Published in Cell Cycle on August 01, 2009
Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle (2010) 2.67
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy. Nat Med (2016) 2.27
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal (2016) 1.38
Focal adhesion kinase as a cancer therapy target. Anticancer Agents Med Chem (2010) 1.19
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Mol Cancer Ther (2012) 1.10
Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin. Diabetes (2011) 1.03
Targeting FAK in human cancer: from finding to first clinical trials. Front Biosci (Landmark Ed) (2014) 0.99
MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells. Anticancer Agents Med Chem (2014) 0.97
A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Mol Carcinog (2010) 0.95
Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1. J Biol Chem (2011) 0.94
Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway. Br J Cancer (2013) 0.94
β1 integrin: an emerging player in the modulation of tumorigenesis and response to therapy. Cell Adh Migr (2012) 0.94
Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem (2012) 0.91
Evolving therapies and FAK inhibitors for the treatment of cancer. Anticancer Agents Med Chem (2010) 0.90
Emerging roles of focal adhesion kinase in cancer. Biomed Res Int (2015) 0.90
Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. Cancer Biol Ther (2013) 0.89
Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle (2012) 0.89
Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion. J Biol Chem (2011) 0.89
Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells. Lab Invest (2016) 0.87
The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. Oncotarget (2013) 0.86
A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle (2014) 0.86
FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells. PLoS One (2011) 0.85
Angiopoietin-like 3 induces podocyte F-actin rearrangement through integrin α(V)β₃/FAK/PI3K pathway-mediated Rac1 activation. Biomed Res Int (2013) 0.84
The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide. Anticancer Agents Med Chem (2014) 0.83
FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo. Transl Oncol (2013) 0.83
FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res (2014) 0.82
Targeting the p53 pathway. Surg Oncol Clin N Am (2013) 0.82
3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling. Oncotarget (2015) 0.82
FAK and Nanog cross talk with p53 in cancer stem cells. Anticancer Agents Med Chem (2013) 0.82
Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine Tumors. J Natl Cancer Inst (2015) 0.82
Focal adhesion kinase overexpression and its impact on human osteosarcoma. Oncotarget (2015) 0.82
In vitro activities of hexaazatrinaphthylenes against Leishmania spp. Antimicrob Agents Chemother (2015) 0.81
Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. Oncotarget (2015) 0.81
Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.). J Mol Cell Cardiol (2013) 0.81
Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities. Anticancer Agents Med Chem (2013) 0.81
Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses. J Virol (2014) 0.80
Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells. Invest Ophthalmol Vis Sci (2013) 0.80
Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15. J Cancer Res Clin Oncol (2015) 0.80
Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles. J Oncol (2010) 0.79
Inhibition of cell-matrix adhesions prevents cartilage chondrocyte death following impact injury. J Orthop Res (2013) 0.79
Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells. PLoS One (2013) 0.79
Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights. J Histochem Cytochem (2014) 0.79
Extracellular pressure stimulates adhesion of sarcoma cells via activation of focal adhesion kinase and Akt. Am J Surg (2010) 0.79
Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. J Biol Chem (2015) 0.79
High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer (2014) 0.78
FAK and paxillin, two potential targets in pancreatic cancer. Oncotarget (2016) 0.78
Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience (2015) 0.77
Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways. Br J Cancer (2016) 0.77
AURKA promotes cell migration and invasion of head and neck squamous cell carcinoma through regulation of the AURKA/Akt/FAK signaling pathway. Oncol Lett (2016) 0.76
A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network. BMC Syst Biol (2012) 0.75
Addressing the functional determinants of FAK during ciliogenesis in multiciliated cells. J Biol Chem (2016) 0.75
Aurora kinase A revives dormant laryngeal squamous cell carcinoma cells via FAK/PI3K/Akt pathway activation. Oncotarget (2016) 0.75
Targeting focal adhesion kinase in neuroblastoma. Anticancer Agents Med Chem (2010) 0.75
Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells. Transl Oncol (2016) 0.75
In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate. Mol Biol Cell (2017) 0.75
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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol (1994) 7.53
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Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther (2007) 1.97
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Res (2007) 1.90
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem (2005) 1.83
Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem (2002) 1.82
Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer. Genes Chromosomes Cancer (2002) 1.81
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog (2007) 1.74
Metastatic pancreatic cancer 2008: is the glass less empty? Oncologist (2008) 1.70
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p53 regulates FAK expression in human tumor cells. Mol Carcinog (2008) 1.52
Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer: results of secondary end points analyses. Br J Cancer (2008) 1.50
Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery (2004) 1.45
The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells. Cell Growth Differ (1998) 1.44
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis (2008) 1.43
TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Mol Carcinog (2008) 1.39
Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation]. J Med Chem (2005) 1.32
Impairment of mobility in endodermal cells by FAK deficiency. Exp Cell Res (1996) 1.22
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet (2013) 10.66
Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle (2010) 2.67
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem (2008) 2.31
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest (2008) 2.15
Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer (2006) 2.04
Clinical short-term results of radiofrequency ablation in liver cancers. World J Gastroenterol (2002) 2.04
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem (2005) 1.83
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol (2004) 1.79
The impact of assessing specimen adequacy and number of needle passes for fine-needle aspiration biopsy of thyroid nodules. Thyroid (2006) 1.76
