1.31
Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. Biochem J (2003) 1.25
Cytoplasmic p53: bax and forward. Cell Cycle (2004) 1.21
Loss of focal adhesion kinase (FAK) inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells. Cancer Res (2001) 1.15
Nuclear localization and apoptotic regulation of an amino-terminal domain focal adhesion kinase fragment in endothelial cells. Biochem Biophys Res Commun (2000) 1.08
The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning. Biochem J (2008) 1.04
Nuclear import of N-terminal FAK by activation of the FcepsilonRI receptor in RBL-2H3 cells. Biochem Biophys Res Commun (2004) 0.85
Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle (2010) 2.67
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle (2009) 1.79
Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo. Cell Cycle (2009) 1.61
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis (2008) 1.43
N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem (2007) 1.41
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res (2006) 1.31
Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res (2005) 1.24
Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses. Clin Cancer Res (2008) 1.03
Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Mol Carcinog (2010) 1.01
MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells. Anticancer Agents Med Chem (2014) 0.97
Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer (2013) 0.96
Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B. Life Sci (2009) 0.95
Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem (2012) 0.91
TAE226 inhibits human neuroblastoma cell survival. Cancer Invest (2008) 0.91
Evolving therapies and FAK inhibitors for the treatment of cancer. Anticancer Agents Med Chem (2010) 0.90
FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes. Anticancer Agents Med Chem (2013) 0.89
Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. Cancer Biol Ther (2013) 0.89
Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis. Anticancer Agents Med Chem (2011) 0.88
Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate. Mol Biol Cell (2011) 0.88
Targeting focal adhesion kinase in cancer-part I. Anticancer Agents Med Chem (2010) 0.82
The prognostic significance of focal adhesion kinase expression in stage I non-small-cell lung cancer. J Thorac Oncol (2014) 0.78
Editorial: Focal adhesion kinase signaling in cancer--Part II. Anticancer Agents Med Chem (2011) 0.75
Survival signaling through focal adhesion kinase in tumors. Anticancer Agents Med Chem (2013) 0.75