Published in Hum Mol Genet on May 29, 2008
Pharmacogenomic discovery using cell-based models. Pharmacol Rev (2009) 1.96
Physiological roles of aquaporin-4 in brain. Physiol Rev (2013) 1.48
Aquaporins: translating bench research to human disease. J Exp Biol (2009) 1.31
Hypoxia-inducible factor-1alpha signaling in aquaporin upregulation after traumatic brain injury. Neurosci Lett (2009) 0.99
Orthogonal array formation by human aquaporin-4: examination of neuromyelitis optica-associated aquaporin-4 polymorphisms. J Neuroimmunol (2011) 0.87
AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury. J Neurotrauma (2014) 0.86
Integrative sequence and tissue expression profiling of chicken and mammalian aquaporins. BMC Genomics (2009) 0.84
Investigating the genetic role of aquaporin4 gene in migraine. J Headache Pain (2009) 0.82
The pathophysiology of repetitive concussive traumatic brain injury in experimental models; new developments and open questions. Mol Cell Neurosci (2015) 0.80
Posterior reversible encephalopathy syndrome is not associated with mutations in aquaporin-4. Neurol Genet (2015) 0.75
No association of AQP4 polymorphisms with neuromyelitis optica and multiple sclerosis. Transl Neurosci (2016) 0.75
Hyponatraemic encephalopathy: an unusual stroke mimic. BMJ Case Rep (2015) 0.75
Genetic analysis of the aquaporin-4 gene for anti-AQP4 antibody-positive neuromyelitis optica in a Japanese population. Jpn J Ophthalmol (2016) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. Genetics (1964) 35.22
Predicting deleterious amino acid substitutions. Genome Res (2001) 28.95
A tutorial on statistical methods for population association studies. Nat Rev Genet (2006) 12.49
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med (2000) 6.27
SNPs, protein structure, and disease. Hum Mutat (2001) 6.14
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Performance evaluation of amino acid substitution matrices. Proteins (1993) 4.46
The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. J Biol Chem (1993) 3.80
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci U S A (1994) 3.20
Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. Nature (1997) 3.10
Prediction of protein stability changes for single-site mutations using support vector machines. Proteins (2006) 3.00
Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proc Natl Acad Sci U S A (2001) 2.88
Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q. Nat Genet (2000) 2.77
Molecular structure of the water channel through aquaporin CHIP. The hourglass model. J Biol Chem (1994) 2.65
Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes. J Biol Chem (1997) 2.56
Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1. Neuroscience (2004) 2.54
Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol (2005) 2.50
Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci (2005) 2.48
The three-dimensional structure of aquaporin-1. Nature (1997) 2.28
Heterotetrameric composition of aquaporin-4 water channels. Biochemistry (1999) 2.05
Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochim Biophys Acta (2006) 2.03
Functional reconstitution of the isolated erythrocyte water channel CHIP28. J Biol Chem (1992) 1.85
Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus. J Am Soc Nephrol (2005) 1.49
Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport (2004) 1.38
Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes. EMBO J (2001) 1.35
Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing. J Clin Invest (1995) 1.32
Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine. Am J Physiol Renal Physiol (2002) 1.31
Water permeability measurement in living cells and complex tissues. J Membr Biol (2000) 1.30
New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB J (2005) 1.28
Functional genomics of membrane transporters in human populations. Genome Res (2005) 1.27
Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus. Hum Mol Genet (2002) 1.18
Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis, Crohn's disease and infectious colitis. Cell Tissue Res (2004) 1.14
Selected cysteine point mutations confer mercurial sensitivity to the mercurial-insensitive water channel MIWC/AQP-4. Biochemistry (1996) 1.11
Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy. Acta Neuropathol (2004) 1.10
Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells. J Biol Chem (2003) 1.09
Bilateral congenital cataracts result from a gain-of-function mutation in the gene for aquaporin-0 in mice. Genomics (2003) 1.06
Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol (2000) 1.05
Aquaporin-mediated fluid regulation in the inner ear. Cell Mol Neurobiol (2003) 1.04
Functional water channels are present in clathrin-coated vesicles from bovine kidney but not from brain. J Biol Chem (1989) 1.02
Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families. J Clin Endocrinol Metab (2002) 1.00
Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. Biochim Biophys Acta (2003) 0.97
Reduced aquaporin 4 expression in the muscle plasma membrane of patients with Duchenne muscular dystrophy. Arch Neurol (2002) 0.96
Absence of aquaporin-4 expression in lesions of neuromyelitis optica but increased expression in multiple sclerosis lesions and normal-appearing white matter. Acta Neuropathol (2006) 0.95
An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. J Biol Chem (2000) 0.95
Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesis. J Neurovirol (2005) 0.93
Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response. Hum Mol Genet (1997) 0.93
Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation. Neurobiol Aging (2007) 0.92
Aquaporin 4 expression in the mammalian inner ear and its role in hearing. Biochem Biophys Res Commun (2002) 0.91
Isolation and functional analysis of alternative promoters in the human aquaporin-4 water channel gene. Genomics (1998) 0.91
A 76-bp deletion in the Mip gene causes autosomal dominant cataract in Hfi mice. Genomics (2001) 0.88
Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes. Hum Mutat (2002) 0.86
Novel mutations underlying nephrogenic diabetes insipidus in Arab families. Genet Med (2006) 0.84
A role of the C-terminus of aquaporin 4 in its membrane expression in cultured astrocytes. Genes Cells (2002) 0.80
Autosomal recessive nephrogenic diabetes insipidus caused by an aquaporin-2 mutation. J Clin Endocrinol Metab (1997) 0.79
Membrane transporters in drug development. Nat Rev Drug Discov (2010) 8.56
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest (2007) 4.47
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J (2004) 3.80
Classification of traumatic brain injury for targeted therapies. J Neurotrauma (2008) 3.58
Very early administration of progesterone for acute traumatic brain injury. N Engl J Med (2014) 3.20
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res (2011) 2.52
Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci (2005) 2.48
Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation. J Neurotrauma (2007) 2.39
Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia (2006) 2.39
Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res (2006) 2.37
Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med (2008) 2.34