SDF-1alpha/CXCR4: a mechanism for hepatic oval cell activation and bone marrow stem cell recruitment to the injured liver of rats. Cloning Stem Cells (2002) 1.71
HAIRY-like transcription factors and the evolution of the nematode vulva equivalence group. Curr Biol (2006) 1.69
Focal adhesion kinase and p53 signaling in cancer cells. Int Rev Cytol (2007) 1.64
A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Biol Ther (2008) 1.62
Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo. Cell Cycle (2009) 1.61
Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin Cancer Res (2003) 1.61
Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomas. Ann Surg Oncol (2006) 1.61
An epididymis-specific beta-defensin is important for the initiation of sperm maturation. Nat Cell Biol (2004) 1.56
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Gastroenterology (2007) 1.54
p53 regulates FAK expression in human tumor cells. Mol Carcinog (2008) 1.52
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat (2004) 1.49
Focal adhesion kinase and cancer. Histol Histopathol (2009) 1.46
Assessment of Clostridium difficile infections by quantitative detection of tcdB toxin by use of a real-time cell analysis system. J Clin Microbiol (2010) 1.45
Noise contributions in an inducible genetic switch: a whole-cell simulation study. PLoS Comput Biol (2011) 1.44
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis (2008) 1.43
High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis. PLoS One (2012) 1.43
Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation. Exp Dermatol (2014) 1.42
Presentation and management of gastrointestinal stromal tumors of the duodenum. Am Surg (2006) 1.42
N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem (2007) 1.41
TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Mol Carcinog (2008) 1.39
Focal adhesion kinase versus p53: apoptosis or survival? Sci Signal (2008) 1.36
Retroperitoneal soft tissue sarcoma. Cancer (2005) 1.35
Firefly luciferase mutants as sensors of proteome stress. Nat Methods (2011) 1.35
FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer (2009) 1.35
Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. Arch Gynecol Obstet (2014) 1.35
Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. Clin Cancer Res (2010) 1.34
Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Mol Cancer Res (2003) 1.32
Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. PLoS One (2012) 1.31
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res (2006) 1.31
Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Res (2009) 1.27
Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. Biochem J (2003) 1.25
Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res (2005) 1.24
Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression. Cancer Res (2006) 1.20
Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell Res (2011) 1.20
Extracapsular extension of the sentinel lymph node metastasis: a predictor of nonsentinel node tumor burden. Ann Surg (2003) 1.19
The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. Carcinogenesis (2008) 1.17
Is there a role for routine use of MRI in selection of patients for breast-conserving cancer therapy? J Am Coll Surg (2008) 1.13
Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem (2009) 1.11
Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Mol Cancer Ther (2012) 1.10
Perceptions of diagnostic terminology and cytopathologic reporting of fine-needle aspiration biopsies of thyroid nodules: a survey of clinicians and pathologists. Thyroid (2006) 1.09
Identification of a gene-expression signature for predicting lymph node metastasis in patients with early stage cervical carcinoma. Cancer (2011) 1.09
Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis. Mol Med (2006) 1.09
A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review). Oncol Lett (2013) 1.09
FAK and p53 protein interactions. Anticancer Agents Med Chem (2011) 1.09
Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma. Oral Oncol (2010) 1.07
Molecular and morphologic distinctions between infiltrating ductal and lobular carcinoma of the breast. Breast J (2007) 1.07
Uterine-like mass with features of an extrauterine adenomyoma presenting 22 years after total abdominal hysterectomy-bilateral salpingo-oophorectomy: a case report and review of the literature. Arch Pathol Lab Med (2005) 1.06
Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease. World J Gastroenterol (2002) 1.06
Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. J Biol Chem (2011) 1.04
The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning. Biochem J (2008) 1.04
Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss. Am J Physiol Endocrinol Metab (2007) 1.03
Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses. Clin Cancer Res (2008) 1.03
Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen. Mol Vis (2012) 1.03
T cell-mediated hypersensitivity reactions to drugs. Annu Rev Med (2014) 1.03
Determinants that control the specific interactions between TAB1 and p38alpha. Mol Cell Biol (2006) 1.02
Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma. Oral Oncol (2010) 1.02
Immune responses of pigs inoculated with a recombinant fowlpox virus coexpressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL-18. Vaccine (2007) 1.02
Highly luminescent S, N co-doped graphene quantum dots with broad visible absorption bands for visible light photocatalysts. Nanoscale (2013) 1.02
Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med (2012) 1.02
Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol (2013) 1.01
Characterization of purified New Delhi metallo-β-lactamase-1. Biochemistry (2011) 1.01
Coexpression of hypoxia-inducible factor-2α, TWIST2, and SIP1 may correlate with invasion and metastasis of salivary adenoid cystic carcinoma. J Oral Pathol Med (2011) 1.01
SAG/ROC2/RBX2 E3 ligase promotes UVB-induced skin hyperplasia, but not skin tumors, by simultaneously targeting c-Jun/AP-1 and p27. Carcinogenesis (2008) 1.01
An epididymis-specific secretory protein HongrES1 critically regulates sperm capacitation and male fertility. PLoS One (2008) 1.01
Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Mol Carcinog (2010) 1.01
Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities. J Pharmacol Exp Ther (2012) 1.01
Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. Mol Cancer Ther (2008) 1.00
The herpes simplex virus-1 transactivator infected cell protein-4 drives VEGF-A dependent neovascularization. PLoS Pathog (2011) 1.00
Arabidopsis AUGMIN subunit8 is a microtubule plus-end binding protein that promotes microtubule reorientation in hypocotyls. Plant Cell (2013) 1.00
MicroRNAs, an active and versatile group in cancers. Int J Oral Sci (2011) 1.00
The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. BMC Cancer (2009) 0.99
A decade of tyrosine kinases: from gene discovery to therapeutics. Surg Oncol (2003) 0.99
Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol Carcinog (2009) 0.99