Published in PLoS One on August 24, 2011
FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer (2014) 2.46
A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling. Sci Signal (2014) 1.15
Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1. Mucosal Immunol (2013) 1.13
Digitoxin and its analogs as novel cancer therapeutics. Exp Hematol Oncol (2012) 1.06
Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation. PLoS One (2013) 0.99
Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages. PLoS Pathog (2014) 0.98
Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases. BMC Immunol (2012) 0.91
Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model. J Physiol (2016) 0.89
Activation of PKCβII by PMA facilitates enhanced epithelial wound repair through increased cell spreading and migration. PLoS One (2013) 0.83
Saccharomyces boulardii improves intestinal epithelial cell restitution by inhibiting αvβ5 integrin activation state. PLoS One (2012) 0.79
C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation. Mucosal Immunol (2014) 0.79
The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis. Am J Physiol Lung Cell Mol Physiol (2016) 0.78
FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique. Biol Open (2013) 0.78
Focal adhesion kinase knockdown modulates the response of human corneal epithelial cells to topographic cues. Acta Biomater (2012) 0.78
Early responses of vascular endothelial cells to topographic cues. Am J Physiol Cell Physiol (2013) 0.78
Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo. Immunity (2016) 0.77
Barrier protection via Toll-like receptor 2 signaling in porcine intestinal epithelial cells damaged by deoxynivalnol. Vet Res (2016) 0.77
Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in Macrophages. MBio (2016) 0.76
Phospholipid binding to the FAK catalytic domain impacts function. PLoS One (2017) 0.75
Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology (1990) 11.22
The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev (1993) 8.03
A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74
Focal adhesion kinase: the first ten years. J Cell Sci (2003) 6.83
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
Decision making by p53: life, death and cancer. Cell Death Differ (2003) 5.52
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell (2001) 4.32
Src family kinases, key regulators of signal transduction. Oncogene (2004) 4.30
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol (1995) 4.26
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta (2001) 3.25
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron (2003) 2.86
Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. Am J Physiol Gastrointest Liver Physiol (2005) 2.80
Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene (2006) 2.57
New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J Cell Biochem (2006) 2.42
Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening. Curr Biol (2009) 2.37
Restoration of barrier function in injured intestinal mucosa. Physiol Rev (2007) 2.31
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell (2003) 2.09
Efficient colonic mucosal wound repair requires Trem2 signaling. Proc Natl Acad Sci U S A (2008) 1.93
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol (2008) 1.82
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell (2001) 1.75
Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One (2010) 1.70
Focal adhesion kinase and p53 signaling in cancer cells. Int Rev Cytol (2007) 1.64
Intestinal fibrosis in IBD--a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol (2009) 1.51
Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol (2006) 1.44
Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models. Am J Physiol Gastrointest Liver Physiol (2000) 1.43
Regulation of c-SRC activity and function by the adapter protein CAS. Mol Cell Biol (2000) 1.40
Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol (2007) 1.39
Focal adhesion kinase versus p53: apoptosis or survival? Sci Signal (2008) 1.36
Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice. Oncol Rep (2010) 1.27
B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis (2008) 1.22
Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma. Cancer Res (2009) 1.20
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1. J Biol Chem (2006) 1.18
Cellular localization of procollagen gene transcripts in inflammatory bowel diseases. Gastroenterology (1992) 1.17
Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. Am J Physiol Cell Physiol (2005) 1.16
The long-term outcome in Crohn's disease. Dis Colon Rectum (1987) 1.09
A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells. Oncogene (2005) 1.07
Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector. J Inflamm (Lond) (2005) 1.07
Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis. Oncogene (1989) 1.01
Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J (2006) 0.92
Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells. J Biol Chem (2001) 0.89
Progress in researches about focal adhesion kinase in gastrointestinal tract. World J Gastroenterol (2009) 0.84
Insulin stimulates secretion of a collagenase inhibitor by Swarm rat chondrosarcoma chondrocytes. Biochem Biophys Res Commun (1987) 0.79
