Comparison of human solute carriers.

PubWeight™: 1.29‹?› | Rank: Top 10%

🔗 View Article (PMC 2866268)

Published in Protein Sci on March 01, 2010

Authors

Avner Schlessinger1, Pär Matsson, James E Shima, Ursula Pieper, Sook Wah Yee, Libusha Kelly, Leonard Apeltsin, Robert M Stroud, Thomas E Ferrin, Kathleen M Giacomini, Andrej Sali

Author Affiliations

1: Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California. schles@salilab.org

Articles citing this

ModBase, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2010) 2.96

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics (2013) 2.53

Crystal structure of a eukaryotic phosphate transporter. Nature (2013) 1.60

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A (2011) 1.29

Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc Natl Acad Sci U S A (2012) 1.19

Improving the quality of protein similarity network clustering algorithms using the network edge weight distribution. Bioinformatics (2010) 1.09

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A (2013) 1.06

Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol (2013) 1.05

SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov (2015) 1.02

An ovary transcriptome for all maturational stages of the striped bass (Morone saxatilis), a highly advanced perciform fish. BMC Res Notes (2012) 0.98

Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr Top Med Chem (2013) 0.95

Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters. Nat Commun (2014) 0.94

A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol (2013) 0.93

Adaptation to Low Salinity Promotes Genomic Divergence in Atlantic Cod (Gadus morhua L.). Genome Biol Evol (2015) 0.89

Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective. AAPS J (2012) 0.89

SLC classification: an update. Clin Pharmacol Ther (2013) 0.88

The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2-positive breast tumors. BMC Cancer (2012) 0.82

The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis. PLoS One (2016) 0.81

Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes. Biology (Basel) (2013) 0.79

SLC Transporters: Structure, Function, and Drug Discovery. Medchemcomm (2016) 0.79

Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake. Pharmacol Res Perspect (2014) 0.78

Computational modeling to predict the functions and impact of drug transporters. In Silico Pharmacol (2015) 0.77

Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening. ACS Chem Biol (2016) 0.76

The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake. J Mol Neurosci (2016) 0.76

Efficacy of Resistance to Francisella Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection. Front Immunol (2017) 0.75

Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer. PLoS Genet (2016) 0.75

Gene expression related to oxidative stress in the heart of mice after intestinal ischemia. Arq Bras Cardiol (2013) 0.75

SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. J Immunol (2017) 0.75

Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Open Biol (2017) 0.75

Community detection in sequence similarity networks based on attribute clustering. PLoS One (2017) 0.75

Articles cited by this

(truncated to the top 100)

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res (2004) 168.89

Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76

SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol (1995) 74.88

Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61

A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81

Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins (1991) 32.50

An efficient algorithm for large-scale detection of protein families. Nucleic Acids Res (2002) 25.81

Ensembl 2009. Nucleic Acids Res (2008) 25.38

The Jalview Java alignment editor. Bioinformatics (2004) 21.74

Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2001) 19.13

The relation between the divergence of sequence and structure in proteins. EMBO J (1986) 16.66

The universal protein resource (UniProt). Nucleic Acids Res (2007) 16.33

MEME: discovering and analyzing DNA and protein sequence motifs. Nucleic Acids Res (2006) 15.32

A hidden Markov model for predicting transmembrane helices in protein sequences. Proc Int Conf Intell Syst Mol Biol (1998) 14.18

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature (2005) 12.56

Protein structure prediction and structural genomics. Science (2001) 11.76

GenBank. Nucleic Acids Res (2009) 11.11

Structure and mechanism of the lactose permease of Escherichia coli. Science (2003) 10.57

Twilight zone of protein sequence alignments. Protein Eng (1999) 9.83

Statistical potential for assessment and prediction of protein structures. Protein Sci (2006) 8.98

Neurobiology of depression. Neuron (2002) 8.56

Docking and scoring in virtual screening for drug discovery: methods and applications. Nat Rev Drug Discov (2004) 8.10

Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science (2003) 7.96

Simple allosteric model for membrane pumps. Nature (1966) 7.78

Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships. Proc Natl Acad Sci U S A (1998) 7.18

Phylogenomics: improving functional predictions for uncharacterized genes by evolutionary analysis. Genome Res (1998) 6.45

Enzyme function less conserved than anticipated. J Mol Biol (2002) 6.07

Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature (2004) 6.02

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet (2008) 5.93

OPM: orientations of proteins in membranes database. Bioinformatics (2006) 5.87

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77

A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev (2000) 5.65

The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science (2008) 4.94

Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics (2004) 4.88

A competitive inhibitor traps LeuT in an open-to-out conformation. Science (2008) 4.86

Virtual screening of chemical libraries. Nature (2004) 4.84

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest (2007) 4.47

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature (2007) 4.29

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol Cell (2008) 4.29

Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature (2003) 4.27

The Transporter Classification Database: recent advances. Nucleic Acids Res (2008) 4.26