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat Rev Drug Discov (2007) 2.32
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol (2009) 2.20
Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring. J Neurotrauma (2007) 2.15
The concentrative nucleoside transporter family, SLC28. Pflugers Arch (2003) 2.06
Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury. Brain (2008) 2.06
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A (2003) 2.03
IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway. Nat Immunol (2012) 2.00
Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol (2003) 1.99
K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods (2005) 1.98
Pharmacogenomics: challenges and opportunities. Ann Intern Med (2006) 1.96
Aquaporin-4-deficient mice have increased extracellular space without tortuosity change. J Neurosci (2008) 1.87
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics (2003) 1.79
Coagulopathy after traumatic brain injury. Neurosurgery (2012) 1.78
Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J (2006) 1.72
Clinical trials in traumatic brain injury: past experience and current developments. Neurotherapeutics (2010) 1.69
Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J (2004) 1.68
Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds. J Neurotrauma (2007) 1.67
Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds. J Neurotrauma (2007) 1.67
cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A (2008) 1.62
Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports. Surg Neurol (2008) 1.57
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics (2002) 1.57
Resting state magnetoencephalography functional connectivity in traumatic brain injury. J Neurosurg (2013) 1.56
Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury. J Neurosurg (2008) 1.55
Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury. Ann Neurol (2012) 1.55
Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care (2010) 1.55
Survival with good outcome after cerebral herniation and Duret hemorrhage caused by traumatic brain injury. J Neurosurg (2009) 1.55
Role of aquaporin-4 in cerebral edema and stroke. Handb Exp Pharmacol (2009) 1.54
Early management of severe traumatic brain injury. Lancet (2012) 1.52
Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study. J Neurotrauma (2013) 1.51
Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. J Neurochem (2005) 1.51
Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research. J Neurotrauma (2011) 1.50
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenet Genomics (2010) 1.48
Temporizing treatment of hyperacute subdural hemorrhage by subdural evacuation port system placement. J Neurosurg (2011) 1.48
Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. J Pharm Sci (2006) 1.48
Transcranial motor evoked potential recording in a case of Kernohan's notch syndrome: case report. Neurosurgery (2004) 1.48
Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations. Proc Natl Acad Sci U S A (2008) 1.47
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics (2009) 1.46
An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza A antibodies. Cell Host Microbe (2013) 1.46
Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI. J Neurotrauma (2008) 1.42
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab (2006) 1.42
The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial. J Trauma (2004) 1.41
Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein. J Neurotrauma (2013) 1.40
Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma (2006) 1.39
Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther (2006) 1.38
Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport (2004) 1.38
Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics (2012) 1.38
Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J Biol Chem (2008) 1.37
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. J Clin Invest (2010) 1.36
Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins. Mol Cancer Ther (2011) 1.35
Guidelines for the management of severe traumatic brain injury. XIII. Antiseizure prophylaxis. J Neurotrauma (2007) 1.34
Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther (2007) 1.33
New approaches to physiological informatics in neurocritical care. Neurocrit Care (2007) 1.33
Pregnancy-related vertebral hemangioma. Case report, review of the literature, and management algorithm. Neurosurg Focus (2005) 1.31
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem (2011) 1.30
Renal transporters in drug development. Annu Rev Pharmacol Toxicol (2012) 1.30
Comparison of human solute carriers. Protein Sci (2010) 1.29
Guidelines for the management of severe traumatic brain injury. XIV. Hyperventilation. J Neurotrauma (2007) 1.29
Estimating the contribution of genes and environment to variation in renal drug clearance. Pharmacogenetics (2003) 1.29
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A (2011) 1.29
Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury. J Neurotrauma (2013) 1.28
Functional genomics of membrane transporters in human populations. Genome Res (2005) 1.27
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res (2011) 1.26
Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy. J Neurotrauma (2007) 1.26
Creating and evaluating genetic tests predictive of drug response. Nat Rev Drug Discov (2008) 1.24
Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharm Res (2002) 1.24
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nat Immunol (2013) 1.24
Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds. J Neurotrauma (2007) 1.24
Bypass surgery for complex brain aneurysms: an assessment of intracranial-intracranial bypass. Neurosurgery (2009) 1.24
Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. J Neurotrauma (2011) 1.23
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. J Pharmacol Exp Ther (2008) 1.23
Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology. J Neurotrauma (2007) 1.21
Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB J (2008) 1.19
Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J (2009) 1.18
Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. FASEB J (2007) 1.17
Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci (2010) 1.17
Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial. J Trauma (2005) 1.16
Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma (2007) 1.16
GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma (2013) 1.15
The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol (2005) 1.15
Axial mechanical properties of fresh human cerebral blood vessels. J Biomech Eng (2003) 1.14
Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention. J Immunol (2002) 1.12
Volumetric proton spectroscopic imaging of mild traumatic brain injury. AJNR Am J Neuroradiol (2004) 1.12
Expression of the aquaporin-1 water channel in human glial tumors. Neurosurgery (2005) 1.11
Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase. Pharmacogenet Genomics (2010) 1.10
Common data elements for research on traumatic brain injury and psychological health: current status and future development. Arch Phys Med Rehabil (2010) 1.08