Collagen IV regulates Caco-2 cell spreading and p130Cas phosphorylation by FAK-dependent and FAK-independent pathways. Biol Chem (2008) 0.78
Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem (2007) 3.87
Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nat Cell Biol (2007) 2.23
Pathways to tamoxifen resistance. Cancer Lett (2007) 2.12
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr Biol (2005) 1.82
Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Curr Biol (2010) 1.68
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther (2011) 1.61
The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr Biol (2006) 1.59
Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends Cell Biol (2008) 1.58
A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium. J Cell Biol (2007) 1.52
Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A (2011) 1.47
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci (2008) 1.36
Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer. Vitam Horm (2005) 1.33
Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. Cancer Res (2007) 1.33
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol Biol Cell (2003) 1.29
Mechanisms of Salmonella entry into host cells. Cell Microbiol (2007) 1.29
Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins. Proc Natl Acad Sci U S A (2009) 1.26
Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J Biol Chem (2003) 1.24
Regulation of dendritic development by the ARF exchange factor ARNO. Nat Neurosci (2002) 1.22
The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. Mol Cell Biol (2004) 1.22
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. J Cell Sci (2006) 1.21
Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway. J Cell Sci (2004) 1.15
A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. Cancer Res (2008) 1.10
WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium. J Biol Chem (2005) 1.09
Rab14 regulates apical targeting in polarized epithelial cells. Traffic (2008) 1.06
Cell adhesion promotes Ebola virus envelope glycoprotein-mediated binding and infection. J Virol (2008) 1.05
Coordinate regulation of Salmonella enterica serovar Typhimurium invasion of epithelial cells by the Arp2/3 complex and Rho GTPases. Infect Immun (2003) 1.03
Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways. Infect Immun (2005) 1.03
Interaction of the Salmonella-containing vacuole with the endocytic recycling system. J Biol Chem (2005) 1.02
Neuroendocrine dysfunction in polycystic ovary syndrome. Steroids (2011) 0.98
Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages. PLoS Pathog (2014) 0.98
Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication. J Virol (2010) 0.97
ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells. J Biol Chem (2006) 0.96
BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem (2009) 0.96
BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5). J Biol Chem (2012) 0.95
ARF6: a newly appreciated player in G protein-coupled receptor desensitization. FEBS Lett (2002) 0.95
Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas. Mol Biol Cell (2006) 0.95
Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake. J Cell Sci (2002) 0.94
A fluorescence resonance energy transfer activation sensor for Arf6. Anal Biochem (2007) 0.93
Abelson tyrosine kinase facilitates Salmonella enterica serovar Typhimurium entry into epithelial cells. Infect Immun (2008) 0.93
The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin. BMC Cell Biol (2003) 0.93
The differential expression of Yersinia pseudotuberculosis adhesins determines the requirement for FAK and/or Pyk2 during bacterial phagocytosis by macrophages. Cell Microbiol (2006) 0.91
Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Mol Cancer Res (2003) 0.91
Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events. J Leukoc Biol (2010) 0.90
Substrate specificities and activities of AZAP family Arf GAPs in vivo. Am J Physiol Cell Physiol (2007) 0.90
Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP. Curr Biol (2007) 0.89
Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. PLoS One (2013) 0.89
Arf6-GEF BRAG1 regulates JNK-mediated synaptic removal of GluA1-containing AMPA receptors: a new mechanism for nonsyndromic X-linked mental disorder. J Neurosci (2012) 0.88
Distinct mechanisms of integrin binding by Yersinia pseudotuberculosis adhesins determine the phagocytic response of host macrophages. Cell Microbiol (2005) 0.88
Regulation of osteoclast structure and function by FAK family kinases. J Leukoc Biol (2012) 0.85
Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2. Traffic (2007) 0.84
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. Genes Cancer (2012) 0.83
GTPase signaling: bridging the GAP between ARF and Rho. Curr Biol (2002) 0.83
Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune cell localization in a mouse model of systemic infection. Infect Immun (2006) 0.81
Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis (2013) 0.81
Role of androgen receptor CAG repeat polymorphism length in hypothalamic progesterone sensitivity in hyperandrogenic adolescent girls. Endocrine (2011) 0.75
There goes the neighborhood. Focus on "localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion". Am J Physiol Cell Physiol (2006) 0.75