Large-scale protein structure modeling of the Saccharomyces cerevisiae genome. Proc Natl Acad Sci U S A (1998) 4.17

Empirical statistical estimates for sequence similarity searches. J Mol Biol (1998) 4.14

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (2007) 4.08

The HUGO Gene Nomenclature Committee (HGNC). Hum Genet (2001) 3.89

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch (2003) 3.76

Lessons from lactose permease. Annu Rev Biophys Biomol Struct (2006) 3.69

Tools for comparative protein structure modeling and analysis. Nucleic Acids Res (2003) 3.68

Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science (2008) 3.39

Structure and mechanism of a Na+-independent amino acid transporter. Science (2009) 3.30

Phylogenetic analysis using PHYLIP. Methods Mol Biol (2000) 3.27

Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP. Nature (2009) 3.27

Mechanism for alternating access in neurotransmitter transporters. Proc Natl Acad Sci U S A (2008) 3.24

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23

Unlocking the molecular secrets of sodium-coupled transporters. Nature (2009) 3.23

The cellular neurobiology of depression. Nat Med (2001) 3.19

Using sequence similarity networks for visualization of relationships across diverse protein superfamilies. PLoS One (2009) 3.03

Moonlighting proteins: old proteins learning new tricks. Trends Genet (2003) 2.97

Structure of the multidrug transporter EmrD from Escherichia coli. Science (2006) 2.93

Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. EMBO J (2006) 2.92

SLC2A9 is a high-capacity urate transporter in humans. PLoS Med (2008) 2.87

Annotation transfer for genomics: measuring functional divergence in multi-domain proteins. Genome Res (2001) 2.81

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther (2007) 2.80

The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72

The SLC2 family of facilitated hexose and polyol transporters. Pflugers Arch (2003) 2.58

Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Nature (2009) 2.53

The generation of new protein functions by the combination of domains. Structure (2007) 2.51

Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch (2003) 2.45

Structure and mechanism of an amino acid antiporter. Science (2009) 2.40

Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res (2006) 2.37

Identification of a chloride ion binding site in Na+/Cl -dependent transporters. Proc Natl Acad Sci U S A (2007) 2.32

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25

Structure and function of Na(+)-symporters with inverted repeats. Curr Opin Struct Biol (2009) 2.10

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A (2003) 2.03

MODBASE, a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res (2008) 2.02

Neurotransmitter transporters: molecular function of important drug targets. Trends Pharmacol Sci (2006) 2.01

A brighter future for protein structure prediction. Nat Struct Biol (1999) 1.93

On the accuracy of homology modeling and sequence alignment methods applied to membrane proteins. Biophys J (2006) 1.79

Organic cation transporters. Rev Physiol Biochem Pharmacol (2003) 1.77

Critical review of the role of HTS in drug discovery. Drug Discov Today (2006) 1.58

Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation. J Am Chem Soc (2008) 1.50

Beyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery. Drug Discov Today (2005) 1.46

GAT1 (GABA:Na+:Cl-) cotransport function. Database reconstruction with an alternating access model. J Gen Physiol (1999) 1.46

What are artificial neural networks? Nat Biotechnol (2008) 1.43

Lactose permease as a paradigm for membrane transport proteins (Review). Mol Membr Biol (2004) 1.43

Alignment of multiple protein structures based on sequence and structure features. Protein Eng Des Sel (2009) 1.43

The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett (2008) 1.34

Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications. J Biol Chem (2007) 1.32

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem (2008) 1.32

An approach to membrane protein structure without crystals. Proc Natl Acad Sci U S A (2002) 1.28

A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. Mol Membr Biol (2007) 1.27

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. Chem Commun (Camb) (2009) 1.21

Membrane protein prediction methods. Methods (2007) 1.17

Secret life of genes. Nature (2002) 1.12

Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics (2007) 1.09

Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease. J Mol Biol (2006) 1.09

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philos Trans R Soc Lond B Biol Sci (2006) 1.08

Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). J Pharmacol Exp Ther (2000) 1.06

Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease. J Mol Biol (2006) 1.04

Articles by these authors

UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47

Statistical potential for assessment and prediction of protein structures. Protein Sci (2006) 8.98

Membrane transporters in drug development. Nat Rev Drug Discov (2010) 8.56

Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol (2003) 7.15

The molecular architecture of the nuclear pore complex. Nature (2007) 6.93

Protein structure modeling with MODELLER. Methods Mol Biol (2008) 6.28

Comparative protein structure modeling using MODELLER. Curr Protoc Protein Sci (2007) 5.81

Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science (2002) 5.78

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77

Visualizing density maps with UCSF Chimera. J Struct Biol (2006) 5.75

Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Science (2004) 5.42

Determining the architectures of macromolecular assemblies. Nature (2007) 4.94

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res (2003) 4.83

MODBASE, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2004) 4.54

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest (2007) 4.47

Outcome of the first electron microscopy validation task force meeting. Structure (2012) 4.35

