Published in Science on August 18, 2000
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol (2010) 4.50
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Interplay between antibacterial effectors: a macrophage antimicrobial peptide impairs intracellular Salmonella replication. Proc Natl Acad Sci U S A (2004) 2.00
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev (2010) 1.97
Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest (2004) 1.75
Neutrophil elastase in cyclic and severe congenital neutropenia. Blood (2006) 1.74
Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life. PLoS One (2008) 1.67
Myeloperoxidase: a front-line defender against phagocytosed microorganisms. J Leukoc Biol (2012) 1.60
Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. J Leukoc Biol (2015) 1.51
Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing. J Immunol (2008) 1.48
Macrophage elastase kills bacteria within murine macrophages. Nature (2009) 1.42
Lung injury following acute kidney injury: kidney-lung crosstalk. Clin Exp Nephrol (2011) 1.38
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection. J Exp Med (2007) 1.37
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS Pathog (2006) 1.35
Antimicrobial peptides: old molecules with new ideas. J Invest Dermatol (2011) 1.34
Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol (2009) 1.30
Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol (2008) 1.27
Entry and intracellular replication of Escherichia coli K1 in macrophages require expression of outer membrane protein A. Infect Immun (2003) 1.16
ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology. Hematol Oncol Clin North Am (2012) 1.14
Importance of lysosomal cysteine proteases in lung disease. Respir Res (2000) 1.13
Neutrophil serine proteases fine-tune the inflammatory response. Int J Biochem Cell Biol (2007) 1.12
The signaling pathway involved in neutrophil elastase stimulated MUC1 transcription. Am J Respir Cell Mol Biol (2007) 1.11
Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease. Proc Am Thorac Soc (2005) 1.08
Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. Infect Immun (2011) 1.06
Neutrophil serine proteases promote IL-1β generation and injury in necrotizing crescentic glomerulonephritis. J Am Soc Nephrol (2012) 1.06
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PLoS One (2011) 1.06
The major cold shock gene, cspA, is involved in the susceptibility of Staphylococcus aureus to an antimicrobial peptide of human cathepsin G. Infect Immun (2003) 1.05
The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J (2004) 1.05
NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Front Immunol (2013) 1.04
Inhibition of apoptosis by Escherichia coli K1 is accompanied by increased expression of BclXL and blockade of mitochondrial cytochrome c release in macrophages. Infect Immun (2004) 1.00
Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells. J Biol Chem (2012) 0.98
Klebsiella pneumoniae outer membrane protein A is required to prevent the activation of airway epithelial cells. J Biol Chem (2011) 0.98
Neutrophil elastase, an innate immunity effector molecule, represses flagellin transcription in Pseudomonas aeruginosa. Infect Immun (2006) 0.97
An engineered innate immune defense protects grapevines from Pierce disease. Proc Natl Acad Sci U S A (2012) 0.97
Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. Antimicrob Agents Chemother (2008) 0.96
Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors. Proc Natl Acad Sci U S A (2014) 0.95
Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy. Am J Pathol (2010) 0.95
Outer membrane protein A (OmpA) of Shigella flexneri 2a, induces protective immune response in a mouse model. PLoS One (2011) 0.94
The inflammatory response to miniaturised extracorporeal circulation: a review of the literature. Mediators Inflamm (2010) 0.94
Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. J Periodontal Res (2009) 0.91
Protecting the boundary: the sentinel role of host defense peptides in the skin. Cell Mol Life Sci (2011) 0.89
Role of wall teichoic acids in Staphylococcus aureus endophthalmitis. Invest Ophthalmol Vis Sci (2011) 0.89
Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function. Biochimie (2010) 0.88
A DNA methylation network interaction measure, and detection of network oncomarkers. PLoS One (2014) 0.86
Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli. PLoS One (2011) 0.86
Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia. J Biol Chem (2012) 0.85
Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils. J Innate Immun (2013) 0.84
The role of nitrite ion in phagocyte function--perspectives and puzzles. Arch Biochem Biophys (2009) 0.84
Neutrophil serine proteases in antibacterial defense. Curr Opin Microbiol (2014) 0.84
Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. Mucosal Immunol (2014) 0.83
A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense. Curr Respir Med Rev (2006) 0.83
Differences in the gene expression profiles of haemocytes from schistosome-susceptible and -resistant biomphalaria glabrata exposed to Schistosoma mansoni excretory-secretory products. PLoS One (2014) 0.83
The role of short-chain conjugated poly-(R)-3-hydroxybutyrate (cPHB) in protein folding. Int J Mol Sci (2013) 0.81
Differentially expressed outer membrane proteins of Vibrio alginolyticus in response to six types of antibiotics. Mar Biotechnol (NY) (2010) 0.80
Differential expression of long non-coding RNAs in three genetic lines of rainbow trout in response to infection with Flavobacterium psychrophilum. Sci Rep (2016) 0.79
Loss of O-antigen increases cell shape abnormalities in penicillin-binding protein mutants of Escherichia coli. FEMS Microbiol Lett (2006) 0.79
