Published in Crit Care on February 02, 2010
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Novel integration of hospital electronic medical records and gene expression measurements to identify genetic markers of maturation. Pac Symp Biocomput (2008) 1.27
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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
Clinical assessment incorporating a personal genome. Lancet (2010) 10.18
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Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics (2002) 7.07
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Performance comparison of whole-genome sequencing platforms. Nat Biotechnol (2011) 5.79
Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med (2011) 5.30
Cell type-specific gene expression differences in complex tissues. Nat Methods (2010) 4.75
An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One (2010) 4.42
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J (2004) 3.80
Classification of traumatic brain injury for targeted therapies. J Neurotrauma (2008) 3.58
FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell (2009) 3.54
Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 3.27
Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol (2010) 3.23
Very early administration of progesterone for acute traumatic brain injury. N Engl J Med (2014) 3.20
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
Challenges in the clinical application of whole-genome sequencing. Lancet (2010) 2.92
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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol (2005) 2.68
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell (2008) 2.67
Computerized recruiting for clinical trials in real time. Ann Emerg Med (2003) 2.59
Exploiting drug-disease relationships for computational drug repositioning. Brief Bioinform (2011) 2.52
Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics (2004) 2.51
Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int (2011) 2.50
Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci (2005) 2.48
AILUN: reannotating gene expression data automatically. Nat Methods (2007) 2.47
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov (2013) 2.46
MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44
Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol (2012) 2.42
Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation. J Neurotrauma (2007) 2.39
Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia (2006) 2.39
Translational bioinformatics: linking knowledge across biological and clinical realms. J Am Med Inform Assoc (2011) 2.36
Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med (2008) 2.34
Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet (2010) 2.24
Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics (2003) 2.20
A nutrient-wide association study on blood pressure. Circulation (2012) 2.19
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16
Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring. J Neurotrauma (2007) 2.15
Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One (2010) 2.10
Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury. Brain (2008) 2.06
Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet (2012) 2.02
Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol (2003) 1.99
K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods (2005) 1.98
Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet (2009) 1.96
Disease signatures are robust across tissues and experiments. Mol Syst Biol (2009) 1.93
Defining the limits of resuscitative emergency department thoracotomy: a contemporary Western Trauma Association perspective. J Trauma (2011) 1.91
Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell (2004) 1.87
Aquaporin-4-deficient mice have increased extracellular space without tortuosity change. J Neurosci (2008) 1.87
In silico research in the era of cloud computing. Nat Biotechnol (2010) 1.81
Coagulopathy after traumatic brain injury. Neurosurgery (2012) 1.78
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J (2006) 1.72
Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis. Diabetes Care (2013) 1.70
Clinical trials in traumatic brain injury: past experience and current developments. Neurotherapeutics (2010) 1.69
Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int (2009) 1.68
Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J (2004) 1.68
Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds. J Neurotrauma (2007) 1.67
Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds. J Neurotrauma (2007) 1.67
Splenic embolization revisited: a multicenter review. J Trauma (2004) 1.64
Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg (2004) 1.62
Translational bioinformatics in the cloud: an affordable alternative. Genome Med (2010) 1.61
Enabling integrative genomic analysis of high-impact human diseases through text mining. Pac Symp Biocomput (2008) 1.61
FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease. Genome Biol (2008) 1.58
Management of patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trial. J Trauma (2009) 1.57
Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports. Surg Neurol (2008) 1.57
Profile of mothers at risk: an analysis of injury and pregnancy loss in 1,195 trauma patients. J Am Coll Surg (2005) 1.56
Resting state magnetoencephalography functional connectivity in traumatic brain injury. J Neurosurg (2013) 1.56
Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury. J Neurosurg (2008) 1.55
Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury. Ann Neurol (2012) 1.55
Survival with good outcome after cerebral herniation and Duret hemorrhage caused by traumatic brain injury. J Neurosurg (2009) 1.55
Predicting environmental chemical factors associated with disease-related gene expression data. BMC Med Genomics (2010) 1.55
Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet (2012) 1.55
Role of aquaporin-4 in cerebral edema and stroke. Handb Exp Pharmacol (2009) 1.54
The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury. J Trauma (2003) 1.52
Early management of severe traumatic brain injury. Lancet (2012) 1.52
Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study. J Neurotrauma (2013) 1.51
Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. J Neurochem (2005) 1.51
Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research. J Neurotrauma (2011) 1.50
Serum levels of Hsp 72 measured early after trauma correlate with survival. J Trauma (2002) 1.49
Transcranial motor evoked potential recording in a case of Kernohan's notch syndrome: case report. Neurosurgery (2004) 1.48
Temporizing treatment of hyperacute subdural hemorrhage by subdural evacuation port system placement. J Neurosurg (2011) 1.48
ImmPort: disseminating data to the public for the future of immunology. Immunol Res (2014) 1.48
Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Hum Genet (2013) 1.48
Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proc Natl Acad Sci U S A (2009) 1.47
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation. J Exp Med (2013) 1.47
Emergency traumatologist or trauma and acute care surgeon: decision time. J Am Coll Surg (2009) 1.46
Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI. J Neurotrauma (2008) 1.42
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab (2006) 1.42
Blood doping in the surgical intensive care unit. Surgery (2006) 1.41
The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial. J Trauma (2004) 1.41
Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein. J Neurotrauma (2013) 1.40
Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma (2006) 1.39
Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport (2004) 1.38