On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25

Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell (2008) 4.00

Protein production and purification. Nat Methods (2008) 3.97

FoXS: a web server for rapid computation and fitting of SAXS profiles. Nucleic Acids Res (2010) 3.91

The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87

Postmeiotic sex chromatin in the male germline of mice. Curr Biol (2006) 3.80

Global landscape of HIV-human protein complexes. Nature (2011) 3.70

Tools for comparative protein structure modeling and analysis. Nucleic Acids Res (2003) 3.68

MODBASE: a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res (2006) 3.56

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A (2012) 3.42

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40

ModLoop: automated modeling of loops in protein structures. Bioinformatics (2003) 3.31

The molecular sociology of the cell. Nature (2007) 3.23

Protein structure fitting and refinement guided by cryo-EM density. Structure (2008) 3.12

Designed divergent evolution of enzyme function. Nature (2006) 3.09

LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources. Bioinformatics (2005) 3.05

Study of the structural dynamics of the E coli 70S ribosome using real-space refinement. Cell (2003) 3.03

Using sequence similarity networks for visualization of relationships across diverse protein superfamilies. PLoS One (2009) 3.03

Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90. Structure (2008) 2.98

ModBase, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2010) 2.96

Statistical potentials for fold assessment. Protein Sci (2002) 2.92

Substrate twinning activates the signal recognition particle and its receptor. Nature (2004) 2.91

Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol (2004) 2.90

Alignment of protein sequences by their profiles. Protein Sci (2004) 2.80

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature (2011) 2.71

The channel architecture of aquaporin 0 at a 2.2-A resolution. Proc Natl Acad Sci U S A (2004) 2.69

Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database. Biochemistry (2006) 2.65

Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov (2008) 2.58

clusterMaker: a multi-algorithm clustering plugin for Cytoscape. BMC Bioinformatics (2011) 2.56

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res (2011) 2.52

EVA: Evaluation of protein structure prediction servers. Nucleic Acids Res (2003) 2.50

Comparative protein structure modeling by iterative alignment, model building and model assessment. Nucleic Acids Res (2003) 2.44

The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure (2006) 2.40

PIBASE: a comprehensive database of structurally defined protein interfaces. Bioinformatics (2005) 2.39

Reliability of assessment of protein structure prediction methods. Structure (2002) 2.39

Tools for integrated sequence-structure analysis with UCSF Chimera. BMC Bioinformatics (2006) 2.38

Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res (2006) 2.37

Putting the pieces together: integrative modeling platform software for structure determination of macromolecular assemblies. PLoS Biol (2012) 2.37

Simple fold composition and modular architecture of the nuclear pore complex. Proc Natl Acad Sci U S A (2006) 2.35

Integrating diverse data for structure determination of macromolecular assemblies. Annu Rev Biochem (2008) 2.35

A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics (2011) 2.34

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat Rev Drug Discov (2007) 2.32

Outcome of a workshop on archiving structural models of biological macromolecules. Structure (2006) 2.32

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proc Natl Acad Sci U S A (2009) 2.28

Androgens regulate the permeability of the blood-testis barrier. Proc Natl Acad Sci U S A (2005) 2.25

Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments. Environ Microbiol (2010) 2.23

Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol (2009) 2.20

Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol (2005) 2.18

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A (2010) 2.18

Comparative Protein Structure Modeling Using MODELLER. Curr Protoc Bioinformatics (2014) 2.17

The C-type lectin fold as an evolutionary solution for massive sequence variation. Nat Struct Mol Biol (2005) 2.13

Software extensions to UCSF chimera for interactive visualization of large molecular assemblies. Structure (2005) 2.12

Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z. PLoS Biol (2003) 2.11

Structure of the mammalian 80S ribosome at 8.7 A resolution. Structure (2008) 2.11

Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat Chem Biol (2011) 2.10

UCSF Chimera, MODELLER, and IMP: an integrated modeling system. J Struct Biol (2011) 2.10

The concentrative nucleoside transporter family, SLC28. Pflugers Arch (2003) 2.06

Refinement of protein structures by iterative comparative modeling and CryoEM density fitting. J Mol Biol (2006) 2.06

Outcome of a workshop on applications of protein models in biomedical research. Structure (2009) 2.05

Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies. J Mol Biol (2008) 2.05

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A (2003) 2.03

Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics (2012) 2.03

MODBASE, a database of annotated comparative protein structure models and associated resources. Nucleic Acids Res (2008) 2.02

MODBASE, a database of annotated comparative protein structure models. Nucleic Acids Res (2002) 2.01

ModView, visualization of multiple protein sequences and structures. Bioinformatics (2003) 1.99

A structural perspective on protein-protein interactions. Curr Opin Struct Biol (2004) 1.98

Pharmacogenomics: challenges and opportunities. Ann Intern Med (2006) 1.96