With Friends Like These: The Complex Role of Neutrophils in the Progression of Severe Pneumonia. Front Cell Infect Microbiol (2017) 0.78
Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells. Self Nonself (2011) 0.78
Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling. Mol Med Rep (2016) 0.77
Regulation of apoptosis and priming of neutrophil oxidative burst by diisopropyl fluorophosphate. J Inflamm (Lond) (2010) 0.77
Neutrophils Contribute to the Protection Conferred by ArtinM against Intracellular Pathogens: A Study on Leishmania major. PLoS Negl Trop Dis (2016) 0.76
Allelic Variation in Outer Membrane Protein A and Its Influence on Attachment of Escherichia coli to Corn Stover. Front Microbiol (2017) 0.75
Evading pre-existing anti-hinge antibody binding by hinge engineering. MAbs (2016) 0.75
Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium. Respir Res (2016) 0.75
Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice. Am J Respir Cell Mol Biol (2012) 0.75
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors. Bioorg Med Chem Lett (2013) 0.75
The Burkholderia cenocepacia OmpA-like protein BCAL2958: identification, characterization, and detection of anti-BCAL2958 antibodies in serum from B. cepacia complex-infected Cystic Fibrosis patients. AMB Express (2016) 0.75
Identification of α1-Antitrypsin as a Potential Candidate for Internal Control for Human Synovial Fluid in Western Blot. Rheumatology (Sunnyvale) (2015) 0.75
Pharmacological Stimulation of Phagocytosis Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model of ATTR Neuropathy. Front Mol Neurosci (2017) 0.75
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science (1997) 8.19
Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J (2003) 6.23
Disseminated Kaposi's sarcoma in homosexual men. Ann Intern Med (1982) 4.98
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest (2000) 4.90
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med (1999) 4.85
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest (2000) 4.16
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med (1998) 4.04
Functional dissection and sequence of yeast HAP1 activator. Cell (1989) 3.56
Outer membrane protein A of Escherichia coli contributes to invasion of brain microvascular endothelial cells. Infect Immun (1996) 3.53
Selective expression of adhesion molecules on human brain microvascular endothelial cells. J Neuroimmunol (1997) 3.22
Mycobacterium. Bacteriol Rev (1977) 3.20
Purification and properties of staphylococcal delta hemolysin. Infect Immun (1971) 3.19
Dexamethasone therapy for children with bacterial meningitis. Meningitis Study Group. Pediatrics (1995) 2.98
Anaerobic degradation of toluene by a denitrifying bacterium. Appl Environ Microbiol (1991) 2.98
Invasion of brain microvascular endothelial cells by group B streptococci. Infect Immun (1997) 2.97
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc Natl Acad Sci U S A (1996) 2.93
Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10. Infect Immun (1995) 2.91
Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol (2000) 2.90
Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc Natl Acad Sci U S A (1999) 2.80
K-ras activation generates an inflammatory response in lung tumors. Oncogene (2006) 2.78
Human 92- and 72-kilodalton type IV collagenases are elastases. J Biol Chem (1991) 2.71
Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. Circ Res (2000) 2.66
Infection of Phaseolus vulgaris by bean golden mosaic virus: ultrastructural aspects. Virology (1978) 2.64
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell (2000) 2.49
Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J Clin Invest (1998) 2.43
Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol Pharmacol (2001) 2.38
Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med (2000) 2.36
Importance of bacterial growth phase in determining minimal bactericidal concentrations of penicillin and methicillin. Antimicrob Agents Chemother (1981) 2.35
Retracted Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature (2000) 2.31
Acute otitis media due to penicillin-nonsusceptible Streptococcus pneumoniae before and after the introduction of the pneumococcal conjugate vaccine. Clin Infect Dis (2005) 2.28
Mechanical ventilation with or without 7-day circuit changes. A randomized controlled trial. Ann Intern Med (1995) 2.26
Staphylococcal sphingomyelinase (beta-hemolysin). Ann N Y Acad Sci (1974) 2.22
Binding characteristics of S fimbriated Escherichia coli to isolated brain microvascular endothelial cells. Am J Pathol (1994) 2.21
Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflamm Res (2007) 2.21
Matrix metalloproteinases in lung biology. Respir Res (2000) 2.18
A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med (1997) 2.18
Structure-activity relationships of chemokines. J Leukoc Biol (1995) 2.15
A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J Immunol (1997) 2.15
Fractionation of the DD-carboxypeptidase-transpeptidase activities solubilized from membranes of Escherichia coli K12, strain 44. Eur J Biochem (1974) 2.06
Growth of murine cytomegalovirus in various cell lines. J Virol (1971) 2.06
Endothelial cell GlcNAc beta 1-4GlcNAc epitopes for outer membrane protein A enhance traversal of Escherichia coli across the blood-brain barrier. Infect Immun (1996) 2.02
Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. J Biol Chem (1997) 2.00
Importance of medium in demonstrating penicillin tolerance by group B streptococci. Antimicrob Agents Chemother (1979) 1.92
Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc Natl Acad Sci U S A (1996) 1.92
Production and characterization of monoclonal antibodies specific for a glycosylated polypeptide of human cytomegalovirus. J Clin Microbiol (1983) 1.91
Ultrathin single-crystalline silver nanowire arrays formed in an ambient solution phase. Science (2001) 1.90
Molecular location of a species-specific epitope on the hamster scrapie agent protein. J Virol (1991) 1.89
Matrix metalloproteinases generate angiostatin: effects on neovascularization. J Immunol (1998) 1.87
Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am J Pathol (1999) 1.86
Evaluation of a direct blood culture disk diffusion antimicrobial susceptibility test. Antimicrob Agents Chemother (1981) 1.85
Saccharomyces cerevisiae contains two functional citrate synthase genes. Mol Cell Biol (1986) 1.82
Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3. J Biol Chem (2000) 1.82
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy. Nat Med (2001) 1.81
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet (2001) 1.80
Penicillin tolerance in group B streptococci isolated from infected neonates. J Infect Dis (1981) 1.75
Antiviral activity of arildone on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother (1980) 1.75
Nitrogen fixation by symbiotic and free-living spirochetes. Science (2001) 1.75
Mitochondrial and nonmitochondrial citrate synthases in Saccharomyces cerevisiae are encoded by distinct homologous genes. Mol Cell Biol (1986) 1.73
Role of lipopolysaccharide and capsule in the serum resistance of bacteremic strains of Escherichia coli. J Infect Dis (1986) 1.73
Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: development of an immortalized cell line to study pathophysiology of CNS disease. In Vitro Cell Dev Biol Anim (1997) 1.72
Three-year multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use. Pediatrics (1998) 1.69
A role for reactive oxygen species in endothelial cell anoikis. Circ Res (1999) 1.69
Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: InlB-dependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells. Infect Immun (1998) 1.68
A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Hum Gene Ther (2001) 1.68
Physical properties of human Mycoplasma species. J Bacteriol (1966) 1.68
A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol (1999) 1.67
Citrobacter freundii invades and replicates in human brain microvascular endothelial cells. Infect Immun (1999) 1.66
Electron microscopic observations on the nature of vaccinia virus particle aggregation. J Immunol (1966) 1.65
TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier. Mol Med (1997) 1.65
Cerebral lipiodol embolism during transcatheter arterial chemoembolization. Neurology (2004) 1.63
Elastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis. J Biol Chem (1997) 1.62
The kinin-forming and kininase activities of rabbit polymorphonuclear leucocytes. Br J Pharmacol Chemother (1967) 1.61
Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states. Am J Pathol (1998) 1.60
Endotoxin-mediated endothelial cell injury and activation: role of soluble CD14. Infect Immun (1993) 1.59
Analysis of structural polypeptides of purified human cytomegalovirus. J Virol (1976) 1.55
Adhesion of S-fimbriated Escherichia coli to brain glycolipids mediated by sfaA gene-encoded protein of S-fimbriae. J Biol Chem (1993) 1.55
Normal neutrophil function in cathepsin G-deficient mice. Blood (1999) 1.53
The structural basis for the elastolytic activity of the 92-kDa and 72-kDa gelatinases. Role of the fibronectin type II-like repeats. J Biol Chem (1996) 1.53
Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol (1998) 1.52
Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun (2000) 1.52
Identification of Escherichia coli K1 genes contributing to human brain microvascular endothelial cell invasion by differential fluorescence induction. Mol Microbiol (2000) 1.52
Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest (1998) 1.51
Identification and characterization of an Escherichia coli invasion gene locus, ibeB, required for penetration of brain microvascular endothelial cells. Infect Immun (1999) 1.51
Chronic obstructive pulmonary disease * 3: Experimental animal models of pulmonary emphysema. Thorax (2002) 1.51
Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease. Inflamm Res (2005) 1.50
Multiplicity reactivation and radiation survival of aggregated vaccinia virus. Calculation of plaque titer based on MR and particle aggregation seen in the electron microscope. Virology (1966) 1.50
Genital and intestinal carriage of group B streptococci during pregnancy. J Infect Dis (1981) 1.49
Octopine-type Ti plasmids code for a mannopine-inducible dominant-negative allele of traR, the quorum-sensing activator that regulates Ti plasmid conjugal transfer. Mol Microbiol (1998) 1.48
Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am J Pathol (1998) 1.48
A novel flagellar Ca2+-binding protein in trypanosomes. J Biol Chem (1989) 1.47
Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis (2001) 1.46
End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on. Am J Respir Crit Care Med (2001) 1.45
Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling. Biochem J (1999) 1.45
Traversal of Candida albicans across human blood-brain barrier in vitro. Infect Immun (2001) 1.45
Deletions of the long arm of chromosome 10. Am J Med Genet (1985) 1.44
Prevention of clinical and subclinical rubella infection. Efficacy of three HPV-77 derivative vaccines. Am J Dis Child (1969) 1.43
Abortive infection of human diploid cells by murine cytomegalovirus. Infect Immun (1972) 1.43
Invasion of Europe by the western corn rootworm, Diabrotica virgifera virgifera: multiple transatlantic introductions with various reductions of genetic diversity. Mol Ecol (2008) 1.42